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Entry version 129 (02 Dec 2020)
Sequence version 2 (18 May 2010)
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Protein

Keratin, type I cytoskeletal 27

Gene

KRT27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z3Y8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 27
Alternative name(s):
Cytokeratin-27
Short name:
CK-27
Keratin-25C
Short name:
K25C
Keratin-27
Short name:
K27
Type I inner root sheath-specific keratin-K25irs3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT27Imported
Synonyms:KRT25CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000171446.6

Human Gene Nomenclature Database

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HGNCi
HGNC:30841, KRT27

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616676, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q7Z3Y8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000171446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134990976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z3Y8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434549

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003127011 – 459Keratin, type I cytoskeletal 27Add BLAST459

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z3Y8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z3Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z3Y8

PeptideAtlas

More...
PeptideAtlasi
Q7Z3Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z3Y8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69096

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q7Z3Y8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z3Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z3Y8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z3Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171446, Expressed in upper arm skin and 74 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z3Y8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171446, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

Interacts with KRT6A to form filaments (By similarity).

By similarityCurated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z3Y8
With#Exp.IntAct
AARD [Q4LEZ3]6EBI-3044087,EBI-5463075
ABI2 - isoform 2 [Q9NYB9-2]3EBI-3044087,EBI-11096309
AMOT [A2BDD9]3EBI-3044087,EBI-17286414
ARFIP1 [P53367]3EBI-3044087,EBI-2808808
ARHGEF6 [Q15052]3EBI-3044087,EBI-1642523
ATP6V1D [Q9Y5K8]3EBI-3044087,EBI-2684998
BCAS2 [O75934]3EBI-3044087,EBI-1050106
BEX2 [Q9BXY8]3EBI-3044087,EBI-745073
BFSP1 - isoform 2 [Q12934-2]3EBI-3044087,EBI-12123320
BFSP2 [Q13515]3EBI-3044087,EBI-10229433
C19orf44 - isoform 2 [Q9H6X5-2]3EBI-3044087,EBI-12061599
C1orf216 [Q8TAB5]3EBI-3044087,EBI-747505
C21orf58 [Q0VAL7]3EBI-3044087,EBI-10226774
CCBE1 - isoform 3 [Q6UXH8-3]3EBI-3044087,EBI-12013534
CCDC138 - isoform 2 [Q96M89-2]3EBI-3044087,EBI-10972887
CCDC146 [Q8IYE0]3EBI-3044087,EBI-10749669
CCDC151 [A5D8V7]3EBI-3044087,EBI-8466445
CCDC185 [Q8N715]3EBI-3044087,EBI-740814
CCDC22 [O60826]3EBI-3044087,EBI-3943153
CCDC68 [Q9H2F9]3EBI-3044087,EBI-2813327
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-3044087,EBI-10175300
CCNC [P24863]3EBI-3044087,EBI-395261
CEP95 [Q96GE4]3EBI-3044087,EBI-372775
CFAP58 [Q5T655]3EBI-3044087,EBI-10245749
COX5B [P10606]3EBI-3044087,EBI-1053725
DPPA3 [Q6W0C5]3EBI-3044087,EBI-12082590
DTNB - isoform 5 [O60941-5]3EBI-3044087,EBI-11984733
DUSP26 [Q9BV47]3EBI-3044087,EBI-2924519
EXOC3L1 [Q86VI1]3EBI-3044087,EBI-2813180
EXOSC5 [Q9NQT4]3EBI-3044087,EBI-371876
FAM107A - isoform 4 [O95990-4]3EBI-3044087,EBI-11977223
FAM110A [Q9BQ89]3EBI-3044087,EBI-1752811
GADD45GIP1 [Q8TAE8]3EBI-3044087,EBI-372506
GAS8 [O95995]3EBI-3044087,EBI-1052570
GFAP [P14136]3EBI-3044087,EBI-744302
GNG13 [Q9P2W3]3EBI-3044087,EBI-11427343
GOLGA1 [Q92805]3EBI-3044087,EBI-6164177
GPS2 [Q13227]3EBI-3044087,EBI-713355
GSTK1 - isoform 2 [Q9Y2Q3-2]3EBI-3044087,EBI-12013556
HAPLN2 [Q9GZV7]3EBI-3044087,EBI-11956675
HDAC4 - isoform 2 [P56524-2]3EBI-3044087,EBI-11953488
HGS [O14964]3EBI-3044087,EBI-740220
HOOK3 [Q86VS8]3EBI-3044087,EBI-1777078
HOXB9 [P17482]3EBI-3044087,EBI-745290
ICA1L - isoform 2 [Q8NDH6-2]3EBI-3044087,EBI-12141931
JOSD1 [Q15040]3EBI-3044087,EBI-2510602
KANK2 [Q63ZY3]3EBI-3044087,EBI-2556193
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-3044087,EBI-10188326
KLHL38 [Q2WGJ6]3EBI-3044087,EBI-6426443
KRT1 [P04264]3EBI-3044087,EBI-298429
KRT2 [P35908]3EBI-3044087,EBI-1247312
KRT20 [P35900]3EBI-3044087,EBI-742094
KRT3 [P12035]3EBI-3044087,EBI-2430095
KRT4 [P19013]3EBI-3044087,EBI-2371606
KRT5 [P13647]3EBI-3044087,EBI-702187
KRT6A [P02538]3EBI-3044087,EBI-702198
KRT6B [P04259]3EBI-3044087,EBI-740907
KRT6C [P48668]3EBI-3044087,EBI-2564105
KRT71 [Q3SY84]3EBI-3044087,EBI-2952676
KRT72 [Q14CN4]3EBI-3044087,EBI-1221280
KRT74 [Q7RTS7]3EBI-3044087,EBI-968660
KRT75 [O95678]3EBI-3044087,EBI-2949715
KRT76 [Q01546]3EBI-3044087,EBI-2952745
KRT77 [Q7Z794]3EBI-3044087,EBI-3045529
KRT78 [Q8N1N4]3EBI-3044087,EBI-1056564
KRT79 [Q5XKE5]4EBI-3044087,EBI-2514135
KRT8 [P05787]3EBI-3044087,EBI-297852
KRT81 [Q14533]3EBI-3044087,EBI-739648
KRT82 [Q9NSB4]3EBI-3044087,EBI-1045341
KRT83 [P78385]3EBI-3044087,EBI-10221390
KRT85 [P78386]3EBI-3044087,EBI-1049371
KRT86 [O43790]3EBI-3044087,EBI-9996498
LKAAEAR1 - isoform 2 [Q8TD35-2]3EBI-3044087,EBI-12159375
LMNTD2 [Q8IXW0]3EBI-3044087,EBI-12028858
MATR3 [P43243]3EBI-3044087,EBI-352602
MBD3L2 [Q8NHZ7]3EBI-3044087,EBI-11989378
MGC50722 [Q8IVT4]3EBI-3044087,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-3044087,EBI-10172526
MORN4 [Q8NDC4]3EBI-3044087,EBI-10269566
MOS [P00540]3EBI-3044087,EBI-1757866
MTMR9 [Q96QG7]3EBI-3044087,EBI-744593
NDC80 [O14777]3EBI-3044087,EBI-715849
NDUFAF3 [Q9BU61]3EBI-3044087,EBI-2114801
NTAQ1 [Q96HA8]3EBI-3044087,EBI-741158
NUP54 [Q7Z3B4]3EBI-3044087,EBI-741048
NUP58 [Q9BVL2]3EBI-3044087,EBI-2811583
OIP5 [O43482]3EBI-3044087,EBI-536879
PBX3 [Q96AL5]3EBI-3044087,EBI-741171
PCDHB14 [Q9Y5E9]3EBI-3044087,EBI-10329013
PNN [Q9H307]3EBI-3044087,EBI-681904
POLL - isoform 2 [Q9UGP5-2]3EBI-3044087,EBI-10320765
PPP1R18 [Q6NYC8]3EBI-3044087,EBI-2557469
PRPH [P41219]3EBI-3044087,EBI-752074
PSMC5 [P62195]3EBI-3044087,EBI-357745
RASAL3 [Q86YV0]3EBI-3044087,EBI-3437896
RBM41 [Q96IZ5]3EBI-3044087,EBI-740773
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-3044087,EBI-1504830
RNF39 [Q9H2S5]3EBI-3044087,EBI-12235180
RTP5 [Q14D33]3EBI-3044087,EBI-10217913
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-3044087,EBI-11984663
SCNM1 [Q9BWG6]3EBI-3044087,EBI-748391
SDHAF1 [A6NFY7]3EBI-3044087,EBI-12011488
SEMA4C [Q9C0C4]3EBI-3044087,EBI-10303490
SGF29 [Q96ES7]3EBI-3044087,EBI-743117
SLC22A5 [O76082]3EBI-3044087,EBI-9846338
SLIRP [Q9GZT3]3EBI-3044087,EBI-1050793
SMARCC2 - isoform 2 [Q8TAQ2-2]3EBI-3044087,EBI-11990400
SMARCD1 [Q96GM5]3EBI-3044087,EBI-358489
SMARCE1 [Q969G3]3EBI-3044087,EBI-455078
SNAPIN [O95295]3EBI-3044087,EBI-296723
SSC5D [A1L4H1]3EBI-3044087,EBI-10172867
SSX3 [Q99909]3EBI-3044087,EBI-10295431
SUFU [Q9UMX1]3EBI-3044087,EBI-740595
SUOX [P51687]3EBI-3044087,EBI-3921347
TBRG4 [Q969Z0]3EBI-3044087,EBI-702328
TEAD4 [Q15561]3EBI-3044087,EBI-747736
TEDC2 [Q7L2K0]3EBI-3044087,EBI-8465456
TEX28P2 [O15482]3EBI-3044087,EBI-751954
THAP7 [Q9BT49]3EBI-3044087,EBI-741350
TNNT1 - isoform 3 [P13805-3]3EBI-3044087,EBI-12151635
TRAF3IP3 [Q9Y228]3EBI-3044087,EBI-765817
TRIML2 [Q8N7C3]3EBI-3044087,EBI-11059915
TSKS [Q9UJT2]3EBI-3044087,EBI-852101
TTC23 - isoform 3 [Q5W5X9-3]3EBI-3044087,EBI-9090990
TXLNA [P40222]3EBI-3044087,EBI-359793
TXLNB [Q8N3L3]3EBI-3044087,EBI-6116822
TXN2 [Q99757]3EBI-3044087,EBI-2932492
USHBP1 [Q8N6Y0]3EBI-3044087,EBI-739895
USP2 [O75604]3EBI-3044087,EBI-743272
VPS37C [A5D8V6]3EBI-3044087,EBI-2559305
WASHC3 [Q9Y3C0]3EBI-3044087,EBI-712969
XRCC4 [Q13426]3EBI-3044087,EBI-717592
ZC3H14 - isoform 6 [Q6PJT7-6]3EBI-3044087,EBI-12147703
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-3044087,EBI-8656416
ZNF3 [P17036]3EBI-3044087,EBI-1640965
ZNF580 [Q9UK33]3EBI-3044087,EBI-746277
ZNF581 [Q9P0T4]3EBI-3044087,EBI-745520
ZNF669 [Q96BR6]3EBI-3044087,EBI-12006574
ZNF80 [P51504]3EBI-3044087,EBI-12013828
Q6ZN963EBI-3044087,EBI-10255097

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131185, 146 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z3Y8, 142 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301656

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z3Y8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z3Y8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 399IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 83HeadSequence analysisAdd BLAST83
Regioni84 – 119Coil 1ASequence analysisAdd BLAST36
Regioni120 – 141Linker 1Sequence analysisAdd BLAST22
Regioni142 – 233Coil 1BSequence analysisAdd BLAST92
Regioni234 – 256Linker 12Sequence analysisAdd BLAST23
Regioni257 – 395Coil 2Sequence analysisAdd BLAST139
Regioni396 – 459TailSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 82Gly-richSequence analysisAdd BLAST70

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SIHJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161982

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z3Y8

Identification of Orthologs from Complete Genome Data

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OMAi
SRVHTME

Database of Orthologous Groups

More...
OrthoDBi
805081at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z3Y8

TreeFam database of animal gene trees

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TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

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PANTHERi
PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z3Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCGVPG IGSGFSCAFG
60 70 80 90 100
GSSSAGGYGG GLGGGSASCA AFTGNEHGLL SGNEKVTMQN LNDRLASYLE
110 120 130 140 150
NVRALEEANA DLEQKIKGWY EKFGPGSCRG LDHDYSRYFP IIDELKNQII
160 170 180 190 200
SATTSNAHVV LQNDNARLTA DDFRLKFENE LALHQSVEAD INGLRRVLDE
210 220 230 240 250
LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN VNVEMNAAPG
260 270 280 290 300
VDLTVLLNNM RAEYEALAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA
310 320 330 340 350
RNELIEMKRT LQTLEIELQS LLATKHSLEC SLTETESNYC AQLAQIQAQI
360 370 380 390 400
GALEEQLHQV RTETEGQKLE YEQLLDIKVH LEKEIETYCL LIDGEDGSCS
410 420 430 440 450
KSKGYGGPGN QTKDSSKTTI VKTVVEEIDP RGKVLSSRVH TVEEKSTKVN

NKNEQRVSS
Length:459
Mass (Da):49,822
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5DD71FE7FEFFF62
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06313852S → T1 PublicationCorresponds to variant dbSNP:rs2469826Ensembl.1
Natural variantiVAR_063139144E → K1 PublicationCorresponds to variant dbSNP:rs12453124Ensembl.1
Natural variantiVAR_056007193G → S. Corresponds to variant dbSNP:rs17558560Ensembl.1
Natural variantiVAR_056008284A → T. Corresponds to variant dbSNP:rs17558532Ensembl.1
Natural variantiVAR_063140305I → T1 PublicationCorresponds to variant dbSNP:rs981684Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ564206 mRNA Translation: CAD91906.1
AC090283 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11375.1

NCBI Reference Sequences

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RefSeqi
NP_853515.2, NM_181537.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301656; ENSP00000301656; ENSG00000171446

Database of genes from NCBI RefSeq genomes

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GeneIDi
342574

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:342574

UCSC genome browser

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UCSCi
uc002hvg.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564206 mRNA Translation: CAD91906.1
AC090283 Genomic DNA No translation available.
CCDSiCCDS11375.1
RefSeqiNP_853515.2, NM_181537.3

3D structure databases

SMRiQ7Z3Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131185, 146 interactors
IntActiQ7Z3Y8, 142 interactors
STRINGi9606.ENSP00000301656

PTM databases

iPTMnetiQ7Z3Y8
PhosphoSitePlusiQ7Z3Y8
SwissPalmiQ7Z3Y8

Polymorphism and mutation databases

BioMutaiKRT27
DMDMi296434549

Proteomic databases

jPOSTiQ7Z3Y8
MassIVEiQ7Z3Y8
PaxDbiQ7Z3Y8
PeptideAtlasiQ7Z3Y8
PRIDEiQ7Z3Y8
ProteomicsDBi69096
TopDownProteomicsiQ7Z3Y8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55223, 12 antibodies

The DNASU plasmid repository

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DNASUi
342574

Genome annotation databases

EnsembliENST00000301656; ENSP00000301656; ENSG00000171446
GeneIDi342574
KEGGihsa:342574
UCSCiuc002hvg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
342574
EuPathDBiHostDB:ENSG00000171446.6

GeneCards: human genes, protein and diseases

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GeneCardsi
KRT27
HGNCiHGNC:30841, KRT27
HPAiENSG00000171446, Tissue enriched (skin)
MIMi616676, gene
neXtProtiNX_Q7Z3Y8
OpenTargetsiENSG00000171446
PharmGKBiPA134990976

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SIHJ, Eukaryota
GeneTreeiENSGT00940000161982
HOGENOMiCLU_012560_8_3_1
InParanoidiQ7Z3Y8
OMAiSRVHTME
OrthoDBi805081at2759
PhylomeDBiQ7Z3Y8
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiQ7Z3Y8
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
342574, 4 hits in 843 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
342574
PharosiQ7Z3Y8, Tdark

Protein Ontology

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PROi
PR:Q7Z3Y8
RNActiQ7Z3Y8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171446, Expressed in upper arm skin and 74 other tissues
GenevisibleiQ7Z3Y8, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C27_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3Y8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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