ADM2

Functionⁱ

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.1 Publication

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20596610

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
angiogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 20596610
digestion Source: Ensembl
feeding behavior Source: Ensembl
G-protein coupled receptor signaling pathway Source: Reactome
negative regulation of blood pressure Source: Ensembl
positive regulation of angiogenesis
Source: MGI
Inferred from direct assayⁱ
- 19592612
positive regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 20596610
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20596610

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418555 G alpha (s) signalling events R-HSA-419812 Calcitonin-like ligand receptors

Reactomeⁱ

R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADM2 Alternative name(s): Intermedin Cleaved into the following 2 chains: Adrenomedullin-2 Short name: AM2 Alternative name(s): Intermedin-long Short name: IMDL Intermedin-short Short name: IMDS
Gene namesⁱ	Name:ADM2 Synonyms:AM2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128165.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28898 ADM2
MIMⁱ	608682 gene
neXtProtⁱ	NX_Q7Z4H4

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79924
Open Targets More...OpenTargetsⁱ	ENSG00000128165
PharmGKBⁱ	PA134898869

Chemistry databases

ChEMBLⁱ	CHEMBL5267

ChEMBLⁱ

CHEMBL5267

Polymorphism and mutation databases

BioMutaⁱ	ADM2
DMDMⁱ	47115749

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	By similarityAdd BLAST	24
PropeptideⁱPRO_0000000977	25 – 98	By similarityAdd BLAST	74
PeptideⁱPRO_0000000978	101 – 147	Adrenomedullin-2By similarityAdd BLAST	47
PeptideⁱPRO_0000000979	108 – 147	Intermedin-shortSequence analysisAdd BLAST	40

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	110 ↔ 115	By similarity
Modified residueⁱ	147	Tyrosine amideBy similarity		1

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	Q7Z4H4
PeptideAtlas More...PeptideAtlasⁱ	Q7Z4H4
PRIDEⁱ	Q7Z4H4
ProteomicsDBⁱ	69182

PTM databases

PhosphoSitePlusⁱ	Q7Z4H4

PhosphoSitePlusⁱ

Q7Z4H4

Expressionⁱ

Tissue specificityⁱ

Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000128165 Expressed in 87 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_ADM2
Genevisibleⁱ	Q7Z4H4 HS

Interactionⁱ

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123001, 1 interactor
STRINGⁱ	9606.ENSP00000379086

Chemistry databases

BindingDBⁱ

Q7Z4H4

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z4H4
SMRⁱ	Q7Z4H4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the adrenomedullin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J3UK Eukaryota ENOG410Z5UT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064523
HOGENOMⁱ	HOG000033820
HOVERGENⁱ	HBG048691
InParanoidⁱ	Q7Z4H4
OMAⁱ	PAMGHPL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZSV
PhylomeDBⁱ	Q7Z4H4
TreeFamⁱ	TF338591

Family and domain databases

InterProⁱ	View protein in InterPro IPR021116 Calcitonin/adrenomedullin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00214 Calc_CGRP_IAPP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q7Z4H4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARIPTAALG CISLLCLQLP GSLSRSLGGD PRPVKPREPP ARSPSSSLQP 
        60         70         80         90        100
RHPAPRPVVW KLHRALQAQR GAGLAPVMGQ PLRDGGRQHS GPRRHSGPRR 
       110        120        130        140 
TQAQLLRVGC VLGTCQVQNL SHRLWQLMGP AGRQDSAPVD PSSPHSYG

Length:148

Mass (Da):15,865

Last modified:October 1, 2003 - v1

Checksum:ⁱ6E0E3098CFCE5BF2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF529213 mRNA Translation: AAQ09100.1 AB121034 mRNA Translation: BAD07411.1 AB236970 mRNA Translation: BAE46395.1 AL096767 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33682.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001240774.1, NM_001253845.1 XP_016884429.1, XM_017028940.1
UniGeneⁱ	Hs.449099 Hs.743540

