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UniProtKB - Q7Z417 (NUFP2_HUMAN)

Entry version 147 (07 Oct 2020)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

Nuclear fragile X mental retardation-interacting protein 2

Gene

NUFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds RNA.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z417

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 2
Alternative name(s):
82 kDa FMRP-interacting protein
Short name:
82-FIP
Cell proliferation-inducing gene 1 protein
FMRP-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUFIP2
Synonyms:KIAA1321
ORF Names:PIG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108256.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:17634, NUFIP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609356, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z417

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57532

Open Targets

More...OpenTargetsi		ENSG00000108256

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485564

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z417, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NUFIP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74713454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455211 – 695Nuclear fragile X mental retardation-interacting protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87PhosphothreonineCombined sources1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei112PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei212PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei218PhosphotyrosineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei291Omega-N-methylarginineCombined sources1
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei304PhosphoserineCombined sources1
Cross-linki307Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei376PhosphoserineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1 Publication1
Modified residuei633PhosphothreonineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei692PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-985

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z417

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z417

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z417

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z417

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z417

PeptideAtlas

More...PeptideAtlasi		Q7Z417

PRoteomics IDEntifications database

More...PRIDEi		Q7Z417

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69128 [Q7Z417-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z417

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q7Z417

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z417

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7Z417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108256, Expressed in blood and 218 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z417, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108256, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FMR1 (via N-terminus).

Interacts with DDX6 (PubMed:26184334).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z417
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-1210753,EBI-10173507
AMOT [A2BDD9]3EBI-1210753,EBI-17286414
COMP [P49747]3EBI-1210753,EBI-2531022
CYSRT1 [A8MQ03]3EBI-1210753,EBI-3867333
EFEMP2 [O95967]6EBI-1210753,EBI-743414
ESM1 [Q9NQ30]3EBI-1210753,EBI-12260294
FBLN5 [Q9UBX5]3EBI-1210753,EBI-947897
FHL5 [Q5TD97]3EBI-1210753,EBI-750641
FUCA2 [Q9BTY2]3EBI-1210753,EBI-9050116
G3BP2 - isoform B [Q9UN86-2]4EBI-1210753,EBI-11035716
GRN [P28799]6EBI-1210753,EBI-747754
KPRP [Q5T749]5EBI-1210753,EBI-10981970
KRT31 [Q15323]3EBI-1210753,EBI-948001
KRT37 [O76014]3EBI-1210753,EBI-1045716
KRTAP1-5 [Q9BYS1]5EBI-1210753,EBI-11741292
KRTAP10-5 [P60370]6EBI-1210753,EBI-10172150
KRTAP10-7 [P60409]6EBI-1210753,EBI-10172290
KRTAP10-8 [P60410]6EBI-1210753,EBI-10171774
KRTAP10-9 [P60411]8EBI-1210753,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-1210753,EBI-1052037
KRTAP12-3 [P60328]3EBI-1210753,EBI-11953334
KRTAP2-4 [Q9BYR9]3EBI-1210753,EBI-14065470
KRTAP3-2 [Q9BYR7]6EBI-1210753,EBI-751260
KRTAP3-3 [Q9BYR6]3EBI-1210753,EBI-3957694
KRTAP4-1 [A0A087WY89]3EBI-1210753,EBI-11957260
KRTAP4-11 [Q9BYQ6]6EBI-1210753,EBI-10302392
KRTAP4-12 [Q9BQ66]8EBI-1210753,EBI-739863
KRTAP4-2 [Q9BYR5]6EBI-1210753,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-1210753,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-1210753,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-1210753,EBI-11993296
KRTAP5-2 [Q701N4]3EBI-1210753,EBI-11958178
KRTAP5-3 [Q6L8H2]3EBI-1210753,EBI-11974251
KRTAP5-4 [Q6L8H1]3EBI-1210753,EBI-11963072
KRTAP5-6 [Q6L8G9]6EBI-1210753,EBI-10250562
KRTAP5-9 [P26371]5EBI-1210753,EBI-3958099
KRTAP9-2 [Q9BYQ4]6EBI-1210753,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-1210753,EBI-1043191
KRTAP9-4 [Q9BYQ2]3EBI-1210753,EBI-10185730
KRTAP9-8 [Q9BYQ0]3EBI-1210753,EBI-11958364
LCE1B [Q5T7P3]3EBI-1210753,EBI-10245913
LCE2C [Q5TA81]3EBI-1210753,EBI-11973993
LCE2D [Q5TA82]3EBI-1210753,EBI-10246750
LGALS13 [Q9UHV8]3EBI-1210753,EBI-3957707
MDFI [Q99750]3EBI-1210753,EBI-724076
MEGF11 [A6BM72]3EBI-1210753,EBI-947743
PCSK5 [Q92824]3EBI-1210753,EBI-751290
PCSK5 - isoform PC6A [Q92824-2]3EBI-1210753,EBI-11956269
PEAR1 [Q5VY43]3EBI-1210753,EBI-1249608
PRDX5 [P30044]3EBI-1210753,EBI-722161
RGS17 [Q9UGC6]3EBI-1210753,EBI-3918154
RGS19 [P49795]3EBI-1210753,EBI-874907
RGS20 - isoform 5 [O76081-6]3EBI-1210753,EBI-10178530
TRAF1 [Q13077]3EBI-1210753,EBI-359224

