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Entry version 154 (17 Jun 2020)
Sequence version 5 (28 Mar 2018)
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Protein

Polycystic kidney disease protein 1-like 2

Gene

PKD1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an ion-channel regulator. May function as a G-protein-coupled receptor.1 Publication

Caution

PKD1L2 is both a gene and a pseudogene in the human population. The reference genome assembly corresponds currently to the non-functional allele while the sequence shown here is the one of the functional protein.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandLectin

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.038

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 2
Alternative name(s):
PC1-like 2 protein
Polycystin-1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKD1L2
Synonyms:KIAA1879, PC1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166473.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21715 PKD1L2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607894 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z442

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 1344ExtracellularSequence analysisAdd BLAST1327
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1345 – 1365HelicalSequence analysisAdd BLAST21
Topological domaini1366 – 1552CytoplasmicSequence analysisAdd BLAST187
Transmembranei1553 – 1573HelicalSequence analysisAdd BLAST21
Topological domaini1574 – 1594ExtracellularSequence analysisAdd BLAST21
Transmembranei1595 – 1615HelicalSequence analysisAdd BLAST21
Topological domaini1616 – 1818CytoplasmicSequence analysisAdd BLAST203
Transmembranei1819 – 1839HelicalSequence analysisAdd BLAST21
Topological domaini1840 – 1865ExtracellularSequence analysisAdd BLAST26
Transmembranei1866 – 1886HelicalSequence analysisAdd BLAST21
Topological domaini1887 – 1943CytoplasmicSequence analysisAdd BLAST57
Transmembranei1944 – 1964HelicalSequence analysisAdd BLAST21
Topological domaini1965 – 2143ExtracellularSequence analysisAdd BLAST179
Transmembranei2144 – 2166HelicalSequence analysisAdd BLAST23
Topological domaini2167 – 2182CytoplasmicSequence analysisAdd BLAST16
Transmembranei2183 – 2203HelicalSequence analysisAdd BLAST21
Topological domaini2204 – 2218ExtracellularSequence analysisAdd BLAST15
Transmembranei2219 – 2239HelicalSequence analysisAdd BLAST21
Topological domaini2240 – 2270CytoplasmicSequence analysisAdd BLAST31
Transmembranei2271 – 2291HelicalSequence analysisAdd BLAST21
Topological domaini2292 – 2312ExtracellularSequence analysisAdd BLAST21
Transmembranei2313 – 2333HelicalSequence analysisAdd BLAST21
Topological domaini2334 – 2377CytoplasmicSequence analysisAdd BLAST44
Transmembranei2378 – 2398HelicalSequence analysisAdd BLAST21
Topological domaini2399 – 2459ExtracellularSequence analysisAdd BLAST61

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114780

Open Targets

More...
OpenTargetsi
ENSG00000166473

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134874396

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z442 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKD1L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373538

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032257618 – 2459Polycystic kidney disease protein 1-like 2Add BLAST2442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 152By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 144By similarity
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z442

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z442

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z442

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z442

PeptideAtlas

More...
PeptideAtlasi
Q7Z442

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z442

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69140 [Q7Z442-1]
69141 [Q7Z442-2]
69142 [Q7Z442-3]
69143 [Q7Z442-4]
69145 [Q7Z442-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z442

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z442

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166473 Expressed in subcutaneous adipose tissue and 102 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z442 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z442 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact via its C-terminus with GNAS and GNAI1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125342, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z442, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000485172

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z442 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z442

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 153C-type lectinPROSITE-ProRule annotationAdd BLAST119
Domaini161 – 252SUEL-type lectinPROSITE-ProRule annotationAdd BLAST92
Domaini422 – 1123REJPROSITE-ProRule annotationAdd BLAST702
Domaini1279 – 1328GPSPROSITE-ProRule annotationAdd BLAST50
Domaini1390 – 1507PLATPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2340 – 2362Channel pore-regionAdd BLAST23
Regioni2379 – 2459Interaction with GNAS and GNAI11 PublicationAdd BLAST81

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JFZI Eukaryota
ENOG410Z7Z0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_908990_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z442

KEGG Orthology (KO)

