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Protein

Myosin-14

Gene

MYH14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 205ATPSequence analysis8

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • motor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processCell shape
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-14
Alternative name(s):
Myosin heavy chain 14
Myosin heavy chain, non-muscle IIc
Non-muscle myosin heavy chain IIc
Short name:
NMHC II-C
Gene namesi
Name:MYH14
Synonyms:KIAA2034
ORF Names:FP17425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105357.15
HGNCiHGNC:23212 MYH14
MIMi608568 gene
neXtProtiNX_Q7Z406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 4A (DFNA4A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:600652
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037302120S → L in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103281EnsemblClinVar.1
Natural variantiVAR_022867376G → C in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103280EnsemblClinVar.1
Natural variantiVAR_022868726R → S in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940307Ensembl.1
Natural variantiVAR_022869976L → F in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940306Ensembl.1
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
See also OMIM:614369
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066338933R → L in PNMHH. 1 PublicationCorresponds to variant dbSNP:rs113993956Ensembl.1

Keywords - Diseasei

Deafness, Disease mutation, Neuropathy, Non-syndromic deafness

Organism-specific databases

DisGeNETi79784
GeneReviewsiMYH14
MalaCardsiMYH14
MIMi600652 phenotype
614369 phenotype
OpenTargetsiENSG00000105357
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
397744 Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
PharmGKBiPA134935217

Chemistry databases

DrugBankiDB01944 (S)-blebbistatin
DB03126 Mant-Adp
DB08276 N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
DB04444 Tetrafluoroaluminate Ion

Polymorphism and mutation databases

BioMutaiMYH14
DMDMi327478526

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001234312 – 1995Myosin-14Add BLAST1994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei60PhosphoserineCombined sources1
Modified residuei1194PhosphothreonineCombined sources1
Modified residuei1969PhosphoserineCombined sources1
Modified residuei1980PhosphoserineCombined sources1
Modified residuei1983PhosphoserineCombined sources1
Modified residuei1989PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z406
MaxQBiQ7Z406
PaxDbiQ7Z406
PeptideAtlasiQ7Z406
PRIDEiQ7Z406
ProteomicsDBi69113
69114 [Q7Z406-2]
69115 [Q7Z406-4]
69116 [Q7Z406-5]
69117 [Q7Z406-6]

PTM databases

iPTMnetiQ7Z406
PhosphoSitePlusiQ7Z406
SwissPalmiQ7Z406

Expressioni

Tissue specificityi

High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes.3 Publications

Gene expression databases

BgeeiENSG00000105357 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ7Z406 baseline and differential
GenevisibleiQ7Z406 HS

Organism-specific databases

HPAiHPA062391
HPA067889
HPA070260

Interactioni

Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122884, 50 interactors
DIPiDIP-33170N
IntActiQ7Z406, 29 interactors
MINTiQ7Z406
STRINGi9606.ENSP00000262269

Structurei

Secondary structure

11995
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7Z406
SMRiQ7Z406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 101Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini105 – 800Myosin motorPROSITE-ProRule annotationAdd BLAST696
Domaini803 – 832IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni678 – 700Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili862 – 1947Sequence analysisAdd BLAST1086

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOVERGENiHBG004704
InParanoidiQ7Z406
KOiK10352
OMAiCSHYRFL
OrthoDBiEOG091G009J
PhylomeDBiQ7Z406
TreeFamiTF333601