Genome annotation databases

Ensemblⁱ	ENST00000395737; ENSP00000379086; ENSG00000128165 ENST00000395738; ENSP00000379087; ENSG00000128165
GeneIDⁱ	79924
KEGGⁱ	hsa:79924
UCSC genome browser More...UCSCⁱ	uc003blj.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z4H4	ADM2 isoform 1		PANTR		148	UniRef90_Q7Z4H4
Uncharacterized protein		GORGO		148
Adrenomedullin 2		MACFA		148
Uncharacterized protein		MACMU		148
Adrenomedullin 2		MACNE		148
+11

Protein	Similar proteins		Species	Score	Length	Source
Q7Z4H4	Adrenomedullin 2		COLAP		148	UniRef50_Q7Z4H4
Adrenomedullin 2		RHIRO		148
Adrenomedullin 2		RHIBE		148
Adrenomedullin 2		PAPAN		148
Adrenomedullin 2		CHLSB		148
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF529213 mRNA Translation: AAQ09100.1 AB121034 mRNA Translation: BAD07411.1 AB236970 mRNA Translation: BAE46395.1 AL096767 Genomic DNA No translation available.
CCDSⁱ	CCDS33682.1
RefSeqⁱ	NP_001240774.1, NM_001253845.1 XP_016884429.1, XM_017028940.1
UniGeneⁱ	Hs.449099 Hs.743540

3D structure databases

ProteinModelPortalⁱ	Q7Z4H4
SMRⁱ	Q7Z4H4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123001, 1 interactor
STRINGⁱ	9606.ENSP00000379086

Chemistry databases

BindingDBⁱ	Q7Z4H4
ChEMBLⁱ	CHEMBL5267

PTM databases

PhosphoSitePlusⁱ	Q7Z4H4

PhosphoSitePlusⁱ

Q7Z4H4

Polymorphism and mutation databases

BioMutaⁱ	ADM2
DMDMⁱ	47115749

Proteomic databases

PaxDbⁱ	Q7Z4H4
PeptideAtlasⁱ	Q7Z4H4
PRIDEⁱ	Q7Z4H4
ProteomicsDBⁱ	69182

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79924
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000395737; ENSP00000379086; ENSG00000128165 ENST00000395738; ENSP00000379087; ENSG00000128165
GeneIDⁱ	79924
KEGGⁱ	hsa:79924
UCSCⁱ	uc003blj.4 human

Organism-specific databases

CTDⁱ	79924
DisGeNETⁱ	79924
EuPathDBⁱ	HostDB:ENSG00000128165.8
GeneCardsⁱ	ADM2
HGNCⁱ	HGNC:28898 ADM2
MIMⁱ	608682 gene
neXtProtⁱ	NX_Q7Z4H4
OpenTargetsⁱ	ENSG00000128165
PharmGKBⁱ	PA134898869
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J3UK Eukaryota ENOG410Z5UT LUCA
GeneTreeⁱ	ENSGT00530000064523
HOGENOMⁱ	HOG000033820
HOVERGENⁱ	HBG048691
InParanoidⁱ	Q7Z4H4
OMAⁱ	PAMGHPL
OrthoDBⁱ	EOG091G0ZSV
PhylomeDBⁱ	Q7Z4H4
TreeFamⁱ	TF338591

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418555 G alpha (s) signalling events R-HSA-419812 Calcitonin-like ligand receptors

Reactomeⁱ

R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Miscellaneous databases

ChiTaRSⁱ	ADM2 human
GeneWikiⁱ	ADM2
GenomeRNAiⁱ	79924
Protein Ontology More...PROⁱ	PR:Q7Z4H4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128165 Expressed in 87 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_ADM2
Genevisibleⁱ	Q7Z4H4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR021116 Calcitonin/adrenomedullin
Pfamⁱ	View protein in Pfam PF00214 Calc_CGRP_IAPP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADM2_HUMAN
Accessionⁱ	Q7Z4H4Primary (citable) accession number: Q7Z4H4 Secondary accession number(s): Q3LFQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	October 1, 2003
	Last modified:	September 12, 2018
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7Z4H4 (ADM2_HUMAN)

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ADM2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