More...
KOi
K04988

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z442

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752 PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000203 GPS
IPR000922 Lectin_gal-bd_dom
IPR043159 Lectin_gal-bd_sf
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR003915 PKD_2
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
IPR014010 REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF00059 Lectin_C, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01433 POLYCYSTIN2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS50228 SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z442-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAVGLVLLV LALRLRATTV KPEEGSFCSN SQVAFRDACY EFVPLGRTFR
60 70 80 90 100
DAQSWCEGQG GHLVFIQDEG TQWFLQKHIS QDREWWIGLT WNLARNGTTE
110 120 130 140 150
GPGTWLDTSN VTYSNWHGGQ AAAAPDTCGH IGRGPSSEWV TSDCAQTFAF
160 170 180 190 200
MCEFRVGQSL ACEGLNATVH CGLGQVIQVQ DAVYGRQNPH FCTQDAGRPS
210 220 230 240 250
DLEQGCSWAN VKEEVAGQCQ ELQSCQVAAD ETYFGNLCPT QGSYLWVQYQ
260 270 280 290 300
CREALQLMVS SESFIFDNVT ISLTWLLSPY IGNLSCIIST GDSHTFDPYN
310 320 330 340 350
PPSVSSNVTH QFTSPGEFTV FAECTTSEWH VTAQRQVTVR DKMETLSVTA
360 370 380 390 400
CSGLSQSGAG PLCQAVFGDP LWIQVELDGG TGVTYTVLLG DITLAESTTQ
410 420 430 440 450
KGSLPYNLIL DRETQKLMGP GRHRLEIQAT GNTTTSTISR NITVHLVELL
460 470 480 490 500
SGLQASWASD HLELGQDLLI TISLAQGTPE ELTFEVAGLN ATFSHEQVSF
510 520 530 540 550
GEPFGICRLA VPVEGTFLVT MLVRNAFSNL SLEIGNITIT APSGLQEPSG
560 570 580 590 600
MNAEGKSKDK GDMEVYIQPG PYVDPFTTVT LGWPDNDKEL RFQWSCGSCW
610 620 630 640 650
ALWSSCVERQ LLRTDQRELV VPASCLPPPD SAVTLRLAVL RGQELENRAE
660 670 680 690 700
QCLYVSAPWE LRPRVSCERN CRPVNASKDI LLRVTMGEDS PVAMFSWYLD
710 720 730 740 750
NTPTEQAEPL LDACRLRGFW PRSLTLLQSN TSTLLLNSSF LQSRGEVIRI
760 770 780 790 800
RATALTRHAY GEDTYVISTV PPREVPACTI APEEGTVLTS FAIFCNASTA
810 820 830 840 850
LGPLEFCFCL ESGSCLHCGP EPALPSVYLP LGEENNDFVL TVVISATNRA
860 870 880 890 900
GDTQQTQAMA KVALGDTCVE DVAFQAAVSE KIPTALQGEG GPEQLLQLAK
910 920 930 940 950
AVSSMLNQEH ESQGSGQSLS IDVRQKVREH VLGSLSAVTT GLEDVQRVQE
960 970 980 990 1000
LAEVLREVTC RSKELTPSAQ WEASLALQHA SEALLTVSAK ARPEDQRRQA
1010 1020 1030 1040 1050
ATRDLFQAVG SVLEASLSNR PEEPAEASSS QIATVLRLLR VMEHVQTTLL