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW
60 70 80 90 100
TARRLVWVPS ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN
110 120 130 140 150
PPKFSKAEDM AELTCLNEAS VLHNLRERYY SGLIYTYSGL FCVVINPYKQ
160 170 180 190 200
LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG AYRSMLQDRE DQSILCTGES
210 220 230 240 250
GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PGELERQLLQ ANPILEAFGN
260 270 280 290 300
AKTVKNDNSS RFGKFIRINF DVAGYIVGAN IETYLLEKSR AIRQAKDECS
310 320 330 340 350
FHIFYQLLGG AGEQLKADLL LEPCSHYRFL TNGPSSSPGQ ERELFQETLE
360 370 380 390 400
SLRVLGFSHE EIISMLRMVS AVLQFGNIAL KRERNTDQAT MPDNTAAQKL
410 420 430 440 450
CRLLGLGVTD FSRALLTPRI KVGRDYVQKA QTKEQADFAL EALAKATYER
460 470 480 490 500
LFRWLVLRLN RALDRSPRQG ASFLGILDIA GFEIFQLNSF EQLCINYTNE
510 520 530 540 550
KLQQLFNHTM FVLEQEEYQR EGIPWTFLDF GLDLQPCIDL IERPANPPGL
560 570 580 590 600
LALLDEECWF PKATDKSFVE KVAQEQGGHP KFQRPRHLRD QADFSVLHYA
610 620 630 640 650
GKVDYKANEW LMKNMDPLND NVAALLHQST DRLTAEIWKD VEGIVGLEQV
660 670 680 690 700
SSLGDGPPGG RPRRGMFRTV GQLYKESLSR LMATLSNTNP SFVRCIVPNH
710 720 730 740 750
EKRAGKLEPR LVLDQLRCNG VLEGIRICRQ GFPNRILFQE FRQRYEILTP
760 770 780 790 800
NAIPKGFMDG KQACEKMIQA LELDPNLYRV GQSKIFFRAG VLAQLEEERD
810 820 830 840 850
LKVTDIIVSF QAAARGYLAR RAFQKRQQQQ SALRVMQRNC AAYLKLRHWQ
860 870 880 890 900
WWRLFTKVKP LLQVTRQDEV LQARAQELQK VQELQQQSAR EVGELQGRVA
910 920 930 940 950
QLEEERARLA EQLRAEAELC AEAEETRGRL AARKQELELV VSELEARVGE
960 970 980 990 1000
EEECSRQMQT EKKRLQQHIQ ELEAHLEAEE GARQKLQLEK VTTEAKMKKF
1010 1020 1030 1040 1050
EEDLLLLEDQ NSKLSKERKL LEDRLAEFSS QAAEEEEKVK SLNKLRLKYE
1060 1070 1080 1090 1100
ATIADMEDRL RKEEKGRQEL EKLKRRLDGE SSELQEQMVE QQQRAEELRA
1110 1120 1130 1140 1150
QLGRKEEELQ AALARAEDEG GARAQLLKSL REAQAALAEA QEDLESERVA
1160 1170 1180 1190 1200
RTKAEKQRRD LGEELEALRG ELEDTLDSTN AQQELRSKRE QEVTELKKTL
1210 1220 1230 1240 1250
EEETRIHEAA VQELRQRHGQ ALGELAEQLE QARRGKGAWE KTRLALEAEV
1260 1270 1280 1290 1300
SELRAELSSL QTARQEGEQR RRRLELQLQE VQGRAGDGER ARAEAAEKLQ
1310 1320 1330 1340 1350
RAQAELENVS GALNEAESKT IRLSKELSST EAQLHDAQEL LQEETRAKLA
1360 1370 1380 1390 1400
LGSRVRAMEA EAAGLREQLE EEAAARERAG RELQTAQAQL SEWRRRQEEE
1410 1420 1430 1440 1450
AGALEAGEEA RRRAAREAEA LTQRLAEKTE TVDRLERGRR RLQQELDDAT
1460 1470 1480 1490 1500
MDLEQQRQLV STLEKKQRKF DQLLAEEKAA VLRAVEERER AEAEGREREA
1510 1520 1530 1540 1550
RALSLTRALE EEQEAREELE RQNRALRAEL EALLSSKDDV GKSVHELERA
1560 1570 1580 1590 1600
CRVAEQAAND LRAQVTELED ELTAAEDAKL RLEVTVQALK TQHERDLQGR
1610 1620 1630 1640 1650
DEAGEERRRQ LAKQLRDAEV ERDEERKQRT LAVAARKKLE GELEELKAQM
1660 1670 1680 1690 1700
ASAGQGKEEA VKQLRKMQAQ MKELWREVEE TRTSREEIFS QNRESEKRLK
1710 1720 1730 1740 1750
GLEAEVLRLQ EELAASDRAR RQAQQDRDEM ADEVANGNLS KAAILEEKRQ
1760 1770 1780 1790 1800
LEGRLGQLEE ELEEEQSNSE LLNDRYRKLL LQVESLTTEL SAERSFSAKA
1810 1820 1830 1840 1850
ESGRQQLERQ IQELRGRLGE EDAGARARHK MTIAALESKL AQAEEQLEQE
1860 1870 1880 1890 1900
TRERILSGKL VRRAEKRLKE VVLQVEEERR VADQLRDQLE KGNLRVKQLK
1910 1920 1930 1940 1950
RQLEEAEEEA SRAQAGRRRL QRELEDVTES AESMNREVTT LRNRLRRGPL
1960 1970 1980 1990
TFTTRTVRQV FRLEEGVASD EEAEEAQPGS GPSPEPEGSP PAHPQ
Length:1,995
Mass (Da):227,871
Last modified:April 5, 2011 - v2
Checksum:iC77AAB26817B773B
GO
Isoform 2 (identifier: Q7Z406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-231: P → PASVSTVSY
     640-640: D → DEHGGFQQFSFLGSFPPSPPGSAERCSSAISPPG

Show »
Length:2,036
Mass (Da):232,011
Checksum:i44C56941E575A56D
GO
Isoform 4 (identifier: Q7Z406-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1532: Missing.

Show »
Length:1,779
Mass (Da):202,995
Checksum:iCB3D84684472B2A1
GO
Isoform 5 (identifier: Q7Z406-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1451-1478: MDLEQQRQLVSTLEKKQRKFDQLLAEEK → LSPDALTDGAQPPSSLDPTGPCPRNPAL
     1479-1995: Missing.

Show »
Length:1,478
Mass (Da):167,896
Checksum:i24968D882FF859BD
GO
Isoform 6 (identifier: Q7Z406-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-231: P → PASVSTVSY

Show »
Length:2,003
Mass (Da):228,665
Checksum:iA8B40CFA23A27902
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY43M0QY43_HUMAN
Myosin-14
MYH14
1,002Annotation score:
A0A2R8Y4C3A0A2R8Y4C3_HUMAN
Myosin-14
MYH14
371Annotation score:
A0A2R8Y454A0A2R8Y454_HUMAN
Myosin-14
MYH14
135Annotation score:
A1L2Z2A1L2Z2_HUMAN
MYH14 protein
MYH14
638Annotation score:
A0A0C4DFM8A0A0C4DFM8_HUMAN
Myosin-14
MYH14
508Annotation score:

Sequence cautioni

The sequence AAO39147 differs from that shown. Reason: Frameshift at positions 1017 and 1057.Curated
The sequence AAP34449 differs from that shown. Reason: Frameshift at positions 1016, 1057, 1490 and 1755.Curated
The sequence AAP34449 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14735 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BG468611 differs from that shown. Reason: Erroneous termination at position 403. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411F → S in BG468611 (PubMed:15489334).Curated1
Sequence conflicti444A → G in BG468611 (PubMed:15489334).Curated1
Sequence conflicti446A → D in BG468611 (PubMed:15489334).Curated1
Sequence conflicti458R → S in BG468611 (PubMed:15489334).Curated1
Sequence conflicti466S → D in BG468611 (PubMed:15489334).Curated1
Sequence conflicti473F → L in BG468611 (PubMed:15489334).Curated1
Sequence conflicti997M → I in AAH18933 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037302120S → L in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103281EnsemblClinVar.1
Natural variantiVAR_022866266I → V1 PublicationCorresponds to variant dbSNP:rs200424400Ensembl.1
Natural variantiVAR_056176334P → A. Corresponds to variant dbSNP:rs34498817EnsemblClinVar.1
Natural variantiVAR_022867376G → C in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103280EnsemblClinVar.1
Natural variantiVAR_022868726R → S in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940307Ensembl.1
Natural variantiVAR_066338933R → L in PNMHH. 1 PublicationCorresponds to variant dbSNP:rs113993956Ensembl.1
Natural variantiVAR_022869976L → F in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940306Ensembl.1
Natural variantiVAR_0663391154A → V1 PublicationCorresponds to variant dbSNP:rs910420638Ensembl.1
Natural variantiVAR_0561771209A → E. Corresponds to variant dbSNP:rs11669191EnsemblClinVar.1
Natural variantiVAR_0561781540V → I. Corresponds to variant dbSNP:rs680446Ensembl.1
Natural variantiVAR_0228701559N → S1 PublicationCorresponds to variant dbSNP:rs769482601Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040881231P → PASVSTVSY in isoform 2 and isoform 6. 3 Publications1
Alternative sequenceiVSP_040882640D → DEHGGFQQFSFLGSFPPSPP GSAERCSSAISPPG in isoform 2. 2 Publications1
Alternative sequenceiVSP_0146281317 – 1532Missing in isoform 4. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_0146291451 – 1478MDLEQ…LAEEK → LSPDALTDGAQPPSSLDPTG PCPRNPAL in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0146301479 – 1995Missing in isoform 5. 1 PublicationAdd BLAST517

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165122 mRNA Translation: AAO39147.1 Frameshift.
AB111886 mRNA Translation: BAC98374.1
AB290169 mRNA Translation: BAG06723.1
AC008655 Genomic DNA No translation available.
AC010515 Genomic DNA No translation available.
AC020906 Genomic DNA No translation available.
BC000676 mRNA Translation: AAH00676.2
BC004396 mRNA Translation: AAH04396.1
BC007877 mRNA Translation: AAH07877.2
BC018933 mRNA Translation: AAH18933.2
FJ041910 mRNA Translation: ACM78630.1
BG468611 mRNA No translation available.
AY203926 mRNA Translation: AAP34449.1 Sequence problems.
CR936653 mRNA Translation: CAI56791.1
AK023943 mRNA Translation: BAB14735.1 Different initiation.
CCDSiCCDS46151.1 [Q7Z406-6]
CCDS54295.1 [Q7Z406-2]
CCDS59411.1 [Q7Z406-1]
RefSeqiNP_001070654.1, NM_001077186.1 [Q7Z406-6]
NP_001139281.1, NM_001145809.1 [Q7Z406-2]
NP_079005.3, NM_024729.3 [Q7Z406-1]
XP_006723449.1, XM_006723386.3 [Q7Z406-6]
XP_011525625.1, XM_011527323.2 [Q7Z406-6]
UniGeneiHs.467142

Genome annotation databases

EnsembliENST00000376970; ENSP00000366169; ENSG00000105357 [Q7Z406-1]
ENST00000425460; ENSP00000407879; ENSG00000105357 [Q7Z406-6]
ENST00000596571; ENSP00000472819; ENSG00000105357 [Q7Z406-1]
ENST00000598205; ENSP00000472543; ENSG00000105357 [Q7Z406-6]
ENST00000601313; ENSP00000470298; ENSG00000105357 [Q7Z406-2]
ENST00000642316; ENSP00000493594; ENSG00000105357 [Q7Z406-2]
GeneIDi79784
KEGGihsa:79784
UCSCiuc002prq.2 human [Q7Z406-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165122 mRNA Translation: AAO39147.1 Frameshift.
AB111886 mRNA Translation: BAC98374.1
AB290169 mRNA Translation: BAG06723.1
AC008655 Genomic DNA No translation available.
AC010515 Genomic DNA No translation available.
AC020906 Genomic DNA No translation available.
BC000676 mRNA Translation: AAH00676.2
BC004396 mRNA Translation: AAH04396.1
BC007877 mRNA Translation: AAH07877.2
BC018933 mRNA Translation: AAH18933.2
FJ041910 mRNA Translation: ACM78630.1
BG468611 mRNA No translation available.
AY203926 mRNA Translation: AAP34449.1 Sequence problems.
CR936653 mRNA Translation: CAI56791.1
AK023943 mRNA Translation: BAB14735.1 Different initiation.
CCDSiCCDS46151.1 [Q7Z406-6]
CCDS54295.1 [Q7Z406-2]
CCDS59411.1 [Q7Z406-1]
RefSeqiNP_001070654.1, NM_001077186.1 [Q7Z406-6]
NP_001139281.1, NM_001145809.1 [Q7Z406-2]
NP_079005.3, NM_024729.3 [Q7Z406-1]
XP_006723449.1, XM_006723386.3 [Q7Z406-6]
XP_011525625.1, XM_011527323.2 [Q7Z406-6]
UniGeneiHs.467142

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I4EX-ray2.25A47-784[»]
5JLHelectron microscopy3.90F/G1-799[»]
ProteinModelPortaliQ7Z406
SMRiQ7Z406
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122884, 50 interactors
DIPiDIP-33170N
IntActiQ7Z406, 29 interactors
MINTiQ7Z406
STRINGi9606.ENSP00000262269

Chemistry databases

DrugBankiDB01944 (S)-blebbistatin
DB03126 Mant-Adp
DB08276 N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
DB04444 Tetrafluoroaluminate Ion

PTM databases

iPTMnetiQ7Z406
PhosphoSitePlusiQ7Z406
SwissPalmiQ7Z406

Polymorphism and mutation databases

BioMutaiMYH14
DMDMi327478526

Proteomic databases

EPDiQ7Z406
MaxQBiQ7Z406
PaxDbiQ7Z406
PeptideAtlasiQ7Z406
PRIDEiQ7Z406
ProteomicsDBi69113
69114 [Q7Z406-2]
69115 [Q7Z406-4]
69116 [Q7Z406-5]
69117 [Q7Z406-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376970; ENSP00000366169; ENSG00000105357 [Q7Z406-1]
ENST00000425460; ENSP00000407879; ENSG00000105357 [Q7Z406-6]
ENST00000596571; ENSP00000472819; ENSG00000105357 [Q7Z406-1]
ENST00000598205; ENSP00000472543; ENSG00000105357 [Q7Z406-6]
ENST00000601313; ENSP00000470298; ENSG00000105357 [Q7Z406-2]
ENST00000642316; ENSP00000493594; ENSG00000105357 [Q7Z406-2]
GeneIDi79784
KEGGihsa:79784
UCSCiuc002prq.2 human [Q7Z406-1]

Organism-specific databases

CTDi79784
DisGeNETi79784
EuPathDBiHostDB:ENSG00000105357.15
GeneCardsiMYH14
GeneReviewsiMYH14
H-InvDBiHIX0015356
HGNCiHGNC:23212 MYH14
HPAiHPA062391
HPA067889
HPA070260
MalaCardsiMYH14
MIMi600652 phenotype
608568 gene
614369 phenotype
neXtProtiNX_Q7Z406
OpenTargetsiENSG00000105357
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
397744 Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
PharmGKBiPA134935217
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOVERGENiHBG004704
InParanoidiQ7Z406
KOiK10352
OMAiCSHYRFL
OrthoDBiEOG091G009J
PhylomeDBiQ7Z406
TreeFamiTF333601

Enzyme and pathway databases

ReactomeiR-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

Miscellaneous databases

ChiTaRSiMYH14 human
GeneWikiiMYH14
GenomeRNAii79784
PROiPR:Q7Z406
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105357 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ7Z406 baseline and differential
GenevisibleiQ7Z406 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYH14_HUMAN
AccessioniPrimary (citable) accession number: Q7Z406
Secondary accession number(s): B0I1S2
, C3TTN4, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 5, 2011
Last modified: October 10, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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