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UniProtKB - Q7Z478 (DHX29_HUMAN)

>sp|Q7Z478|DHX29_HUMAN ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2
MGGKNKKHKAPAAAVVRAAVSASRAKSAEAGIAGEAQSKKPVSRPATAAAAAAGSREPRV
KQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVINEHKKQNNDKGMISGRLT
AKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALDWLCLNLSDDALPEGFSQEFE
EQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKPKKEEKNMEVNMKEWILRYAEQQ
NEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKEQAATFKLEKNKQGQKEAQEKIRKF
QREMETLEDHPVFNPAMKISHQQNERKKPPVATEGESALNFNLFEKSAAATEEEKDKKKE
PHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVPVGRYWKCRVRVIKSEDD
VLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDAEKKREELN
KMETNKPRDLFIAKLLNKLKQQQQQQQQHSENKRENSEDPEESWENLVSDEDFSALSLES
ANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSG
KSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCG
YQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKE
ILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKD
SEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYM
NPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYKV
IALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESS
QMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCL
HIMKCNLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNV
KIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYN
AYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWE
GNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSS
VNRDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQ
APVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN

Entry version 166 (23 Feb 2022)
Sequence version 2 (11 Jul 2006)
Previous versions | rss

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Protein

ATP-dependent RNA helicase DHX29

Gene

DHX29

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

UniRule annotation2 Publications

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_03068
EC:
3.6.4.13
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_03068
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
H₂O
=
ADP
+
H⁺
+
phosphate
zoom

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	595 – 602	ATPUniRule annotation		8

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, Initiation factor
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q7Z478
SignaLinkⁱ	Q7Z478

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-dependent RNA helicase DHX29UniRule annotation (EC:3.6.4.13UniRule annotation) Alternative name(s): DEAH box protein 29UniRule annotation Nucleic acid helicase DDXx
Gene namesⁱ	Name:DHX29UniRule annotation Synonyms:DDX29
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15815, DHX29
MIMⁱ	612720, gene
neXtProtⁱ	NX_Q7Z478
VEuPathDBⁱ	HostDB:ENSG00000067248

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54505
Open Targets More...OpenTargetsⁱ	ENSG00000067248
PharmGKBⁱ	PA27215

Miscellaneous databases

Pharosⁱ	Q7Z478, Tbio

Pharosⁱ

Q7Z478, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL4105909

ChEMBLⁱ

CHEMBL4105909

Genetic variation databases

BioMutaⁱ	DHX29
DMDMⁱ	110278938

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000245535	1 – 1369	ATP-dependent RNA helicase DHX29Add BLAST		1369

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	71	PhosphoserineCombined sources	1
Modified residueⁱ	192	PhosphoserineCombined sources	1
Modified residueⁱ	200	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7Z478
jPOSTⁱ	Q7Z478
MassIVEⁱ	Q7Z478
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z478
PaxDbⁱ	Q7Z478
PeptideAtlas More...PeptideAtlasⁱ	Q7Z478
PRIDEⁱ	Q7Z478
ProteomicsDBⁱ	69161

PTM databases

GlyGenⁱ	Q7Z478, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q7Z478
PhosphoSitePlusⁱ	Q7Z478

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000067248, Expressed in female gonad and 246 other tissues
ExpressionAtlasⁱ	Q7Z478, baseline and differential
Genevisibleⁱ	Q7Z478, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000067248, Low tissue specificity

HPAⁱ

ENSG00000067248, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

UniRule annotation1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- "E-cadherin interactome complexity and robustness resolved by quantitative proteomics."
  Guo Z., Neilson L.J., Zhong H., Murray P.S., Zanivan S., Zaidel-Bar R.
  Sci Signal 7:rs7-rs7(2014) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	120001, 66 interactors
IntActⁱ	Q7Z478, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q7Z478
STRINGⁱ	9606.ENSP00000251636

Chemistry databases

BindingDBⁱ

Q7Z478

Miscellaneous databases

RNActⁱ	Q7Z478, protein

RNActⁱ

Q7Z478, protein

Structureⁱ

3D structure databases

SMRⁱ	Q7Z478
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	582 – 755	Helicase ATP-bindingUniRule annotationAdd BLAST		174
Domainⁱ	849 – 1026	Helicase C-terminalUniRule annotationAdd BLAST		178

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	27 – 75	DisorderedSequence analysisAdd BLAST	49
Regionⁱ	176 – 226	DisorderedSequence analysisAdd BLAST	51
Regionⁱ	502 – 526	DisorderedSequence analysisAdd BLAST	25

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	222 – 256	UniRule annotationAdd BLAST	35
Coiled coilⁱ	283 – 310	UniRule annotationAdd BLAST	28
Coiled coilⁱ	492 – 519	UniRule annotationAdd BLAST	28

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	702 – 705	DEAH boxUniRule annotation		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	186 – 205	Polar residuesSequence analysisAdd BLAST		20
Compositional biasⁱ	208 – 226	Basic and acidic residuesSequence analysisAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DEAH subfamily.UniRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0920, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157286
HOGENOMⁱ	CLU_001832_1_4_1
InParanoidⁱ	Q7Z478
OMAⁱ	WGASKCN
Database of Orthologous Groups More...OrthoDBⁱ	278674at2759
PhylomeDBⁱ	Q7Z478
TreeFamⁱ	TF324744

Family and domain databases

Gene3Dⁱ	3.40.50.300, 2 hits
HAMAPⁱ	MF_03068, DHX29, 1 hit
InterProⁱ	View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR034730, DHX29 IPR002464, DNA/RNA_helicase_DEAH_CS IPR011709, DUF1605 IPR007502, Helicase-assoc_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270, DEAD, 1 hit PF04408, HA2, 1 hit PF00271, Helicase_C, 1 hit PF07717, OB_NTP_bind, 1 hit
SMARTⁱ	View protein in SMART SM00487, DEXDc, 1 hit SM00847, HA2, 1 hit SM00490, HELICc, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q7Z478-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGGKNKKHKA PAAAVVRAAV SASRAKSAEA GIAGEAQSKK PVSRPATAAA 
        60         70         80         90        100
AAAGSREPRV KQGPKIYSFN STNDSSGPAN LDKSILKVVI NNKLEQRIIG 
       110        120        130        140        150
VINEHKKQNN DKGMISGRLT AKKLQDLYMA LQAFSFKTKD IEDAMTNTLL 
       160        170        180        190        200
YGGDLHSALD WLCLNLSDDA LPEGFSQEFE EQQPKSRPKF QSPQIQATIS 
       210        220        230        240        250
PPLQPKTKTY EEDPKSKPKK EEKNMEVNMK EWILRYAEQQ NEEEKNENSK 
       260        270        280        290        300
SLEEEEKFDP NERYLHLAAK LLDAKEQAAT FKLEKNKQGQ KEAQEKIRKF 
       310        320        330        340        350
QREMETLEDH PVFNPAMKIS HQQNERKKPP VATEGESALN FNLFEKSAAA 
       360        370        380        390        400
TEEEKDKKKE PHDVRNFDYT ARSWTGKSPK QFLIDWVRKN LPKSPNPSFE 
       410        420        430        440        450
KVPVGRYWKC RVRVIKSEDD VLVVCPTILT EDGMQAQHLG ATLALYRLVK 
       460        470        480        490        500
GQSVHQLLPP TYRDVWLEWS DAEKKREELN KMETNKPRDL FIAKLLNKLK 
       510        520        530        540        550
QQQQQQQQHS ENKRENSEDP EESWENLVSD EDFSALSLES ANVEDLEPVR 
       560        570        580        590        600
NLFRKLQSTP KYQKLLKERQ QLPVFKHRDS IVETLKRHRV VVVAGETGSG 
       610        620        630        640        650
KSTQVPHFLL EDLLLNEWEA SKCNIVCTQP RRISAVSLAN RVCDELGCEN 
       660        670        680        690        700
GPGGRNSLCG YQIRMESRAC ESTRLLYCTT GVLLRKLQED GLLSNVSHVI 
       710        720        730        740        750
VDEVHERSVQ SDFLLIILKE ILQKRSDLHL ILMSATVDSE KFSTYFTHCP 
       760        770        780        790        800
ILRISGRSYP VEVFHLEDII EETGFVLEKD SEYCQKFLEE EEEVTINVTS 
       810        820        830        840        850
KAGGIKKYQE YIPVQTGAHA DLNPFYQKYS SRTQHAILYM NPHKINLDLI 
       860        870        880        890        900
LELLAYLDKS PQFRNIEGAV LIFLPGLAHI QQLYDLLSND RRFYSERYKV 
       910        920        930        940        950
IALHSILSTQ DQAAAFTLPP PGVRKIVLAT NIAETGITIP DVVFVIDTGR 
       960        970        980        990       1000
TKENKYHESS QMSSLVETFV SKASALQRQG RAGRVRDGFC FRMYTRERFE 
      1010       1020       1030       1040       1050
GFMDYSVPEI LRVPLEELCL HIMKCNLGSP EDFLSKALDP PQLQVISNAM 
      1060       1070       1080       1090       1100
NLLRKIGACE LNEPKLTPLG QHLAALPVNV KIGKMLIFGA IFGCLDPVAT 
      1110       1120       1130       1140       1150
LAAVMTEKSP FTTPIGRKDE ADLAKSALAM ADSDHLTIYN AYLGWKKARQ 
      1160       1170       1180       1190       1200
EGGYRSEITY CRRNFLNRTS LLTLEDVKQE LIKLVKAAGF SSSTTSTSWE 
      1210       1220       1230       1240       1250
GNRASQTLSF QEIALLKAVL VAGLYDNVGK IIYTKSVDVT EKLACIVETA 
      1260       1270       1280       1290       1300
QGKAQVHPSS VNRDLQTHGW LLYQEKIRYA RVYLRETTLI TPFPVLLFGG 
      1310       1320       1330       1340       1350
DIEVQHRERL LSIDGWIYFQ APVKIAVIFK QLRVLIDSVL RKKLENPKMS 
      1360 
LENDKILQII TELIKTENN

Length:1,369

Mass (Da):155,236

Last modified:July 11, 2006 - v2

Checksum:ⁱF720A77D224C7F59

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WYN9	A0A087WYN9_HUMAN	ATP-dependent RNA helicase DHX29 ATP-dependent RNA helicase DHX29, EC 3.6.4.13 (DEAH box protein 29)	DHX29	1,370	Annotation score:
H0Y8L1	H0Y8L1_HUMAN	ATP-dependent RNA helicase DHX29 ATP-dependent RNA helicase DHX29	DHX29	160	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	121	A → D in CAH56172 (PubMed:17974005).Curated	1
Sequence conflictⁱ	185	K → E in CAH56153 (PubMed:17974005).Curated	1
Sequence conflictⁱ	356	D → G in AAK64516 (Ref. 1) Curated	1
Sequence conflictⁱ	885	D → G in CAH56172 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052180	309	D → A. Corresponds to variant dbSNP:rs35874395Ensembl.		1
Natural variantⁱVAR_026985	630	P → H1 PublicationCorresponds to variant dbSNP:rs17854904Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY036974 mRNA Translation: AAK64516.1 BC056219 mRNA Translation: AAH56219.1 AL834496 mRNA Translation: CAD39154.1 BX648101 mRNA Translation: CAH56172.1 BX648269 mRNA Translation: CAH56153.1 AL079292 mRNA Translation: CAB45191.1 AF070639 mRNA Translation: AAC25394.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34158.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001332893.1, NM_001345964.1 NP_001332894.1, NM_001345965.1 NP_061903.2, NM_019030.3

Genome annotation databases

Ensemblⁱ	ENST00000251636; ENSP00000251636; ENSG00000067248
GeneIDⁱ	54505
KEGGⁱ	hsa:54505
MANE-Selectⁱ	ENST00000251636.10; ENSP00000251636.5; NM_019030.4; NP_061903.2
UCSC genome browser More...UCSCⁱ	uc003jpx.4, human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z478	ATP-dependent RNA helicase DHX29		MOUSE		1365	UniRef90_Q7Z478
ATP-dependent RNA helicase DHX29		TUPCH		1404
ATP-dependent RNA helicase DHX29		VICPA		1389
ATP-dependent RNA helicase DHX29		MONMO		1384
Uncharacterized protein		PIG		1384
+261

Protein	Similar proteins		Species	Score	Length	Source
Q7Z478	ATP-dependent RNA helicase DHX29		MOUSE		1365	UniRef50_Q7Z478
ATP-dependent RNA helicase dhx29		XENLA		1362
ATP-dependent RNA helicase DHX29		TUPCH		1404
ATP-dependent RNA helicase DHX29		VICPA		1389
ATP-dependent RNA helicase DHX29		MONMO		1384
+979

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY036974 mRNA Translation: AAK64516.1 BC056219 mRNA Translation: AAH56219.1 AL834496 mRNA Translation: CAD39154.1 BX648101 mRNA Translation: CAH56172.1 BX648269 mRNA Translation: CAH56153.1 AL079292 mRNA Translation: CAB45191.1 AF070639 mRNA Translation: AAC25394.1
CCDSⁱ	CCDS34158.1
RefSeqⁱ	NP_001332893.1, NM_001345964.1 NP_001332894.1, NM_001345965.1 NP_061903.2, NM_019030.3

3D structure databases

SMRⁱ	Q7Z478
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	120001, 66 interactors
IntActⁱ	Q7Z478, 24 interactors
MINTⁱ	Q7Z478
STRINGⁱ	9606.ENSP00000251636

Chemistry databases

BindingDBⁱ	Q7Z478
ChEMBLⁱ	CHEMBL4105909

PTM databases

GlyGenⁱ	Q7Z478, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q7Z478
PhosphoSitePlusⁱ	Q7Z478

Genetic variation databases

BioMutaⁱ	DHX29
DMDMⁱ	110278938

Proteomic databases

EPDⁱ	Q7Z478
jPOSTⁱ	Q7Z478
MassIVEⁱ	Q7Z478
MaxQBⁱ	Q7Z478
PaxDbⁱ	Q7Z478
PeptideAtlasⁱ	Q7Z478
PRIDEⁱ	Q7Z478
ProteomicsDBⁱ	69161

Protocols and materials databases

Antibodypediaⁱ	11081, 94 antibodies from 21 providers
The DNASU plasmid repository More...DNASUⁱ	54505

Genome annotation databases

Ensemblⁱ	ENST00000251636; ENSP00000251636; ENSG00000067248
GeneIDⁱ	54505
KEGGⁱ	hsa:54505
MANE-Selectⁱ	ENST00000251636.10; ENSP00000251636.5; NM_019030.4; NP_061903.2
UCSCⁱ	uc003jpx.4, human

Organism-specific databases

CTDⁱ	54505
DisGeNETⁱ	54505
GeneCardsⁱ	DHX29
HGNCⁱ	HGNC:15815, DHX29
HPAⁱ	ENSG00000067248, Low tissue specificity
MIMⁱ	612720, gene
neXtProtⁱ	NX_Q7Z478
OpenTargetsⁱ	ENSG00000067248
PharmGKBⁱ	PA27215
VEuPathDBⁱ	HostDB:ENSG00000067248
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0920, Eukaryota
GeneTreeⁱ	ENSGT00940000157286
HOGENOMⁱ	CLU_001832_1_4_1
InParanoidⁱ	Q7Z478
OMAⁱ	WGASKCN
OrthoDBⁱ	278674at2759
PhylomeDBⁱ	Q7Z478
TreeFamⁱ	TF324744

Enzyme and pathway databases

PathwayCommonsⁱ	Q7Z478
SignaLinkⁱ	Q7Z478

Miscellaneous databases

BioGRID-ORCSⁱ	54505, 106 hits in 1061 CRISPR screens
ChiTaRSⁱ	DHX29, human
GenomeRNAiⁱ	54505
Pharosⁱ	Q7Z478, Tbio
Protein Ontology More...PROⁱ	PR:Q7Z478
RNActⁱ	Q7Z478, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000067248, Expressed in female gonad and 246 other tissues
ExpressionAtlasⁱ	Q7Z478, baseline and differential
Genevisibleⁱ	Q7Z478, HS

Family and domain databases

Gene3Dⁱ	3.40.50.300, 2 hits
HAMAPⁱ	MF_03068, DHX29, 1 hit
InterProⁱ	View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR034730, DHX29 IPR002464, DNA/RNA_helicase_DEAH_CS IPR011709, DUF1605 IPR007502, Helicase-assoc_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00270, DEAD, 1 hit PF04408, HA2, 1 hit PF00271, Helicase_C, 1 hit PF07717, OB_NTP_bind, 1 hit
SMARTⁱ	View protein in SMART SM00487, DEXDc, 1 hit SM00847, HA2, 1 hit SM00490, HELICc, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHX29_HUMAN
Accessionⁱ	Q7Z478Primary (citable) accession number: Q7Z478 Secondary accession number(s): O75549 , Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
	Last sequence update:	July 11, 2006
	Last modified:	February 23, 2022
	This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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Help

UniRef

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Supporting data

UniProtKB - Q7Z478 (DHX29_HUMAN)

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ATP-dependent RNA helicase DHX29

DHX29

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