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Protein

COMM domain-containing protein 6

Gene

COMMD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.1 Publication2 Publications

GO - Molecular functioni

  • NF-kappaB binding Source: MGI

GO - Biological processi

  • negative regulation of NF-kappaB transcription factor activity Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 6
Gene namesi
Name:COMMD6
ORF Names:MSTP076
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000188243.12
HGNCiHGNC:24015 COMMD6
MIMi612377 gene
neXtProtiNX_Q7Z4G1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24W → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-41. 1 Publication1
Mutagenesisi41P → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-24. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000188243
PharmGKBiPA134906013

Polymorphism and mutation databases

DMDMi51315937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773981 – 85COMM domain-containing protein 6Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z4G1
MaxQBiQ7Z4G1
PeptideAtlasiQ7Z4G1
PRIDEiQ7Z4G1
ProteomicsDBi69174
69175 [Q7Z4G1-2]

PTM databases

iPTMnetiQ7Z4G1
PhosphoSitePlusiQ7Z4G1

Expressioni

Tissue specificityi

Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta.2 Publications

Gene expression databases

BgeeiENSG00000188243 Expressed in 199 organ(s), highest expression level in metanephros
CleanExiHS_COMMD6
ExpressionAtlasiQ7Z4G1 baseline and differential
GenevisibleiQ7Z4G1 HS

Interactioni

Subunit structurei

Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22, CCDC93, SCNN1B, CUL4A.6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128071, 31 interactors
CORUMiQ7Z4G1
IntActiQ7Z4G1, 13 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7Z4G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 85COMMPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

GeneTreeiENSGT00390000018369
HOGENOMiHOG000038017
HOVERGENiHBG051071
InParanoidiQ7Z4G1
KOiK22562
OMAiQQFKDMS
PhylomeDBiQ7Z4G1

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4G1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASSEPPLD AKSDVTNQLV DFQWKLGMAV SSDTCRSLKY PYVAVMLKVA
60 70 80
DHSGQVKTKC FEMTIPQFQN FYRQFKEIAA VIETV
Length:85
Mass (Da):9,638
Last modified:October 1, 2003 - v1
Checksum:iFBF29F240EA8756B
GO
Isoform 2 (identifier: Q7Z4G1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: Q → QPQLLATSSLLSAS

Show »
Length:98
Mass (Da):10,908
Checksum:iBADF400B61D3C3FB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QZ40B0QZ40_HUMAN
COMM domain-containing protein 6
COMMD6
100Annotation score:
H7C607H7C607_HUMAN
COMM domain-containing protein 6
COMMD6
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04881352H → N. Corresponds to variant dbSNP:rs1063485Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02659369Q → QPQLLATSSLLSAS in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542161 mRNA Translation: AAS22243.1
AF169971 mRNA Translation: AAQ13599.1
AL137244 Genomic DNA No translation available.
BC117391 mRNA Translation: AAI17392.1
BC143912 mRNA Translation: AAI43913.1
BC171758 mRNA Translation: AAI71758.1
CCDSiCCDS9451.1 [Q7Z4G1-1]
CCDS9452.1 [Q7Z4G1-2]
RefSeqiNP_987091.1, NM_203495.3 [Q7Z4G1-1]
NP_987093.1, NM_203497.3 [Q7Z4G1-2]
UniGeneiHs.508266
Hs.713055

Genome annotation databases

EnsembliENST00000355801; ENSP00000348054; ENSG00000188243 [Q7Z4G1-2]
ENST00000377615; ENSP00000366841; ENSG00000188243 [Q7Z4G1-1]
ENST00000406936; ENSP00000385660; ENSG00000188243 [Q7Z4G1-1]
GeneIDi170622
KEGGihsa:170622
UCSCiuc001vjn.3 human [Q7Z4G1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542161 mRNA Translation: AAS22243.1
AF169971 mRNA Translation: AAQ13599.1
AL137244 Genomic DNA No translation available.
BC117391 mRNA Translation: AAI17392.1
BC143912 mRNA Translation: AAI43913.1
BC171758 mRNA Translation: AAI71758.1
CCDSiCCDS9451.1 [Q7Z4G1-1]
CCDS9452.1 [Q7Z4G1-2]
RefSeqiNP_987091.1, NM_203495.3 [Q7Z4G1-1]
NP_987093.1, NM_203497.3 [Q7Z4G1-2]
UniGeneiHs.508266
Hs.713055

3D structure databases

ProteinModelPortaliQ7Z4G1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128071, 31 interactors
CORUMiQ7Z4G1
IntActiQ7Z4G1, 13 interactors

PTM databases

iPTMnetiQ7Z4G1
PhosphoSitePlusiQ7Z4G1

Polymorphism and mutation databases

DMDMi51315937

Proteomic databases

EPDiQ7Z4G1
MaxQBiQ7Z4G1
PeptideAtlasiQ7Z4G1
PRIDEiQ7Z4G1
ProteomicsDBi69174
69175 [Q7Z4G1-2]

Protocols and materials databases

DNASUi170622
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355801; ENSP00000348054; ENSG00000188243 [Q7Z4G1-2]
ENST00000377615; ENSP00000366841; ENSG00000188243 [Q7Z4G1-1]
ENST00000406936; ENSP00000385660; ENSG00000188243 [Q7Z4G1-1]
GeneIDi170622
KEGGihsa:170622
UCSCiuc001vjn.3 human [Q7Z4G1-1]

Organism-specific databases

CTDi170622
EuPathDBiHostDB:ENSG00000188243.12
GeneCardsiCOMMD6
HGNCiHGNC:24015 COMMD6
MIMi612377 gene
neXtProtiNX_Q7Z4G1
OpenTargetsiENSG00000188243
PharmGKBiPA134906013
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000018369
HOGENOMiHOG000038017
HOVERGENiHBG051071
InParanoidiQ7Z4G1
KOiK22562
OMAiQQFKDMS
PhylomeDBiQ7Z4G1

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCOMMD6 human
GenomeRNAii170622
PROiPR:Q7Z4G1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188243 Expressed in 199 organ(s), highest expression level in metanephros
CleanExiHS_COMMD6
ExpressionAtlasiQ7Z4G1 baseline and differential
GenevisibleiQ7Z4G1 HS

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD6_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4G1
Secondary accession number(s): A6NF28, B7ZLN0, Q5TBK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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