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UniProtKB - Q7Z406 (MYH14_HUMAN)

Entry version 173 (02 Jun 2021)
Sequence version 2 (05 Apr 2011)
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Protein

Myosin-14

Gene

MYH14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi198 – 205ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processCell shape
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z406

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3928663, EPHA-mediated growth cone collapse
R-HSA-416572, Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5625900, RHO GTPases activate CIT
R-HSA-5627117, RHO GTPases Activate ROCKs
R-HSA-5627123, RHO GTPases activate PAKs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-14
Alternative name(s):
Myosin heavy chain 14
Myosin heavy chain, non-muscle IIc
Non-muscle myosin heavy chain IIc
Short name:
NMHC II-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH14
Synonyms:KIAA2034
ORF Names:FP17425
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23212, MYH14

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608568, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z406

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105357.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal dominant, 4A (DFNA4A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037302120S → L in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103281EnsemblClinVar.1
Natural variantiVAR_022867376G → C in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103280Ensembl.1
Natural variantiVAR_022868726R → S in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940307Ensembl.1
Natural variantiVAR_022869976L → F in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940306Ensembl.1
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066338933R → L in PNMHH. 1 PublicationCorresponds to variant dbSNP:rs113993956Ensembl.1

Keywords - Diseasei

Deafness, Disease variant, Neuropathy, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		79784

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MYH14

MalaCards human disease database

More...MalaCardsi		MYH14
MIMi600652, phenotype
614369, phenotype

Open Targets

More...OpenTargetsi		ENSG00000105357

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA
171215, Low isolated anorectal malformation
397744, Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134935217

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z406, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105888

Drug and drug target database

More...DrugBanki		DB07470, (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07468, (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07469, (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB01944, (S)-blebbistatin
DB03126, Mant-Adp
DB04444, Tetrafluoroaluminate Ion
DB08276, trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-)

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYH14

Domain mapping of disease mutations (DMDM)

More...DMDMi		327478526

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234312 – 1995Myosin-14Add BLAST1994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei60PhosphoserineCombined sources1
Modified residuei1194PhosphothreonineCombined sources1
Modified residuei1969PhosphoserineCombined sources1
Modified residuei1980PhosphoserineCombined sources1
Modified residuei1983PhosphoserineCombined sources1
Modified residuei1989PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-240
CPTAC-241

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z406

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z406

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z406

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z406

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z406

PeptideAtlas

More...PeptideAtlasi		Q7Z406

PRoteomics IDEntifications database

More...PRIDEi		Q7Z406

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69113 [Q7Z406-1]
69114 [Q7Z406-2]
69115 [Q7Z406-4]
69116 [Q7Z406-5]
69117 [Q7Z406-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7Z406, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z406

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z406

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7Z406

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105357, Expressed in mucosa of transverse colon and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z406, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z406, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105357, Tissue enhanced (intestine, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122884, 98 interactors

Database of interacting proteins

More...DIPi		DIP-33170N

Protein interaction database and analysis system

More...IntActi		Q7Z406, 49 interactors

Molecular INTeraction database

More...MINTi		Q7Z406

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000470298

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z406, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11995
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z406

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 101Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini105 – 800Myosin motorPROSITE-ProRule annotationAdd BLAST696
Domaini803 – 832IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni678 – 700Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1371 – 1415DisorderedSequence analysisAdd BLAST45
Regioni1592 – 1623DisorderedSequence analysisAdd BLAST32
Regioni1905 – 1942DisorderedSequence analysisAdd BLAST38
Regioni1958 – 1995DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili862 – 1947Sequence analysisAdd BLAST1086

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1392 – 1415Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1905 – 1932Basic and acidic residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0161, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000192_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z406

Identification of Orthologs from Complete Genome Data

More...OMAi		DAIMDLE

Database of Orthologous Groups

More...OrthoDBi		47111at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z406

