UniProtKB - Q7Z497 (Q7Z497_HUMAN)
Protein
Submitted name:
SF3B1 protein
Gene
SF3B1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- mRNA binding Source: InterPro
GO - Biological processi
- spliceosomal complex assembly Source: InterPro
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Submitted name: SF3B1 proteinImported |
Gene namesi | Name:SF3B1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- spliceosomal complex Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotation, SpliceosomeARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 329 – 451 | SF3b1InterPro annotationAdd BLAST | 123 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 119 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 124 – 148 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 173 – 360 | DisorderedSequence analysisAdd BLAST | 188 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 28 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 104 – 119 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 204 – 224 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 342 – 356 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the SF3B1 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationFamily and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015016, SF3b_su1 IPR038737, SF3b_su1-like |
PANTHERi | PTHR12097, PTHR12097, 1 hit |
Pfami | View protein in Pfam PF08920, SF3b1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q7Z497-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR
60 70 80 90 100
FAGYVTSIAA TELEDDDDDY SSSTSLLGQK KPGYHAPVAL LNDIPQSTEQ
110 120 130 140 150
YDPFAEHRPP KIADREDEYK KHRRTMIISP ERLDPFADGG KTPDPKMNAR
160 170 180 190 200
TYMDVMREQH LTKEEREIRQ QLAEKAKAGE LKVVNGAAAS QPPSKRKRRW
210 220 230 240 250
DQTADQTPGA TPKKLSSWDQ AETPGHTPSL RWDETPGRAK GSETPGATPG
260 270 280 290 300
SKIWDPTPSH TPAGAATPGR GDTPGHATPG HGGATSSARK NRWDETPKTE
310 320 330 340 350
RDTPGHGSGW AETPRTDRGG DSIGETPTPG ASKRKSRWDE TPASQMGGST
360 370 380 390 400
PVLTPGKTPI GTPAMNMATP TPGHIMSMTP EQLQAWRWER EIDERNRPLS
410 420 430 440 450
DEELDAMFPE GYKVLPPPAG YVPIRTPARK LTATPTPLGG MTGFHMQTED
460 470 480 490 500
RTMKSVNDQP SGNLPFLKPD DIQYFDKLLV DVDESTLSPE EQKERKIMKL
510 520 530 540 550
LLKIKNGTPP MRKAALRQIT DKAREFGAGP LFNQILPLLM SPTLEDQERH
560 570 580 590 600
LLVKVIDRIL YKLDDLVRPY VHKILVVIEP LLIDEDYYAR VEGREIISNL
610 620 630 640 650
AKAAGLATMI STMRPDIDNM DEYVRNTTAR AFAVVASALG IPSLLPFLKA
660 670 680 690 700
VCKSKKSWQA RHTGIKIVQQ IAILMGCAIL PHLRSLVEII EHGLVDEQQK
710 720 730 740 750
VRTISALAIA ALAEAATPYG IESFDSVLKP LWKGIRQHRG KGLAAFLKAI
760 770 780
GYLIPLMDAE YANYYTREVM LILIREFQSP DEEMKKKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 789 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC056155 mRNA Translation: AAH56155.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC056155 mRNA Translation: AAH56155.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q7Z497 |
PRIDEi | Q7Z497 |
Organism-specific databases
PharmGKBi | PA35686 |
Miscellaneous databases
ChiTaRSi | SF3B1, human |
Gene expression databases
Genevisiblei | Q7Z497, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015016, SF3b_su1 IPR038737, SF3b_su1-like |
PANTHERi | PTHR12097, PTHR12097, 1 hit |
Pfami | View protein in Pfam PF08920, SF3b1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7Z497_HUMAN | |
Accessioni | Q7Z497Primary (citable) accession number: Q7Z497 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2003 |
Last sequence update: | October 1, 2003 | |
Last modified: | October 7, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |