Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - Q7Z3S9 (NT2NA_HUMAN)

Entry version 173 (07 Apr 2021)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Notch homolog 2 N-terminal-like protein A

Gene

NOTCH2NLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Notch signaling pathway
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z3S9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Notch homolog 2 N-terminal-like protein A2 Publications
Alternative name(s):
Notch homolog 2 N-terminal-like protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH2NLA2 PublicationsImported
Synonyms:N2N1 Publication, NOTCH2NLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:31862, NOTCH2NLA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618023, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z3S9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000264343.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in NOTCH2NLA may be a cause of chromosome 1q21.1 deletion/duplication syndrome (PubMed:29856954). Deletions of NOTCH2NL (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC) are present in patients affected by microcephaly, whereas macrocephaly is observed in patients with NOTCH2NL duplications (PubMed:29856954).1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		388677

Open Targets

More...OpenTargetsi		ENSG00000264343

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134983899

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z3S9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NOTCH2NL

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750065

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371031 – 236Notch homolog 2 N-terminal-like protein AAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi14 ↔ 23PROSITE-ProRule annotation
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Disulfide bondi34 ↔ 51PROSITE-ProRule annotation
Disulfide bondi53 ↔ 62PROSITE-ProRule annotation
Disulfide bondi70 ↔ 82PROSITE-ProRule annotation
Disulfide bondi76 ↔ 92PROSITE-ProRule annotation
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Disulfide bondi114 ↔ 129PROSITE-ProRule annotation
Disulfide bondi131 ↔ 140PROSITE-ProRule annotation
Disulfide bondi147 ↔ 159PROSITE-ProRule annotation
Disulfide bondi153 ↔ 168PROSITE-ProRule annotation
Disulfide bondi170 ↔ 179PROSITE-ProRule annotation
Disulfide bondi186 ↔ 197PROSITE-ProRule annotation
Disulfide bondi191 ↔ 207PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by ELANE.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z3S9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z3S9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z3S9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z3S9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z3S9

PeptideAtlas

More...PeptideAtlasi		Q7Z3S9

PRoteomics IDEntifications database

More...PRIDEi		Q7Z3S9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69079 [Q7Z3S9-1]
69080 [Q7Z3S9-2]
69081 [Q7Z3S9-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q7Z3S9-3 [Q7Z3S9-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7Z3S9, 1 site

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher levels in leukocytes and lymph nodes (PubMed:14673143). Expressed in radial glia neural stem cells during cortical development (PubMed:29856954).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low levels at 7-9 gestational weeks and then increases at later stages, including in the non-cortical plate region at gestational week 21, containing the outer-subventricular zone (PubMed:29856955). Expressed at lower level than NOTCH2NLB (PubMed:29856955).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000264343, Expressed in colon and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z3S9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z3S9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000264343, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ELANE (PubMed:14673143).

Interacts with NOTCH2 (PubMed:29856954).

