UniProtKB - Q7Z406 (MYH14_HUMAN)
Myosin-14
MYH14
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 198 – 205 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin-dependent ATPase activity Source: Ensembl
- actin filament binding Source: Ensembl
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- microfilament motor activity Source: Ensembl
GO - Biological processi
- actin filament-based movement Source: Ensembl
- actomyosin structure organization Source: UniProtKB
- mitochondrion morphogenesis Source: UniProtKB
- neuronal action potential Source: UniProtKB
- regulation of cell shape Source: UniProtKB-KW
- sensory perception of sound Source: UniProtKB
- skeletal muscle contraction Source: UniProtKB
- skeletal muscle tissue development Source: UniProtKB
- vocalization behavior Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | Cell shape |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q7Z406 |
Reactomei | R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625900, RHO GTPases activate CIT R-HSA-5627117, RHO GTPases Activate ROCKs R-HSA-5627123, RHO GTPases activate PAKs |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-14Alternative name(s): Myosin heavy chain 14 Myosin heavy chain, non-muscle IIc Non-muscle myosin heavy chain IIc Short name: NMHC II-C |
Gene namesi | Name:MYH14 Synonyms:KIAA2034 ORF Names:FP17425 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105357.15 |
HGNCi | HGNC:23212, MYH14 |
MIMi | 608568, gene |
neXtProti | NX_Q7Z406 |
Subcellular locationi
Cytoskeleton
- actomyosin Source: UniProtKB
- myosin II complex Source: UniProtKB
- stress fiber Source: Ensembl
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- brush border Source: Ensembl
- growth cone Source: Ensembl
- membrane Source: UniProtKB
- myosin II filament Source: UniProtKB
Pathology & Biotechi
Involvement in diseasei
Deafness, autosomal dominant, 4A (DFNA4A)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037302 | 120 | S → L in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103281EnsemblClinVar. | 1 | |
Natural variantiVAR_022867 | 376 | G → C in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103280Ensembl. | 1 | |
Natural variantiVAR_022868 | 726 | R → S in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940307Ensembl. | 1 | |
Natural variantiVAR_022869 | 976 | L → F in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940306Ensembl. | 1 |
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066338 | 933 | R → L in PNMHH. 1 PublicationCorresponds to variant dbSNP:rs113993956Ensembl. | 1 |
Keywords - Diseasei
Deafness, Disease mutation, Neuropathy, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 79784 |
GeneReviewsi | MYH14 |
MalaCardsi | MYH14 |
MIMi | 600652, phenotype 614369, phenotype |
OpenTargetsi | ENSG00000105357 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA 171215, Low isolated anorectal malformation 397744, Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome |
PharmGKBi | PA134935217 |
Miscellaneous databases
Pharosi | Q7Z406, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105888 |
DrugBanki | DB07470, (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one DB07468, (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one DB07469, (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one DB01944, (S)-blebbistatin DB03126, Mant-Adp DB04444, Tetrafluoroaluminate Ion DB08276, trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-) |
Polymorphism and mutation databases
