We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q7Z4H4 (ADM2_HUMAN)
Protein
Protein ADM2
Gene
ADM2
Organism
Homo sapiens (Human)
Status
Functioni
May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
1 PublicationMay play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
1 PublicationGO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- protein-containing complex binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- angiogenesis Source: UniProtKB
- digestion Source: Ensembl
- feeding behavior Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- positive regulation of angiogenesis Source: MGI
- positive regulation of gene expression Source: UniProtKB
- protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | Q7Z4H4 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-419812, Calcitonin-like ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Protein ADM2Alternative name(s): Intermedin Cleaved into the following 2 chains: Alternative name(s): Intermedin-long Short name: IMDL |
Gene namesi | Name:ADM2 Synonyms:AM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28898, ADM2 |
MIMi | 608682, gene |
neXtProti | NX_Q7Z4H4 |
VEuPathDBi | HostDB:ENSG00000128165 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 79924 |
OpenTargetsi | ENSG00000128165 |
PharmGKBi | PA134898869 |
Miscellaneous databases
Pharosi | Q7Z4H4, Tbio |
Genetic variation databases
BioMutai | ADM2 |
DMDMi | 47115749 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
PropeptideiPRO_0000000977 | 25 – 98 | By similarityAdd BLAST | 74 | |
PeptideiPRO_0000000978 | 101 – 147 | Adrenomedullin-2By similarityAdd BLAST | 47 | |
PeptideiPRO_0000000979 | 108 – 147 | Intermedin-shortSequence analysisAdd BLAST | 40 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 110 ↔ 115 | By similarity | ||
Modified residuei | 147 | Tyrosine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bondProteomic databases
jPOSTi | Q7Z4H4 |
PaxDbi | Q7Z4H4 |
PeptideAtlasi | Q7Z4H4 |
PRIDEi | Q7Z4H4 |
ProteomicsDBi | 69182 |
PTM databases
PhosphoSitePlusi | Q7Z4H4 |
Expressioni
Tissue specificityi
Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.2 Publications
Gene expression databases
Bgeei | ENSG00000128165, Expressed in pancreas and 119 other tissues |
Genevisiblei | Q7Z4H4, HS |
Organism-specific databases
HPAi | ENSG00000128165, Tissue enhanced (kidney, pancreas, thyroid gland) |
Interactioni
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 123001, 1 interactor |
STRINGi | 9606.ENSP00000379087 |
Chemistry databases
BindingDBi | Q7Z4H4 |
Miscellaneous databases
RNActi | Q7Z4H4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q7Z4H4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 57 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 70 – 101 | DisorderedSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the adrenomedullin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7F2, Eukaryota |
GeneTreei | ENSGT00940000154380 |
HOGENOMi | CLU_134508_0_0_1 |
InParanoidi | Q7Z4H4 |
OMAi | RLWQLVR |
OrthoDBi | 1381783at2759 |
PhylomeDBi | Q7Z4H4 |
TreeFami | TF338591 |
Family and domain databases
InterProi | View protein in InterPro IPR021116, Calcitonin/adrenomedullin |
Pfami | View protein in Pfam PF00214, Calc_CGRP_IAPP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7Z4H4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARIPTAALG CISLLCLQLP GSLSRSLGGD PRPVKPREPP ARSPSSSLQP
60 70 80 90 100
RHPAPRPVVW KLHRALQAQR GAGLAPVMGQ PLRDGGRQHS GPRRHSGPRR
110 120 130 140
TQAQLLRVGC VLGTCQVQNL SHRLWQLMGP AGRQDSAPVD PSSPHSYG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF529213 mRNA Translation: AAQ09100.1 AB121034 mRNA Translation: BAD07411.1 AB236970 mRNA Translation: BAE46395.1 AL096767 Genomic DNA No translation available. |
CCDSi | CCDS33682.1 |
RefSeqi | NP_001240774.1, NM_001253845.1 XP_016884429.1, XM_017028940.1 |
Genome annotation databases
Ensembli | ENST00000395737; ENSP00000379086; ENSG00000128165 ENST00000395738; ENSP00000379087; ENSG00000128165 |
GeneIDi | 79924 |
KEGGi | hsa:79924 |
MANE-Selecti | ENST00000395737.2; ENSP00000379086.1; NM_001253845.2; NP_001240774.1 |
UCSCi | uc003blj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF529213 mRNA Translation: AAQ09100.1 AB121034 mRNA Translation: BAD07411.1 AB236970 mRNA Translation: BAE46395.1 AL096767 Genomic DNA No translation available. |
CCDSi | CCDS33682.1 |
RefSeqi | NP_001240774.1, NM_001253845.1 XP_016884429.1, XM_017028940.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6D1U | X-ray | 2.05 | D/E/F | 129-147 | [»] | |
6UVA | electron microscopy | 2.30 | P | 101-147 | [»] | |
SMRi | Q7Z4H4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123001, 1 interactor |
STRINGi | 9606.ENSP00000379087 |
Chemistry databases
BindingDBi | Q7Z4H4 |
PTM databases
PhosphoSitePlusi | Q7Z4H4 |
Genetic variation databases
BioMutai | ADM2 |
DMDMi | 47115749 |
Proteomic databases
jPOSTi | Q7Z4H4 |
PaxDbi | Q7Z4H4 |
PeptideAtlasi | Q7Z4H4 |
PRIDEi | Q7Z4H4 |
ProteomicsDBi | 69182 |
Protocols and materials databases
Antibodypediai | 52597, 168 antibodies from 19 providers |
DNASUi | 79924 |
Genome annotation databases
Ensembli | ENST00000395737; ENSP00000379086; ENSG00000128165 ENST00000395738; ENSP00000379087; ENSG00000128165 |
GeneIDi | 79924 |
KEGGi | hsa:79924 |
MANE-Selecti | ENST00000395737.2; ENSP00000379086.1; NM_001253845.2; NP_001240774.1 |
UCSCi | uc003blj.4, human |
Organism-specific databases
CTDi | 79924 |
DisGeNETi | 79924 |
GeneCardsi | ADM2 |
HGNCi | HGNC:28898, ADM2 |
HPAi | ENSG00000128165, Tissue enhanced (kidney, pancreas, thyroid gland) |
MIMi | 608682, gene |
neXtProti | NX_Q7Z4H4 |
OpenTargetsi | ENSG00000128165 |
PharmGKBi | PA134898869 |
VEuPathDBi | HostDB:ENSG00000128165 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7F2, Eukaryota |
GeneTreei | ENSGT00940000154380 |
HOGENOMi | CLU_134508_0_0_1 |
InParanoidi | Q7Z4H4 |
OMAi | RLWQLVR |
OrthoDBi | 1381783at2759 |
PhylomeDBi | Q7Z4H4 |
TreeFami | TF338591 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z4H4 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-419812, Calcitonin-like ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 79924, 9 hits in 1043 CRISPR screens |
ChiTaRSi | ADM2, human |
GeneWikii | ADM2 |
GenomeRNAii | 79924 |
Pharosi | Q7Z4H4, Tbio |
PROi | PR:Q7Z4H4 |
RNActi | Q7Z4H4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128165, Expressed in pancreas and 119 other tissues |
Genevisiblei | Q7Z4H4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR021116, Calcitonin/adrenomedullin |
Pfami | View protein in Pfam PF00214, Calc_CGRP_IAPP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADM2_HUMAN | |
Accessioni | Q7Z4H4Primary (citable) accession number: Q7Z4H4 Secondary accession number(s): Q3LFQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families