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121591, 153 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q7Z417

Database of interacting proteins

More...DIPi		DIP-29023N

Protein interaction database and analysis system

More...IntActi		Q7Z417, 83 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000225388

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z417, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 60His-richAdd BLAST49
Compositional biasi373 – 415Ser-richAdd BLAST43

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPMD, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000038328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020745_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z417

Identification of Orthologs from Complete Genome Data

More...OMAi		EMESVWN

Database of Orthologous Groups

More...OrthoDBi		331657at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z417

TreeFam database of animal gene trees

More...TreeFami		TF332832

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032747, NUFIP2

The PANTHER Classification System

More...PANTHERi		PTHR28333, PTHR28333, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15293, NUFIP2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKPGQPQP QHHHSHHHPH HHPQQQQQQP HHHHHYYFYN HSHNHHHHHH 
        60         70         80         90        100
HQQPHQYLQH GAEGSPKAQP KPLKHEQKHT LQQHQETPKK KTGYGELNGN 
       110        120        130        140        150
AGEREISLKN LSSDEATNPI SRVLNGNQQV VDTSLKQTVK ANTFGKAGIK 
       160        170        180        190        200
TKNFIQKNSM DKKNGKSYEN KSGENQSVDK SDTIPIPNGV VTNNSGYITN 
       210        220        230        240        250
GYMGKGADND GSGSESGYTT PKKRKARRNS AKGCENLNIV QDKIMQQETS 
       260        270        280        290        300
VPTLKQGLET FKPDYSEQKG NRVDGSKPIW KYETGPGGTS RGKPAVGDML 
       310        320        330        340        350
RKSSDSKPGV SSKKFDDRPK GKHASAVASK EDSWTLFKPP PVFPVDNSSA 
       360        370        380        390        400
KIVPKISYAS KVKENLNKTI QNSSVSPTSS SSSSSSTGET QTQSSSRLSQ 
       410        420        430        440        450
VPMSALKSVT SANFSNGPVL AGTDGNVYPP GGQPLLTTAA NTLTPISSGT 
       460        470        480        490        500
DSVLQDMSLT SAAVEQIKTS LFIYPSNMQT MLLSTAQVDL PSQTDQQNLG 
       510        520        530        540        550
DIFQNQWGLS FINEPSAGPE TVTGKSSEHK VMEVTFQGEY PATLVSQGAE 
       560        570        580        590        600
IIPSGTEHPV FPKAYELEKR TSPQVLGSIL KSGTTSESGA LSLEPSHIGD 
       610        620        630        640        650
LQKADTSSQG ALVFLSKDYE IESQNPLASP TNTLLGSAKE QRYQRGLERN 
       660        670        680        690 
DSWGSFDLRA AIVYHTKEME SIWNLQKQDP KRIITYNEAM DSPDQ
Length:695
Mass (Da):76,121
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB5C94131F5B5426
GO
Isoform 2 (identifier: Q7Z417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-667: Missing.

Show »
Length:120
Mass (Da):14,643
Checksum:i3C9F1A1AAACA7535
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92559 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05617793 – 667Missing in isoform 2. 2 PublicationsAdd BLAST575

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ493465 mRNA Translation: CAD38278.1
AY232289 mRNA Translation: AAP69984.1
AB037742 mRNA Translation: BAA92559.1 Different initiation.
AK297732 mRNA Translation: BAG60082.1
AK293075 mRNA Translation: BAF85764.1
AC005412 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51186.1
CH471159 Genomic DNA Translation: EAW51187.1
BC129989 mRNA Translation: AAI29990.1
BC129990 mRNA Translation: AAI29991.1
BC108307 mRNA Translation: AAI08308.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32600.1 [Q7Z417-1]

NCBI Reference Sequences

More...RefSeqi		NP_065823.1, NM_020772.2 [Q7Z417-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000225388; ENSP00000225388; ENSG00000108256 [Q7Z417-1]
ENST00000579665; ENSP00000463450; ENSG00000108256 [Q7Z417-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57532

UCSC genome browser

More...UCSCi		uc002hdx.5, human [Q7Z417-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ493465 mRNA Translation: CAD38278.1
AY232289 mRNA Translation: AAP69984.1
AB037742 mRNA Translation: BAA92559.1 Different initiation.
AK297732 mRNA Translation: BAG60082.1
AK293075 mRNA Translation: BAF85764.1
AC005412 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51186.1
CH471159 Genomic DNA Translation: EAW51187.1
BC129989 mRNA Translation: AAI29990.1
BC129990 mRNA Translation: AAI29991.1
BC108307 mRNA Translation: AAI08308.1
CCDSiCCDS32600.1 [Q7Z417-1]
RefSeqiNP_065823.1, NM_020772.2 [Q7Z417-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121591, 153 interactors
CORUMiQ7Z417
DIPiDIP-29023N
IntActiQ7Z417, 83 interactors
STRINGi9606.ENSP00000225388

PTM databases

iPTMnetiQ7Z417
MetOSiteiQ7Z417
PhosphoSitePlusiQ7Z417
SwissPalmiQ7Z417

Polymorphism and mutation databases

BioMutaiNUFIP2
DMDMi74713454

Proteomic databases

CPTACiCPTAC-985
EPDiQ7Z417
jPOSTiQ7Z417
MassIVEiQ7Z417
MaxQBiQ7Z417
PaxDbiQ7Z417
PeptideAtlasiQ7Z417
PRIDEiQ7Z417
ProteomicsDBi69128 [Q7Z417-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2837, 82 antibodies

Genome annotation databases

EnsembliENST00000225388; ENSP00000225388; ENSG00000108256 [Q7Z417-1]
ENST00000579665; ENSP00000463450; ENSG00000108256 [Q7Z417-2]
GeneIDi57532
KEGGihsa:57532
UCSCiuc002hdx.5, human [Q7Z417-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57532
DisGeNETi57532
EuPathDBiHostDB:ENSG00000108256.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		NUFIP2
HGNCiHGNC:17634, NUFIP2
HPAiENSG00000108256, Low tissue specificity
MIMi609356, gene
neXtProtiNX_Q7Z417
OpenTargetsiENSG00000108256
PharmGKBiPA143485564

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPMD, Eukaryota
GeneTreeiENSGT00440000038328
HOGENOMiCLU_020745_0_0_1
InParanoidiQ7Z417
OMAiEMESVWN
OrthoDBi331657at2759
PhylomeDBiQ7Z417
TreeFamiTF332832

Enzyme and pathway databases

PathwayCommonsiQ7Z417

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57532, 26 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NUFIP2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NUFIP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57532
PharosiQ7Z417, Tbio

Protein Ontology

More...PROi		PR:Q7Z417
RNActiQ7Z417, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108256, Expressed in blood and 218 other tissues
GenevisibleiQ7Z417, HS

Family and domain databases

InterProiView protein in InterPro
IPR032747, NUFIP2
PANTHERiPTHR28333, PTHR28333, 1 hit
PfamiView protein in Pfam
PF15293, NUFIP2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUFP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z417
Secondary accession number(s): A1L3A6, A1L3A7, Q9P2M5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2003
Last modified: October 7, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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