UniProtKB - Q7Z417 (NUFP2_HUMAN)
Protein
Nuclear fragile X mental retardation-interacting protein 2
Gene
NUFIP2
Organism
Homo sapiens (Human)
Status
Functioni
Binds RNA.1 Publication
GO - Molecular functioni
- RNA binding Source: HGNC-UCL
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q7Z417 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear fragile X mental retardation-interacting protein 2Alternative name(s): 82 kDa FMRP-interacting protein Short name: 82-FIP Cell proliferation-inducing gene 1 protein FMRP-interacting protein 2 |
Gene namesi | Name:NUFIP2 Synonyms:KIAA1321 ORF Names:PIG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17634, NUFIP2 |
MIMi | 609356, gene |
neXtProti | NX_Q7Z417 |
VEuPathDBi | HostDB:ENSG00000108256.8 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Other locations
- Cytoplasm 2 Publications
- Stress granule 1 Publication
Note: Distribution is cell cycle-modulated, being cytoplasmic in the G2/M phase and accumulating in nucleus during the G1 phase (PubMed:12837692).2 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB
- membrane Source: UniProtKB
- polysomal ribosome Source: HGNC-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57532 |
OpenTargetsi | ENSG00000108256 |
PharmGKBi | PA143485564 |
Miscellaneous databases
Pharosi | Q7Z417, Tbio |
Genetic variation databases
BioMutai | NUFIP2 |
DMDMi | 74713454 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245521 | 1 – 695 | Nuclear fragile X mental retardation-interacting protein 2Add BLAST | 695 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 87 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 109 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 112 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Cross-linki | 136 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 146 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 157 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 171 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 212 | PhosphoserineCombined sources | 1 | |
Modified residuei | 214 | PhosphoserineCombined sources | 1 | |
Modified residuei | 218 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 219 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 220 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 262 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 281 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 291 | Omega-N-methylarginineCombined sources | 1 | |
Cross-linki | 293 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Cross-linki | 307 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 376 | PhosphoserineCombined sources | 1 | |
Modified residuei | 571 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 572 | PhosphoserineCombined sources | 1 | |
Modified residuei | 592 | PhosphoserineCombined sources | 1 | |
Modified residuei | 608 | PhosphoserineCombined sources | 1 | |
Modified residuei | 629 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 633 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 637 | PhosphoserineCombined sources | 1 | |
Modified residuei | 652 | PhosphoserineCombined sources | 1 | |
Modified residuei | 655 | PhosphoserineCombined sources | 1 | |
Modified residuei | 692 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-985 |
EPDi | Q7Z417 |
jPOSTi | Q7Z417 |
MassIVEi | Q7Z417 |
MaxQBi | Q7Z417 |
PaxDbi | Q7Z417 |
PeptideAtlasi | Q7Z417 |
PRIDEi | Q7Z417 |
ProteomicsDBi | 69128 [Q7Z417-1] |
PTM databases
iPTMneti | Q7Z417 |
MetOSitei | Q7Z417 |
PhosphoSitePlusi | Q7Z417 |
SwissPalmi | Q7Z417 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108256, Expressed in blood and 218 other tissues |
Genevisiblei | Q7Z417, HS |
Organism-specific databases
HPAi | ENSG00000108256, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q7Z417
Protein-protein interaction databases
BioGRIDi | 121591, 159 interactors |
CORUMi | Q7Z417 |
DIPi | DIP-29023N |
IntActi | Q7Z417, 96 interactors |
STRINGi | 9606.ENSP00000225388 |
Miscellaneous databases
RNActi | Q7Z417, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 60 | His-richAdd BLAST | 49 | |
Compositional biasi | 373 – 415 | Ser-richAdd BLAST | 43 |
Phylogenomic databases
eggNOGi | ENOG502QPMD, Eukaryota |
GeneTreei | ENSGT00440000038328 |
HOGENOMi | CLU_020745_0_0_1 |
InParanoidi | Q7Z417 |
OMAi | EMESVWN |
OrthoDBi | 331657at2759 |
PhylomeDBi | Q7Z417 |
TreeFami | TF332832 |
Family and domain databases
InterProi | View protein in InterPro IPR032747, NUFIP2 |
PANTHERi | PTHR28333, PTHR28333, 1 hit |
Pfami | View protein in Pfam PF15293, NUFIP2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q7Z417-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEKPGQPQP QHHHSHHHPH HHPQQQQQQP HHHHHYYFYN HSHNHHHHHH