TreeFam database of animal gene trees

More...TreeFami		TF333601

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00063, Myosin_head, 1 hit
PF01576, Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW 
        60         70         80         90        100
TARRLVWVPS ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN 
       110        120        130        140        150
PPKFSKAEDM AELTCLNEAS VLHNLRERYY SGLIYTYSGL FCVVINPYKQ 
       160        170        180        190        200
LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG AYRSMLQDRE DQSILCTGES 
       210        220        230        240        250
GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PGELERQLLQ ANPILEAFGN 
       260        270        280        290        300
AKTVKNDNSS RFGKFIRINF DVAGYIVGAN IETYLLEKSR AIRQAKDECS 
       310        320        330        340        350
FHIFYQLLGG AGEQLKADLL LEPCSHYRFL TNGPSSSPGQ ERELFQETLE 
       360        370        380        390        400
SLRVLGFSHE EIISMLRMVS AVLQFGNIAL KRERNTDQAT MPDNTAAQKL 
       410        420        430        440        450
CRLLGLGVTD FSRALLTPRI KVGRDYVQKA QTKEQADFAL EALAKATYER 
       460        470        480        490        500
LFRWLVLRLN RALDRSPRQG ASFLGILDIA GFEIFQLNSF EQLCINYTNE 
       510        520        530        540        550
KLQQLFNHTM FVLEQEEYQR EGIPWTFLDF GLDLQPCIDL IERPANPPGL 
       560        570        580        590        600
LALLDEECWF PKATDKSFVE KVAQEQGGHP KFQRPRHLRD QADFSVLHYA 
       610        620        630        640        650
GKVDYKANEW LMKNMDPLND NVAALLHQST DRLTAEIWKD VEGIVGLEQV 
       660        670        680        690        700
SSLGDGPPGG RPRRGMFRTV GQLYKESLSR LMATLSNTNP SFVRCIVPNH 
       710        720        730        740        750
EKRAGKLEPR LVLDQLRCNG VLEGIRICRQ GFPNRILFQE FRQRYEILTP 
       760        770        780        790        800
NAIPKGFMDG KQACEKMIQA LELDPNLYRV GQSKIFFRAG VLAQLEEERD 
       810        820        830        840        850
LKVTDIIVSF QAAARGYLAR RAFQKRQQQQ SALRVMQRNC AAYLKLRHWQ 
       860        870        880        890        900
WWRLFTKVKP LLQVTRQDEV LQARAQELQK VQELQQQSAR EVGELQGRVA 
       910        920        930        940        950
QLEEERARLA EQLRAEAELC AEAEETRGRL AARKQELELV VSELEARVGE 
       960        970        980        990       1000
EEECSRQMQT EKKRLQQHIQ ELEAHLEAEE GARQKLQLEK VTTEAKMKKF 
      1010       1020       1030       1040       1050
EEDLLLLEDQ NSKLSKERKL LEDRLAEFSS QAAEEEEKVK SLNKLRLKYE 
      1060       1070       1080       1090       1100
ATIADMEDRL RKEEKGRQEL EKLKRRLDGE SSELQEQMVE QQQRAEELRA 
      1110       1120       1130       1140       1150
QLGRKEEELQ AALARAEDEG GARAQLLKSL REAQAALAEA QEDLESERVA 
      1160       1170       1180       1190       1200
RTKAEKQRRD LGEELEALRG ELEDTLDSTN AQQELRSKRE QEVTELKKTL 
      1210       1220       1230       1240       1250
EEETRIHEAA VQELRQRHGQ ALGELAEQLE QARRGKGAWE KTRLALEAEV 
      1260       1270       1280       1290       1300
SELRAELSSL QTARQEGEQR RRRLELQLQE VQGRAGDGER ARAEAAEKLQ 
      1310       1320       1330       1340       1350
RAQAELENVS GALNEAESKT IRLSKELSST EAQLHDAQEL LQEETRAKLA 
      1360       1370       1380       1390       1400
LGSRVRAMEA EAAGLREQLE EEAAARERAG RELQTAQAQL SEWRRRQEEE 
      1410       1420       1430       1440       1450
AGALEAGEEA RRRAAREAEA LTQRLAEKTE TVDRLERGRR RLQQELDDAT 
      1460       1470       1480       1490       1500
MDLEQQRQLV STLEKKQRKF DQLLAEEKAA VLRAVEERER AEAEGREREA 
      1510       1520       1530       1540       1550
RALSLTRALE EEQEAREELE RQNRALRAEL EALLSSKDDV GKSVHELERA 
      1560       1570       1580       1590       1600
CRVAEQAAND LRAQVTELED ELTAAEDAKL RLEVTVQALK TQHERDLQGR 
      1610       1620       1630       1640       1650
DEAGEERRRQ LAKQLRDAEV ERDEERKQRT LAVAARKKLE GELEELKAQM 
      1660       1670       1680       1690       1700
ASAGQGKEEA VKQLRKMQAQ MKELWREVEE TRTSREEIFS QNRESEKRLK 
      1710       1720       1730       1740       1750
GLEAEVLRLQ EELAASDRAR RQAQQDRDEM ADEVANGNLS KAAILEEKRQ 
      1760       1770       1780       1790       1800
LEGRLGQLEE ELEEEQSNSE LLNDRYRKLL LQVESLTTEL SAERSFSAKA 
      1810       1820       1830       1840       1850
ESGRQQLERQ IQELRGRLGE EDAGARARHK MTIAALESKL AQAEEQLEQE 
      1860       1870       1880       1890       1900
TRERILSGKL VRRAEKRLKE VVLQVEEERR VADQLRDQLE KGNLRVKQLK 
      1910       1920       1930       1940       1950
RQLEEAEEEA SRAQAGRRRL QRELEDVTES AESMNREVTT LRNRLRRGPL 
      1960       1970       1980       1990 
TFTTRTVRQV FRLEEGVASD EEAEEAQPGS GPSPEPEGSP PAHPQ
Length:1,995
Mass (Da):227,871
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC77AAB26817B773B
GO
Isoform 2 (identifier: Q7Z406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-231: P → PASVSTVSY
     640-640: D → DEHGGFQQFSFLGSFPPSPPGSAERCSSAISPPG

