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Protein

Nuclear fragile X mental retardation-interacting protein 2

Gene

NUFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds RNA.1 Publication

GO - Molecular functioni

  • RNA binding Source: HGNC

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 2
Alternative name(s):
82 kDa FMRP-interacting protein
Short name:
82-FIP
Cell proliferation-inducing gene 1 protein
FMRP-interacting protein 2
Gene namesi
Name:NUFIP2
Synonyms:KIAA1321
ORF Names:PIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108256.8
HGNCiHGNC:17634 NUFIP2
MIMi609356 gene
neXtProtiNX_Q7Z417

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57532
OpenTargetsiENSG00000108256
PharmGKBiPA143485564

Polymorphism and mutation databases

BioMutaiNUFIP2
DMDMi74713454

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455211 – 695Nuclear fragile X mental retardation-interacting protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei87PhosphothreonineCombined sources1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei112PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei212PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei218PhosphotyrosineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei291Omega-N-methylarginineCombined sources1
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei304PhosphoserineCombined sources1
Cross-linki307Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei376PhosphoserineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1 Publication1
Modified residuei633PhosphothreonineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei692PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7Z417
MaxQBiQ7Z417
PaxDbiQ7Z417
PeptideAtlasiQ7Z417
PRIDEiQ7Z417
ProteomicsDBi69128

PTM databases

iPTMnetiQ7Z417
PhosphoSitePlusiQ7Z417
SwissPalmiQ7Z417

Expressioni

Gene expression databases

BgeeiENSG00000108256 Expressed in 207 organ(s), highest expression level in blood
CleanExiHS_NUFIP2
GenevisibleiQ7Z417 HS

Organism-specific databases

HPAiHPA067443

Interactioni

Subunit structurei

Interacts with FMR1 (via N-terminus). Interacts with DDX6 (PubMed:26184334).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121591, 91 interactors
DIPiDIP-29023N
IntActiQ7Z417, 70 interactors
STRINGi9606.ENSP00000225388

Structurei

3D structure databases

ProteinModelPortaliQ7Z417
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 60His-richAdd BLAST49
Compositional biasi373 – 415Ser-richAdd BLAST43

Phylogenomic databases

eggNOGiENOG410IGEW Eukaryota
ENOG41102P5 LUCA
GeneTreeiENSGT00440000038328
HOGENOMiHOG000220869
HOVERGENiHBG065794
InParanoidiQ7Z417
OMAiEMESVWN
OrthoDBiEOG091G040J
PhylomeDBiQ7Z417
TreeFamiTF332832

Family and domain databases

InterProiView protein in InterPro
IPR032747 NUFIP2
PANTHERiPTHR28333 PTHR28333, 1 hit
PfamiView protein in Pfam
PF15293 NUFIP2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKPGQPQP QHHHSHHHPH HHPQQQQQQP HHHHHYYFYN HSHNHHHHHH
60 70 80 90 100
HQQPHQYLQH GAEGSPKAQP KPLKHEQKHT LQQHQETPKK KTGYGELNGN
110 120 130 140 150
AGEREISLKN LSSDEATNPI SRVLNGNQQV VDTSLKQTVK ANTFGKAGIK
160 170 180 190 200
TKNFIQKNSM DKKNGKSYEN KSGENQSVDK SDTIPIPNGV VTNNSGYITN
210 220 230 240 250
GYMGKGADND GSGSESGYTT PKKRKARRNS AKGCENLNIV QDKIMQQETS
260 270 280 290 300
VPTLKQGLET FKPDYSEQKG NRVDGSKPIW KYETGPGGTS RGKPAVGDML
310 320 330 340 350
RKSSDSKPGV SSKKFDDRPK GKHASAVASK EDSWTLFKPP PVFPVDNSSA
360 370 380 390 400
KIVPKISYAS KVKENLNKTI QNSSVSPTSS SSSSSSTGET QTQSSSRLSQ
410 420 430 440 450
VPMSALKSVT SANFSNGPVL AGTDGNVYPP GGQPLLTTAA NTLTPISSGT
460 470 480 490 500
DSVLQDMSLT SAAVEQIKTS LFIYPSNMQT MLLSTAQVDL PSQTDQQNLG
510 520 530 540 550
DIFQNQWGLS FINEPSAGPE TVTGKSSEHK VMEVTFQGEY PATLVSQGAE
560 570 580 590 600
IIPSGTEHPV FPKAYELEKR TSPQVLGSIL KSGTTSESGA LSLEPSHIGD
610 620 630 640 650
LQKADTSSQG ALVFLSKDYE IESQNPLASP TNTLLGSAKE QRYQRGLERN
660 670 680 690
DSWGSFDLRA AIVYHTKEME SIWNLQKQDP KRIITYNEAM DSPDQ
Length:695
Mass (Da):76,121
Last modified:October 1, 2003 - v1
Checksum:iBB5C94131F5B5426
GO
Isoform 2 (identifier: Q7Z417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-667: Missing.

Show »
Length:120
Mass (Da):14,643
Checksum:i3C9F1A1AAACA7535
GO

Sequence cautioni

The sequence BAA92559 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05617793 – 667Missing in isoform 2. 2 PublicationsAdd BLAST575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ493465 mRNA Translation: CAD38278.1
AY232289 mRNA Translation: AAP69984.1
AB037742 mRNA Translation: BAA92559.1 Different initiation.
AK297732 mRNA Translation: BAG60082.1
AK293075 mRNA Translation: BAF85764.1
AC005412 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51186.1
CH471159 Genomic DNA Translation: EAW51187.1
BC129989 mRNA Translation: AAI29990.1
BC129990 mRNA Translation: AAI29991.1
BC108307 mRNA Translation: AAI08308.1
CCDSiCCDS32600.1 [Q7Z417-1]
RefSeqiNP_065823.1, NM_020772.2 [Q7Z417-1]
UniGeneiHs.462598

Genome annotation databases

EnsembliENST00000225388; ENSP00000225388; ENSG00000108256 [Q7Z417-1]
ENST00000579665; ENSP00000463450; ENSG00000108256 [Q7Z417-2]
GeneIDi57532
KEGGihsa:57532
UCSCiuc002hdx.5 human [Q7Z417-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ493465 mRNA Translation: CAD38278.1
AY232289 mRNA Translation: AAP69984.1
AB037742 mRNA Translation: BAA92559.1 Different initiation.
AK297732 mRNA Translation: BAG60082.1
AK293075 mRNA Translation: BAF85764.1
AC005412 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51186.1
CH471159 Genomic DNA Translation: EAW51187.1
BC129989 mRNA Translation: AAI29990.1
BC129990 mRNA Translation: AAI29991.1
BC108307 mRNA Translation: AAI08308.1
CCDSiCCDS32600.1 [Q7Z417-1]
RefSeqiNP_065823.1, NM_020772.2 [Q7Z417-1]
UniGeneiHs.462598

3D structure databases

ProteinModelPortaliQ7Z417
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121591, 91 interactors
DIPiDIP-29023N
IntActiQ7Z417, 70 interactors
STRINGi9606.ENSP00000225388

PTM databases

iPTMnetiQ7Z417
PhosphoSitePlusiQ7Z417
SwissPalmiQ7Z417

Polymorphism and mutation databases

BioMutaiNUFIP2
DMDMi74713454

Proteomic databases

EPDiQ7Z417
MaxQBiQ7Z417
PaxDbiQ7Z417
PeptideAtlasiQ7Z417
PRIDEiQ7Z417
ProteomicsDBi69128

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225388; ENSP00000225388; ENSG00000108256 [Q7Z417-1]
ENST00000579665; ENSP00000463450; ENSG00000108256 [Q7Z417-2]
GeneIDi57532
KEGGihsa:57532
UCSCiuc002hdx.5 human [Q7Z417-1]

Organism-specific databases

CTDi57532
DisGeNETi57532
EuPathDBiHostDB:ENSG00000108256.8
GeneCardsiNUFIP2
HGNCiHGNC:17634 NUFIP2
HPAiHPA067443
MIMi609356 gene
neXtProtiNX_Q7Z417
OpenTargetsiENSG00000108256
PharmGKBiPA143485564
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGEW Eukaryota
ENOG41102P5 LUCA
GeneTreeiENSGT00440000038328
HOGENOMiHOG000220869
HOVERGENiHBG065794
InParanoidiQ7Z417
OMAiEMESVWN
OrthoDBiEOG091G040J
PhylomeDBiQ7Z417
TreeFamiTF332832

Miscellaneous databases

ChiTaRSiNUFIP2 human
GeneWikiiNUFIP2
GenomeRNAii57532
PROiPR:Q7Z417
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108256 Expressed in 207 organ(s), highest expression level in blood
CleanExiHS_NUFIP2
GenevisibleiQ7Z417 HS

Family and domain databases

InterProiView protein in InterPro
IPR032747 NUFIP2
PANTHERiPTHR28333 PTHR28333, 1 hit
PfamiView protein in Pfam
PF15293 NUFIP2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUFP2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z417
Secondary accession number(s): A1L3A6, A1L3A7, Q9P2M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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