60 70 80 90 100
HQQPHQYLQH GAEGSPKAQP KPLKHEQKHT LQQHQETPKK KTGYGELNGN
110 120 130 140 150
AGEREISLKN LSSDEATNPI SRVLNGNQQV VDTSLKQTVK ANTFGKAGIK
160 170 180 190 200
TKNFIQKNSM DKKNGKSYEN KSGENQSVDK SDTIPIPNGV VTNNSGYITN
210 220 230 240 250
GYMGKGADND GSGSESGYTT PKKRKARRNS AKGCENLNIV QDKIMQQETS
260 270 280 290 300
VPTLKQGLET FKPDYSEQKG NRVDGSKPIW KYETGPGGTS RGKPAVGDML
310 320 330 340 350
RKSSDSKPGV SSKKFDDRPK GKHASAVASK EDSWTLFKPP PVFPVDNSSA
360 370 380 390 400
KIVPKISYAS KVKENLNKTI QNSSVSPTSS SSSSSSTGET QTQSSSRLSQ
410 420 430 440 450
VPMSALKSVT SANFSNGPVL AGTDGNVYPP GGQPLLTTAA NTLTPISSGT
460 470 480 490 500
DSVLQDMSLT SAAVEQIKTS LFIYPSNMQT MLLSTAQVDL PSQTDQQNLG
510 520 530 540 550
DIFQNQWGLS FINEPSAGPE TVTGKSSEHK VMEVTFQGEY PATLVSQGAE
560 570 580 590 600
IIPSGTEHPV FPKAYELEKR TSPQVLGSIL KSGTTSESGA LSLEPSHIGD
610 620 630 640 650
LQKADTSSQG ALVFLSKDYE IESQNPLASP TNTLLGSAKE QRYQRGLERN
660 670 680 690
DSWGSFDLRA AIVYHTKEME SIWNLQKQDP KRIITYNEAM DSPDQ
Sequence cautioni
The sequence BAA92559 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056177 | 93 – 667 | Missing in isoform 2. 2 PublicationsAdd BLAST | 575 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ493465 mRNA Translation: CAD38278.1 AY232289 mRNA Translation: AAP69984.1 AB037742 mRNA Translation: BAA92559.1 Different initiation. AK297732 mRNA Translation: BAG60082.1 AK293075 mRNA Translation: BAF85764.1 AC005412 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51186.1 CH471159 Genomic DNA Translation: EAW51187.1 BC129989 mRNA Translation: AAI29990.1 BC129990 mRNA Translation: AAI29991.1 BC108307 mRNA Translation: AAI08308.1 |
CCDSi | CCDS32600.1 [Q7Z417-1] |
RefSeqi | NP_065823.1, NM_020772.2 [Q7Z417-1] |
Genome annotation databases
Ensembli | ENST00000225388; ENSP00000225388; ENSG00000108256 [Q7Z417-1] ENST00000579665; ENSP00000463450; ENSG00000108256 [Q7Z417-2] |
GeneIDi | 57532 |
KEGGi | hsa:57532 |
UCSCi | uc002hdx.5, human [Q7Z417-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ493465 mRNA Translation: CAD38278.1 AY232289 mRNA Translation: AAP69984.1 AB037742 mRNA Translation: BAA92559.1 Different initiation. AK297732 mRNA Translation: BAG60082.1 AK293075 mRNA Translation: BAF85764.1 AC005412 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51186.1 CH471159 Genomic DNA Translation: EAW51187.1 BC129989 mRNA Translation: AAI29990.1 BC129990 mRNA Translation: AAI29991.1 BC108307 mRNA Translation: AAI08308.1 |
CCDSi | CCDS32600.1 [Q7Z417-1] |
RefSeqi | NP_065823.1, NM_020772.2 [Q7Z417-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121591, 159 interactors |
CORUMi | Q7Z417 |
DIPi | DIP-29023N |
IntActi | Q7Z417, 96 interactors |
STRINGi | 9606.ENSP00000225388 |
PTM databases
iPTMneti | Q7Z417 |
MetOSitei | Q7Z417 |
PhosphoSitePlusi | Q7Z417 |
SwissPalmi | Q7Z417 |
Genetic variation databases
BioMutai | NUFIP2 |
DMDMi | 74713454 |
Proteomic databases
CPTACi | CPTAC-985 |
EPDi | Q7Z417 |
jPOSTi | Q7Z417 |
MassIVEi | Q7Z417 |
MaxQBi | Q7Z417 |
PaxDbi | Q7Z417 |
PeptideAtlasi | Q7Z417 |
PRIDEi | Q7Z417 |
ProteomicsDBi | 69128 [Q7Z417-1] |
Protocols and materials databases
Antibodypediai | 2837, 83 antibodies |
Genome annotation databases
Ensembli | ENST00000225388; ENSP00000225388; ENSG00000108256 [Q7Z417-1] ENST00000579665; ENSP00000463450; ENSG00000108256 [Q7Z417-2] |
GeneIDi | 57532 |
KEGGi | hsa:57532 |
UCSCi | uc002hdx.5, human [Q7Z417-1] |
Organism-specific databases
CTDi | 57532 |
DisGeNETi | 57532 |
GeneCardsi | NUFIP2 |
HGNCi | HGNC:17634, NUFIP2 |
HPAi | ENSG00000108256, Low tissue specificity |
MIMi | 609356, gene |
neXtProti | NX_Q7Z417 |
OpenTargetsi | ENSG00000108256 |
PharmGKBi | PA143485564 |
VEuPathDBi | HostDB:ENSG00000108256.8 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPMD, Eukaryota |
GeneTreei | ENSGT00440000038328 |
HOGENOMi | CLU_020745_0_0_1 |
InParanoidi | Q7Z417 |
OMAi | EMESVWN |
OrthoDBi | 331657at2759 |
PhylomeDBi | Q7Z417 |
TreeFami | TF332832 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z417 |
Miscellaneous databases
BioGRID-ORCSi | 57532, 28 hits in 877 CRISPR screens |
ChiTaRSi | NUFIP2, human |
GeneWikii | NUFIP2 |
GenomeRNAii | 57532 |
Pharosi | Q7Z417, Tbio |
PROi | PR:Q7Z417 |
RNActi | Q7Z417, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108256, Expressed in blood and 218 other tissues |
Genevisiblei | Q7Z417, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032747, NUFIP2 |
PANTHERi | PTHR28333, PTHR28333, 1 hit |
Pfami | View protein in Pfam PF15293, NUFIP2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUFP2_HUMAN | |
Accessioni | Q7Z417Primary (citable) accession number: Q7Z417 Secondary accession number(s): A1L3A6, A1L3A7, Q9P2M5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM