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Entry version 139 (05 Jun 2019)
Sequence version 3 (03 Sep 2014)
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Protein

Protein MON2 homolog

Gene

MON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for traffic between late Golgi and early endosomes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MON2 homolog
Alternative name(s):
Protein SF21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MON2
Synonyms:KIAA1040, SF21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29177 MON2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z3U7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23041

Open Targets

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OpenTargetsi
ENSG00000061987

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485545

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4105804

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MON2

Domain mapping of disease mutations (DMDM)

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DMDMi
156632594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002979022 – 1717Protein MON2 homologAdd BLAST1716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei537PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z3U7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z3U7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z3U7

PeptideAtlas

More...
PeptideAtlasi
Q7Z3U7

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z3U7

ProteomicsDB human proteome resource

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ProteomicsDBi
69085
69086 [Q7Z3U7-2]
69087 [Q7Z3U7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z3U7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z3U7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000061987 Expressed in 228 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z3U7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z3U7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038697
HPA057607

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GGA1Q9UJY52EBI-358882,EBI-447141

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116680, 25 interactors

Protein interaction database and analysis system

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IntActi
Q7Z3U7, 20 interactors

Molecular INTeraction database

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MINTi
Q7Z3U7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000377250

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000008113

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z3U7

Identification of Orthologs from Complete Genome Data

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OMAi
NICYESD

Database of Orthologous Groups

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OrthoDBi
411011at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314287

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N

The PANTHER Classification System

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PANTHERi
PTHR10663:SF333 PTHR10663:SF333, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGTSSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA
60 70 80 90 100
ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS
110 120 130 140 150
ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD EALSKAIVLC
160 170 180 190 200
FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDERHRDI IEQPVLVQGN
210 220 230 240 250
SNRRSVSTLK PCAKDAYMLF QDLCQLVNAD APYWLVGMTE MTRTFGLELL
260 270 280 290 300
ESVLNDFPQV FLQHQEFSFL LKERVCPLVI KLFSPNIKFR QGSSTSSSPA
310 320 330 340 350
PVEKPYFPIC MRLLRVVSVL IKQFYSLLVT ECEIFLSLLV KFLDADKPQW
360 370 380 390 400
LRAVAVESIH RFCVQPQLLR SFCQSYDMKQ HSTKVFRDIV NALGSFIQSL
410 420 430 440 450
FLVPPTGNPA TSNQAGNNNL GGSVSAPANS GMVGIGGGVT LLPAFEYRGT
460 470 480 490 500
WIPILTITVQ GSAKATYLEM LDKVEPPTIP EGYAMSVAFH CLLDLVRGIT
510 520 530 540 550
SMIEGELGEL ETECQTTTEE GSSPTQSTEQ QDLQSTSDQM DKEIVSRAVW
560 570 580 590 600
EEMVNACWCG LLAALSLLLD ASTDEAATEN ILKAELTMAA LCGRLGLVTS
610 620 630 640 650
RDAFITAICK GSLPPHYALT VLNTTTAATL SNKSYSVQGQ SVMMISPSSE
660 670 680 690 700
SHQQVVAVGQ PLAVQPQGTV MLTSKNIQCM RTLLNLAHCH GAVLGTSWQL
710 720 730 740 750
VLATLQHLVW ILGLKPSSGG ALKPGRAVEG PSTVLTTAVM TDLPVISNIL
760 770 780 790 800
SRLFESSQYL DDVSLHHLIN ALCSLSLEAM DMAYGNNKEP SLFAVAKLLE
810 820 830 840 850
TGLVNMHRIE ILWRPLTGHL LEVCQHPNSR MREWGAEALT SLIKAGLTFN
860 870 880 890 900
HDPPLSQNQR LQLLLLNPLK EMSNINHPDI RLKQLECVLQ ILQSQGDSLG
910 920 930 940 950
PGWPLVLGVM GAIRNDQGES LIRTAFQCLQ LVVTDFLPTM PCTCLQIVVD
960 970 980 990 1000
VAGSFGLHNQ ELNISLTSIG LLWNISDYFF QRGETIEKEL NKEEAAQQKQ
1010 1020 1030 1040 1050
AEEKGVVLNR PFHPAPPFDC LWLCLYAKLG ELCVDPRPAV RKSAGQTLFS
1060 1070 1080 1090 1100
TIGAHGTLLQ HSTWHTVIWK VLFHLLDRVR ESSTTADKEK IESGGGNILI
1110 1120 1130 1140 1150
HHSRDTAEKQ WAETWVLTLA GVARIFNTRR YLLQPLGDFS RAWDVLLDHI
1160 1170 1180 1190 1200
QSAALSKNNE VSLAALKSFQ EILQIVSPVR DSDKPETPPV VNVPVPVLIG
1210 1220 1230 1240 1250
PISGMSRPFV RTDSIGEKLG RYSSSEPPIV TDELEDLNLW WAAWNTWYRI
1260 1270 1280 1290 1300
GSESTKPPIT FDKLTFIPSQ PFLTALIQIF PALYQHIKTG FNMDDLQKLG
1310 1320 1330 1340 1350
VILHSAISVP ISSDASPFIL PSYTEAVLTS LQEAVLTALD VLQKAICVGP
1360 1370 1380 1390 1400
ENMQIMYPAI FDQLLAFVEF SCKPPQYGQL ETKHIANAKY NQIQLFAPAE
1410 1420 1430 1440 1450
WVALNYVPFA ERSLEVVVDL YQKTACHKAV VNEKVLQNII KTLRVPLSLK
1460 1470 1480 1490 1500
YSCPSESTWK LAVSSLLRVL SIGLPVARQH ASSGKFDSMW PELANTFEDF
1510 1520 1530 1540 1550
LFTKSIPPDN LSIQEFQRNE NIDVEVVQLI SNEILPYANF IPKEFVGQIM
1560 1570 1580 1590 1600
TMLNKGSIHS QSSSFTEAEI DIRLREEFSK MCFETLLQFS FSNKVTTPQE
1610 1620 1630 1640 1650
GYISRMALSV LLKRSQDVLH RYIEDERLSG KCPLPRQQVT EIIFVLKAVS
1660 1670 1680 1690 1700
TLIDSLKKTQ PENVDGNTWA QVIALYPTLV ECITCSSSEV CSALKEALVP
1710
FKDFMQPPAS RVQNGES
Length:1,717
Mass (Da):190,359
Last modified:September 3, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA95DCDF2A69BC0D2
GO
Isoform 2 (identifier: Q7Z3U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1675: VDGNTWAQVIAL → ACISLFGIPPYF
     1676-1717: Missing.

Note: No experimental confirmation available.
Show »
Length:1,675
Mass (Da):185,855
Checksum:iB91F7B0CF95A6FB8
GO
Isoform 3 (identifier: Q7Z3U7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1125: Missing.
     1126-1136: FNTRRYLLQPL → MIIVFFSLPNI
     1393-1398: Missing.

Show »
Length:586
Mass (Da):65,692
Checksum:i831DB2B1E162C8F2
GO
Isoform 5 (identifier: Q7Z3U7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1393-1398: Missing.

Note: No experimental confirmation available.
Show »
Length:1,711
Mass (Da):189,689
Checksum:iF889187A46C1D400
GO
Isoform 6 (identifier: Q7Z3U7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-634: GSLPPHYALTVLNTTTAATLSNKS → A
     1393-1398: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,688
Mass (Da):187,320
Checksum:i7DC2953A2BFE5D24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YFF8A0A286YFF8_HUMAN
Protein MON2 homolog
MON2
1,718Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZV1F8VZV1_HUMAN
Protein MON2 homolog
MON2
1,072Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQS2F8VQS2_HUMAN
Protein MON2 homolog
MON2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZV6F8VZV6_HUMAN
Protein MON2 homolog
MON2
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA82992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti163N → D in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti197V → I in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti238M → T in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti268S → G in CAD89933 (PubMed:17974005).Curated1
Sequence conflicti650E → G in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti734V → A in CAD89933 (PubMed:17974005).Curated1
Sequence conflicti822E → EK in BAA82992 (PubMed:10470851).Curated1
Sequence conflicti822E → EK in AAI41818 (PubMed:15489334).Curated1
Sequence conflicti822E → EK in AAI42711 (PubMed:15489334).Curated1
Sequence conflicti822E → EK in AAI51242 (PubMed:15489334).Curated1
Sequence conflicti1002E → K in CAD89933 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034689548A → T2 PublicationsCorresponds to variant dbSNP:rs10219555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0273891 – 1125Missing in isoform 3. 1 PublicationAdd BLAST1125
Alternative sequenceiVSP_055628611 – 634GSLPP…LSNKS → A in isoform 6. CuratedAdd BLAST24
Alternative sequenceiVSP_0273901126 – 1136FNTRRYLLQPL → MIIVFFSLPNI in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0273911393 – 1398Missing in isoform 3, isoform 5 and isoform 6. 2 Publications6
Alternative sequenceiVSP_0273921664 – 1675VDGNT…QVIAL → ACISLFGIPPYF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0273931676 – 1717Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017814 mRNA Translation: BAC11707.1
AB028963 mRNA Translation: BAA82992.3 Different initiation.
AK092646 mRNA Translation: BAC03935.1
AL834320 mRNA Translation: CAD38989.1
BX537415 mRNA Translation: CAD97657.1
AL833066 mRNA Translation: CAD89933.1
AC026115 Genomic DNA No translation available.
AC079035 Genomic DNA No translation available.
BC136621 mRNA Translation: AAI36622.1
BC141817 mRNA Translation: AAI41818.1
BC142710 mRNA Translation: AAI42711.1
BC151241 mRNA Translation: AAI51242.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31849.1 [Q7Z3U7-1]
CCDS61175.1 [Q7Z3U7-6]
CCDS61177.1 [Q7Z3U7-2]
CCDS61178.1 [Q7Z3U7-5]

NCBI Reference Sequences

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RefSeqi
NP_001265398.1, NM_001278469.1 [Q7Z3U7-2]
NP_001265399.1, NM_001278470.1 [Q7Z3U7-5]
NP_055841.2, NM_015026.2 [Q7Z3U7-1]
XP_016874530.1, XM_017019041.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000393629; ENSP00000377249; ENSG00000061987 [Q7Z3U7-5]
ENST00000393630; ENSP00000377250; ENSG00000061987 [Q7Z3U7-1]
ENST00000546600; ENSP00000447407; ENSG00000061987 [Q7Z3U7-2]
ENST00000552738; ENSP00000449215; ENSG00000061987 [Q7Z3U7-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23041

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23041

UCSC genome browser

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UCSCi
uc001sre.4 human [Q7Z3U7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017814 mRNA Translation: BAC11707.1
AB028963 mRNA Translation: BAA82992.3 Different initiation.
AK092646 mRNA Translation: BAC03935.1
AL834320 mRNA Translation: CAD38989.1
BX537415 mRNA Translation: CAD97657.1
AL833066 mRNA Translation: CAD89933.1
AC026115 Genomic DNA No translation available.
AC079035 Genomic DNA No translation available.
BC136621 mRNA Translation: AAI36622.1
BC141817 mRNA Translation: AAI41818.1
BC142710 mRNA Translation: AAI42711.1
BC151241 mRNA Translation: AAI51242.1
CCDSiCCDS31849.1 [Q7Z3U7-1]
CCDS61175.1 [Q7Z3U7-6]
CCDS61177.1 [Q7Z3U7-2]
CCDS61178.1 [Q7Z3U7-5]
RefSeqiNP_001265398.1, NM_001278469.1 [Q7Z3U7-2]
NP_001265399.1, NM_001278470.1 [Q7Z3U7-5]
NP_055841.2, NM_015026.2 [Q7Z3U7-1]
XP_016874530.1, XM_017019041.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116680, 25 interactors
IntActiQ7Z3U7, 20 interactors
MINTiQ7Z3U7
STRINGi9606.ENSP00000377250

Chemistry databases

ChEMBLiCHEMBL4105804

PTM databases

iPTMnetiQ7Z3U7
PhosphoSitePlusiQ7Z3U7

Polymorphism and mutation databases

BioMutaiMON2
DMDMi156632594

Proteomic databases

EPDiQ7Z3U7
jPOSTiQ7Z3U7
PaxDbiQ7Z3U7
PeptideAtlasiQ7Z3U7
PRIDEiQ7Z3U7
ProteomicsDBi69085
69086 [Q7Z3U7-2]
69087 [Q7Z3U7-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23041
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393629; ENSP00000377249; ENSG00000061987 [Q7Z3U7-5]
ENST00000393630; ENSP00000377250; ENSG00000061987 [Q7Z3U7-1]
ENST00000546600; ENSP00000447407; ENSG00000061987 [Q7Z3U7-2]
ENST00000552738; ENSP00000449215; ENSG00000061987 [Q7Z3U7-6]
GeneIDi23041
KEGGihsa:23041
UCSCiuc001sre.4 human [Q7Z3U7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23041
DisGeNETi23041

GeneCards: human genes, protein and diseases

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GeneCardsi
MON2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0010775
HGNCiHGNC:29177 MON2
HPAiHPA038697
HPA057607
neXtProtiNX_Q7Z3U7
OpenTargetsiENSG00000061987
PharmGKBiPA143485545

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
InParanoidiQ7Z3U7
OMAiNICYESD
OrthoDBi411011at2759
TreeFamiTF314287

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MON2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MON2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23041

Protein Ontology

More...
PROi
PR:Q7Z3U7

Gene expression databases

BgeeiENSG00000061987 Expressed in 228 organ(s), highest expression level in intestine
ExpressionAtlasiQ7Z3U7 baseline and differential
GenevisibleiQ7Z3U7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR10663:SF333 PTHR10663:SF333, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMON2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3U7
Secondary accession number(s): A5D8U7
, A7E2Y0, B9EGP5, F8VWA6, F8W1Z6, Q86TA2, Q8N3I5, Q8NAI0, Q8NHE2, Q9UPW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: September 3, 2014
Last modified: June 5, 2019
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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