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Protein

Protein MON2 homolog

Gene

MON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for traffic between late Golgi and early endosomes.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MON2 homolog
Alternative name(s):
Protein SF21
Gene namesi
Name:MON2
Synonyms:KIAA1040, SF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000061987.14
HGNCiHGNC:29177 MON2
neXtProtiNX_Q7Z3U7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23041
OpenTargetsiENSG00000061987
PharmGKBiPA143485545

Polymorphism and mutation databases

BioMutaiMON2
DMDMi156632594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002979022 – 1717Protein MON2 homologAdd BLAST1716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei537PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z3U7
PaxDbiQ7Z3U7
PeptideAtlasiQ7Z3U7
PRIDEiQ7Z3U7
ProteomicsDBi69085
69086 [Q7Z3U7-2]
69087 [Q7Z3U7-3]

PTM databases

iPTMnetiQ7Z3U7
PhosphoSitePlusiQ7Z3U7

Expressioni

Gene expression databases

BgeeiENSG00000061987 Expressed in 228 organ(s), highest expression level in intestine
CleanExiHS_MON2
ExpressionAtlasiQ7Z3U7 baseline and differential
GenevisibleiQ7Z3U7 HS

Organism-specific databases

HPAiHPA038697
HPA057607

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GGA1Q9UJY52EBI-358882,EBI-447141

Protein-protein interaction databases

BioGridi116680, 22 interactors
IntActiQ7Z3U7, 18 interactors
MINTiQ7Z3U7
STRINGi9606.ENSP00000377252

Structurei

3D structure databases

ProteinModelPortaliQ7Z3U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
HOVERGENiHBG108142
InParanoidiQ7Z3U7
OMAiNICYESD
OrthoDBiEOG091G00D1
TreeFamiTF314287

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR44195 PTHR44195, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGTSSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA
60 70 80 90 100
ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS
110 120 130 140 150
ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD EALSKAIVLC
160 170 180 190 200
FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDERHRDI IEQPVLVQGN
210 220 230 240 250
SNRRSVSTLK PCAKDAYMLF QDLCQLVNAD APYWLVGMTE MTRTFGLELL
260 270 280 290 300
ESVLNDFPQV FLQHQEFSFL LKERVCPLVI KLFSPNIKFR QGSSTSSSPA
310 320 330 340 350
PVEKPYFPIC MRLLRVVSVL IKQFYSLLVT ECEIFLSLLV KFLDADKPQW
360 370 380 390 400
LRAVAVESIH RFCVQPQLLR SFCQSYDMKQ HSTKVFRDIV NALGSFIQSL
410 420 430 440 450
FLVPPTGNPA TSNQAGNNNL GGSVSAPANS GMVGIGGGVT LLPAFEYRGT
460 470 480 490 500
WIPILTITVQ GSAKATYLEM LDKVEPPTIP EGYAMSVAFH CLLDLVRGIT
510 520 530 540 550
SMIEGELGEL ETECQTTTEE GSSPTQSTEQ QDLQSTSDQM DKEIVSRAVW
560 570 580 590 600
EEMVNACWCG LLAALSLLLD ASTDEAATEN ILKAELTMAA LCGRLGLVTS
610 620 630 640 650
RDAFITAICK GSLPPHYALT VLNTTTAATL SNKSYSVQGQ SVMMISPSSE
660 670 680 690 700
SHQQVVAVGQ PLAVQPQGTV MLTSKNIQCM RTLLNLAHCH GAVLGTSWQL
710 720 730 740 750
VLATLQHLVW ILGLKPSSGG ALKPGRAVEG PSTVLTTAVM TDLPVISNIL
760 770 780 790 800
SRLFESSQYL DDVSLHHLIN ALCSLSLEAM DMAYGNNKEP SLFAVAKLLE
810 820 830 840 850
TGLVNMHRIE ILWRPLTGHL LEVCQHPNSR MREWGAEALT SLIKAGLTFN
860 870 880 890 900
HDPPLSQNQR LQLLLLNPLK EMSNINHPDI RLKQLECVLQ ILQSQGDSLG
910 920 930 940 950
PGWPLVLGVM GAIRNDQGES LIRTAFQCLQ LVVTDFLPTM PCTCLQIVVD
960 970 980 990 1000
VAGSFGLHNQ ELNISLTSIG LLWNISDYFF QRGETIEKEL NKEEAAQQKQ
1010 1020 1030 1040 1050
AEEKGVVLNR PFHPAPPFDC LWLCLYAKLG ELCVDPRPAV RKSAGQTLFS
1060 1070 1080 1090 1100
TIGAHGTLLQ HSTWHTVIWK VLFHLLDRVR ESSTTADKEK IESGGGNILI
1110 1120 1130 1140 1150
HHSRDTAEKQ WAETWVLTLA GVARIFNTRR YLLQPLGDFS RAWDVLLDHI
1160 1170 1180 1190 1200
QSAALSKNNE VSLAALKSFQ EILQIVSPVR DSDKPETPPV VNVPVPVLIG
1210 1220 1230 1240 1250
PISGMSRPFV RTDSIGEKLG RYSSSEPPIV TDELEDLNLW WAAWNTWYRI
1260 1270 1280 1290 1300
GSESTKPPIT FDKLTFIPSQ PFLTALIQIF PALYQHIKTG FNMDDLQKLG
1310 1320 1330 1340 1350
VILHSAISVP ISSDASPFIL PSYTEAVLTS LQEAVLTALD VLQKAICVGP
1360 1370 1380 1390 1400
ENMQIMYPAI FDQLLAFVEF SCKPPQYGQL ETKHIANAKY NQIQLFAPAE
1410 1420 1430 1440 1450
WVALNYVPFA ERSLEVVVDL YQKTACHKAV VNEKVLQNII KTLRVPLSLK
1460 1470 1480 1490 1500
YSCPSESTWK LAVSSLLRVL SIGLPVARQH ASSGKFDSMW PELANTFEDF
1510 1520 1530 1540 1550
LFTKSIPPDN LSIQEFQRNE NIDVEVVQLI SNEILPYANF IPKEFVGQIM
1560 1570 1580 1590 1600
TMLNKGSIHS QSSSFTEAEI DIRLREEFSK MCFETLLQFS FSNKVTTPQE
1610 1620 1630 1640 1650
GYISRMALSV LLKRSQDVLH RYIEDERLSG KCPLPRQQVT EIIFVLKAVS
1660 1670 1680 1690 1700
TLIDSLKKTQ PENVDGNTWA QVIALYPTLV ECITCSSSEV CSALKEALVP
1710
FKDFMQPPAS RVQNGES
Length:1,717
Mass (Da):190,359
Last modified:September 3, 2014 - v3
Checksum:iA95DCDF2A69BC0D2
GO
Isoform 2 (identifier: Q7Z3U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1675: VDGNTWAQVIAL → ACISLFGIPPYF
     1676-1717: Missing.

Note: No experimental confirmation available.
Show »
Length:1,675
Mass (Da):185,855
Checksum:iB91F7B0CF95A6FB8
GO
Isoform 3 (identifier: Q7Z3U7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1125: Missing.
     1126-1136: FNTRRYLLQPL → MIIVFFSLPNI
     1393-1398: Missing.

Show »
Length:586
Mass (Da):65,692
Checksum:i831DB2B1E162C8F2
GO
Isoform 5 (identifier: Q7Z3U7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1393-1398: Missing.

Note: No experimental confirmation available.
Show »
Length:1,711
Mass (Da):189,689
Checksum:iF889187A46C1D400
GO
Isoform 6 (identifier: Q7Z3U7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-634: GSLPPHYALTVLNTTTAATLSNKS → A
     1393-1398: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,688
Mass (Da):187,320
Checksum:i7DC2953A2BFE5D24
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZV1F8VZV1_HUMAN
Protein MON2 homolog
MON2
1,072Annotation score:
F8VQS2F8VQS2_HUMAN
Protein MON2 homolog
MON2
59Annotation score:
A0A286YFF8A0A286YFF8_HUMAN
Protein MON2 homolog
MON2
1,718Annotation score:
F8VZV6F8VZV6_HUMAN
Protein MON2 homolog
MON2
43Annotation score:

Sequence cautioni

The sequence BAA82992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163N → D in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti197V → I in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti238M → T in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti268S → G in CAD89933 (PubMed:17974005).Curated1
Sequence conflicti650E → G in CAD97657 (PubMed:17974005).Curated1
Sequence conflicti734V → A in CAD89933 (PubMed:17974005).Curated1
Sequence conflicti822E → EK in BAA82992 (PubMed:10470851).Curated1
Sequence conflicti822E → EK in AAI41818 (PubMed:15489334).Curated1
Sequence conflicti822E → EK in AAI42711 (PubMed:15489334).Curated1
Sequence conflicti822E → EK in AAI51242 (PubMed:15489334).Curated1
Sequence conflicti1002E → K in CAD89933 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034689548A → T2 PublicationsCorresponds to variant dbSNP:rs10219555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273891 – 1125Missing in isoform 3. 1 PublicationAdd BLAST1125
Alternative sequenceiVSP_055628611 – 634GSLPP…LSNKS → A in isoform 6. CuratedAdd BLAST24
Alternative sequenceiVSP_0273901126 – 1136FNTRRYLLQPL → MIIVFFSLPNI in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0273911393 – 1398Missing in isoform 3, isoform 5 and isoform 6. 2 Publications6
Alternative sequenceiVSP_0273921664 – 1675VDGNT…QVIAL → ACISLFGIPPYF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0273931676 – 1717Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017814 mRNA Translation: BAC11707.1
AB028963 mRNA Translation: BAA82992.3 Different initiation.
AK092646 mRNA Translation: BAC03935.1
AL834320 mRNA Translation: CAD38989.1
BX537415 mRNA Translation: CAD97657.1
AL833066 mRNA Translation: CAD89933.1
AC026115 Genomic DNA No translation available.
AC079035 Genomic DNA No translation available.
BC136621 mRNA Translation: AAI36622.1
BC141817 mRNA Translation: AAI41818.1
BC142710 mRNA Translation: AAI42711.1
BC151241 mRNA Translation: AAI51242.1
CCDSiCCDS31849.1 [Q7Z3U7-1]
CCDS61175.1 [Q7Z3U7-6]
CCDS61177.1 [Q7Z3U7-2]
CCDS61178.1 [Q7Z3U7-5]
RefSeqiNP_001265398.1, NM_001278469.1 [Q7Z3U7-2]
NP_001265399.1, NM_001278470.1 [Q7Z3U7-5]
NP_055841.2, NM_015026.2 [Q7Z3U7-1]
XP_016874530.1, XM_017019041.1
UniGeneiHs.389378

Genome annotation databases

EnsembliENST00000393629; ENSP00000377249; ENSG00000061987 [Q7Z3U7-5]
ENST00000393630; ENSP00000377250; ENSG00000061987 [Q7Z3U7-1]
ENST00000546600; ENSP00000447407; ENSG00000061987 [Q7Z3U7-2]
ENST00000552738; ENSP00000449215; ENSG00000061987 [Q7Z3U7-6]
GeneIDi23041
KEGGihsa:23041
UCSCiuc001sre.4 human [Q7Z3U7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017814 mRNA Translation: BAC11707.1
AB028963 mRNA Translation: BAA82992.3 Different initiation.
AK092646 mRNA Translation: BAC03935.1
AL834320 mRNA Translation: CAD38989.1
BX537415 mRNA Translation: CAD97657.1
AL833066 mRNA Translation: CAD89933.1
AC026115 Genomic DNA No translation available.
AC079035 Genomic DNA No translation available.
BC136621 mRNA Translation: AAI36622.1
BC141817 mRNA Translation: AAI41818.1
BC142710 mRNA Translation: AAI42711.1
BC151241 mRNA Translation: AAI51242.1
CCDSiCCDS31849.1 [Q7Z3U7-1]
CCDS61175.1 [Q7Z3U7-6]
CCDS61177.1 [Q7Z3U7-2]
CCDS61178.1 [Q7Z3U7-5]
RefSeqiNP_001265398.1, NM_001278469.1 [Q7Z3U7-2]
NP_001265399.1, NM_001278470.1 [Q7Z3U7-5]
NP_055841.2, NM_015026.2 [Q7Z3U7-1]
XP_016874530.1, XM_017019041.1
UniGeneiHs.389378

3D structure databases

ProteinModelPortaliQ7Z3U7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116680, 22 interactors
IntActiQ7Z3U7, 18 interactors
MINTiQ7Z3U7
STRINGi9606.ENSP00000377252

PTM databases

iPTMnetiQ7Z3U7
PhosphoSitePlusiQ7Z3U7

Polymorphism and mutation databases

BioMutaiMON2
DMDMi156632594

Proteomic databases

EPDiQ7Z3U7
PaxDbiQ7Z3U7
PeptideAtlasiQ7Z3U7
PRIDEiQ7Z3U7
ProteomicsDBi69085
69086 [Q7Z3U7-2]
69087 [Q7Z3U7-3]

Protocols and materials databases

DNASUi23041
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393629; ENSP00000377249; ENSG00000061987 [Q7Z3U7-5]
ENST00000393630; ENSP00000377250; ENSG00000061987 [Q7Z3U7-1]
ENST00000546600; ENSP00000447407; ENSG00000061987 [Q7Z3U7-2]
ENST00000552738; ENSP00000449215; ENSG00000061987 [Q7Z3U7-6]
GeneIDi23041
KEGGihsa:23041
UCSCiuc001sre.4 human [Q7Z3U7-1]

Organism-specific databases

CTDi23041
DisGeNETi23041
EuPathDBiHostDB:ENSG00000061987.14
GeneCardsiMON2
H-InvDBiHIX0010775
HGNCiHGNC:29177 MON2
HPAiHPA038697
HPA057607
neXtProtiNX_Q7Z3U7
OpenTargetsiENSG00000061987
PharmGKBiPA143485545
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
HOVERGENiHBG108142
InParanoidiQ7Z3U7
OMAiNICYESD
OrthoDBiEOG091G00D1
TreeFamiTF314287

Miscellaneous databases

ChiTaRSiMON2 human
GeneWikiiMON2
GenomeRNAii23041
PROiPR:Q7Z3U7

Gene expression databases

BgeeiENSG00000061987 Expressed in 228 organ(s), highest expression level in intestine
CleanExiHS_MON2
ExpressionAtlasiQ7Z3U7 baseline and differential
GenevisibleiQ7Z3U7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR44195 PTHR44195, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMON2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3U7
Secondary accession number(s): A5D8U7
, A7E2Y0, B9EGP5, F8VWA6, F8W1Z6, Q86TA2, Q8N3I5, Q8NAI0, Q8NHE2, Q9UPW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: September 3, 2014
Last modified: November 7, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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