1060 1070 1080 1090 1100
LGKLPGGLPA MLATPSISVY TNRIQPWSWQ GSSLRPDAAD SATFMLPAAS
1110 1120 1130 1140 1150
SLSSLEGGQE PVDIKIMSFP KSPFPARSHF DVSGTVGGLR VTSPSGQLIP
1160 1170 1180 1190 1200
VKNLSENIEI LLPRHSQRHS QPTVLNLTSP EALWVNVTSG EATLGIQLHW
1210 1220 1230 1240 1250
RPDIALTLSL GYGYHPNKSS YDAQTHLVPM VAPDELPTWI LSPQDLRFGE
1260 1270 1280 1290 1300
GVYYLTVVPE SDLEPAPGRD LTVGITTFLS HCVFWDEVQE TWDDSGCQVG
1310 1320 1330 1340 1350
PRTSPYQTHC LCNHLTFFGS TFLVMSNAIN IHQTAELFAT FEDNPVVVTT
1360 1370 1380 1390 1400
VGCLCVVYVL VVIWARRKDA QDQAKVKVTV LEDNDPFAQY HYLVTVYTGH
1410 1420 1430 1440 1450
RRGAATSSKV TVTLYGLDGE REPHHLADPD TPVFERGAVD AFLLSTLFPL
1460 1470 1480 1490 1500
GELRSLRLWH DNSGDRPSWY VSRVLVYDLV MDRKWYFLCN SWLSINVGDC
1510 1520 1530 1540 1550
VLDKVFPVAT EQDRKQFSHL FFMKTSAGFQ DGHIWYSIFS RCARSSFTRV
1560 1570 1580 1590 1600
QRVSCCFSLL LCTMLTSIMF WGVPKDPAEQ KMDLGKIEFT WQEVMIGLES
1610 1620 1630 1640 1650
SILMFPINLL IVQIFQNTRP RVAKEQNTGK WDRGSPNLTP SPQPMEDGLL
1660 1670 1680 1690 1700
TPEAVTKDVS RIVSSLFKAL KVPSPALGWD SVNLMDINSL LALVEDVIYP
1710 1720 1730 1740 1750
QNTSGQVFWE EAKKREDPVT LTLGSSEMKE KSQCPKPKAA RSGPWKDSAY
1760 1770 1780 1790 1800
RQCLYLQLEH VEQELRLVGP RGFSQPHSHA QALRQLQTLK GGLGVQPGTW
1810 1820 1830 1840 1850
APAHASALQV SKPPQGLPWW CILVGWLLVA ATSGVAAFFT MLYGLHYGRA
1860 1870 1880 1890 1900
SSLRWLISMA VSFVESMFVT QPLKVLGFAA FFALVLKRVD DEEDTVAPLP
1910 1920 1930 1940 1950
GHLLGPDPYA LFRARRNSSR DVYQPPLTAA IEKMKTTHLK EQKAFALIRE
1960 1970 1980 1990 2000
ILAYLGFLWM LLLVAYGQRD PSAYHLNRHL QHSFTRGFSG VLGFREFFKW
2010 2020 2030 2040 2050
ANTTLVSNLY GHPPGFITDG NSKLVGSAQI RQVRVQESSC PLAQQPQAYL
2060 2070 2080 2090 2100
NGCRAPYSLD AEDMADYGEG WNATTLSEWQ YQSQDQRQGY PIWGKLTVYR
2110 2120 2130 2140 2150
GGGYVVPLGT DRQSTSRILR YLFDNTWLDA LTRAVFVEST VYNANVNLFC
2160 2170 2180 2190 2200
IVTLTLETSA LGTFFTHAAL QSLRLYPFTD GWHPFVVAAE LIYFLFLLYY
2210 2220 2230 2240 2250
MVVQGKRMSK ETWGYFCSKW NLLELAIILA SWSALAVFVK RAVLAERDLQ
2260 2270 2280 2290 2300
RCRNHREEGI SFSETAAADA ALGYIIAFLV LLSTVKLWHL LRLNPKMNMI
2310 2320 2330 2340 2350
TAALRRAWGD ISGFMIVILT MLLAYSIASN LIFGWKLRSY KTLFDAAETM
2360 2370 2380 2390 2400
VSLQLGIFNY EEVLDYSPVL GSFLIGSCIV FMTFVVLNLF ISVILVAFSE
2410 2420 2430 2440 2450
EQKYYQLSEE GEIVDLLLMK ILSFLGIKSK REEPGSSREQ PGSLSQTRHS

RPAQALPKD
Length:2,459
Mass (Da):272,514
Last modified:March 28, 2018 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92F85B3CF8B46F36
GO
Isoform 2 (identifier: Q7Z442-2) [UniParc]FASTAAdd to basket
Also known as: Long isoform

The sequence of this isoform differs from the canonical sequence as follows:
     1-685: Missing.

Show »
Length:1,774
Mass (Da):197,393
Checksum:i94373128504D0D43
GO
Isoform 3 (identifier: Q7Z442-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     971-991: WEASLALQHASEALLTVSAKA → GSCMGDSWEGAPPAAHVSHAR
     992-2459: Missing.

Show »
Length:991
Mass (Da):107,943
Checksum:iD0ED4E4407E96514
GO
Isoform 4 (identifier: Q7Z442-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-685: Missing.
     971-991: WEASLALQHASEALLTVSAKA → GSCMGDSWEGAPPAAHVSHAR
     992-2459: Missing.

Show »
Length:306
Mass (Da):32,823
Checksum:iD4A87793F6B42B31
GO
Isoform 6 (identifier: Q7Z442-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-685: Missing.
     754-812: Missing.
     928-984: REHVLGSLSA...LALQHASEAL → PVGSWGAPFI...SLVFWVSDIK
     985-2459: Missing.

Show »
Length:240
Mass (Da):26,012
Checksum:iC20F77C3BBD8C521
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEQ7H0YEQ7_HUMAN
Polycystic kidney disease protein 1...
PKD1L2
519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ73173 differs from that shown. Reason: Frameshift.Curated
The sequence BAB67772 differs from that shown. Intron retention.Curated
The sequence BAC05222 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD18529 differs from that shown. Reason: Erroneous translation. Wrong CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti783E → G in BAC05222 (PubMed:14702039).Curated1
Sequence conflicti1421R → S in AAO32796 (PubMed:12782129).Curated1
Sequence conflicti1774S → P in BAB67772 (PubMed:11572484).Curated1
Sequence conflicti1776P → H in BAB67772 (PubMed:11572484).Curated1
Sequence conflicti2049Y → S in AAQ73173 (PubMed:15203210).Curated1
Sequence conflicti2078E → A in AAQ73173 (PubMed:15203210).Curated1
Sequence conflicti2114 – 2117STSR → KHVK in AAO32796 (PubMed:12782129).Curated4
Sequence conflicti2202V → G in AAQ73173 (PubMed:15203210).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03942720V → A. Corresponds to variant dbSNP:rs9924530Ensembl.1
Natural variantiVAR_03942873W → R1 PublicationCorresponds to variant dbSNP:rs9924371Ensembl.1
Natural variantiVAR_03942977K → N1 PublicationCorresponds to variant dbSNP:rs9934272Ensembl.1
Natural variantiVAR_039430120Q → L. Corresponds to variant dbSNP:rs7191351Ensembl.1
Natural variantiVAR_039431129G → D. Corresponds to variant dbSNP:rs7185774Ensembl.1
Natural variantiVAR_039432156V → I. Corresponds to variant dbSNP:rs35528333Ensembl.1
Natural variantiVAR_039433162C → S. Corresponds to variant dbSNP:rs35970134Ensembl.1
Natural variantiVAR_039434169V → M. Corresponds to variant dbSNP:rs36099350Ensembl.1
Natural variantiVAR_039435173L → S. Corresponds to variant dbSNP:rs8060294Ensembl.1
Natural variantiVAR_039436183V → I1 PublicationCorresponds to variant dbSNP:rs12933806Ensembl.1
Natural variantiVAR_039437205G → R. Corresponds to variant dbSNP:rs34719852Ensembl.1
Natural variantiVAR_039438221E → G. Corresponds to variant dbSNP:rs6564838Ensembl.1
Natural variantiVAR_039439252R → W. Corresponds to variant dbSNP:rs6420424Ensembl.1
Natural variantiVAR_039440301P → A1 PublicationCorresponds to variant dbSNP:rs11150370Ensembl.1
Natural variantiVAR_039441407N → S. Corresponds to variant dbSNP:rs9937169Ensembl.1
Natural variantiVAR_039442416K → Q. Corresponds to variant dbSNP:rs7194871Ensembl.1
Natural variantiVAR_039443462L → V. Corresponds to variant dbSNP:rs9934856Ensembl.1
