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UniProtKB - Q7Z4F1 (LRP10_HUMAN)

Entry version 162 (10 Feb 2021)
Sequence version 2 (13 Apr 2004)
Previous versions | rss
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Protein

Low-density lipoprotein receptor-related protein 10

Gene

LRP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z4F1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-975634, Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 10
Short name:
LRP-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRP10
ORF Names:MSTP087, SP220, UNQ389/PRO724
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14553, LRP10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609921, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z4F1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197324.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 440ExtracellularSequence analysisAdd BLAST424
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 713CytoplasmicSequence analysisAdd BLAST252

Keywords - Cellular componenti

Coated pit, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26020

Open Targets

More...OpenTargetsi		ENSG00000197324

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z4F1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRP10

Domain mapping of disease mutations (DMDM)

More...DMDMi		46396347

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001733517 – 713Low-density lipoprotein receptor-related protein 10Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 57By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 98By similarity
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 152By similarity
Disulfide bondi147 ↔ 165By similarity
Disulfide bondi159 ↔ 174By similarity
Disulfide bondi192 ↔ 220By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi308 ↔ 331By similarity
Disulfide bondi315 ↔ 344By similarity
Disulfide bondi338 ↔ 353By similarity
Disulfide bondi356 ↔ 374By similarity
Disulfide bondi363 ↔ 387By similarity
Disulfide bondi381 ↔ 396By similarity
Disulfide bondi399 ↔ 411By similarity
Disulfide bondi406 ↔ 424By similarity
Disulfide bondi418 ↔ 433By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei596PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z4F1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z4F1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z4F1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z4F1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z4F1

PeptideAtlas

More...PeptideAtlasi		Q7Z4F1

PRoteomics IDEntifications database

More...PRIDEi		Q7Z4F1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69172 [Q7Z4F1-1]
69173 [Q7Z4F1-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1465, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7Z4F1, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z4F1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z4F1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7Z4F1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197324, Expressed in stromal cell of endometrium and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z4F1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z4F1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197324, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117491, 68 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z4F1, 57 interactors

Molecular INTeraction database

More...MINTi		Q7Z4F1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352601

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z4F1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z4F1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 136CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini139 – 175LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini192 – 305CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini307 – 354LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST48
Domaini355 – 397LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST43
Domaini398 – 434LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi545 – 579Arg-richAdd BLAST35
Compositional biasi614 – 678Pro-richAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1215, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013747_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z4F1

Identification of Orthologs from Complete Genome Data

More...OMAi		GHFPCGP

Database of Orthologous Groups

More...OrthoDBi		135036at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z4F1

TreeFam database of animal gene trees

More...TreeFami		TF332149

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 2 hits
cd00112, LDLa, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.290, 2 hits
4.10.400.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 1 hit
PF00057, Ldl_recept_a, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4F1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS 
        60         70         80         90        100
RTSPANCTWL ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA 
       110        120        130        140        150
PPSPLQLPGG NVTITYSYAG ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH 
       160        170        180        190        200
RCVSAVQRCD GVDACGDGSD EAGCSSDPFP GLTPRPVPSL PCNVTLEDFY 
       210        220        230        240        250
GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD LGFGDAVHVY 
       260        270        280        290        300
DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA 
       310        320        330        340        350
TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE 
       360        370        380        390        400
EDCPGCPPGH FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ 
       410        420        430        440        450
PGNFRCRDEK CVYETWVCDG QPDCADGSDE WDCSYVLPRK VITAAVIGSL 
       460        470        480        490        500
VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL SRMEAEIVQQ QAPPSYGQLI 
       510        520        530        540        550
AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG GPGARRRQRG 
       560        570        580        590        600
RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR 
       610        620        630        640        650
EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL 
       660        670        680        690        700
LSGVVQALRG RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG 
       710 
VWVAEAEDEP LLT
Length:713
Mass (Da):76,193
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA463FB5584322220
GO
Isoform 2 (identifier: Q7Z4F1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-713: Missing.

Show »
Length:556
Mass (Da):60,213
Checksum:i1CCA7CAEA16A0AB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHW7H0YHW7_HUMAN
Low-density lipoprotein receptor-re...
LRP10
458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD20037 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG17980 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ13610 differs from that shown. Reason: Frameshift.Curated
The sequence CAD39174 differs from that shown. Chimera.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti365A → T (PubMed:15498874).Curated1
Sequence conflicti434S → C (PubMed:15498874).Curated1
Sequence conflicti558R → H in CAB45753 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01817248R → W. Corresponds to variant dbSNP:rs2273837Ensembl.1
Natural variantiVAR_034097139M → V. Corresponds to variant dbSNP:rs28534929Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009820557 – 713Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY358399 mRNA Translation: AAQ88765.1
BX161500 mRNA Translation: CAD61944.1
AK291030 mRNA Translation: BAF83719.1
AL080164 mRNA Translation: CAB45753.1
AL834518 mRNA Translation: CAD39174.2 Sequence problems.
CH471078 Genomic DNA Translation: EAW66232.1
CH471078 Genomic DNA Translation: EAW66235.1
BC064901 mRNA Translation: AAH64901.1
BC113714 mRNA Translation: AAI13715.1
BC113716 mRNA Translation: AAI13717.1
AF172816 mRNA Translation: AAQ13610.1 Frameshift.
AF177336 mRNA Translation: AAG17980.1 Frameshift.
AF131760 mRNA Translation: AAD20037.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS86372.1 [Q7Z4F1-2]
CCDS9578.1 [Q7Z4F1-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T12469

NCBI Reference Sequences

More...RefSeqi		NP_001316155.1, NM_001329226.1 [Q7Z4F1-2]
NP_054764.2, NM_014045.4 [Q7Z4F1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1]
ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26020

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26020

UCSC genome browser

More...UCSCi		uc001whd.4, human [Q7Z4F1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358399 mRNA Translation: AAQ88765.1
BX161500 mRNA Translation: CAD61944.1
AK291030 mRNA Translation: BAF83719.1
AL080164 mRNA Translation: CAB45753.1
AL834518 mRNA Translation: CAD39174.2 Sequence problems.
CH471078 Genomic DNA Translation: EAW66232.1
CH471078 Genomic DNA Translation: EAW66235.1
BC064901 mRNA Translation: AAH64901.1
BC113714 mRNA Translation: AAI13715.1
BC113716 mRNA Translation: AAI13717.1
AF172816 mRNA Translation: AAQ13610.1 Frameshift.
AF177336 mRNA Translation: AAG17980.1 Frameshift.
AF131760 mRNA Translation: AAD20037.1 Different initiation.
CCDSiCCDS86372.1 [Q7Z4F1-2]
CCDS9578.1 [Q7Z4F1-1]
PIRiT12469
RefSeqiNP_001316155.1, NM_001329226.1 [Q7Z4F1-2]
NP_054764.2, NM_014045.4 [Q7Z4F1-1]

3D structure databases

SMRiQ7Z4F1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117491, 68 interactors
IntActiQ7Z4F1, 57 interactors
MINTiQ7Z4F1
STRINGi9606.ENSP00000352601

PTM databases

GlyConnecti1465, 1 N-Linked glycan (1 site)
GlyGeniQ7Z4F1, 4 sites
iPTMnetiQ7Z4F1
PhosphoSitePlusiQ7Z4F1
SwissPalmiQ7Z4F1

Genetic variation databases

BioMutaiLRP10
DMDMi46396347

Proteomic databases

EPDiQ7Z4F1
jPOSTiQ7Z4F1
MassIVEiQ7Z4F1
MaxQBiQ7Z4F1
PaxDbiQ7Z4F1
PeptideAtlasiQ7Z4F1
PRIDEiQ7Z4F1
ProteomicsDBi69172 [Q7Z4F1-1]
69173 [Q7Z4F1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		95, 109 antibodies

Genome annotation databases

EnsembliENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1]
ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2]
GeneIDi26020
KEGGihsa:26020
UCSCiuc001whd.4, human [Q7Z4F1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26020
DisGeNETi26020

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRP10
HGNCiHGNC:14553, LRP10
HPAiENSG00000197324, Low tissue specificity
MIMi609921, gene
neXtProtiNX_Q7Z4F1
OpenTargetsiENSG00000197324
PharmGKBiPA38383
VEuPathDBiHostDB:ENSG00000197324.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
GeneTreeiENSGT00940000160783
HOGENOMiCLU_013747_2_0_1
InParanoidiQ7Z4F1
OMAiGHFPCGP
OrthoDBi135036at2759
PhylomeDBiQ7Z4F1
TreeFamiTF332149

Enzyme and pathway databases

PathwayCommonsiQ7Z4F1
ReactomeiR-HSA-975634, Retinoid metabolism and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26020, 11 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRP10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LRP10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26020
PharosiQ7Z4F1, Tdark

Protein Ontology

More...PROi		PR:Q7Z4F1
RNActiQ7Z4F1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197324, Expressed in stromal cell of endometrium and 241 other tissues
ExpressionAtlasiQ7Z4F1, baseline and differential
GenevisibleiQ7Z4F1, HS

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00112, LDLa, 3 hits
Gene3Di2.60.120.290, 2 hits
4.10.400.10, 4 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF00057, Ldl_recept_a, 2 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 4 hits
SUPFAMiSSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4F1
Secondary accession number(s): A8K4R5
, D3DS31, O95882, Q14CK7, Q86T02, Q8NCZ4, Q9HC42, Q9UG33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 10, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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