UniProtKB - Q7Z4F1 (LRP10_HUMAN)

BLAST

>sp|Q7Z4F1|LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 OS=Homo sapiens OX=9606 GN=LRP10 PE=1 SV=2
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWL
ILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAG
ARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP
GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALD
LGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA
TYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH
FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG
QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPL
SRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG
GPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAR
EGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRG
RLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT

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History
Entry version 144 (07 Nov 2018)
Sequence version 2 (13 Apr 2004)
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Protein

Low-density lipoprotein receptor-related protein 10

Gene

LRP10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).By similarity

GO - Molecular functionⁱ

low-density lipoprotein particle receptor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inner ear development Source: Ensembl
lipid metabolic process Source: Ensembl
lipid transport Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Endocytosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975634 Retinoid metabolism and transport

Reactomeⁱ

R-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Low-density lipoprotein receptor-related protein 10 Short name: LRP-10
Gene namesⁱ	Name:LRP10 ORF Names:MSTP087, SP220, UNQ389/PRO724
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197324.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14553 LRP10
MIMⁱ	609921 gene
neXtProtⁱ	NX_Q7Z4F1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	17 – 440	ExtracellularSequence analysisAdd BLAST	424
Transmembraneⁱ	441 – 461	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	462 – 713	CytoplasmicSequence analysisAdd BLAST	252

Keywords - Cellular componentⁱ

Coated pit, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26020
Open Targets More...OpenTargetsⁱ	ENSG00000197324
PharmGKBⁱ	PA38383

Polymorphism and mutation databases

BioMutaⁱ	LRP10
DMDMⁱ	46396347

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 16	Sequence analysisAdd BLAST		16
ChainⁱPRO_0000017335	17 – 713	Low-density lipoprotein receptor-related protein 10Add BLAST		697

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	28 ↔ 57	By similarity
Glycosylationⁱ	56	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	80 ↔ 98	By similarity
Glycosylationⁱ	111	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	140 ↔ 152	By similarity
Disulfide bondⁱ	147 ↔ 165	By similarity
Disulfide bondⁱ	159 ↔ 174	By similarity
Disulfide bondⁱ	192 ↔ 220	By similarity
Glycosylationⁱ	193	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	299	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	308 ↔ 331	By similarity
Disulfide bondⁱ	315 ↔ 344	By similarity
Disulfide bondⁱ	338 ↔ 353	By similarity
Disulfide bondⁱ	356 ↔ 374	By similarity
Disulfide bondⁱ	363 ↔ 387	By similarity
Disulfide bondⁱ	381 ↔ 396	By similarity
Disulfide bondⁱ	399 ↔ 411	By similarity
Disulfide bondⁱ	406 ↔ 424	By similarity
Disulfide bondⁱ	418 ↔ 433	By similarity
Modified residueⁱ	596	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q7Z4F1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z4F1
PaxDbⁱ	Q7Z4F1
PeptideAtlas More...PeptideAtlasⁱ	Q7Z4F1
PRIDEⁱ	Q7Z4F1
ProteomicsDBⁱ	69172 69173 [Q7Z4F1-2]

PTM databases

GlyConnectⁱ	1465
iPTMnetⁱ	Q7Z4F1
PhosphoSitePlusⁱ	Q7Z4F1
SwissPalmⁱ	Q7Z4F1

Expressionⁱ

Tissue specificityⁱ

Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000197324 Expressed in 228 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_LRP10
ExpressionAtlasⁱ	Q7Z4F1 baseline and differential
Genevisibleⁱ	Q7Z4F1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000932

HPAⁱ

HPA000932

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	117491, 40 interactors
IntActⁱ	Q7Z4F1, 26 interactors
Molecular INTeraction database More...MINTⁱ	Q7Z4F1
STRINGⁱ	9606.ENSP00000352601

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z4F1
SMRⁱ	Q7Z4F1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 136	CUB 1PROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	139 – 175	LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	192 – 305	CUB 2PROSITE-ProRule annotationAdd BLAST	114
Domainⁱ	307 – 354	LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST	48
Domainⁱ	355 – 397	LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	398 – 434	LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST	37

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	545 – 579	Arg-richAdd BLAST		35
Compositional biasⁱ	614 – 678	Pro-richAdd BLAST		65

Sequence similaritiesⁱ

Belongs to the LDLR family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPT0 Eukaryota ENOG410XV08 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125405
HOVERGENⁱ	HBG049162
InParanoidⁱ	Q7Z4F1
KEGG Orthology (KO) More...KOⁱ	K20050
OMAⁱ	WDCSYAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04LP
PhylomeDBⁱ	Q7Z4F1
TreeFamⁱ	TF332149

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 3 hits
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR035914 Sperma_CUB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00057 Ldl_recept_a, 2 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 4 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 2 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q7Z4F1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS 
        60         70         80         90        100
RTSPANCTWL ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA 
       110        120        130        140        150
PPSPLQLPGG NVTITYSYAG ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH 
       160        170        180        190        200
RCVSAVQRCD GVDACGDGSD EAGCSSDPFP GLTPRPVPSL PCNVTLEDFY 
       210        220        230        240        250
GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD LGFGDAVHVY 
       260        270        280        290        300
DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA 
       310        320        330        340        350
TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE 
       360        370        380        390        400
EDCPGCPPGH FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ 
       410        420        430        440        450
PGNFRCRDEK CVYETWVCDG QPDCADGSDE WDCSYVLPRK VITAAVIGSL 
       460        470        480        490        500
VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL SRMEAEIVQQ QAPPSYGQLI 
       510        520        530        540        550
AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG GPGARRRQRG 
       560        570        580        590        600
RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR 
       610        620        630        640        650
EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL 
       660        670        680        690        700
LSGVVQALRG RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG 
       710 
VWVAEAEDEP LLT

Length:713

Mass (Da):76,193

Last modified:April 13, 2004 - v2

Checksum:ⁱA463FB5584322220

Isoform 2 (identifier: Q7Z4F1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
557-713: Missing.

« Hide

        10         20         30         40         50
MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS 
        60         70         80         90        100
RTSPANCTWL ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA 
       110        120        130        140        150
PPSPLQLPGG NVTITYSYAG ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH 
       160        170        180        190        200
RCVSAVQRCD GVDACGDGSD EAGCSSDPFP GLTPRPVPSL PCNVTLEDFY 
       210        220        230        240        250
GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD LGFGDAVHVY 
       260        270        280        290        300
DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA 
       310        320        330        340        350
TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE 
       360        370        380        390        400
EDCPGCPPGH FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ 
       410        420        430        440        450
PGNFRCRDEK CVYETWVCDG QPDCADGSDE WDCSYVLPRK VITAAVIGSL 
       460        470        480        490        500
VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL SRMEAEIVQQ QAPPSYGQLI 
       510        520        530        540        550
AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG GPGARRRQRG 

RLMRRL

Note: No experimental confirmation available.

Show »

Length:556

Mass (Da):60,213

Checksum:ⁱ1CCA7CAEA16A0AB1

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YHW7	H0YHW7_HUMAN		Low-density lipoprotein receptor-re... Low-density lipoprotein receptor-related protein 10	LRP10	458	Annotation score:

Sequence cautionⁱ

The sequence AAD20037 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAG17980 differs from that shown. Reason: Frameshift at positions 370 and 700.Curated

The sequence AAQ13610 differs from that shown. Reason: Frameshift at positions 312, 337, 496, 502 and 512.Curated

The sequence CAD39174 differs from that shown. Chimera.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	365	A → T (PubMed:15498874).Curated	1
Sequence conflictⁱ	434	S → C (PubMed:15498874).Curated	1
Sequence conflictⁱ	558	R → H in CAB45753 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_018172	48	R → W. Corresponds to variant dbSNP:rs2273837Ensembl.		1
Natural variantⁱVAR_034097	139	M → V. Corresponds to variant dbSNP:rs28534929Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009820	557 – 713	Missing in isoform 2. 1 PublicationAdd BLAST		157

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358399 mRNA Translation: AAQ88765.1 BX161500 mRNA Translation: CAD61944.1 AK291030 mRNA Translation: BAF83719.1 AL080164 mRNA Translation: CAB45753.1 AL834518 mRNA Translation: CAD39174.2 Sequence problems. CH471078 Genomic DNA Translation: EAW66232.1 CH471078 Genomic DNA Translation: EAW66235.1 BC064901 mRNA Translation: AAH64901.1 BC113714 mRNA Translation: AAI13715.1 BC113716 mRNA Translation: AAI13717.1 AF172816 mRNA Translation: AAQ13610.1 Frameshift. AF177336 mRNA Translation: AAG17980.1 Frameshift. AF131760 mRNA Translation: AAD20037.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS86372.1 [Q7Z4F1-2] CCDS9578.1 [Q7Z4F1-1]
PIRⁱ	T12469
NCBI Reference Sequences More...RefSeqⁱ	NP_001316155.1, NM_001329226.1 [Q7Z4F1-2] NP_054764.2, NM_014045.4 [Q7Z4F1-1]
UniGeneⁱ	Hs.525232 Hs.657588

Genome annotation databases

Ensemblⁱ	ENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1] ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2]
GeneIDⁱ	26020
KEGGⁱ	hsa:26020
UCSC genome browser More...UCSCⁱ	uc001whd.4 human [Q7Z4F1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z4F1	Isoform 2 of Low-density lipoprotein receptor-related protein 10		HUMAN		556	UniRef90_Q7Z4F1
low-density lipoprotein receptor-related protein 10		TARSY		732
Uncharacterized protein		CERAT		718
Uncharacterized protein		MACMU		718
Uncharacterized protein		COLAP		716
+76

Protein	Similar proteins		Species	Score	Length	Source
Q7Z4F1	Isoform 2 of Low-density lipoprotein receptor-related protein 10		HUMAN		556	UniRef50_Q7Z4F1
low-density lipoprotein receptor-related protein 10		TARSY		732
Uncharacterized protein		CERAT		718
Uncharacterized protein		MACMU		718
Uncharacterized protein		COLAP		716
+80

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358399 mRNA Translation: AAQ88765.1 BX161500 mRNA Translation: CAD61944.1 AK291030 mRNA Translation: BAF83719.1 AL080164 mRNA Translation: CAB45753.1 AL834518 mRNA Translation: CAD39174.2 Sequence problems. CH471078 Genomic DNA Translation: EAW66232.1 CH471078 Genomic DNA Translation: EAW66235.1 BC064901 mRNA Translation: AAH64901.1 BC113714 mRNA Translation: AAI13715.1 BC113716 mRNA Translation: AAI13717.1 AF172816 mRNA Translation: AAQ13610.1 Frameshift. AF177336 mRNA Translation: AAG17980.1 Frameshift. AF131760 mRNA Translation: AAD20037.1 Different initiation.
CCDSⁱ	CCDS86372.1 [Q7Z4F1-2] CCDS9578.1 [Q7Z4F1-1]
PIRⁱ	T12469
RefSeqⁱ	NP_001316155.1, NM_001329226.1 [Q7Z4F1-2] NP_054764.2, NM_014045.4 [Q7Z4F1-1]
UniGeneⁱ	Hs.525232 Hs.657588

3D structure databases

ProteinModelPortalⁱ	Q7Z4F1
SMRⁱ	Q7Z4F1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117491, 40 interactors
IntActⁱ	Q7Z4F1, 26 interactors
MINTⁱ	Q7Z4F1
STRINGⁱ	9606.ENSP00000352601

PTM databases

GlyConnectⁱ	1465
iPTMnetⁱ	Q7Z4F1
PhosphoSitePlusⁱ	Q7Z4F1
SwissPalmⁱ	Q7Z4F1

Polymorphism and mutation databases

BioMutaⁱ	LRP10
DMDMⁱ	46396347

Proteomic databases

EPDⁱ	Q7Z4F1
MaxQBⁱ	Q7Z4F1
PaxDbⁱ	Q7Z4F1
PeptideAtlasⁱ	Q7Z4F1
PRIDEⁱ	Q7Z4F1
ProteomicsDBⁱ	69172 69173 [Q7Z4F1-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1] ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2]
GeneIDⁱ	26020
KEGGⁱ	hsa:26020
UCSCⁱ	uc001whd.4 human [Q7Z4F1-1]

Organism-specific databases

CTDⁱ	26020
DisGeNETⁱ	26020
EuPathDBⁱ	HostDB:ENSG00000197324.8
GeneCardsⁱ	LRP10
HGNCⁱ	HGNC:14553 LRP10
HPAⁱ	HPA000932
MIMⁱ	609921 gene
neXtProtⁱ	NX_Q7Z4F1
OpenTargetsⁱ	ENSG00000197324
PharmGKBⁱ	PA38383
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPT0 Eukaryota ENOG410XV08 LUCA
GeneTreeⁱ	ENSGT00810000125405
HOVERGENⁱ	HBG049162
InParanoidⁱ	Q7Z4F1
KOⁱ	K20050
OMAⁱ	WDCSYAL
OrthoDBⁱ	EOG091G04LP
PhylomeDBⁱ	Q7Z4F1
TreeFamⁱ	TF332149

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975634 Retinoid metabolism and transport

Reactomeⁱ

R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	LRP10 human
GeneWikiⁱ	LRP10
GenomeRNAiⁱ	26020
Protein Ontology More...PROⁱ	PR:Q7Z4F1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197324 Expressed in 228 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_LRP10
ExpressionAtlasⁱ	Q7Z4F1 baseline and differential
Genevisibleⁱ	Q7Z4F1 HS

Family and domain databases

CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 3 hits
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR035914 Sperma_CUB_dom_sf
Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00057 Ldl_recept_a, 2 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 4 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 2 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRP10_HUMAN
Accessionⁱ	Q7Z4F1Primary (citable) accession number: Q7Z4F1 Secondary accession number(s): A8K4R5 Q9UG33
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	April 13, 2004
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q7Z4F1 (LRP10_HUMAN)

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Low-density lipoprotein receptor-related protein 10

LRP10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