Natural variantiVAR_039444512P → L. Corresponds to variant dbSNP:rs7205673Ensembl.1
Natural variantiVAR_039445636R → H. Corresponds to variant dbSNP:rs13339342Ensembl.1
Natural variantiVAR_039446711L → P4 PublicationsCorresponds to variant dbSNP:rs4889261Ensembl.1
Natural variantiVAR_039447785G → C. Corresponds to variant dbSNP:rs9935113Ensembl.1
Natural variantiVAR_039448849R → H. Corresponds to variant dbSNP:rs1869349Ensembl.1
Natural variantiVAR_039449863A → V2 PublicationsCorresponds to variant dbSNP:rs12596941Ensembl.1
Natural variantiVAR_039450919L → M. Corresponds to variant dbSNP:rs745211Ensembl.1
Natural variantiVAR_061525998R → C. Corresponds to variant dbSNP:rs34504526Ensembl.1
Natural variantiVAR_061526999Q → H. Corresponds to variant dbSNP:rs35292101Ensembl.1
Natural variantiVAR_0394511036L → P. Corresponds to variant dbSNP:rs12597040Ensembl.1
Natural variantiVAR_0394521042M → V. Corresponds to variant dbSNP:rs12931227Ensembl.1
Natural variantiVAR_0567051048T → A. Corresponds to variant dbSNP:rs12931217Ensembl.1
Natural variantiVAR_0567061081G → V. Corresponds to variant dbSNP:rs16954794Ensembl.1
Natural variantiVAR_0567071251G → W. Corresponds to variant dbSNP:rs734824Ensembl.1
Natural variantiVAR_0567081326S → P3 PublicationsCorresponds to variant dbSNP:rs1453324Ensembl.1
Natural variantiVAR_0615271330N → D2 PublicationsCorresponds to variant dbSNP:rs1453325Ensembl.1
Natural variantiVAR_0615281331I → V1 PublicationCorresponds to variant dbSNP:rs9938333Ensembl.1
Natural variantiVAR_0567091335A → D. Corresponds to variant dbSNP:rs1453326Ensembl.1
Natural variantiVAR_0567101406T → M. Corresponds to variant dbSNP:rs8050904Ensembl.1
Natural variantiVAR_0567111527A → V. Corresponds to variant dbSNP:rs16954775Ensembl.1
Natural variantiVAR_0567121616Q → R. Corresponds to variant dbSNP:rs9921827Ensembl.1
Natural variantiVAR_0567131645M → V. Corresponds to variant dbSNP:rs9921748Ensembl.1
Natural variantiVAR_0567141665S → Y. Corresponds to variant dbSNP:rs7192948Ensembl.1
Natural variantiVAR_0567151701Q → H. Corresponds to variant dbSNP:rs7194136Ensembl.1
Natural variantiVAR_0615291739A → V. Corresponds to variant dbSNP:rs35941327Ensembl.1
Natural variantiVAR_0567161848G → R. Corresponds to variant dbSNP:rs4889244Ensembl.1
Natural variantiVAR_0567171867M → V1 PublicationCorresponds to variant dbSNP:rs12918619Ensembl.1
Natural variantiVAR_0567182036Q → R1 PublicationCorresponds to variant dbSNP:rs16954722Ensembl.1
Natural variantiVAR_0567192046P → L1 PublicationCorresponds to variant dbSNP:rs7206183Ensembl.1
Natural variantiVAR_0567202055A → T1 PublicationCorresponds to variant dbSNP:rs16954717Ensembl.1
Natural variantiVAR_0595512119L → I. Corresponds to variant dbSNP:rs8050204Ensembl.1
Natural variantiVAR_0595522139S → F3 PublicationsCorresponds to variant dbSNP:rs4889241Ensembl.1
Natural variantiVAR_0615302209S → R2 PublicationsCorresponds to variant dbSNP:rs4889238Ensembl.1
Natural variantiVAR_0595532315M → I2 PublicationsCorresponds to variant dbSNP:rs8054182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0319421 – 685Missing in isoform 2, isoform 4 and isoform 6. 3 PublicationsAdd BLAST685
Alternative sequenceiVSP_031944754 – 812Missing in isoform 6. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_031945928 – 984REHVL…ASEAL → PVGSWGAPFIPFLWGPRVCV RPFGLWIKVHGSGEKPVVSP KRLTPPPSLVFWVSDIK in isoform 6. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_031946971 – 991WEASL…VSAKA → GSCMGDSWEGAPPAAHVSHA R in isoform 3 and isoform 4. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_031947985 – 2459Missing in isoform 6. 1 PublicationAdd BLAST1475
Alternative sequenceiVSP_031948992 – 2459Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST1468

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY164483 mRNA Translation: AAO32796.1
AY371495 mRNA Translation: AAQ73173.1 Frameshift.
AB067466 mRNA Translation: BAB67772.1 Sequence problems.
AK098052 mRNA Translation: BAC05222.1 Different initiation.
AK127266 mRNA Translation: BAC86906.1
AK131378 mRNA Translation: BAD18529.1 Sequence problems.
AC092718 Genomic DNA No translation available.
AC131888 Genomic DNA No translation available.
BC004562 mRNA Translation: AAH04562.1
BC014157 mRNA Translation: AAH14157.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61999.1 [Q7Z442-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001070248.1, NM_001076780.1 [Q7Z442-3]
NP_001265352.1, NM_001278423.1 [Q7Z442-4]
NP_001265354.1, NM_001278425.1 [Q7Z442-2]
NP_443124.3, NM_052892.3 [Q7Z442-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337114; ENSP00000337397; ENSG00000166473 [Q7Z442-3]
ENST00000527937; ENSP00000432818; ENSG00000166473 [Q7Z442-6]
ENST00000531391; ENSP00000436309; ENSG00000166473 [Q7Z442-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114780

UCSC genome browser

More...
UCSCi
uc002fgi.5 human [Q7Z442-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164483 mRNA Translation: AAO32796.1
AY371495 mRNA Translation: AAQ73173.1 Frameshift.
AB067466 mRNA Translation: BAB67772.1 Sequence problems.
AK098052 mRNA Translation: BAC05222.1 Different initiation.
AK127266 mRNA Translation: BAC86906.1
AK131378 mRNA Translation: BAD18529.1 Sequence problems.
AC092718 Genomic DNA No translation available.
AC131888 Genomic DNA No translation available.
BC004562 mRNA Translation: AAH04562.1
BC014157 mRNA Translation: AAH14157.1
CCDSiCCDS61999.1 [Q7Z442-4]
RefSeqiNP_001070248.1, NM_001076780.1 [Q7Z442-3]
NP_001265352.1, NM_001278423.1 [Q7Z442-4]
NP_001265354.1, NM_001278425.1 [Q7Z442-2]
NP_443124.3, NM_052892.3 [Q7Z442-1]

3D structure databases

SMRiQ7Z442
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125342, 3 interactors
IntActiQ7Z442, 2 interactors
STRINGi9606.ENSP00000485172

Protein family/group databases

MEROPSiP02.038

PTM databases

iPTMnetiQ7Z442
PhosphoSitePlusiQ7Z442

Polymorphism and mutation databases

BioMutaiPKD1L2
DMDMi317373538

Proteomic databases

EPDiQ7Z442
jPOSTiQ7Z442
MassIVEiQ7Z442
PaxDbiQ7Z442
PeptideAtlasiQ7Z442
PRIDEiQ7Z442
ProteomicsDBi69140 [Q7Z442-1]
69141 [Q7Z442-2]
69142 [Q7Z442-3]
69143 [Q7Z442-4]
69145 [Q7Z442-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2579 83 antibodies

The DNASU plasmid repository

More...
DNASUi
114780

Genome annotation databases

EnsembliENST00000337114; ENSP00000337397; ENSG00000166473 [Q7Z442-3]
ENST00000527937; ENSP00000432818; ENSG00000166473 [Q7Z442-6]
ENST00000531391; ENSP00000436309; ENSG00000166473 [Q7Z442-4]
GeneIDi114780
KEGGihsa:114780
UCSCiuc002fgi.5 human [Q7Z442-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114780
DisGeNETi114780
EuPathDBiHostDB:ENSG00000166473.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PKD1L2
HGNCiHGNC:21715 PKD1L2
MIMi607894 gene
neXtProtiNX_Q7Z442
OpenTargetsiENSG00000166473
PharmGKBiPA134874396

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JFZI Eukaryota
ENOG410Z7Z0 LUCA
GeneTreeiENSGT00940000161577
HOGENOMiCLU_908990_0_0_1
InParanoidiQ7Z442
KOiK04988
OrthoDBi1276906at2759
PhylomeDBiQ7Z442

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
114780 1 hit in 381 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PKD1L2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114780
PharosiQ7Z442 Tdark

Protein Ontology

More...
PROi
PR:Q7Z442
RNActiQ7Z442 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166473 Expressed in subcutaneous adipose tissue and 102 other tissues
ExpressionAtlasiQ7Z442 baseline and differential
GenevisibleiQ7Z442 HS

Family and domain databases

CDDicd01752 PLAT_polycystin, 1 hit
Gene3Di2.60.120.740, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000203 GPS
IPR000922 Lectin_gal-bd_dom
IPR043159 Lectin_gal-bd_sf
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR003915 PKD_2
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
IPR014010 REJ_dom
PfamiView protein in Pfam
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF00059 Lectin_C, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PRINTSiPR01433 POLYCYSTIN2
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS50228 SUEL_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK1L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z442
Secondary accession number(s): Q6UEE1
, Q6ZN46, Q6ZSP2, Q8N1H9, Q96CL2, Q96Q08
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 28, 2018
Last modified: June 17, 2020
This is version 154 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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