Show »
Length:2,036
Mass (Da):232,011
Checksum:i44C56941E575A56D
GO
Isoform 4 (identifier: Q7Z406-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1532: Missing.

Show »
Length:1,779
Mass (Da):202,995
Checksum:iCB3D84684472B2A1
GO
Isoform 5 (identifier: Q7Z406-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1451-1478: MDLEQQRQLVSTLEKKQRKFDQLLAEEK → LSPDALTDGAQPPSSLDPTGPCPRNPAL
     1479-1995: Missing.

Show »
Length:1,478
Mass (Da):167,896
Checksum:i24968D882FF859BD
GO
Isoform 6 (identifier: Q7Z406-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-231: P → PASVSTVSY

Show »
Length:2,003
Mass (Da):228,665
Checksum:iA8B40CFA23A27902
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY43M0QY43_HUMAN
Myosin-14
MYH14
1,002Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4C3A0A2R8Y4C3_HUMAN
Myosin-14
MYH14
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y454A0A2R8Y454_HUMAN
Myosin-14
MYH14
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1L2Z2A1L2Z2_HUMAN
MYH14 protein
MYH14
638Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFM8A0A0C4DFM8_HUMAN
Myosin-14
MYH14
508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO39147 differs from that shown. Reason: Frameshift.Curated
The sequence AAP34449 differs from that shown. Reason: Frameshift.Curated
The sequence AAP34449 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14735 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BG468611 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti411F → S in BG468611 (PubMed:15489334).Curated1
Sequence conflicti444A → G in BG468611 (PubMed:15489334).Curated1
Sequence conflicti446A → D in BG468611 (PubMed:15489334).Curated1
Sequence conflicti458R → S in BG468611 (PubMed:15489334).Curated1
Sequence conflicti466S → D in BG468611 (PubMed:15489334).Curated1
Sequence conflicti473F → L in BG468611 (PubMed:15489334).Curated1
Sequence conflicti997M → I in AAH18933 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037302120S → L in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103281EnsemblClinVar.1
Natural variantiVAR_022866266I → V1 PublicationCorresponds to variant dbSNP:rs200424400Ensembl.1
Natural variantiVAR_056176334P → A. Corresponds to variant dbSNP:rs34498817Ensembl.1
Natural variantiVAR_022867376G → C in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103280Ensembl.1
Natural variantiVAR_022868726R → S in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940307Ensembl.1
Natural variantiVAR_066338933R → L in PNMHH. 1 PublicationCorresponds to variant dbSNP:rs113993956Ensembl.1
Natural variantiVAR_022869976L → F in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940306Ensembl.1
Natural variantiVAR_0663391154A → V1 PublicationCorresponds to variant dbSNP:rs910420638Ensembl.1
Natural variantiVAR_0561771209A → E. Corresponds to variant dbSNP:rs11669191Ensembl.1
Natural variantiVAR_0561781540V → I. Corresponds to variant dbSNP:rs680446Ensembl.1
Natural variantiVAR_0228701559N → S1 PublicationCorresponds to variant dbSNP:rs769482601Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040881231P → PASVSTVSY in isoform 2 and isoform 6. 3 Publications1
Alternative sequenceiVSP_040882640D → DEHGGFQQFSFLGSFPPSPP GSAERCSSAISPPG in isoform 2. 2 Publications1
Alternative sequenceiVSP_0146281317 – 1532Missing in isoform 4. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_0146291451 – 1478MDLEQ…LAEEK → LSPDALTDGAQPPSSLDPTG PCPRNPAL in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0146301479 – 1995Missing in isoform 5. 1 PublicationAdd BLAST517

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY165122 mRNA Translation: AAO39147.1 Frameshift.
AB111886 mRNA Translation: BAC98374.1
AB290169 mRNA Translation: BAG06723.1
AC008655 Genomic DNA No translation available.
AC010515 Genomic DNA No translation available.
AC020906 Genomic DNA No translation available.
BC000676 mRNA Translation: AAH00676.2
BC004396 mRNA Translation: AAH04396.1
BC007877 mRNA Translation: AAH07877.2
BC018933 mRNA Translation: AAH18933.2
FJ041910 mRNA Translation: ACM78630.1
BG468611 mRNA No translation available.
AY203926 mRNA Translation: AAP34449.1 Sequence problems.
CR936653 mRNA Translation: CAI56791.1
AK023943 mRNA Translation: BAB14735.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46151.1 [Q7Z406-6]
CCDS54295.1 [Q7Z406-2]
CCDS59411.1 [Q7Z406-1]

NCBI Reference Sequences

More...RefSeqi		NP_001070654.1, NM_001077186.1 [Q7Z406-6]
NP_001139281.1, NM_001145809.1 [Q7Z406-2]
NP_079005.3, NM_024729.3 [Q7Z406-1]
XP_006723449.1, XM_006723386.3 [Q7Z406-6]
XP_011525625.1, XM_011527323.2 [Q7Z406-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376970; ENSP00000366169; ENSG00000105357 [Q7Z406-1]
ENST00000425460; ENSP00000407879; ENSG00000105357 [Q7Z406-6]
ENST00000596571; ENSP00000472819; ENSG00000105357 [Q7Z406-1]
ENST00000598205; ENSP00000472543; ENSG00000105357 [Q7Z406-6]
ENST00000642316; ENSP00000493594; ENSG00000105357 [Q7Z406-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79784

UCSC genome browser

More...UCSCi		uc002prq.2, human [Q7Z406-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165122 mRNA Translation: AAO39147.1 Frameshift.
AB111886 mRNA Translation: BAC98374.1
AB290169 mRNA Translation: BAG06723.1
AC008655 Genomic DNA No translation available.
AC010515 Genomic DNA No translation available.
AC020906 Genomic DNA No translation available.
BC000676 mRNA Translation: AAH00676.2
BC004396 mRNA Translation: AAH04396.1
BC007877 mRNA Translation: AAH07877.2
BC018933 mRNA Translation: AAH18933.2
FJ041910 mRNA Translation: ACM78630.1
BG468611 mRNA No translation available.
AY203926 mRNA Translation: AAP34449.1 Sequence problems.
CR936653 mRNA Translation: CAI56791.1
AK023943 mRNA Translation: BAB14735.1 Different initiation.
CCDSiCCDS46151.1 [Q7Z406-6]
CCDS54295.1 [Q7Z406-2]
CCDS59411.1 [Q7Z406-1]
RefSeqiNP_001070654.1, NM_001077186.1 [Q7Z406-6]
NP_001139281.1, NM_001145809.1 [Q7Z406-2]
NP_079005.3, NM_024729.3 [Q7Z406-1]
XP_006723449.1, XM_006723386.3 [Q7Z406-6]
XP_011525625.1, XM_011527323.2 [Q7Z406-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I4EX-ray2.25A47-784[»]
5JLHelectron microscopy3.90F/G1-799[»]
SMRiQ7Z406
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122884, 98 interactors
DIPiDIP-33170N
IntActiQ7Z406, 49 interactors
MINTiQ7Z406
STRINGi9606.ENSP00000470298

