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Protein

Zinc finger protein 571

Gene

ZNF571

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri164 – 189C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 571
Gene namesi
Name:ZNF571
ORF Names:HSPC059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000180479.13
HGNCiHGNC:25000 ZNF571
neXtProtiNX_Q7Z3V5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180479
PharmGKBiPA134892585

Polymorphism and mutation databases

BioMutaiZNF571
DMDMi134047978

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476621 – 609Zinc finger protein 571Add BLAST609

Proteomic databases

EPDiQ7Z3V5
MaxQBiQ7Z3V5
PaxDbiQ7Z3V5
PeptideAtlasiQ7Z3V5
PRIDEiQ7Z3V5
ProteomicsDBi69092

PTM databases

iPTMnetiQ7Z3V5
PhosphoSitePlusiQ7Z3V5

Expressioni

Gene expression databases

BgeeiENSG00000180479 Expressed in 152 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF571
ExpressionAtlasiQ7Z3V5 baseline and differential
GenevisibleiQ7Z3V5 HS

Organism-specific databases

HPAiHPA054762

Interactioni

Protein-protein interaction databases

BioGridi119428, 2 interactors
STRINGi9606.ENSP00000333660

Structurei

3D structure databases

ProteinModelPortaliQ7Z3V5
SMRiQ7Z3V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri164 – 189C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7Z3V5
KOiK09228
OMAiNQRLGPT
OrthoDBiEOG091G02KC
PhylomeDBiQ7Z3V5
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7Z3V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHLLVTFRD VAIDFSQEEW ECLDPAQRDL YRDVMLENYS NLISLDLESS
60 70 80 90 100
CVTKKLSPEK EIYEMESLQW ENMGKRINHH LQYNGLGDNM ECKGNLEGQE
110 120 130 140 150
ASQEGLYMCV KITCEEKATE SHSTSSTFHR IIPTKEKLYK CKECRQGFSY
160 170 180 190 200
LSCLIQHEEN HNIEKCSEVK KHRNTFSKKP SYIQHQRIQT GEKPYECMEC
210 220 230 240 250
GKAFGRTSDL IQHQKIHTNE KPYQCNACGK AFIRGSQLTE HQRVHTGEKP
260 270 280 290 300
YECKKCGKAF SYCSQYTLHQ RIHSGEKPYE CKDCGKAFIL GSQLTYHQRI
310 320 330 340 350
HSGEKPYECK ECGKAFILGS HLTYHQRVHT GEKPYICKEC GKAFLCASQL
360 370 380 390 400
NEHQRIHTGE KPYECKECGK TFFRGSQLTY HLRVHSGERP YKCKECGKAF
410 420 430 440 450
ISNSNLIQHQ RIHTGEKPYK CKECGKAFIC GKQLSEHQRI HTGEKPFECK
460 470 480 490 500
ECGKAFIRVA YLTQHEKIHG EKHYECKECG KTFVRATQLT YHQRIHTGEK
510 520 530 540 550
PYKCKECDKA FIYGSQLSEH QRIHRGEKPY ECKQCGKAFI RGSHLTEHLR
560 570 580 590 600
THTGEKPYEC KECGRAFSRG SELTLHQRIH TGEKPYTCVQ CGKDFRCPSQ

LTQHTRLHN
Length:609
Mass (Da):70,792
Last modified:March 20, 2007 - v3
Checksum:i7DAA91B38A806EF1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERB9K7ERB9_HUMAN
Zinc finger protein 571
ZNF571
142Annotation score:
K7ELU5K7ELU5_HUMAN
Zinc finger protein 571
ZNF571
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62I → V in CAD97643 (PubMed:17974005).Curated1
Sequence conflicti102S → N in AAH40591 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052869170K → M. Corresponds to variant dbSNP:rs16973893Ensembl.1
Natural variantiVAR_023953189Q → H2 PublicationsCorresponds to variant dbSNP:rs8111790Ensembl.1
Natural variantiVAR_023954252E → D1 PublicationCorresponds to variant dbSNP:rs28512414Ensembl.1
Natural variantiVAR_023955573L → H1 PublicationCorresponds to variant dbSNP:rs4802029Ensembl.1
Natural variantiVAR_031093593K → E. Corresponds to variant dbSNP:rs16973890Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161544 mRNA Translation: AAF29031.2
BX537401 mRNA Translation: CAD97643.1
BC040591 mRNA Translation: AAH40591.1
BC113870 mRNA Translation: AAI13871.1
CCDSiCCDS12505.1
RefSeqiNP_001277243.1, NM_001290314.1
NP_001308201.1, NM_001321272.1
NP_057620.3, NM_016536.4
UniGeneiHs.590944

Genome annotation databases

EnsembliENST00000328550; ENSP00000333660; ENSG00000180479
ENST00000358744; ENSP00000351594; ENSG00000180479
ENST00000451802; ENSP00000392638; ENSG00000180479
ENST00000593133; ENSP00000467572; ENSG00000180479
GeneIDi51276
KEGGihsa:51276
UCSCiuc002ogt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161544 mRNA Translation: AAF29031.2
BX537401 mRNA Translation: CAD97643.1
BC040591 mRNA Translation: AAH40591.1
BC113870 mRNA Translation: AAI13871.1
CCDSiCCDS12505.1
RefSeqiNP_001277243.1, NM_001290314.1
NP_001308201.1, NM_001321272.1
NP_057620.3, NM_016536.4
UniGeneiHs.590944

3D structure databases

ProteinModelPortaliQ7Z3V5
SMRiQ7Z3V5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119428, 2 interactors
STRINGi9606.ENSP00000333660

PTM databases

iPTMnetiQ7Z3V5
PhosphoSitePlusiQ7Z3V5

Polymorphism and mutation databases

BioMutaiZNF571
DMDMi134047978

Proteomic databases

EPDiQ7Z3V5
MaxQBiQ7Z3V5
PaxDbiQ7Z3V5
PeptideAtlasiQ7Z3V5
PRIDEiQ7Z3V5
ProteomicsDBi69092

Protocols and materials databases

DNASUi51276
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328550; ENSP00000333660; ENSG00000180479
ENST00000358744; ENSP00000351594; ENSG00000180479
ENST00000451802; ENSP00000392638; ENSG00000180479
ENST00000593133; ENSP00000467572; ENSG00000180479
GeneIDi51276
KEGGihsa:51276
UCSCiuc002ogt.4 human

Organism-specific databases

CTDi51276
EuPathDBiHostDB:ENSG00000180479.13
GeneCardsiZNF571
HGNCiHGNC:25000 ZNF571
HPAiHPA054762
neXtProtiNX_Q7Z3V5
OpenTargetsiENSG00000180479
PharmGKBiPA134892585
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7Z3V5
KOiK09228
OMAiNQRLGPT
OrthoDBiEOG091G02KC
PhylomeDBiQ7Z3V5
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GeneWikiiZNF571
GenomeRNAii51276
PROiPR:Q7Z3V5

Gene expression databases

BgeeiENSG00000180479 Expressed in 152 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF571
ExpressionAtlasiQ7Z3V5 baseline and differential
GenevisibleiQ7Z3V5 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN571_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3V5
Secondary accession number(s): Q2HIY0, Q3ZCU3, Q9NZX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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