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Protein

ADM2

Gene

ADM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • protein-containing complex binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
ADM2
Alternative name(s):
Intermedin
Cleaved into the following 2 chains:
Adrenomedullin-2
Short name:
AM2
Alternative name(s):
Intermedin-long
Short name:
IMDL
Intermedin-short
Short name:
IMDS
Gene namesi
Name:ADM2
Synonyms:AM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128165.8
HGNCiHGNC:28898 ADM2
MIMi608682 gene
neXtProtiNX_Q7Z4H4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79924
OpenTargetsiENSG00000128165
PharmGKBiPA134898869

Chemistry databases

ChEMBLiCHEMBL5267

Polymorphism and mutation databases

BioMutaiADM2
DMDMi47115749

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PropeptideiPRO_000000097725 – 98By similarityAdd BLAST74
PeptideiPRO_0000000978101 – 147Adrenomedullin-2By similarityAdd BLAST47
PeptideiPRO_0000000979108 – 147Intermedin-shortSequence analysisAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 115By similarity
Modified residuei147Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ7Z4H4
PeptideAtlasiQ7Z4H4
PRIDEiQ7Z4H4
ProteomicsDBi69182

PTM databases

PhosphoSitePlusiQ7Z4H4

Expressioni

Tissue specificityi

Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.2 Publications

Gene expression databases

BgeeiENSG00000128165 Expressed in 87 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ADM2
GenevisibleiQ7Z4H4 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123001, 1 interactor
STRINGi9606.ENSP00000379086

Chemistry databases

BindingDBiQ7Z4H4

Structurei

3D structure databases

ProteinModelPortaliQ7Z4H4
SMRiQ7Z4H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3UK Eukaryota
ENOG410Z5UT LUCA
GeneTreeiENSGT00530000064523
HOGENOMiHOG000033820
HOVERGENiHBG048691
InParanoidiQ7Z4H4
OMAiPAMGHPL
OrthoDBiEOG091G0ZSV
PhylomeDBiQ7Z4H4
TreeFamiTF338591

Family and domain databases

InterProiView protein in InterPro
IPR021116 Calcitonin/adrenomedullin
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARIPTAALG CISLLCLQLP GSLSRSLGGD PRPVKPREPP ARSPSSSLQP
60 70 80 90 100
RHPAPRPVVW KLHRALQAQR GAGLAPVMGQ PLRDGGRQHS GPRRHSGPRR
110 120 130 140
TQAQLLRVGC VLGTCQVQNL SHRLWQLMGP AGRQDSAPVD PSSPHSYG
Length:148
Mass (Da):15,865
Last modified:October 1, 2003 - v1
Checksum:i6E0E3098CFCE5BF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529213 mRNA Translation: AAQ09100.1
AB121034 mRNA Translation: BAD07411.1
AB236970 mRNA Translation: BAE46395.1
AL096767 Genomic DNA No translation available.
CCDSiCCDS33682.1
RefSeqiNP_001240774.1, NM_001253845.1
XP_016884429.1, XM_017028940.1
UniGeneiHs.449099
Hs.743540

Genome annotation databases

EnsembliENST00000395737; ENSP00000379086; ENSG00000128165
ENST00000395738; ENSP00000379087; ENSG00000128165
GeneIDi79924
KEGGihsa:79924
UCSCiuc003blj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529213 mRNA Translation: AAQ09100.1
AB121034 mRNA Translation: BAD07411.1
AB236970 mRNA Translation: BAE46395.1
AL096767 Genomic DNA No translation available.
CCDSiCCDS33682.1
RefSeqiNP_001240774.1, NM_001253845.1
XP_016884429.1, XM_017028940.1
UniGeneiHs.449099
Hs.743540

3D structure databases

ProteinModelPortaliQ7Z4H4
SMRiQ7Z4H4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123001, 1 interactor
STRINGi9606.ENSP00000379086

Chemistry databases

BindingDBiQ7Z4H4
ChEMBLiCHEMBL5267

PTM databases

PhosphoSitePlusiQ7Z4H4

Polymorphism and mutation databases

BioMutaiADM2
DMDMi47115749

Proteomic databases

PaxDbiQ7Z4H4
PeptideAtlasiQ7Z4H4
PRIDEiQ7Z4H4
ProteomicsDBi69182

Protocols and materials databases

DNASUi79924
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395737; ENSP00000379086; ENSG00000128165
ENST00000395738; ENSP00000379087; ENSG00000128165
GeneIDi79924
KEGGihsa:79924
UCSCiuc003blj.4 human

Organism-specific databases

CTDi79924
DisGeNETi79924
EuPathDBiHostDB:ENSG00000128165.8
GeneCardsiADM2
HGNCiHGNC:28898 ADM2
MIMi608682 gene
neXtProtiNX_Q7Z4H4
OpenTargetsiENSG00000128165
PharmGKBiPA134898869
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3UK Eukaryota
ENOG410Z5UT LUCA
GeneTreeiENSGT00530000064523
HOGENOMiHOG000033820
HOVERGENiHBG048691
InParanoidiQ7Z4H4
OMAiPAMGHPL
OrthoDBiEOG091G0ZSV
PhylomeDBiQ7Z4H4
TreeFamiTF338591

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Miscellaneous databases

ChiTaRSiADM2 human
GeneWikiiADM2
GenomeRNAii79924
PROiPR:Q7Z4H4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128165 Expressed in 87 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ADM2
GenevisibleiQ7Z4H4 HS

Family and domain databases

InterProiView protein in InterPro
IPR021116 Calcitonin/adrenomedullin
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADM2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4H4
Secondary accession number(s): Q3LFQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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