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Protein

CLIP-associating protein 1

Gene

CLASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
  • kinetochore binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • microtubule plus-end binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CLIP-associating protein 1
Alternative name(s):
Cytoplasmic linker-associated protein 1
Multiple asters homolog 1
Protein Orbit homolog 1
Short name:
hOrbit1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLASP1
Synonyms:KIAA0622, MAST1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000074054.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17088 CLASP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605852 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23332

Open Targets

More...
OpenTargetsi
ENSG00000074054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38436

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLASP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898471 – 1538CLIP-associating protein 1Add BLAST1538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei246PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei548PhosphoserineBy similarity1
Modified residuei558PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei656PhosphothreonineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei711PhosphothreonineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1
Modified residuei797PhosphoserineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1095PhosphothreonineBy similarity1
Modified residuei1099PhosphothreonineCombined sources1
Modified residuei1113PhosphoserineBy similarity1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1223PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z460

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z460

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z460

PeptideAtlas

More...
PeptideAtlasi
Q7Z460

PRoteomics IDEntifications database

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PRIDEi
Q7Z460

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69152
69153 [Q7Z460-2]
69154 [Q7Z460-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z460

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z460

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z460

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q7Z460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074054 Expressed in 235 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_CLASP1
HS_MAST1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z460 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z460 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065219

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116919, 39 interactors

Protein interaction database and analysis system

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IntActi
Q7Z460, 38 interactors

Molecular INTeraction database

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MINTi
Q7Z460

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263710

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z460

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z460

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 124HEAT 1Add BLAST38
Repeati163 – 200HEAT 2Add BLAST38
Repeati405 – 440HEAT 3Add BLAST36
Repeati441 – 477HEAT 4Add BLAST37
Repeati974 – 1011HEAT 5Add BLAST38
Repeati1342 – 1379HEAT 6Add BLAST38
Repeati1460 – 1497HEAT 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni662 – 785Interaction with microtubules, MAPRE1 and MAPRE31 PublicationAdd BLAST124
Regioni1254 – 1538Interaction with CLIP2By similarityAdd BLAST285
Regioni1254 – 1538Interaction with PHLDB2 and RSN1 PublicationAdd BLAST285
Regioni1256 – 1538Localization to kinetochoresAdd BLAST283

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1299 – 1330Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi530 – 765Ser-richAdd BLAST236
Compositional biasi1526 – 1532Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLASP family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2956 Eukaryota
ENOG410ZMY0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154817

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236347

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079692

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z460

KEGG Orthology (KO)

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KOi
K16578

Identification of Orthologs from Complete Genome Data

More...
OMAi
MFMDTHT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GTV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z460

TreeFam database of animal gene trees

More...
TreeFami
TF101155

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR21567:SF28 PTHR21567:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01349 TOG, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTMLDKL
60 70 80 90 100
VDGLATSWVN SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL
110 120 130 140 150
GDAKDSVREQ DQTLLLKIMD QAANPQYVWD RMLGGFKHKN FRTREGICLC
160 170 180 190 200
LIATLNASGA QTLTLSKIVP HICNLLGDPN SQVRDAAINS LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANDKN FDDEDSVDGN
260 270 280 290 300
RPSSASSTSS KAPPSSRRNV GMGTTRRLGS STLGSKSSAA KEGAGAVDEE
310 320 330 340 350
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS
360 370 380 390 400
LLLAGAAEYD NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG
410 420 430 440 450
NKFDHGAEAI MPTIFNLIPN SAKIMATSGV VAVRLIIRHT HIPRLIPVIT
460 470 480 490 500
SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL ERHISVLAET IKKGIHDADS
510 520 530 540 550
EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL KNSDSIVSLP
560 570 580 590 600
QSDRSSSSSQ ESLNRPLSAK RSPTGSTTSR ASTVSTKSVS TTGSLQRSRS
610 620 630 640 650
DIDVNAAASA KSKVSSSSGT TPFSSAAALP PGSYASLGRI RTRRQSSGSA
660 670 680 690 700
TNVASTPDNR GRSRAKVVSQ SQRSRSANPA GAGSRSSSPG KLLGSGYGGL
710 720 730 740 750
TGGSSRGPPV TPSSEKRSKI PRSQGCSRET SPNRIGLARS SRIPRPSMSQ
760 770 780 790 800
GCSRDTSRES SRDTSPARGF PPLDRFGLGQ PGRIPGSVNA MRVLSTSTDL
810 820 830 840 850
EAAVADALKK PVRRRYEPYG MYSDDDANSD ASSVCSERSY GSRNGGIPHY
860 870 880 890 900
LRQTEDVAEV LNHCASSNWS ERKEGLLGLQ NLLKSQRTLS RVELKRLCEI
910 920 930 940 950
FTRMFADPHS KRVFSMFLET LVDFIIIHKD DLQDWLFVLL TQLLKKMGAD
960 970 980 990 1000
LLGSVQAKVQ KALDVTRDSF PFDQQFNILM RFIVDQTQTP NLKVKVAILK
1010 1020 1030 1040 1050
YIESLARQMD PTDFVNSSET RLAVSRIITW TTEPKSSDVR KAAQIVLISL
1060 1070 1080 1090 1100
FELNTPEFTM LLGALPKTFQ DGATKLLHNH LKNSSNTSVG SPSNTIGRTP
1110 1120 1130 1140 1150
SRHTSSRTSP LTSPTNCSHG GLSPSRLWGW SADGLAKHPP PFSQPNSIPT
1160 1170 1180 1190 1200
APSHKALRRS YSPSMLDYDT ENLNSEEIYS SLRGVTEAIE KFSFRSQEDL
1210 1220 1230 1240 1250
NEPIKRDGKK ECDIVSRDGG AASPATEGRG GSEVEGGRTA LDNKTSLLNT
1260 1270 1280 1290 1300
QPPRAFPGPR ARDYNPYPYS DAINTYDKTA LKEAVFDDDM EQLRDVPIDH
1310 1320 1330 1340 1350
SDLVADLLKE LSNHNERVEE RKGALLELLK ITREDSLGVW EEHFKTILLL
1360 1370 1380 1390 1400
LLETLGDKDH SIRALALRVL REILRNQPAR FKNYAELTIM KTLEAHKDSH
1410 1420 1430 1440 1450
KEVVRAAEEA ASTLASSIHP EQCIKVLCPI IQTADYPINL AAIKMQTKVV
1460 1470 1480 1490 1500
ERIAKESLLQ LLVDIIPGLL QGYDNTESSV RKASVFCLVA IYSVIGEDLK
1510 1520 1530
PHLAQLTGSK MKLLNLYIKR AQTTNSNSSS SSDVSTHS
Length:1,538
Mass (Da):169,451
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E03BD948C227F8D
GO
Isoform 2 (identifier: Q7Z460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-772: Missing.
     808-808: L → LLLGDSRSK
     1123-1161: Missing.