BioMutai | MYH14 |
DMDMi | 327478526 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000123431 | 2 – 1995 | Myosin-14Add BLAST | 1994 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1194 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1969 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1980 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1983 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1989 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-240 CPTAC-241 |
EPDi | Q7Z406 |
jPOSTi | Q7Z406 |
MassIVEi | Q7Z406 |
MaxQBi | Q7Z406 |
PaxDbi | Q7Z406 |
PeptideAtlasi | Q7Z406 |
PRIDEi | Q7Z406 |
ProteomicsDBi | 69113 [Q7Z406-1] 69114 [Q7Z406-2] 69115 [Q7Z406-4] 69116 [Q7Z406-5] 69117 [Q7Z406-6] |
PTM databases
GlyGeni | Q7Z406, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q7Z406 |
PhosphoSitePlusi | Q7Z406 |
SwissPalmi | Q7Z406 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105357, Expressed in mucosa of transverse colon and 183 other tissues |
ExpressionAtlasi | Q7Z406, baseline and differential |
Genevisiblei | Q7Z406, HS |
Organism-specific databases
HPAi | ENSG00000105357, Tissue enhanced (intestine, skeletal muscle) |
Interactioni
Subunit structurei
Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
By similarityGO - Molecular functioni
- actin filament binding Source: Ensembl
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 122884, 82 interactors |
DIPi | DIP-33170N |
IntActi | Q7Z406, 43 interactors |
MINTi | Q7Z406 |
STRINGi | 9606.ENSP00000470298 |
Miscellaneous databases
RNActi | Q7Z406, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q7Z406 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 101 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 105 – 800 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 696 | |
Domaini | 803 – 832 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 678 – 700 | Actin-bindingPROSITE-ProRule annotationAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 862 – 1947 | Sequence analysisAdd BLAST | 1086 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000158808 |
HOGENOMi | CLU_000192_4_1_1 |
InParanoidi | Q7Z406 |
OMAi | DAIMDLE |
OrthoDBi | 47111at2759 |
PhylomeDBi | Q7Z406 |
TreeFami | TF333601 |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW
60 70 80 90 100
TARRLVWVPS ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN
110 120 130 140 150
PPKFSKAEDM AELTCLNEAS VLHNLRERYY SGLIYTYSGL FCVVINPYKQ
160 170 180 190 200
LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG AYRSMLQDRE DQSILCTGES
210 220 230 240 250
GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PGELERQLLQ ANPILEAFGN
260 270 280 290 300
AKTVKNDNSS RFGKFIRINF DVAGYIVGAN IETYLLEKSR AIRQAKDECS
310 320 330 340 350
FHIFYQLLGG AGEQLKADLL LEPCSHYRFL TNGPSSSPGQ ERELFQETLE
360 370 380 390 400
SLRVLGFSHE EIISMLRMVS AVLQFGNIAL KRERNTDQAT MPDNTAAQKL
410 420 430 440 450
CRLLGLGVTD FSRALLTPRI KVGRDYVQKA QTKEQADFAL EALAKATYER
460 470 480 490 500
LFRWLVLRLN RALDRSPRQG ASFLGILDIA GFEIFQLNSF EQLCINYTNE
510 520 530 540 550
KLQQLFNHTM FVLEQEEYQR EGIPWTFLDF GLDLQPCIDL IERPANPPGL
560 570 580 590 600
LALLDEECWF PKATDKSFVE KVAQEQGGHP KFQRPRHLRD QADFSVLHYA
610 620 630 640 650
GKVDYKANEW LMKNMDPLND NVAALLHQST DRLTAEIWKD VEGIVGLEQV
660 670 680 690 700
SSLGDGPPGG RPRRGMFRTV GQLYKESLSR LMATLSNTNP SFVRCIVPNH
710 720 730 740 750
EKRAGKLEPR LVLDQLRCNG VLEGIRICRQ GFPNRILFQE FRQRYEILTP
760 770 780 790 800
NAIPKGFMDG KQACEKMIQA LELDPNLYRV GQSKIFFRAG VLAQLEEERD
810 820 830 840 850
LKVTDIIVSF QAAARGYLAR RAFQKRQQQQ SALRVMQRNC AAYLKLRHWQ
860 870 880 890 900
WWRLFTKVKP LLQVTRQDEV LQARAQELQK VQELQQQSAR EVGELQGRVA
910 920 930 940 950
QLEEERARLA EQLRAEAELC AEAEETRGRL AARKQELELV VSELEARVGE
960 970 980 990 1000
EEECSRQMQT EKKRLQQHIQ ELEAHLEAEE GARQKLQLEK VTTEAKMKKF
1010 1020 1030 1040 1050
EEDLLLLEDQ NSKLSKERKL LEDRLAEFSS QAAEEEEKVK SLNKLRLKYE
1060 1070 1080 1090 1100
ATIADMEDRL RKEEKGRQEL EKLKRRLDGE SSELQEQMVE QQQRAEELRA
1110 1120 1130 1140 1150
QLGRKEEELQ AALARAEDEG GARAQLLKSL REAQAALAEA QEDLESERVA
1160 1170 1180 1190 1200
RTKAEKQRRD LGEELEALRG ELEDTLDSTN AQQELRSKRE QEVTELKKTL
1210 1220 1230 1240 1250
EEETRIHEAA VQELRQRHGQ ALGELAEQLE QARRGKGAWE KTRLALEAEV
1260 1270 1280 1290 1300
SELRAELSSL QTARQEGEQR RRRLELQLQE VQGRAGDGER ARAEAAEKLQ
1310 1320 1330 1340 1350
RAQAELENVS GALNEAESKT IRLSKELSST EAQLHDAQEL LQEETRAKLA
1360 1370 1380 1390 1400
LGSRVRAMEA EAAGLREQLE EEAAARERAG RELQTAQAQL SEWRRRQEEE
1410 1420 1430 1440 1450
AGALEAGEEA RRRAAREAEA LTQRLAEKTE TVDRLERGRR RLQQELDDAT
1460 1470 1480 1490 1500
MDLEQQRQLV STLEKKQRKF DQLLAEEKAA VLRAVEERER AEAEGREREA
1510 1520 1530 1540 1550
RALSLTRALE EEQEAREELE RQNRALRAEL EALLSSKDDV GKSVHELERA
1560 1570 1580 1590 1600
CRVAEQAAND LRAQVTELED ELTAAEDAKL RLEVTVQALK TQHERDLQGR
1610 1620 1630 1640 1650
DEAGEERRRQ LAKQLRDAEV ERDEERKQRT LAVAARKKLE GELEELKAQM
1660 1670 1680 1690 1700
ASAGQGKEEA VKQLRKMQAQ MKELWREVEE TRTSREEIFS QNRESEKRLK
1710 1720 1730 1740 1750
GLEAEVLRLQ EELAASDRAR RQAQQDRDEM ADEVANGNLS KAAILEEKRQ
1760 1770 1780 1790 1800
LEGRLGQLEE ELEEEQSNSE LLNDRYRKLL LQVESLTTEL SAERSFSAKA
1810 1820 1830 1840 1850
ESGRQQLERQ IQELRGRLGE EDAGARARHK MTIAALESKL AQAEEQLEQE
1860 1870 1880 1890 1900
TRERILSGKL VRRAEKRLKE VVLQVEEERR VADQLRDQLE KGNLRVKQLK
1910 1920 1930 1940 1950
RQLEEAEEEA SRAQAGRRRL QRELEDVTES AESMNREVTT LRNRLRRGPL
1960 1970 1980 1990
TFTTRTVRQV FRLEEGVASD EEAEEAQPGS GPSPEPEGSP PAHPQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QY43 | M0QY43_HUMAN | Myosin-14 | MYH14 | 1,002 | Annotation score: | ||
A0A2R8Y4C3 | A0A2R8Y4C3_HUMAN | Myosin-14 | MYH14 | 371 | Annotation score: | ||
A0A2R8Y454 | A0A2R8Y454_HUMAN | Myosin-14 | MYH14 | 135 | Annotation score: | ||
A1L2Z2 | A1L2Z2_HUMAN | MYH14 protein | MYH14 | 638 | Annotation score: | ||
A0A0C4DFM8 | A0A0C4DFM8_HUMAN | Myosin-14 | MYH14 | 508 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 411 | F → S in BG468611 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 444 | A → G in BG468611 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 446 | A → D in BG468611 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 458 | R → S in BG468611 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 466 | S → D in BG468611 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 473 | F → L in BG468611 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 997 | M → I in AAH18933 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037302 | 120 | S → L in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103281EnsemblClinVar. | 1 | |
Natural variantiVAR_022866 | 266 | I → V1 PublicationCorresponds to variant dbSNP:rs200424400Ensembl. | 1 | |
Natural variantiVAR_056176 | 334 | P → A. Corresponds to variant dbSNP:rs34498817Ensembl. | 1 | |
Natural variantiVAR_022867 | 376 | G → C in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs119103280Ensembl. | 1 | |
Natural variantiVAR_022868 | 726 | R → S in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940307Ensembl. | 1 | |
Natural variantiVAR_066338 | 933 | R → L in PNMHH. 1 PublicationCorresponds to variant dbSNP:rs113993956Ensembl. | 1 | |
Natural variantiVAR_022869 | 976 | L → F in DFNA4A. 1 PublicationCorresponds to variant dbSNP:rs28940306Ensembl. | 1 | |
Natural variantiVAR_066339 | 1154 | A → V1 PublicationCorresponds to variant dbSNP:rs910420638Ensembl. | 1 | |
Natural variantiVAR_056177 | 1209 | A → E. Corresponds to variant dbSNP:rs11669191Ensembl. | 1 | |
Natural variantiVAR_056178 | 1540 | V → I. Corresponds to variant dbSNP:rs680446Ensembl. | 1 | |
Natural variantiVAR_022870 | 1559 | N → S1 PublicationCorresponds to variant dbSNP:rs769482601Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040881 | 231 | P → PASVSTVSY in isoform 2 and isoform 6. 3 Publications | 1 | |
Alternative sequenceiVSP_040882 | 640 | D → DEHGGFQQFSFLGSFPPSPP GSAERCSSAISPPG in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_014628 | 1317 – 1532 | Missing in isoform 4. 1 PublicationAdd BLAST | 216 | |
Alternative sequenceiVSP_014629 | 1451 – 1478 | MDLEQ…LAEEK → LSPDALTDGAQPPSSLDPTG PCPRNPAL in isoform 5. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_014630 | 1479 – 1995 | Missing in isoform 5. 1 PublicationAdd BLAST | 517 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY165122 mRNA Translation: AAO39147.1 Frameshift. AB111886 mRNA Translation: BAC98374.1 AB290169 mRNA Translation: BAG06723.1 AC008655 Genomic DNA No translation available. AC010515 Genomic DNA No translation available. AC020906 Genomic DNA No translation available. BC000676 mRNA Translation: AAH00676.2 BC004396 mRNA Translation: AAH04396.1 BC007877 mRNA Translation: AAH07877.2 BC018933 mRNA Translation: AAH18933.2 FJ041910 mRNA Translation: ACM78630.1 BG468611 mRNA No translation available. AY203926 mRNA Translation: AAP34449.1 Sequence problems. CR936653 mRNA Translation: CAI56791.1 AK023943 mRNA Translation: BAB14735.1 Different initiation. |
CCDSi | CCDS46151.1 [Q7Z406-6] CCDS54295.1 [Q7Z406-2] CCDS59411.1 [Q7Z406-1] |
RefSeqi | NP_001070654.1, NM_001077186.1 [Q7Z406-6] NP_001139281.1, NM_001145809.1 [Q7Z406-2] NP_079005.3, NM_024729.3 [Q7Z406-1] XP_006723449.1, XM_006723386.3 [Q7Z406-6] XP_011525625.1, XM_011527323.2 [Q7Z406-6] |
Genome annotation databases
Ensembli | ENST00000376970; ENSP00000366169; ENSG00000105357 [Q7Z406-1] ENST00000425460; ENSP00000407879; ENSG00000105357 [Q7Z406-6] ENST00000596571; ENSP00000472819; ENSG00000105357 [Q7Z406-1] ENST00000598205; ENSP00000472543; ENSG00000105357 [Q7Z406-6] ENST00000642316; ENSP00000493594; ENSG00000105357 [Q7Z406-2] |
GeneIDi | 79784 |
KEGGi | hsa:79784 |
UCSCi | uc002prq.2, human [Q7Z406-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY165122 mRNA Translation: AAO39147.1 Frameshift. AB111886 mRNA Translation: BAC98374.1 AB290169 mRNA Translation: BAG06723.1 AC008655 Genomic DNA No translation available. AC010515 Genomic DNA No translation available. AC020906 Genomic DNA No translation available. BC000676 mRNA Translation: AAH00676.2 BC004396 mRNA Translation: AAH04396.1 BC007877 mRNA Translation: AAH07877.2 BC018933 mRNA Translation: AAH18933.2 FJ041910 mRNA Translation: ACM78630.1 BG468611 mRNA No translation available. AY203926 mRNA Translation: AAP34449.1 Sequence problems. CR936653 mRNA Translation: CAI56791.1 AK023943 mRNA Translation: BAB14735.1 Different initiation. |
CCDSi | CCDS46151.1 [Q7Z406-6] CCDS54295.1 [Q7Z406-2] CCDS59411.1 [Q7Z406-1] |
RefSeqi | NP_001070654.1, NM_001077186.1 [Q7Z406-6] NP_001139281.1, NM_001145809.1 [Q7Z406-2] NP_079005.3, NM_024729.3 [Q7Z406-1] XP_006723449.1, XM_006723386.3 [Q7Z406-6] XP_011525625.1, XM_011527323.2 [Q7Z406-6] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5I4E | X-ray | 2.25 | A | 47-784 | [»] | |
5JLH | electron microscopy | 3.90 | F/G | 1-799 | [»] | |
SMRi | Q7Z406 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122884, 82 interactors |
DIPi | DIP-33170N |
IntActi | Q7Z406, 43 interactors |
MINTi | Q7Z406 |
STRINGi | 9606.ENSP00000470298 |
Chemistry databases
ChEMBLi | CHEMBL4105888 |
DrugBanki | DB07470, (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one DB07468, (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one DB07469, (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one DB01944, (S)-blebbistatin DB03126, Mant-Adp DB04444, Tetrafluoroaluminate Ion DB08276, trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-) |
PTM databases
GlyGeni | Q7Z406, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q7Z406 |
PhosphoSitePlusi | Q7Z406 |
SwissPalmi | Q7Z406 |
Polymorphism and mutation databases
BioMutai | MYH14 |
DMDMi | 327478526 |
Proteomic databases
CPTACi | CPTAC-240 CPTAC-241 |
EPDi | Q7Z406 |
jPOSTi | Q7Z406 |
MassIVEi | Q7Z406 |
MaxQBi | Q7Z406 |
PaxDbi | Q7Z406 |
PeptideAtlasi | Q7Z406 |
PRIDEi | Q7Z406 |
ProteomicsDBi | 69113 [Q7Z406-1] 69114 [Q7Z406-2] 69115 [Q7Z406-4] 69116 [Q7Z406-5] 69117 [Q7Z406-6] |
Protocols and materials databases
Antibodypediai | 32261, 238 antibodies |
Genome annotation databases
Ensembli | ENST00000376970; ENSP00000366169; ENSG00000105357 [Q7Z406-1] ENST00000425460; ENSP00000407879; ENSG00000105357 [Q7Z406-6] ENST00000596571; ENSP00000472819; ENSG00000105357 [Q7Z406-1] ENST00000598205; ENSP00000472543; ENSG00000105357 [Q7Z406-6] ENST00000642316; ENSP00000493594; ENSG00000105357 [Q7Z406-2] |
GeneIDi | 79784 |
KEGGi | hsa:79784 |
UCSCi | uc002prq.2, human [Q7Z406-1] |
Organism-specific databases
CTDi | 79784 |
DisGeNETi | 79784 |
EuPathDBi | HostDB:ENSG00000105357.15 |
GeneCardsi | MYH14 |
GeneReviewsi | MYH14 |
HGNCi | HGNC:23212, MYH14 |
HPAi | ENSG00000105357, Tissue enhanced (intestine, skeletal muscle) |
MalaCardsi | MYH14 |
MIMi | 600652, phenotype 608568, gene 614369, phenotype |
neXtProti | NX_Q7Z406 |
OpenTargetsi | ENSG00000105357 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA 171215, Low isolated anorectal malformation 397744, Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome |
PharmGKBi | PA134935217 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000158808 |
HOGENOMi | CLU_000192_4_1_1 |
InParanoidi | Q7Z406 |
OMAi | DAIMDLE |
OrthoDBi | 47111at2759 |
PhylomeDBi | Q7Z406 |
TreeFami | TF333601 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z406 |
Reactomei | R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625900, RHO GTPases activate CIT R-HSA-5627117, RHO GTPases Activate ROCKs R-HSA-5627123, RHO GTPases activate PAKs |
Miscellaneous databases
BioGRID-ORCSi | 79784, 5 hits in 843 CRISPR screens |
ChiTaRSi | MYH14, human |
GeneWikii | MYH14 |
GenomeRNAii | 79784 |
Pharosi | Q7Z406, Tbio |
PROi | PR:Q7Z406 |
RNActi | Q7Z406, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105357, Expressed in mucosa of transverse colon and 183 other tissues |
ExpressionAtlasi | Q7Z406, baseline and differential |
Genevisiblei | Q7Z406, HS |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH14_HUMAN | |
Accessioni | Q7Z406Primary (citable) accession number: Q7Z406 Secondary accession number(s): B0I1S2 Q9H882 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations