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UniProtKB - Q7Z3Y8 (K1C27_HUMAN)

Entry version 122 (18 Sep 2019)
Sequence version 2 (18 May 2010)
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Protein

Keratin, type I cytoskeletal 27

Gene

KRT27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 27
Alternative name(s):
Cytokeratin-27
Short name:
CK-27
Keratin-25C
Short name:
K25C
Keratin-27
Short name:
K27
Type I inner root sheath-specific keratin-K25irs3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT27Imported
Synonyms:KRT25CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30841 KRT27

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616676 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z3Y8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000171446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134990976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z3Y8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRT27

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434549

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003127011 – 459Keratin, type I cytoskeletal 27Add BLAST459

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z3Y8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z3Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z3Y8

PeptideAtlas

More...PeptideAtlasi		Q7Z3Y8

PRoteomics IDEntifications database

More...PRIDEi		Q7Z3Y8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69096

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q7Z3Y8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z3Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z3Y8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7Z3Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171446 Expressed in 53 organ(s), highest expression level in upper arm skin

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z3Y8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA055114

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

Interacts with KRT6A to form filaments (By similarity).

By similarityCurated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		131185, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z3Y8, 146 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301656

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z3Y8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 399IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 83HeadSequence analysisAdd BLAST83
Regioni84 – 119Coil 1ASequence analysisAdd BLAST36
Regioni120 – 141Linker 1Sequence analysisAdd BLAST22
Regioni142 – 233Coil 1BSequence analysisAdd BLAST92
Regioni234 – 256Linker 12Sequence analysisAdd BLAST23
Regioni257 – 395Coil 2Sequence analysisAdd BLAST139
Regioni396 – 459TailSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 82Gly-richSequence analysisAdd BLAST70

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161982

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000230975

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z3Y8

KEGG Orthology (KO)

More...KOi		K07604

Identification of Orthologs from Complete Genome Data

More...OMAi		SRVHTME

Database of Orthologous Groups

More...OrthoDBi		805081at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z3Y8

TreeFam database of animal gene trees

More...TreeFami		TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I

The PANTHER Classification System

More...PANTHERi		PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z3Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCGVPG IGSGFSCAFG 
        60         70         80         90        100
GSSSAGGYGG GLGGGSASCA AFTGNEHGLL SGNEKVTMQN LNDRLASYLE 
       110        120        130        140        150
NVRALEEANA DLEQKIKGWY EKFGPGSCRG LDHDYSRYFP IIDELKNQII 
       160        170        180        190        200
SATTSNAHVV LQNDNARLTA DDFRLKFENE LALHQSVEAD INGLRRVLDE 
       210        220        230        240        250
LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN VNVEMNAAPG 
       260        270        280        290        300
VDLTVLLNNM RAEYEALAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA 
       310        320        330        340        350
RNELIEMKRT LQTLEIELQS LLATKHSLEC SLTETESNYC AQLAQIQAQI 
       360        370        380        390        400
GALEEQLHQV RTETEGQKLE YEQLLDIKVH LEKEIETYCL LIDGEDGSCS 
       410        420        430        440        450
KSKGYGGPGN QTKDSSKTTI VKTVVEEIDP RGKVLSSRVH TVEEKSTKVN 

NKNEQRVSS
Length:459
Mass (Da):49,822
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5DD71FE7FEFFF62
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06313852S → T1 PublicationCorresponds to variant dbSNP:rs2469826Ensembl.1
Natural variantiVAR_063139144E → K1 PublicationCorresponds to variant dbSNP:rs12453124Ensembl.1
Natural variantiVAR_056007193G → S. Corresponds to variant dbSNP:rs17558560Ensembl.1
Natural variantiVAR_056008284A → T. Corresponds to variant dbSNP:rs17558532Ensembl.1
Natural variantiVAR_063140305I → T1 PublicationCorresponds to variant dbSNP:rs981684Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ564206 mRNA Translation: CAD91906.1
AC090283 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11375.1

NCBI Reference Sequences

More...RefSeqi		NP_853515.2, NM_181537.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301656; ENSP00000301656; ENSG00000171446

Database of genes from NCBI RefSeq genomes

More...GeneIDi		342574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:342574

UCSC genome browser

More...UCSCi		uc002hvg.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564206 mRNA Translation: CAD91906.1
AC090283 Genomic DNA No translation available.
CCDSiCCDS11375.1
RefSeqiNP_853515.2, NM_181537.3

3D structure databases

SMRiQ7Z3Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131185, 5 interactors
IntActiQ7Z3Y8, 146 interactors
STRINGi9606.ENSP00000301656

PTM databases

iPTMnetiQ7Z3Y8
PhosphoSitePlusiQ7Z3Y8
SwissPalmiQ7Z3Y8

Polymorphism and mutation databases

BioMutaiKRT27
DMDMi296434549

Proteomic databases

jPOSTiQ7Z3Y8
MassIVEiQ7Z3Y8
PaxDbiQ7Z3Y8
PeptideAtlasiQ7Z3Y8
PRIDEiQ7Z3Y8
ProteomicsDBi69096
TopDownProteomicsiQ7Z3Y8

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		342574

Genome annotation databases

EnsembliENST00000301656; ENSP00000301656; ENSG00000171446
GeneIDi342574
KEGGihsa:342574
UCSCiuc002hvg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		342574

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRT27
HGNCiHGNC:30841 KRT27
HPAiHPA055114
MIMi616676 gene
neXtProtiNX_Q7Z3Y8
OpenTargetsiENSG00000171446
PharmGKBiPA134990976

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000161982
HOGENOMiHOG000230975
InParanoidiQ7Z3Y8
KOiK07604
OMAiSRVHTME
OrthoDBi805081at2759
PhylomeDBiQ7Z3Y8
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		342574
PharosiQ7Z3Y8

Protein Ontology

More...PROi		PR:Q7Z3Y8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171446 Expressed in 53 organ(s), highest expression level in upper arm skin
GenevisibleiQ7Z3Y8 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3Y8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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