Show »
Length:1,471
Mass (Da):162,110
Checksum:iF027A39E35F82BA2
GO
Isoform 3 (identifier: Q7Z460-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-772: Missing.
     808-808: L → LLLGDSRSK
     911-911: K → KIADSEAECEDKEGNLFPSEVSCT
     1123-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,494
Mass (Da):164,566
Checksum:i0B69865E7CD5A48F
GO
Isoform 4 (identifier: Q7Z460-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: L → LESRHMREDMEYIGLDS
     673-682: RSRSANPAGA → P
     737-772: Missing.
     808-808: L → LLLGDSRS
     1123-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,477
Mass (Da):163,061
Checksum:i7C56388FDF06760C
GO
Isoform 5 (identifier: Q7Z460-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: L → LDGTTTKAE
     737-772: Missing.
     808-808: L → LLLGDSRSK
     1123-1161: Missing.

Note: No experimental confirmation available.
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Length:1,479
Mass (Da):162,914
Checksum:iEC0A6357FB967AC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WA11F8WA11_HUMAN
CLIP-associating protein 1
CLASP1
1,478Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5T1H0Y5T1_HUMAN
CLIP-associating protein 1
CLASP1
1,275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP76C9JP76_HUMAN
CLIP-associating protein 1
CLASP1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J151C9J151_HUMAN
CLIP-associating protein 1
CLASP1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32563 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAX88872 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251R → G in CAI46251 (PubMed:17974005).Curated1
Sequence conflicti556S → F in CAI46251 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053818233I → T. Corresponds to variant dbSNP:rs17761055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054412637L → LESRHMREDMEYIGLDS in isoform 4. 1 Publication1
Alternative sequenceiVSP_057272637L → LDGTTTKAE in isoform 5. 1 Publication1
Alternative sequenceiVSP_054413673 – 682RSRSANPAGA → P in isoform 4. 1 Publication10
Alternative sequenceiVSP_022386737 – 772Missing in isoform 2, isoform 3 and isoform 4, isoform 5. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_022387808L → LLLGDSRSK in isoform 2, isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_054414808L → LLLGDSRS in isoform 4. 1 Publication1
Alternative sequenceiVSP_022388911K → KIADSEAECEDKEGNLFPSE VSCT in isoform 3. 1 Publication1
Alternative sequenceiVSP_0223891123 – 1161Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF347693 mRNA Translation: AAQ15051.1
AC012447 Genomic DNA No translation available.
AC013399 Genomic DNA Translation: AAX88872.1 Sequence problems.
AC018737 Genomic DNA No translation available.
AC079449 Genomic DNA No translation available.
BC032563 mRNA Translation: AAH32563.1 Different initiation.
BC112940 mRNA Translation: AAI12941.1
BC132723 mRNA Translation: AAI32724.1
BC144107 mRNA Translation: AAI44108.1
AJ288057 mRNA Translation: CAC35156.1
CR933722 mRNA Translation: CAI46251.1
AB014522 mRNA Translation: BAA31597.1

