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Entry version 140 (22 Apr 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Polycystic kidney disease protein 1-like 3

Gene

PKD1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.3 Publications

Caution

PKD1L3 and PKD2L1 have been defined as sour taste receptor in gustatory cells based on a number of indirect evidences in mouse. Some data confirm this hypothesis in human: in 2 patients with sour ageusia that are unresponsive to sour stimuli, but show normal responses to bitter, sweet, and salty stimuli, expression of PKD1L3 and PKD2L1 is absent in the anterior part of the tongue (PubMed:19812697). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The calcium channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Lectin

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.5.1.2 the polycystin cation channel (pcc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 3
Alternative name(s):
PC1-like 3 protein
Polycystin-1L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKD1L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21716 PKD1L3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607895 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z443

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 697ExtracellularSequence analysisAdd BLAST674
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 905CytoplasmicSequence analysisAdd BLAST187
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 939ExtracellularSequence analysisAdd BLAST13
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 1154CytoplasmicSequence analysisAdd BLAST194
Transmembranei1155 – 1175HelicalSequence analysisAdd BLAST21
Topological domaini1176 – 1198ExtracellularSequence analysisAdd BLAST23
Transmembranei1199 – 1219HelicalSequence analysisAdd BLAST21
Topological domaini1220 – 1280CytoplasmicSequence analysisAdd BLAST61
Transmembranei1281 – 1301HelicalSequence analysisAdd BLAST21
Topological domaini1302 – 1462ExtracellularSequence analysisAdd BLAST161
Transmembranei1463 – 1483HelicalSequence analysisAdd BLAST21
Topological domaini1484 – 1501CytoplasmicSequence analysisAdd BLAST18
Transmembranei1502 – 1522HelicalSequence analysisAdd BLAST21
Topological domaini1523 – 1550ExtracellularSequence analysisAdd BLAST28
Transmembranei1551 – 1571HelicalSequence analysisAdd BLAST21
Topological domaini1572 – 1592CytoplasmicSequence analysisAdd BLAST21
Transmembranei1593 – 1613HelicalSequence analysisAdd BLAST21
Topological domaini1614 – 1625ExtracellularSequence analysisAdd BLAST12
Transmembranei1626 – 1646HelicalSequence analysisAdd BLAST21
Topological domaini1647 – 1658CytoplasmicSequence analysisAdd BLAST12
Transmembranei1659 – 1679HelicalSequence analysisAdd BLAST21
Topological domaini1680 – 1732ExtracellularSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
342372

Open Targets

More...
OpenTargetsi
ENSG00000277481

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z443 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11093 Calcium Citrate
DB11348 Calcium Phosphate
DB14481 Calcium phosphate dihydrate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKD1L3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74713456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032257824 – 1732Polycystic kidney disease protein 1-like 3Add BLAST1709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 137PROSITE-ProRule annotation
Disulfide bondi112 ↔ 129PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z443

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z443

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z443

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z443

PeptideAtlas

More...
PeptideAtlasi
Q7Z443

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z443

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69147

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z443

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z443

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, weakly in heart and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000277481 Expressed in right lobe of liver and 23 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000277481 Tissue enhanced (lymphoid tissue, smooth muscle, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of PKD1L3.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131173, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z443, 2 interactors

Molecular INTeraction database

More...
MINTi
Q7Z443

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480090

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z443 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 138C-type lectinAdd BLAST109
Domaini632 – 681GPSPROSITE-ProRule annotationAdd BLAST50
Domaini743 – 860PLATPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1613 – 1651Channel pore-regionAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1274 – 1277Poly-Lys4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162813

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000913_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z443

KEGG Orthology (KO)

More...
KOi
K04989

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKWRFFT

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z443

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752 PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000203 GPS
IPR000434 PC1
IPR013122 PKD1_2_channel
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825 GPS, 1 hit
PF00059 Lectin_C, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00500 POLYCYSTIN1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50221 GPS, 1 hit
PS50095 PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFKGGSWLW LYIRTSIILG SELNSPAPHG QNNCYQLNRF QCSFEEAQHY
60 70 80 90 100
CHVQRGFLAH IWNKEVQDLI RDYLEEGKKW WIGQNVMPLK KHQDNKYPAD
110 120 130 140 150
VAANGPPKPL SCTYLSRNFI RISSKGDKCL LKYYFICQTG DFLDGDAHYE
160 170 180 190 200
RNGNNSHLYQ RHKKTKRGVA IARDKMPPGP GHLPTTCHYP LPAHLSKTLC
210 220 230 240 250
HPISQFPSVL SSITSQVTSA ASEPSSQPLP VITQLTMPVS VTHAGQSLAE
260 270 280 290 300
TTSSPKEEGH PNTFTSYLQV SLQKASGQVI DEIAGNFSRA VHGLQALNKL
310 320 330 340 350
QEACEFLQKL TALTPRFSKP AQVNLINSLI YLSEELLRIP FQNNNSLGFK
360 370 380 390 400
VPPTVCPFHS LNNVTKAGEG SWLESKRHTE PVEDILEMSL VEFGNIGEAF
410 420 430 440 450
LEQNQSPESS VTLTSANATL LLSRQNISTL PLSSYTLGHP APVRLGFPSA
460 470 480 490 500
LALKELLNKH PGVNVQITGL AFNPFKDLDN RNIVGSIGSV LLSANRKLLQ
510 520 530 540 550
VHDLMEDIEI MLWRNVSLET HPTSLNMSTH QLTITVNVTS LEKSLIVSID
560 570 580 590 600
PDSPLLMTLY LGFQYQPNCT HFHLNITLPK DKVWQKDEEY TWVLNPEHLQ
610 620 630 640 650
HGIGTYYITA VLSERQEGAQ QTPSLVSVIT AVTQCYYWEI HNQTWSSAGC
660 670 680 690 700
QVGPQSTILR TQCLCNHLTF FASDFFVVPR TVNVEDTIKL FLRVTNNPVG
710 720 730 740 750
VSLLASLLGF YVITVVWARK KDQADMQKVK VTVLADNDPS AQFHYLIQVY
760 770 780 790 800
TGYRRSAATT AKVVITLYGS EGRSEPHHLC DPQKTVFERG GLDVFLLTTW
810 820 830 840 850
TSLGNLHSLR LWHDNSGVSP SWYVSQVIVC DMAVKRKWHF LCNCWLAVDL
860 870 880 890 900
GDCELDRVFI PVSKRELFSF RHLFSSMIVE KFTQDYLWLS IATRHPWNQF
910 920 930 940 950
TRVQRLSCCM TLLLCNMVIN VMFWKINSTT AKRDEQMRPF AVAWSELLVS
960 970 980 990 1000
IHTAVILFPI NLVIGRLFPL IEPQETLPLF PPIQASCLSD ASVEPLSATM
1010 1020 1030 1040 1050
VVEELKETVR FLLRRNTYLL SKCEQPPWSS WDITKLVKLL SSLVSSHLEG
1060 1070 1080 1090 1100
QGCHQQGERH WARVVPENHH HFCCYLHRVL QRLKSHLGTL GLTQGHQSCD
1110 1120 1130 1140 1150
FLDAASQLQK LQELLETHIL PTEQEPSREV TSFAILSSEE GKKPISNGLS
1160 1170 1180 1190 1200
KWLTSVCWLL LGFTSLASAF FTALYSLELS KDQATSWMIS IILSVLQNIF
1210 1220 1230 1240 1250
ISQPVKVVFF TFLYSLMMSR MPRLNKENEQ QTKRILALLA KCSSSVPGSR
1260 1270 1280 1290 1300
DKNNPVYVAP AINSPTKHPE RTLKKKKLFK LTGDILVQIL FLTLLMTAIY
1310 1320 1330 1340 1350
SAKNSNRFYL HQAIWKTFSH QFSEIKLLQD FYPWANHILL PSLYGDYRGK
1360 1370 1380 1390 1400
NAVLEPSHCK CGVQLIFQIP RTKTYEKVDE GQLAFCDNGH TCGRPKSLFP
1410 1420 1430 1440 1450
GLHLRRFSYI CSPRPMVLIP TDELHERLTS KNENGFSYIM RGAFFTSLRL
1460 1470 1480 1490 1500
ESFTSLQMSK KGCVWSIISQ VIYYLLVCYY AFIQGCQLKQ QKWRFFTGKR
1510 1520 1530 1540 1550
NILDTSIILI SFILLGLDMK SISLHKKNMA RYRDDQDRFI SFYEAVKVNS
1560 1570 1580 1590 1600
AATHLVGFPV LLATVQLWNL LRHSPRLRVI SRTLSRAWDE VVGFLLIILI
1610 1620 1630 1640 1650
LLTGYAIAFN LLFGCSISDY RTFFSSAVTV VGLLMGISHQ EEVFALDPVL
1660 1670 1680 1690 1700
GTFLILTSVI LMVLVVINLF VSAILMAFGK ERKSLKKEAA LIDTLLQKLS
1710 1720 1730
NLLGISWPQK TSSEQAATTA VGSDTEVLDE LP
Length:1,732
Mass (Da):195,894
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64847A1C8BE5A6A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039453120I → F. Corresponds to variant dbSNP:rs16973585Ensembl.1
Natural variantiVAR_039454211S → P. Corresponds to variant dbSNP:rs4788591Ensembl.1
Natural variantiVAR_039455274K → E. Corresponds to variant dbSNP:rs12708923Ensembl.1
Natural variantiVAR_039456429T → S. Corresponds to variant dbSNP:rs7185272Ensembl.1
Natural variantiVAR_039457471A → D. Corresponds to variant dbSNP:rs16973537Ensembl.1
Natural variantiVAR_039458571H → Q. Corresponds to variant dbSNP:rs1559401Ensembl.1
Natural variantiVAR_039459593V → M. Corresponds to variant dbSNP:rs9925415Ensembl.1
Natural variantiVAR_039460903V → I. Corresponds to variant dbSNP:rs9921412Ensembl.1
Natural variantiVAR_0394611176S → R. Corresponds to variant dbSNP:rs1035543Ensembl.1
Natural variantiVAR_0394621474Y → C. Corresponds to variant dbSNP:rs13335617Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY164485 mRNA Translation: AAO32798.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS73912.1

NCBI Reference Sequences

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RefSeqi
NP_853514.1, NM_181536.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000620267; ENSP00000480090; ENSG00000277481

Database of genes from NCBI RefSeq genomes

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GeneIDi
342372

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:342372

UCSC genome browser

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UCSCi
uc059wxm.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164485 mRNA Translation: AAO32798.1
CCDSiCCDS73912.1
RefSeqiNP_853514.1, NM_181536.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi131173, 2 interactors
IntActiQ7Z443, 2 interactors
MINTiQ7Z443
STRINGi9606.ENSP00000480090

Chemistry databases

DrugBankiDB11093 Calcium Citrate
DB11348 Calcium Phosphate
DB14481 Calcium phosphate dihydrate

Protein family/group databases

TCDBi1.A.5.1.2 the polycystin cation channel (pcc) family

PTM databases

iPTMnetiQ7Z443
PhosphoSitePlusiQ7Z443

Polymorphism and mutation databases

BioMutaiPKD1L3
DMDMi74713456

Proteomic databases

EPDiQ7Z443
jPOSTiQ7Z443
MassIVEiQ7Z443
MaxQBiQ7Z443
PeptideAtlasiQ7Z443
PRIDEiQ7Z443
ProteomicsDBi69147

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
72636 44 antibodies

Genome annotation databases

EnsembliENST00000620267; ENSP00000480090; ENSG00000277481
GeneIDi342372
KEGGihsa:342372
UCSCiuc059wxm.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
342372
DisGeNETi342372

GeneCards: human genes, protein and diseases

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GeneCardsi
PKD1L3
HGNCiHGNC:21716 PKD1L3
HPAiENSG00000277481 Tissue enhanced (lymphoid tissue, smooth muscle, testis)
MIMi607895 gene
neXtProtiNX_Q7Z443
OpenTargetsiENSG00000277481

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000162813
HOGENOMiCLU_000913_1_0_1
InParanoidiQ7Z443
KOiK04989
OMAiQKWRFFT
OrthoDBi1276906at2759
PhylomeDBiQ7Z443

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PKD1L3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
342372
PharosiQ7Z443 Tbio

Protein Ontology

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PROi
PR:Q7Z443
RNActiQ7Z443 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000277481 Expressed in right lobe of liver and 23 other tissues

Family and domain databases

CDDicd01752 PLAT_polycystin, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000203 GPS
IPR000434 PC1
IPR013122 PKD1_2_channel
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
PfamiView protein in Pfam
PF01825 GPS, 1 hit
PF00059 Lectin_C, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00500 POLYCYSTIN1
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50221 GPS, 1 hit
PS50095 PLAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK1L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z443
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: April 22, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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