UniProtKB - Q7Z3Y8 (K1C27_HUMAN)
Protein
Keratin, type I cytoskeletal 27
Gene
KRT27
Organism
Homo sapiens (Human)
Status
Functioni
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).By similarity
Miscellaneous
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- cornification Source: Reactome
- hair follicle morphogenesis Source: Ensembl
- keratinization Source: Reactome
Enzyme and pathway databases
Reactomei | R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cytoskeletal 27Alternative name(s): Cytokeratin-27 Short name: CK-27 Keratin-25C Short name: K25C Keratin-27 Short name: K27 Type I inner root sheath-specific keratin-K25irs3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30841 KRT27 |
MIMi | 616676 gene |
neXtProti | NX_Q7Z3Y8 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Intermediate filament, KeratinPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000171446 |
PharmGKBi | PA134990976 |
Miscellaneous databases
Pharosi | Q7Z3Y8 |
Polymorphism and mutation databases
BioMutai | KRT27 |
DMDMi | 296434549 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312701 | 1 – 459 | Keratin, type I cytoskeletal 27Add BLAST | 459 |
Proteomic databases
jPOSTi | Q7Z3Y8 |
MassIVEi | Q7Z3Y8 |
PaxDbi | Q7Z3Y8 |
PeptideAtlasi | Q7Z3Y8 |
PRIDEi | Q7Z3Y8 |
ProteomicsDBi | 69096 |
TopDownProteomicsi | Q7Z3Y8 |
PTM databases
iPTMneti | Q7Z3Y8 |
PhosphoSitePlusi | Q7Z3Y8 |
SwissPalmi | Q7Z3Y8 |
Expressioni
Tissue specificityi
Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications
Gene expression databases
Bgeei | ENSG00000171446 Expressed in 53 organ(s), highest expression level in upper arm skin |
Genevisiblei | Q7Z3Y8 HS |
Organism-specific databases
HPAi | HPA055114 |
Interactioni
Subunit structurei
Heterotetramer of two type I and two type II keratins.
Interacts with KRT6A to form filaments (By similarity).
By similarityCuratedProtein-protein interaction databases
BioGridi | 131185, 5 interactors |
IntActi | Q7Z3Y8, 146 interactors |
STRINGi | 9606.ENSP00000301656 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 399 | IF rodPROSITE-ProRule annotationAdd BLAST | 316 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 83 | HeadSequence analysisAdd BLAST | 83 | |
Regioni | 84 – 119 | Coil 1ASequence analysisAdd BLAST | 36 | |
Regioni | 120 – 141 | Linker 1Sequence analysisAdd BLAST | 22 | |
Regioni | 142 – 233 | Coil 1BSequence analysisAdd BLAST | 92 | |
Regioni | 234 – 256 | Linker 12Sequence analysisAdd BLAST | 23 | |
Regioni | 257 – 395 | Coil 2Sequence analysisAdd BLAST | 139 | |
Regioni | 396 – 459 | TailSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 82 | Gly-richSequence analysisAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410IFTF Eukaryota ENOG410Y9IV LUCA |
GeneTreei | ENSGT00940000161982 |
HOGENOMi | HOG000230975 |
InParanoidi | Q7Z3Y8 |
KOi | K07604 |
OMAi | SRVHTME |
OrthoDBi | 805081at2759 |
PhylomeDBi | Q7Z3Y8 |
TreeFami | TF332742 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR039008 IF_rod_dom IPR042180 IF_rod_dom_coil1B IPR002957 Keratin_I |
PANTHERi | PTHR23239 PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038 Filament, 1 hit |
PRINTSi | PR01248 TYPE1KERATIN |
SMARTi | View protein in SMART SM01391 Filament, 1 hit |
PROSITEi | View protein in PROSITE PS51842 IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7Z3Y8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCGVPG IGSGFSCAFG
60 70 80 90 100
GSSSAGGYGG GLGGGSASCA AFTGNEHGLL SGNEKVTMQN LNDRLASYLE
110 120 130 140 150
NVRALEEANA DLEQKIKGWY EKFGPGSCRG LDHDYSRYFP IIDELKNQII
160 170 180 190 200
SATTSNAHVV LQNDNARLTA DDFRLKFENE LALHQSVEAD INGLRRVLDE
210 220 230 240 250
LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN VNVEMNAAPG
260 270 280 290 300
VDLTVLLNNM RAEYEALAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA
310 320 330 340 350
RNELIEMKRT LQTLEIELQS LLATKHSLEC SLTETESNYC AQLAQIQAQI
360 370 380 390 400
GALEEQLHQV RTETEGQKLE YEQLLDIKVH LEKEIETYCL LIDGEDGSCS
410 420 430 440 450
KSKGYGGPGN QTKDSSKTTI VKTVVEEIDP RGKVLSSRVH TVEEKSTKVN
NKNEQRVSS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063138 | 52 | S → T1 PublicationCorresponds to variant dbSNP:rs2469826Ensembl. | 1 | |
Natural variantiVAR_063139 | 144 | E → K1 PublicationCorresponds to variant dbSNP:rs12453124Ensembl. | 1 | |
Natural variantiVAR_056007 | 193 | G → S. Corresponds to variant dbSNP:rs17558560Ensembl. | 1 | |
Natural variantiVAR_056008 | 284 | A → T. Corresponds to variant dbSNP:rs17558532Ensembl. | 1 | |
Natural variantiVAR_063140 | 305 | I → T1 PublicationCorresponds to variant dbSNP:rs981684Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ564206 mRNA Translation: CAD91906.1 AC090283 Genomic DNA No translation available. |
CCDSi | CCDS11375.1 |
RefSeqi | NP_853515.2, NM_181537.3 |
Genome annotation databases
Ensembli | ENST00000301656; ENSP00000301656; ENSG00000171446 |
GeneIDi | 342574 |
KEGGi | hsa:342574 |
UCSCi | uc002hvg.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ564206 mRNA Translation: CAD91906.1 AC090283 Genomic DNA No translation available. |
CCDSi | CCDS11375.1 |
RefSeqi | NP_853515.2, NM_181537.3 |
3D structure databases
SMRi | Q7Z3Y8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 131185, 5 interactors |
IntActi | Q7Z3Y8, 146 interactors |
STRINGi | 9606.ENSP00000301656 |
PTM databases
iPTMneti | Q7Z3Y8 |
PhosphoSitePlusi | Q7Z3Y8 |
SwissPalmi | Q7Z3Y8 |
Polymorphism and mutation databases
BioMutai | KRT27 |
DMDMi | 296434549 |
Proteomic databases
jPOSTi | Q7Z3Y8 |
MassIVEi | Q7Z3Y8 |
PaxDbi | Q7Z3Y8 |
PeptideAtlasi | Q7Z3Y8 |
PRIDEi | Q7Z3Y8 |
ProteomicsDBi | 69096 |
TopDownProteomicsi | Q7Z3Y8 |
Protocols and materials databases
DNASUi | 342574 |
Genome annotation databases
Ensembli | ENST00000301656; ENSP00000301656; ENSG00000171446 |
GeneIDi | 342574 |
KEGGi | hsa:342574 |
UCSCi | uc002hvg.3 human |
Organism-specific databases
CTDi | 342574 |
GeneCardsi | KRT27 |
HGNCi | HGNC:30841 KRT27 |
HPAi | HPA055114 |
MIMi | 616676 gene |
neXtProti | NX_Q7Z3Y8 |
OpenTargetsi | ENSG00000171446 |
PharmGKBi | PA134990976 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IFTF Eukaryota ENOG410Y9IV LUCA |
GeneTreei | ENSGT00940000161982 |
HOGENOMi | HOG000230975 |
InParanoidi | Q7Z3Y8 |
KOi | K07604 |
OMAi | SRVHTME |
OrthoDBi | 805081at2759 |
PhylomeDBi | Q7Z3Y8 |
TreeFami | TF332742 |
Enzyme and pathway databases
Reactomei | R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope |
Miscellaneous databases
GenomeRNAii | 342574 |
Pharosi | Q7Z3Y8 |
PROi | PR:Q7Z3Y8 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171446 Expressed in 53 organ(s), highest expression level in upper arm skin |
Genevisiblei | Q7Z3Y8 HS |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR039008 IF_rod_dom IPR042180 IF_rod_dom_coil1B IPR002957 Keratin_I |
PANTHERi | PTHR23239 PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038 Filament, 1 hit |
PRINTSi | PR01248 TYPE1KERATIN |
SMARTi | View protein in SMART SM01391 Filament, 1 hit |
PROSITEi | View protein in PROSITE PS51842 IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K1C27_HUMAN | |
Accessioni | Q7Z3Y8Primary (citable) accession number: Q7Z3Y8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | September 18, 2019 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot