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Protein

ATP-dependent RNA helicase DHX29

Gene

DHX29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.UniRule annotation2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi595 – 602ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, Initiation factor
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DHX29UniRule annotation (EC:3.6.4.13UniRule annotation)
Alternative name(s):
DEAH box protein 29UniRule annotation
Nucleic acid helicase DDXx
Gene namesi
Name:DHX29UniRule annotation
Synonyms:DDX29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000067248.9
HGNCiHGNC:15815 DHX29
MIMi612720 gene
neXtProtiNX_Q7Z478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi54505
OpenTargetsiENSG00000067248
PharmGKBiPA27215

Polymorphism and mutation databases

BioMutaiDHX29
DMDMi110278938

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455351 – 1369ATP-dependent RNA helicase DHX29Add BLAST1369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z478
MaxQBiQ7Z478
PaxDbiQ7Z478
PeptideAtlasiQ7Z478
PRIDEiQ7Z478
ProteomicsDBi69161

PTM databases

iPTMnetiQ7Z478
PhosphoSitePlusiQ7Z478

Expressioni

Gene expression databases

BgeeiENSG00000067248 Expressed in 234 organ(s), highest expression level in female gonad
CleanExiHS_DHX29
ExpressionAtlasiQ7Z478 baseline and differential
GenevisibleiQ7Z478 HS

Organism-specific databases

HPAiHPA038317
HPA038318

Interactioni

Subunit structurei

Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.UniRule annotation1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120001, 30 interactors
IntActiQ7Z478, 14 interactors
MINTiQ7Z478
STRINGi9606.ENSP00000251636

Structurei

3D structure databases

ProteinModelPortaliQ7Z478
SMRiQ7Z478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini582 – 755Helicase ATP-bindingUniRule annotationAdd BLAST174
Domaini849 – 1026Helicase C-terminalUniRule annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili222 – 256UniRule annotationAdd BLAST35
Coiled coili283 – 310UniRule annotationAdd BLAST28
Coiled coili492 – 519UniRule annotationAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi702 – 705DEAH boxUniRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 53Ala-richAdd BLAST44
Compositional biasi789 – 793Poly-Glu5

Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00760000119189
HOGENOMiHOG000247063
HOVERGENiHBG081436
InParanoidiQ7Z478
KOiK18995
PhylomeDBiQ7Z478
TreeFamiTF324744

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_03068 DHX29, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR034730 DHX29
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7Z478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGKNKKHKA PAAAVVRAAV SASRAKSAEA GIAGEAQSKK PVSRPATAAA
60 70 80 90 100
AAAGSREPRV KQGPKIYSFN STNDSSGPAN LDKSILKVVI NNKLEQRIIG
110 120 130 140 150
VINEHKKQNN DKGMISGRLT AKKLQDLYMA LQAFSFKTKD IEDAMTNTLL
160 170 180 190 200
YGGDLHSALD WLCLNLSDDA LPEGFSQEFE EQQPKSRPKF QSPQIQATIS
210 220 230 240 250
PPLQPKTKTY EEDPKSKPKK EEKNMEVNMK EWILRYAEQQ NEEEKNENSK
260 270 280 290 300
SLEEEEKFDP NERYLHLAAK LLDAKEQAAT FKLEKNKQGQ KEAQEKIRKF
310 320 330 340 350
QREMETLEDH PVFNPAMKIS HQQNERKKPP VATEGESALN FNLFEKSAAA
360 370 380 390 400
TEEEKDKKKE PHDVRNFDYT ARSWTGKSPK QFLIDWVRKN LPKSPNPSFE
410 420 430 440 450
KVPVGRYWKC RVRVIKSEDD VLVVCPTILT EDGMQAQHLG ATLALYRLVK
460 470 480 490 500
GQSVHQLLPP TYRDVWLEWS DAEKKREELN KMETNKPRDL FIAKLLNKLK
510 520 530 540 550
QQQQQQQQHS ENKRENSEDP EESWENLVSD EDFSALSLES ANVEDLEPVR
560 570 580 590 600
NLFRKLQSTP KYQKLLKERQ QLPVFKHRDS IVETLKRHRV VVVAGETGSG
610 620 630 640 650
KSTQVPHFLL EDLLLNEWEA SKCNIVCTQP RRISAVSLAN RVCDELGCEN
660 670 680 690 700
GPGGRNSLCG YQIRMESRAC ESTRLLYCTT GVLLRKLQED GLLSNVSHVI
710 720 730 740 750
VDEVHERSVQ SDFLLIILKE ILQKRSDLHL ILMSATVDSE KFSTYFTHCP
760 770 780 790 800
ILRISGRSYP VEVFHLEDII EETGFVLEKD SEYCQKFLEE EEEVTINVTS
810 820 830 840 850
KAGGIKKYQE YIPVQTGAHA DLNPFYQKYS SRTQHAILYM NPHKINLDLI
860 870 880 890 900
LELLAYLDKS PQFRNIEGAV LIFLPGLAHI QQLYDLLSND RRFYSERYKV
910 920 930 940 950
IALHSILSTQ DQAAAFTLPP PGVRKIVLAT NIAETGITIP DVVFVIDTGR
960 970 980 990 1000
TKENKYHESS QMSSLVETFV SKASALQRQG RAGRVRDGFC FRMYTRERFE
1010 1020 1030 1040 1050
GFMDYSVPEI LRVPLEELCL HIMKCNLGSP EDFLSKALDP PQLQVISNAM
1060 1070 1080 1090 1100
NLLRKIGACE LNEPKLTPLG QHLAALPVNV KIGKMLIFGA IFGCLDPVAT
1110 1120 1130 1140 1150
LAAVMTEKSP FTTPIGRKDE ADLAKSALAM ADSDHLTIYN AYLGWKKARQ
1160 1170 1180 1190 1200
EGGYRSEITY CRRNFLNRTS LLTLEDVKQE LIKLVKAAGF SSSTTSTSWE
1210 1220 1230 1240 1250
GNRASQTLSF QEIALLKAVL VAGLYDNVGK IIYTKSVDVT EKLACIVETA
1260 1270 1280 1290 1300
QGKAQVHPSS VNRDLQTHGW LLYQEKIRYA RVYLRETTLI TPFPVLLFGG
1310 1320 1330 1340 1350
DIEVQHRERL LSIDGWIYFQ APVKIAVIFK QLRVLIDSVL RKKLENPKMS
1360
LENDKILQII TELIKTENN
Length:1,369
Mass (Da):155,236
Last modified:July 11, 2006 - v2
Checksum:iF720A77D224C7F59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYN9A0A087WYN9_HUMAN
ATP-dependent RNA helicase DHX29
DHX29
1,370Annotation score:
H0Y8L1H0Y8L1_HUMAN
ATP-dependent RNA helicase DHX29
DHX29
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121A → D in CAH56172 (PubMed:17974005).Curated1
Sequence conflicti185K → E in CAH56153 (PubMed:17974005).Curated1
Sequence conflicti356D → G in AAK64516 (Ref. 1) Curated1
Sequence conflicti885D → G in CAH56172 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052180309D → A. Corresponds to variant dbSNP:rs35874395Ensembl.1
Natural variantiVAR_026985630P → H1 PublicationCorresponds to variant dbSNP:rs17854904Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036974 mRNA Translation: AAK64516.1
BC056219 mRNA Translation: AAH56219.1
AL834496 mRNA Translation: CAD39154.1
BX648101 mRNA Translation: CAH56172.1
BX648269 mRNA Translation: CAH56153.1
AL079292 mRNA Translation: CAB45191.1
AF070639 mRNA Translation: AAC25394.1
CCDSiCCDS34158.1
RefSeqiNP_001332893.1, NM_001345964.1
NP_001332894.1, NM_001345965.1
NP_061903.2, NM_019030.3
UniGeneiHs.593268

Genome annotation databases

EnsembliENST00000251636; ENSP00000251636; ENSG00000067248
GeneIDi54505
KEGGihsa:54505
UCSCiuc003jpx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036974 mRNA Translation: AAK64516.1
BC056219 mRNA Translation: AAH56219.1
AL834496 mRNA Translation: CAD39154.1
BX648101 mRNA Translation: CAH56172.1
BX648269 mRNA Translation: CAH56153.1
AL079292 mRNA Translation: CAB45191.1
AF070639 mRNA Translation: AAC25394.1
CCDSiCCDS34158.1
RefSeqiNP_001332893.1, NM_001345964.1
NP_001332894.1, NM_001345965.1
NP_061903.2, NM_019030.3
UniGeneiHs.593268

3D structure databases

ProteinModelPortaliQ7Z478
SMRiQ7Z478
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120001, 30 interactors
IntActiQ7Z478, 14 interactors
MINTiQ7Z478
STRINGi9606.ENSP00000251636

PTM databases

iPTMnetiQ7Z478
PhosphoSitePlusiQ7Z478

Polymorphism and mutation databases

BioMutaiDHX29
DMDMi110278938

Proteomic databases

EPDiQ7Z478
MaxQBiQ7Z478
PaxDbiQ7Z478
PeptideAtlasiQ7Z478
PRIDEiQ7Z478
ProteomicsDBi69161

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251636; ENSP00000251636; ENSG00000067248
GeneIDi54505
KEGGihsa:54505
UCSCiuc003jpx.4 human

Organism-specific databases

CTDi54505
DisGeNETi54505
EuPathDBiHostDB:ENSG00000067248.9
GeneCardsiDHX29
H-InvDBiHIX0004866
HGNCiHGNC:15815 DHX29
HPAiHPA038317
HPA038318
MIMi612720 gene
neXtProtiNX_Q7Z478
OpenTargetsiENSG00000067248
PharmGKBiPA27215
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00760000119189
HOGENOMiHOG000247063
HOVERGENiHBG081436
InParanoidiQ7Z478
KOiK18995
PhylomeDBiQ7Z478
TreeFamiTF324744

Miscellaneous databases

ChiTaRSiDHX29 human
GenomeRNAii54505
PROiPR:Q7Z478
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067248 Expressed in 234 organ(s), highest expression level in female gonad
CleanExiHS_DHX29
ExpressionAtlasiQ7Z478 baseline and differential
GenevisibleiQ7Z478 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_03068 DHX29, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR034730 DHX29
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHX29_HUMAN
AccessioniPrimary (citable) accession number: Q7Z478
Secondary accession number(s): O75549
, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: October 10, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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