Protein sequence database of the Protein Information Resource

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PIRi
T00387

NCBI Reference Sequences

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RefSeqi
NP_001135745.1, NM_001142273.1 [Q7Z460-5]
NP_001135746.1, NM_001142274.1 [Q7Z460-2]
NP_001193980.1, NM_001207051.1 [Q7Z460-4]
NP_056097.1, NM_015282.2 [Q7Z460-1]
XP_011509150.1, XM_011510848.1 [Q7Z460-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.469840
Hs.708183

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000263710; ENSP00000263710; ENSG00000074054 [Q7Z460-1]
ENST00000397587; ENSP00000380717; ENSG00000074054 [Q7Z460-5]
ENST00000409078; ENSP00000386442; ENSG00000074054 [Q7Z460-2]
ENST00000541377; ENSP00000441625; ENSG00000074054 [Q7Z460-4]
ENST00000646274; ENSP00000496269; ENSG00000074054 [Q7Z460-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23332

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23332

UCSC genome browser

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UCSCi
uc061nlf.1 human [Q7Z460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347693 mRNA Translation: AAQ15051.1
AC012447 Genomic DNA No translation available.
AC013399 Genomic DNA Translation: AAX88872.1 Sequence problems.
AC018737 Genomic DNA No translation available.
AC079449 Genomic DNA No translation available.
BC032563 mRNA Translation: AAH32563.1 Different initiation.
BC112940 mRNA Translation: AAI12941.1
BC132723 mRNA Translation: AAI32724.1
BC144107 mRNA Translation: AAI44108.1
AJ288057 mRNA Translation: CAC35156.1
CR933722 mRNA Translation: CAI46251.1
AB014522 mRNA Translation: BAA31597.1
PIRiT00387
RefSeqiNP_001135745.1, NM_001142273.1 [Q7Z460-5]
NP_001135746.1, NM_001142274.1 [Q7Z460-2]
NP_001193980.1, NM_001207051.1 [Q7Z460-4]
NP_056097.1, NM_015282.2 [Q7Z460-1]
XP_011509150.1, XM_011510848.1 [Q7Z460-3]
UniGeneiHs.469840
Hs.708183

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K92X-ray2.00A/B284-552[»]
ProteinModelPortaliQ7Z460
SMRiQ7Z460
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116919, 39 interactors
IntActiQ7Z460, 38 interactors
MINTiQ7Z460
STRINGi9606.ENSP00000263710

PTM databases

iPTMnetiQ7Z460
PhosphoSitePlusiQ7Z460
SwissPalmiQ7Z460

Polymorphism and mutation databases

BioMutaiCLASP1
DMDMi74723323

Proteomic databases

EPDiQ7Z460
MaxQBiQ7Z460
PaxDbiQ7Z460
PeptideAtlasiQ7Z460
PRIDEiQ7Z460
ProteomicsDBi69152
69153 [Q7Z460-2]
69154 [Q7Z460-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263710; ENSP00000263710; ENSG00000074054 [Q7Z460-1]
ENST00000397587; ENSP00000380717; ENSG00000074054 [Q7Z460-5]
ENST00000409078; ENSP00000386442; ENSG00000074054 [Q7Z460-2]
ENST00000541377; ENSP00000441625; ENSG00000074054 [Q7Z460-4]
ENST00000646274; ENSP00000496269; ENSG00000074054 [Q7Z460-1]
GeneIDi23332
KEGGihsa:23332
UCSCiuc061nlf.1 human [Q7Z460-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23332
DisGeNETi23332
EuPathDBiHostDB:ENSG00000074054.17

GeneCards: human genes, protein and diseases

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GeneCardsi
CLASP1
HGNCiHGNC:17088 CLASP1
HPAiHPA065219
MIMi605852 gene
neXtProtiNX_Q7Z460
OpenTargetsiENSG00000074054
PharmGKBiPA38436

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2956 Eukaryota
ENOG410ZMY0 LUCA
GeneTreeiENSGT00940000154817
HOGENOMiHOG000236347
HOVERGENiHBG079692
InParanoidiQ7Z460
KOiK16578
OMAiMFMDTHT
OrthoDBiEOG091G0GTV
PhylomeDBiQ7Z460
TreeFamiTF101155

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLASP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLASP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23332
PMAP-CutDBiQ7Z460

Protein Ontology

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PROi
PR:Q7Z460

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074054 Expressed in 235 organ(s), highest expression level in corpus callosum
CleanExiHS_CLASP1
HS_MAST1
ExpressionAtlasiQ7Z460 baseline and differential
GenevisibleiQ7Z460 HS

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PANTHERiPTHR21567:SF28 PTHR21567:SF28, 1 hit
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 4 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z460
Secondary accession number(s): A2RU21
, B7ZLX3, F5GWS0, O75118, Q2KHQ9, Q5H9P0, Q8N5B8, Q9BQT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2003
Last modified: December 5, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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