UniProtKB - Q7Z3Z5 (Q7Z3Z5_HUMAN)
Protein
Submitted name:
Mediator of RNA polymerase II transcription subunit 12
Gene
MED12
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- beta-catenin binding Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Mediator of RNA polymerase II transcription subunit 12ImportedSubmitted name: Mediator of RNA polymerase II transcription, subunit 12 homolog (Yeast), isoform CRA_eImportedSubmitted name: TNRC11 proteinImported |
Gene namesi | ORF Names:hCG_19960Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11957, MED12 |
VEuPathDBi | HostDB:ENSG00000184634.15 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- mediator complex Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000184634, Expressed in left adrenal gland and 213 other tissues |
ExpressionAtlasi | Q7Z3Z5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 604 | Med12-LCEWAVInterPro annotationAdd BLAST | 472 | |
Domaini | 1666 – 1872 | Med12-PQLInterPro annotationAdd BLAST | 207 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 170 – 191 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 474 – 516 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 537 – 564 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1088 – 1113 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1241 – 1262 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1297 – 1321 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1585 – 1676 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 1805 – 1850 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 1965 – 1999 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 2008 – 2027 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1898 – 1926 | Sequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 485 – 501 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 547 – 563 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1297 – 1318 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1585 – 1607 | Pro-richSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1984 – 1999 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the Mediator complex subunit 12 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00440000037505 |
Family and domain databases
InterProi | View protein in InterPro IPR021989, Mediator_Med12_catenin-bd IPR021990, Mediator_Med12_LCEWAV |
Pfami | View protein in Pfam PF12145, Med12-LCEWAV, 1 hit PF12144, Med12-PQL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q7Z3Z5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAAWLIKMT CAYYAAISET KVKKRHVDPF MEWTQIITKY LWEQLQKMAE
60 70 80 90 100
YYRPGPAGSG GCGSTIGPLP HDVEVAIRQW DYTEKLAMFM FQDGMLDRHE
110 120 130 140 150
FLTWVLECFE KIRPGEDELL KLLLPLLLRY SGEFVQSAYL SRRLAYFCTR
160 170 180 190 200
RLALQLDGVS SHSSHVISAQ STSTLPTTPA PQPPTSSTPS TPFSDLLMCP
210 220 230 240 250
QHRPLVFGLS CILQTILLCC PSALVWHYSL TDSRIKTGSP LDHLPIAPSN
260 270 280 290 300
LPMPEGNSAF TQQVRAKLRE IEQQIKERGQ AVEVRWSFDK CQEATAGFTI
310 320 330 340 350
GRVLHTLEVL DSHSFERSDF SNSLDSLCNR IFGLGPSKDG HEISSDDDAV
360 370 380 390 400
VSLLCEWAVS CKRSGRHRAM VVAKLLEKRQ AEIEAERCGE SEAADEKGSI
410 420 430 440 450
ASGSLSAPSA PIFQDVLLQF LDTQAPMLTD PRSESERVEF FNLVLLFCEL
460 470 480 490 500
IRHDVFSHNM YTCTLISRGD LAFGAPGPRP PSPFDDPADD PEHKEAEGSS
510 520 530 540 550
SSKLEDPGLS ESMDIDPSSS VLFEDMEKPD FSLFSPTMPC EGKGSPSPEK
560 570 580 590 600
PDVEKEVKPP PKEKIEGTLG VLYDQPRHVQ YATHFPIPQE ESCSHECNQR
610 620 630 640 650
LVVLFGVGKQ RDDARHAIKK ITKDILKVLN RKGTAETDQL APIVPLNPGD
660 670 680 690 700
LTFLGGEDGQ KRRRNRPEAF PTAEDIFAKF QHLSHYDQHQ VTAQVSRNVL
710 720 730 740 750
EQITSFALGM SYHLPLVQHV QFIFDLMEYS LSISGLIDFA IQLLNELSVV
760 770 780 790 800
EAELLLKSSD LVGSYTTSLC LCIVAVLRHY HACLILNQDQ MAQVFEGLCG
810 820 830 840 850
VVKHGMNRSD GSSAERCILA YLYDLYTSCS HLKNKFGELF SDFCSKVKNT
860 870 880 890 900
IYCNVEPSES NMRWAPEFMI DTLENPAAHT FTYTGLGKSL SENPANRYSF
910 920 930 940 950
VCNALMHVCV GHHDPDRVND IAILCAELTG YCKSLSAEWL GVLKALCCSS
960 970 980 990 1000
NNGTCGFNDL LCNVDVSDLS FHDSLATFVA ILIARQCLLL EDLIRCAAIP
1010 1020 1030 1040 1050
SLLNAACSEQ DSEPGARLTC RILLHLFKTP QLNPCQSDGN KPTVGIRSSC
1060 1070 1080 1090 1100
DRHLLAASQN RIVDGAVFAV LKAVFVLGDA ELKGSGFTVT GGTEELPEEE
1110 1120 1130 1140 1150
GGGGSGGRRQ GGRNISVETA SLDVYAKYVL RSICQQEWVG ERCLKSLCED
1160 1170 1180 1190 1200
SNDLQDPVLS SAQAQRLMQL ICYPHRLLDN EDGENPQRQR IKRILQNLDQ
1210 1220 1230 1240 1250
WTMRQSSLEL QLMIKQTPNN EMNSLLENIA KATIEVFQQS AETGSSSGST
1260 1270 1280 1290 1300
ASNMPSSSKT KPVLSSLERS GVWLVAPLIA KLPTSVQGHV LKAAGEELEK
1310 1320 1330 1340 1350
GQHLGSSSRK ERDRQKQKSM SLLSQQPFLS LVLTCLKGQD EQREGLLTSL
1360 1370 1380 1390 1400
YSQVHQIVNN WRDDQYLDDC KPKQLMHEAL KLRLNLVGGM FDTVQRSTQQ
1410 1420 1430 1440 1450
TTEWAMLLLE IIISGTVDMQ SNNELFTTVL DMLSVLINGT LAADMSSISQ
1460 1470 1480 1490 1500
GSMEENKRAY MNLAKKLQKE LGERQSDSLE KVRQLLPLPK QTRDVITCEP
1510 1520 1530 1540 1550
QGSLIDTKGN KIAGFDSIFK KEGLQVSTKQ KISPWDLFEG LKPSAPLSWG
1560 1570 1580 1590 1600
WFGTVRVDRR VARGEEQQRL LLYHTHLRPR PRAYYLEPLP LPPEDEEPPA
1610 1620 1630 1640 1650
PTLLEPEKKA PEPPKTDKPG AAPPSTEERK KKSTKGKKRS QPATKTEDYG
1660 1670 1680 1690 1700
MGPGRSGPYG VTVPPDLLHH PNPGSITHLN YRQGSIGLYT QNQPLPAGGP
1710 1720 1730 1740 1750
RVDPYRPVRL PMQKLPTRPT YPGVLPTTMT GVMGLEPSSY KTSVYRQQQP
1760 1770 1780 1790 1800
AVPQGQRLRQ QLQAKIQSQG MLGQSSVHQM TPSSSYGLQT SQGYTPYVSH
1810 1820 1830 1840 1850
VGLQQHTGPA GTMVPPSYSS QPYQSTHPST NPTLVDPTRH LQQRPSGYVH
1860 1870 1880 1890 1900
QQAPTYGHGL TSTQRFSHQT LQQTPMISTM TPMSAQGVQA GVRSTAILPE
1910 1920 1930 1940 1950
QQQQQQQQQQ QQQQQQQQQQ QQQQQQYHIR QQQQQQILRQ QQQQQQQQQQ
1960 1970 1980 1990 2000
QQQQQQQQQQ QQQQQHQQQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ
2010 2020
TAALVRQLQQ QLSNTQPQPS TNIFGRY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ93074 | MED12_HUMAN | Mediator of RNA polymerase II trans... | MED12 ARC240, CAGH45, HOPA, KIAA0192, TNRC11 | 2,177 | Annotation score: | ||
H7C191 | H7C191_HUMAN | Mediator of RNA polymerase II trans... | MED12 | 130 | Annotation score: | ||
H7C274 | H7C274_HUMAN | Mediator of RNA polymerase II trans... | MED12 | 251 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590764 Genomic DNA No translation available. AB102668 mRNA Translation: BAC81137.1 CH471132 Genomic DNA Translation: EAX05318.1 |
Genome annotation databases
Ensembli | ENST00000333646; ENSP00000333125; ENSG00000184634 |
UCSCi | uc064zts.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590764 Genomic DNA No translation available. AB102668 mRNA Translation: BAC81137.1 CH471132 Genomic DNA Translation: EAX05318.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q7Z3Z5 |
Protocols and materials databases
Antibodypediai | 562, 208 antibodies |
Genome annotation databases
Ensembli | ENST00000333646; ENSP00000333125; ENSG00000184634 |
UCSCi | uc064zts.1, human |
Organism-specific databases
HGNCi | HGNC:11957, MED12 |
OpenTargetsi | ENSG00000184634 |
VEuPathDBi | HostDB:ENSG00000184634.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00440000037505 |
Miscellaneous databases
ChiTaRSi | MED12, human |
Gene expression databases
Bgeei | ENSG00000184634, Expressed in left adrenal gland and 213 other tissues |
ExpressionAtlasi | Q7Z3Z5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR021989, Mediator_Med12_catenin-bd IPR021990, Mediator_Med12_LCEWAV |
Pfami | View protein in Pfam PF12145, Med12-LCEWAV, 1 hit PF12144, Med12-PQL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7Z3Z5_HUMAN | |
Accessioni | Q7Z3Z5Primary (citable) accession number: Q7Z3Z5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2003 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |