UniProtKB - Q7Z4F1 (LRP10_HUMAN)
Protein
Low-density lipoprotein receptor-related protein 10
Gene
LRP10
Organism
Homo sapiens (Human)
Status
Functioni
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).By similarity
GO - Molecular functioni
- low-density lipoprotein particle receptor activity Source: Ensembl
GO - Biological processi
- inner ear development Source: Ensembl
- lipid metabolic process Source: Ensembl
- lipid transport Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q7Z4F1 |
Reactomei | R-HSA-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Low-density lipoprotein receptor-related protein 10Short name: LRP-10 |
Gene namesi | Name:LRP10 ORF Names:MSTP087, SP220, UNQ389/PRO724 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14553, LRP10 |
MIMi | 609921, gene |
neXtProti | NX_Q7Z4F1 |
VEuPathDBi | HostDB:ENSG00000197324.8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
- coated pit By similarity
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 440 | ExtracellularSequence analysisAdd BLAST | 424 | |
Transmembranei | 441 – 461 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 462 – 713 | CytoplasmicSequence analysisAdd BLAST | 252 |
Keywords - Cellular componenti
Coated pit, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 26020 |
OpenTargetsi | ENSG00000197324 |
PharmGKBi | PA38383 |
Miscellaneous databases
Pharosi | Q7Z4F1, Tdark |
Genetic variation databases
BioMutai | LRP10 |
DMDMi | 46396347 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000017335 | 17 – 713 | Low-density lipoprotein receptor-related protein 10Add BLAST | 697 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 57 | By similarity | ||
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 80 ↔ 98 | By similarity | ||
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 140 ↔ 152 | By similarity | ||
Disulfide bondi | 147 ↔ 165 | By similarity | ||
Disulfide bondi | 159 ↔ 174 | By similarity | ||
Disulfide bondi | 192 ↔ 220 | By similarity | ||
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 299 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 308 ↔ 331 | By similarity | ||
Disulfide bondi | 315 ↔ 344 | By similarity | ||
Disulfide bondi | 338 ↔ 353 | By similarity | ||
Disulfide bondi | 356 ↔ 374 | By similarity | ||
Disulfide bondi | 363 ↔ 387 | By similarity | ||
Disulfide bondi | 381 ↔ 396 | By similarity | ||
Disulfide bondi | 399 ↔ 411 | By similarity | ||
Disulfide bondi | 406 ↔ 424 | By similarity | ||
Disulfide bondi | 418 ↔ 433 | By similarity | ||
Modified residuei | 596 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q7Z4F1 |
jPOSTi | Q7Z4F1 |
MassIVEi | Q7Z4F1 |
MaxQBi | Q7Z4F1 |
PaxDbi | Q7Z4F1 |
PeptideAtlasi | Q7Z4F1 |
PRIDEi | Q7Z4F1 |
ProteomicsDBi | 69172 [Q7Z4F1-1] 69173 [Q7Z4F1-2] |
PTM databases
GlyConnecti | 1465, 1 N-Linked glycan (1 site) |
GlyGeni | Q7Z4F1, 4 sites |
iPTMneti | Q7Z4F1 |
PhosphoSitePlusi | Q7Z4F1 |
SwissPalmi | Q7Z4F1 |
Expressioni
Tissue specificityi
Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.1 Publication
Gene expression databases
Bgeei | ENSG00000197324, Expressed in stromal cell of endometrium and 241 other tissues |
ExpressionAtlasi | Q7Z4F1, baseline and differential |
Genevisiblei | Q7Z4F1, HS |
Organism-specific databases
HPAi | ENSG00000197324, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ7Z4F1
Protein-protein interaction databases
BioGRIDi | 117491, 68 interactors |
IntActi | Q7Z4F1, 57 interactors |
MINTi | Q7Z4F1 |
STRINGi | 9606.ENSP00000352601 |
Miscellaneous databases
RNActi | Q7Z4F1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 136 | CUB 1PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 139 – 175 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 192 – 305 | CUB 2PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 307 – 354 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 355 – 397 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 398 – 434 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 545 – 579 | Arg-richAdd BLAST | 35 | |
Compositional biasi | 614 – 678 | Pro-richAdd BLAST | 65 |
Sequence similaritiesi
Belongs to the LDLR family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160783 |
HOGENOMi | CLU_013747_2_0_1 |
InParanoidi | Q7Z4F1 |
OMAi | GHFPCGP |
OrthoDBi | 135036at2759 |
PhylomeDBi | Q7Z4F1 |
TreeFami | TF332149 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 3 hits |
Gene3Di | 2.60.120.290, 2 hits 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00057, Ldl_recept_a, 2 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 4 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 2 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z4F1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS
60 70 80 90 100
RTSPANCTWL ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA
110 120 130 140 150
PPSPLQLPGG NVTITYSYAG ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH
160 170 180 190 200
RCVSAVQRCD GVDACGDGSD EAGCSSDPFP GLTPRPVPSL PCNVTLEDFY
210 220 230 240 250
GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD LGFGDAVHVY
260 270 280 290 300
DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA
310 320 330 340 350
TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE
360 370 380 390 400
EDCPGCPPGH FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ
410 420 430 440 450
PGNFRCRDEK CVYETWVCDG QPDCADGSDE WDCSYVLPRK VITAAVIGSL
460 470 480 490 500
VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL SRMEAEIVQQ QAPPSYGQLI
510 520 530 540 550
AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG GPGARRRQRG
560 570 580 590 600
RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR
610 620 630 640 650
EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL
660 670 680 690 700
LSGVVQALRG RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG
710
VWVAEAEDEP LLT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YHW7 | H0YHW7_HUMAN | Low-density lipoprotein receptor-re... | LRP10 | 458 | Annotation score: |
Sequence cautioni
The sequence AAD20037 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG17980 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ13610 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 365 | A → T (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 434 | S → C (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 558 | R → H in CAB45753 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018172 | 48 | R → W. Corresponds to variant dbSNP:rs2273837Ensembl. | 1 | |
Natural variantiVAR_034097 | 139 | M → V. Corresponds to variant dbSNP:rs28534929Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009820 | 557 – 713 | Missing in isoform 2. 1 PublicationAdd BLAST | 157 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358399 mRNA Translation: AAQ88765.1 BX161500 mRNA Translation: CAD61944.1 AK291030 mRNA Translation: BAF83719.1 AL080164 mRNA Translation: CAB45753.1 AL834518 mRNA Translation: CAD39174.2 Sequence problems. CH471078 Genomic DNA Translation: EAW66232.1 CH471078 Genomic DNA Translation: EAW66235.1 BC064901 mRNA Translation: AAH64901.1 BC113714 mRNA Translation: AAI13715.1 BC113716 mRNA Translation: AAI13717.1 AF172816 mRNA Translation: AAQ13610.1 Frameshift. AF177336 mRNA Translation: AAG17980.1 Frameshift. AF131760 mRNA Translation: AAD20037.1 Different initiation. |
CCDSi | CCDS86372.1 [Q7Z4F1-2] CCDS9578.1 [Q7Z4F1-1] |
PIRi | T12469 |
RefSeqi | NP_001316155.1, NM_001329226.1 [Q7Z4F1-2] NP_054764.2, NM_014045.4 [Q7Z4F1-1] |
Genome annotation databases
Ensembli | ENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1] ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2] |
GeneIDi | 26020 |
KEGGi | hsa:26020 |
UCSCi | uc001whd.4, human [Q7Z4F1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358399 mRNA Translation: AAQ88765.1 BX161500 mRNA Translation: CAD61944.1 AK291030 mRNA Translation: BAF83719.1 AL080164 mRNA Translation: CAB45753.1 AL834518 mRNA Translation: CAD39174.2 Sequence problems. CH471078 Genomic DNA Translation: EAW66232.1 CH471078 Genomic DNA Translation: EAW66235.1 BC064901 mRNA Translation: AAH64901.1 BC113714 mRNA Translation: AAI13715.1 BC113716 mRNA Translation: AAI13717.1 AF172816 mRNA Translation: AAQ13610.1 Frameshift. AF177336 mRNA Translation: AAG17980.1 Frameshift. AF131760 mRNA Translation: AAD20037.1 Different initiation. |
CCDSi | CCDS86372.1 [Q7Z4F1-2] CCDS9578.1 [Q7Z4F1-1] |
PIRi | T12469 |
RefSeqi | NP_001316155.1, NM_001329226.1 [Q7Z4F1-2] NP_054764.2, NM_014045.4 [Q7Z4F1-1] |
3D structure databases
SMRi | Q7Z4F1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117491, 68 interactors |
IntActi | Q7Z4F1, 57 interactors |
MINTi | Q7Z4F1 |
STRINGi | 9606.ENSP00000352601 |
PTM databases
GlyConnecti | 1465, 1 N-Linked glycan (1 site) |
GlyGeni | Q7Z4F1, 4 sites |
iPTMneti | Q7Z4F1 |
PhosphoSitePlusi | Q7Z4F1 |
SwissPalmi | Q7Z4F1 |
Genetic variation databases
BioMutai | LRP10 |
DMDMi | 46396347 |
Proteomic databases
EPDi | Q7Z4F1 |
jPOSTi | Q7Z4F1 |
MassIVEi | Q7Z4F1 |
MaxQBi | Q7Z4F1 |
PaxDbi | Q7Z4F1 |
PeptideAtlasi | Q7Z4F1 |
PRIDEi | Q7Z4F1 |
ProteomicsDBi | 69172 [Q7Z4F1-1] 69173 [Q7Z4F1-2] |
Protocols and materials databases
Antibodypediai | 95, 109 antibodies |
Genome annotation databases
Ensembli | ENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1] ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2] |
GeneIDi | 26020 |
KEGGi | hsa:26020 |
UCSCi | uc001whd.4, human [Q7Z4F1-1] |
Organism-specific databases
CTDi | 26020 |
DisGeNETi | 26020 |
GeneCardsi | LRP10 |
HGNCi | HGNC:14553, LRP10 |
HPAi | ENSG00000197324, Low tissue specificity |
MIMi | 609921, gene |
neXtProti | NX_Q7Z4F1 |
OpenTargetsi | ENSG00000197324 |
PharmGKBi | PA38383 |
VEuPathDBi | HostDB:ENSG00000197324.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160783 |
HOGENOMi | CLU_013747_2_0_1 |
InParanoidi | Q7Z4F1 |
OMAi | GHFPCGP |
OrthoDBi | 135036at2759 |
PhylomeDBi | Q7Z4F1 |
TreeFami | TF332149 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z4F1 |
Reactomei | R-HSA-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 26020, 11 hits in 878 CRISPR screens |
ChiTaRSi | LRP10, human |
GeneWikii | LRP10 |
GenomeRNAii | 26020 |
Pharosi | Q7Z4F1, Tdark |
PROi | PR:Q7Z4F1 |
RNActi | Q7Z4F1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197324, Expressed in stromal cell of endometrium and 241 other tissues |
ExpressionAtlasi | Q7Z4F1, baseline and differential |
Genevisiblei | Q7Z4F1, HS |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 3 hits |
Gene3Di | 2.60.120.290, 2 hits 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00057, Ldl_recept_a, 2 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 4 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 2 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRP10_HUMAN | |
Accessioni | Q7Z4F1Primary (citable) accession number: Q7Z4F1 Secondary accession number(s): A8K4R5 Q9UG33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families