Chemistry databases

ChEMBLiCHEMBL4105888
DrugBankiDB07470, (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07468, (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07469, (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB01944, (S)-blebbistatin
DB03126, Mant-Adp
DB04444, Tetrafluoroaluminate Ion
DB08276, trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-)

PTM databases

GlyGeniQ7Z406, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ7Z406
PhosphoSitePlusiQ7Z406
SwissPalmiQ7Z406

Genetic variation databases

BioMutaiMYH14
DMDMi327478526

Proteomic databases

CPTACiCPTAC-240
CPTAC-241
EPDiQ7Z406
jPOSTiQ7Z406
MassIVEiQ7Z406
MaxQBiQ7Z406
PaxDbiQ7Z406
PeptideAtlasiQ7Z406
PRIDEiQ7Z406
ProteomicsDBi69113 [Q7Z406-1]
69114 [Q7Z406-2]
69115 [Q7Z406-4]
69116 [Q7Z406-5]
69117 [Q7Z406-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32261, 247 antibodies

The DNASU plasmid repository

More...DNASUi		79784

Genome annotation databases

EnsembliENST00000376970; ENSP00000366169; ENSG00000105357 [Q7Z406-1]
ENST00000425460; ENSP00000407879; ENSG00000105357 [Q7Z406-6]
ENST00000596571; ENSP00000472819; ENSG00000105357 [Q7Z406-1]
ENST00000598205; ENSP00000472543; ENSG00000105357 [Q7Z406-6]
ENST00000642316; ENSP00000493594; ENSG00000105357 [Q7Z406-2]
GeneIDi79784
KEGGihsa:79784
UCSCiuc002prq.2, human [Q7Z406-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79784
DisGeNETi79784

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYH14
GeneReviewsiMYH14
HGNCiHGNC:23212, MYH14
HPAiENSG00000105357, Tissue enhanced (intestine, skeletal muscle)
MalaCardsiMYH14
MIMi600652, phenotype
608568, gene
614369, phenotype
neXtProtiNX_Q7Z406
OpenTargetsiENSG00000105357
Orphaneti90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA
171215, Low isolated anorectal malformation
397744, Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
PharmGKBiPA134935217
VEuPathDBiHostDB:ENSG00000105357.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0161, Eukaryota
GeneTreeiENSGT00940000158808
HOGENOMiCLU_000192_4_1_1
InParanoidiQ7Z406
OMAiDAIMDLE
OrthoDBi47111at2759
PhylomeDBiQ7Z406
TreeFamiTF333601

Enzyme and pathway databases

PathwayCommonsiQ7Z406
ReactomeiR-HSA-3928663, EPHA-mediated growth cone collapse
R-HSA-416572, Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5625900, RHO GTPases activate CIT
R-HSA-5627117, RHO GTPases Activate ROCKs
R-HSA-5627123, RHO GTPases activate PAKs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79784, 6 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYH14, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MYH14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79784
PharosiQ7Z406, Tbio

Protein Ontology

More...PROi		PR:Q7Z406
RNActiQ7Z406, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105357, Expressed in mucosa of transverse colon and 184 other tissues
ExpressionAtlasiQ7Z406, baseline and differential
GenevisibleiQ7Z406, HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF01576, Myosin_tail_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z406
Secondary accession number(s): B0I1S2
, C3TTN4, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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