Interacts with DLL1; the interaction is direct (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z3S9
With#Exp.IntAct
ACY3 [Q96HD9]3EBI-945833,EBI-3916242
ADAMTSL3 [P82987]3EBI-945833,EBI-10221726
ADAMTSL5 - isoform 2 [Q6ZMM2-2]3EBI-945833,EBI-10254938
ADCK5 [Q3MIX3]4EBI-945833,EBI-3923548
ALDH3B1 [P43353]3EBI-945833,EBI-2558314
ALPI [P09923]4EBI-945833,EBI-1052631
AQP1 [P29972]3EBI-945833,EBI-745213
AQP5 [P55064]3EBI-945833,EBI-746103
ARID3A [Q99856]3EBI-945833,EBI-5458244
ASPSCR1 [Q9BZE9]3EBI-945833,EBI-1993677
ATG9A [Q7Z3C6]3EBI-945833,EBI-727146
BCL6B [A8KA13]3EBI-945833,EBI-10174813
BLCAP [P62952]4EBI-945833,EBI-3895726
BMP7 [A8K571]3EBI-945833,EBI-10174327
C11orf87 [Q6NUJ2]3EBI-945833,EBI-6660291
C5orf60 - isoform 4 [A6NFR6-4]3EBI-945833,EBI-10173955
CA6 [Q8N4G4]4EBI-945833,EBI-10265475
CARHSP1 [Q9Y2V2]3EBI-945833,EBI-718719
CATSPER1 [Q8NEC5]4EBI-945833,EBI-744545
CCDC26 [Q8TAB7]3EBI-945833,EBI-10271580
CCER1 [Q8TC90]4EBI-945833,EBI-746041
CD164 [Q04900]3EBI-945833,EBI-2115896
CDK5R1 [Q8N619]3EBI-945833,EBI-10266998
CDK5R1 [Q8TAM4]3EBI-945833,EBI-10271838
CERK [Q8TCT0]3EBI-945833,EBI-10274247
CHCHD3 [Q9NX63]3EBI-945833,EBI-743375
CHDH [Q8NE62]3EBI-945833,EBI-7127986
CHIC2 [Q9UKJ5]3EBI-945833,EBI-741528
CHRD [Q9H2X0]3EBI-945833,EBI-947551
CHRNG [P07510]5EBI-945833,EBI-9008836
CHRNG - isoform 2 [P07510-2]3EBI-945833,EBI-11979451
CLDN2 [P57739]3EBI-945833,EBI-751440
CLEC18A [A5D8T8]3EBI-945833,EBI-10173491
COL8A1 [P27658]3EBI-945833,EBI-747133
CRACR2A [Q9BSW2]3EBI-945833,EBI-739773
CRCT1 [Q9UGL9]5EBI-945833,EBI-713677
CREB5 - isoform 3 [Q02930-3]3EBI-945833,EBI-10192698
CSF1 [P09603]3EBI-945833,EBI-2872294
CST2 [P09228]3EBI-945833,EBI-8832659
CST9L [Q9H4G1]3EBI-945833,EBI-3923092
CTSG [P08311]3EBI-945833,EBI-5462635
CTSZ [Q9UBR2]4EBI-945833,EBI-8636823
CXCL16 [A0A6I8PIU0]3EBI-945833,EBI-10176529
CXCL5 [Q6I9S7]3EBI-945833,EBI-10249885
DHRS1 [Q96LJ7]3EBI-945833,EBI-746300
DMRT3 [Q9NQL9]3EBI-945833,EBI-9679045
DNAL4 [O96015]3EBI-945833,EBI-742362
DOCK2 [Q92608]3EBI-945833,EBI-448771
EFNA3 [P52797]3EBI-945833,EBI-722730
EIF4E2 [O60573]3EBI-945833,EBI-398610
EPHB6 - isoform 2 [O15197-2]3EBI-945833,EBI-10182490
FAAH [O00519]3EBI-945833,EBI-1389829
FAM124B [Q9H5Z6]3EBI-945833,EBI-741626
FAM71C [Q8NEG0]3EBI-945833,EBI-752049
FAM74A6 [Q5TZK3]3EBI-945833,EBI-10247271
FARS2 [O95363]3EBI-945833,EBI-2513774
FASLG [P48023]3EBI-945833,EBI-495538
FBXL18 [Q96D16]3EBI-945833,EBI-744419
FBXW5 [Q969U6]3EBI-945833,EBI-741068
FOXB1 [Q99853]3EBI-945833,EBI-3916225
FRS3 [O43559]3EBI-945833,EBI-725515
GABRD [O14764]3EBI-945833,EBI-744352
GATA2 [P23769]4EBI-945833,EBI-2806671
GEM [P55040]3EBI-945833,EBI-744104
GFOD1 [Q9NXC2]3EBI-945833,EBI-8799578
GIP [P09681]3EBI-945833,EBI-8588553
GLP1R [P43220]3EBI-945833,EBI-7466542
GLRX3 [O76003]3EBI-945833,EBI-374781
GLYAT [Q6IB77]3EBI-945833,EBI-715463
GNAI2 [P04899]3EBI-945833,EBI-353997
GNE [Q9Y223]4EBI-945833,EBI-4291090
GSTP1 [P09211]3EBI-945833,EBI-353467
GTF3C5 [Q9Y5Q8]3EBI-945833,EBI-1045409
HBZ [P02008]4EBI-945833,EBI-719843
HCK [P08631]3EBI-945833,EBI-346340
HEL-S-182mP [V9HW60]3EBI-945833,EBI-10180762
HEL-S-90n [V9HWJ5]3EBI-945833,EBI-10330335
HIST1H2AK [A4FTV9]3EBI-945833,EBI-10173457
HOXA1 [P49639]3EBI-945833,EBI-740785
HPCAL1 [P37235]3EBI-945833,EBI-749311
HSBP1 [O75506]4EBI-945833,EBI-748664
HSD3B7 [Q9H2F3]3EBI-945833,EBI-3918847
HSPA12B [Q96MM6]3EBI-945833,EBI-10291310
HSPBP1 [Q9NZL4]4EBI-945833,EBI-356763
HSPD1 [P10809]3EBI-945833,EBI-352528
ICAM4 - isoform 3 [Q14773-3]3EBI-945833,EBI-10233928
IFI30 [P13284]3EBI-945833,EBI-2868897
IL2RG [P31785]4EBI-945833,EBI-80475
INPP5D [Q92835]3EBI-945833,EBI-1380477
ITGB2 [P05107]7EBI-945833,EBI-300173
ITGB5 [L7RT22]3EBI-945833,EBI-10178729
JOSD1 [Q15040]3EBI-945833,EBI-2510602
KCTD15 [Q96SI1]3EBI-945833,EBI-715783
KLHL38 [Q2WGJ6]3EBI-945833,EBI-6426443
KLK8 [O60259]3EBI-945833,EBI-3915857
KRT20 [P35900]3EBI-945833,EBI-742094
KRT83 [P78385]3EBI-945833,EBI-10221390
KRTAP10-11 [P60412]3EBI-945833,EBI-10217483
KRTAP10-5 [P60370]3EBI-945833,EBI-10172150
KRTAP10-7 [P60409]3EBI-945833,EBI-10172290
KRTAP10-8 [P60410]3EBI-945833,EBI-10171774
KRTAP10-9 [P60411]3EBI-945833,EBI-10172052
KRTAP12-2 [P59991]3EBI-945833,EBI-10176379
KRTAP12-4 [P60329]3EBI-945833,EBI-10176396
KRTAP13-3 [Q3SY46]3EBI-945833,EBI-10241252
KRTAP26-1 [Q6PEX3]3EBI-945833,EBI-3957672
KRTAP3-1 [Q9BYR8]3EBI-945833,EBI-9996449
KRTAP4-11 [Q9BYQ6]3EBI-945833,EBI-10302392
KRTAP4-12 [Q9BQ66]3EBI-945833,EBI-739863
KRTAP4-2 [Q9BYR5]3EBI-945833,EBI-10172511
KRTAP4-7 [Q9BYR0]3EBI-945833,EBI-10302547
KRTAP5-6 [Q6L8G9]4EBI-945833,EBI-10250562
KRTAP5-9 [P26371]3EBI-945833,EBI-3958099
KRTAP9-2 [Q9BYQ4]3EBI-945833,EBI-1044640
KRTAP9-4 [Q9BYQ2]3EBI-945833,EBI-10185730
LCE1B [Q5T7P3]6EBI-945833,EBI-10245913
LCE2D [Q5TA82]3EBI-945833,EBI-10246750
LCE3C [Q5T5A8]3EBI-945833,EBI-10245291
LCE3E [Q5T5B0]4EBI-945833,EBI-10245456
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-945833,EBI-10257651
LIN7A [O14910]3EBI-945833,EBI-2513988
LINC00526 [Q96FQ7]3EBI-945833,EBI-10286106
LMO2 [P25791]3EBI-945833,EBI-739696
LNX1 [Q8TBB1]4EBI-945833,EBI-739832
LOC200261 [Q17RD9]3EBI-945833,EBI-10239007
LONRF3 [Q496Y0]3EBI-945833,EBI-2690768
LRCH4 [O75427]3EBI-945833,EBI-718707
LRFN4 [Q6PJG9]3EBI-945833,EBI-7910762
MAPKBP1 [O60336]3EBI-945833,EBI-947402
MARK4 [Q6IPE9]3EBI-945833,EBI-10250211
MATN3 [O15232]3EBI-945833,EBI-6262458
MELTF - isoform 2 [P08582-2]3EBI-945833,EBI-10195914
MGC13033 [Q4ZG74]3EBI-945833,EBI-10241963
MRGBP [Q9NV56]3EBI-945833,EBI-399076
MRPL40 [Q9NQ50]3EBI-945833,EBI-1053902
MTA1 [Q13330]3EBI-945833,EBI-714236
MXD3 [Q9BW11]4EBI-945833,EBI-741574
MXI1 - isoform 3 [P50539-3]3EBI-945833,EBI-10211940
NAB2 [Q15742]3EBI-945833,EBI-8641936
NAXD [Q8IW45]3EBI-945833,EBI-8650724
NECTIN2 [Q92692]3EBI-945833,EBI-718419
NECTIN3 [Q9NQS3]4EBI-945833,EBI-2826725
NEU2 [Q9Y3R4]6EBI-945833,EBI-10327976
NMU [P48645]3EBI-945833,EBI-10210351
NPBWR2 [P48146]3EBI-945833,EBI-10210114
NPDC1 [Q9NQX5]3EBI-945833,EBI-748927
NPPB [P16860]4EBI-945833,EBI-747044
NR1D2 [Q6NSM0]4EBI-945833,EBI-10250949
NUBP2 [Q9Y5Y2]3EBI-945833,EBI-1048886
P2RX4 [Q99571]3EBI-945833,EBI-2828248
PCED1A [Q9H1Q7]3EBI-945833,EBI-748452
PCED1B [Q96HM7]3EBI-945833,EBI-1222622
PCSK5 [Q92824]3EBI-945833,EBI-751290
PDE9A [O76083]4EBI-945833,EBI-742764
PID1 [Q7Z2X4]3EBI-945833,EBI-10256685
PIGS [Q96S52]3EBI-945833,EBI-2908273
PLPP2 [O43688]3EBI-945833,EBI-722017
PLSCR4 [Q9NRQ2]5EBI-945833,EBI-769257
POMGNT2 [Q8NAT1]3EBI-945833,EBI-10269044
PRKAA2 [P54646]3EBI-945833,EBI-1383852
PRPF31 [Q8WWY3]6EBI-945833,EBI-1567797
PRPS2 [P11908]3EBI-945833,EBI-4290895
PSMA1 [P25786]3EBI-945833,EBI-359352
PSMG2 [Q969U7]3EBI-945833,EBI-723276
PTGER3 - isoform 12 [P43115-12]3EBI-945833,EBI-10234038
PTPMT1 [Q8WUK0]3EBI-945833,EBI-7199479
PTPN23 [Q9H3S7]4EBI-945833,EBI-724478
PVR [P15151]4EBI-945833,EBI-3919694
R3HDM2 - isoform 2 [Q9Y2K5-2]3EBI-945833,EBI-10326419
RAB3IL1 [Q8TBN0]4EBI-945833,EBI-743796
RAMP3 [O60896]3EBI-945833,EBI-720447
RCHY1 [Q96PM5]4EBI-945833,EBI-947779
RECK [Q6P9E2]3EBI-945833,EBI-10253121
RET [P07949]3EBI-945833,EBI-2480756
RET - isoform 2 [P07949-2]3EBI-945833,EBI-4423689
RGL2 [O15211]3EBI-945833,EBI-712355
RPS28 [P62857]3EBI-945833,EBI-353027
RTN4RL1 [Q86UN2]3EBI-945833,EBI-10258951
SCNM1 [Q9BWG6]3EBI-945833,EBI-748391
SDCBP [O00560]3EBI-945833,EBI-727004
SELENOM [Q8WWX9]3EBI-945833,EBI-10277687
SEMA4C [Q9C0C4]3EBI-945833,EBI-10303490
SHFL [Q9NUL5]3EBI-945833,EBI-10313866
SLC22A23 [A1A5C7]4EBI-945833,EBI-10171756
SLC23A1 [Q9UHI7]3EBI-945833,EBI-1759386
SLC25A10 [Q9UBX3]4EBI-945833,EBI-750394
SLC25A6 [P12236]3EBI-945833,EBI-356254
SLC6A20 [Q9NP91]3EBI-945833,EBI-10311198
SMARCE1 [Q969G3]3EBI-945833,EBI-455078
SMCP [P49901]4EBI-945833,EBI-750494
SMOC1 [Q9H4F8]4EBI-945833,EBI-2801103
SNAI1 [O95863]4EBI-945833,EBI-1045459
SPATA8 [Q6RVD6]3EBI-945833,EBI-8635958
SPG7 [Q9UQ90]3EBI-945833,EBI-717201
SPINK2 [P20155]3EBI-945833,EBI-10200479
SPRY1 [O43609]5EBI-945833,EBI-3866665
STK16 [O75716]3EBI-945833,EBI-749295
TBC1D10C [Q8IV04]3EBI-945833,EBI-10261452
TEDC2 [Q7L2K0]3EBI-945833,EBI-8465456
THAP7 [Q9BT49]4EBI-945833,EBI-741350
THEMIS2 [Q5TEJ8]4EBI-945833,EBI-2806032
TINAGL1 - isoform 3 [Q9GZM7-3]3EBI-945833,EBI-10303636
TLE5 [Q08117]3EBI-945833,EBI-717810
TMEM150A [Q86TG1]3EBI-945833,EBI-2799342
TMEM231 [Q9H6L2]3EBI-945833,EBI-10307654
TMEM41A [Q96HV5]3EBI-945833,EBI-10288884
TNIP3 [Q96KP6]3EBI-945833,EBI-2509913
TNK2 [Q07912]3EBI-945833,EBI-603457
TNP2 [Q4VB56]3EBI-945833,EBI-10241829
TRIM27 [P14373]3EBI-945833,EBI-719493
TRIM42 [Q8IWZ5]6EBI-945833,EBI-5235829
TRPV6 [Q9Y260]3EBI-945833,EBI-750052
TSPAN4 [O14817]4EBI-945833,EBI-8652667
TXNDC5 [Q86UY0]3EBI-945833,EBI-2825190
UTP23 [Q9BRU9]3EBI-945833,EBI-5457544
UXT [Q9UBK9]4EBI-945833,EBI-357355
WDR25 [Q64LD2]3EBI-945833,EBI-744560
WT1-AS [Q06250]3EBI-945833,EBI-10223946
XCL2 [Q9UBD3]3EBI-945833,EBI-10319095
YIPF3 [Q9GZM5]4EBI-945833,EBI-743787
ZFYVE21 [Q9BQ24]3EBI-945833,EBI-2849569
ZNF32 [P17041]3EBI-945833,EBI-1965483
ZNF417 [Q8TAU3]3EBI-945833,EBI-740727
ZNF439 [Q8NDP4]3EBI-945833,EBI-747580
ZNF440 [Q8IYI8]3EBI-945833,EBI-726439
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-945833,EBI-740232
ZNF581 [Q9P0T4]3EBI-945833,EBI-745520
ZNF587 [Q96SQ5]3EBI-945833,EBI-6427977
ZNF688 [A0A0S2Z5X4]3EBI-945833,EBI-16429014
Q5BKY63EBI-945833,EBI-10243533
Q9NWL93EBI-945833,EBI-10315054

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		132802, 363 interactors

Database of interacting proteins

More...DIPi		DIP-47315N

Protein interaction database and analysis system

More...IntActi		Q7Z3S9, 251 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000464060

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z3S9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z3S9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 24EGF-like 1PROSITE-ProRule annotationAdd BLAST24
Domaini25 – 63EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini66 – 104EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini105 – 141EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini143 – 180EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini182 – 219EGF-like 6PROSITE-ProRule annotationAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.Curated

Keywords - Domaini

EGF-like domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1217, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167308

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004826_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z3S9

Identification of Orthologs from Complete Genome Data

More...OMAi		RAGPCHQ

Database of Orthologous Groups

More...OrthoDBi		1033311at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z3S9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 3 hits
PF07645, EGF_CA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 5 hits
SM00179, EGF_CA, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z3S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT 
        60         70         80         90        100
CRCASGFTGE DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG 
       110        120        130        140        150
KECQWTDACL SHPCANGSTC TTVANQFSCK CLTGFTGQKC ETDVNECDIP 
       160        170        180        190        200
GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD SLYVPCAPSP CVNGGTCRQT 
       210        220        230 
GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
Length:236
Mass (Da):25,835
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DF01880A22814C9
GO
Isoform 2 (identifier: Q7Z3S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-236: ETVRRGTELWERDREVWNGKEHDEN → ATWPIFPKLLSLQEKESYC

Show »
Length:230
Mass (Da):24,947
Checksum:i20FEA84A26A5D539
GO
Isoform 3 (identifier: Q7Z3S9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCRDGYEPCVNEGM

Show »
Length:249
Mass (Da):27,289
Checksum:i960F7D405055C9FC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH84572 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11381 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19L → S in BAC11381 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04360167S → P. Corresponds to variant dbSNP:rs10910779Ensembl.1
Natural variantiVAR_043602158T → I1 PublicationCorresponds to variant dbSNP:rs8002Ensembl.1
Natural variantiVAR_043603196T → S. Corresponds to variant dbSNP:rs4649852Ensembl.1
Natural variantiVAR_043604226E → Q. Corresponds to variant dbSNP:rs1053710Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0338951M → MCRDGYEPCVNEGM in isoform 3. 1 Publication1
Alternative sequenceiVSP_033896212 – 236ETVRR…EHDEN → ATWPIFPKLLSLQEKESYC in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK075065 mRNA Translation: BAC11381.1 Different initiation.
BX537434 mRNA Translation: CAD97676.1
AL592307 Genomic DNA Translation: CAH73993.1
AL592307 Genomic DNA Translation: CAH73994.1
BC010154 mRNA Translation: AAH10154.3
BC019835 mRNA Translation: AAH19835.1
BC065219 mRNA Translation: AAH65219.2
BC084572 mRNA Translation: AAH84572.1 Different initiation.
BC090943 mRNA Translation: AAH90943.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS72880.1 [Q7Z3S9-1]

NCBI Reference Sequences

More...RefSeqi		NP_982283.2, NM_203458.4 [Q7Z3S9-1]
XP_006711766.1, XM_006711703.3
XP_006726418.1, XM_006726355.3
XP_016855384.1, XM_016999895.1
XP_016855385.1, XM_016999896.1
XP_016855386.1, XM_016999897.1
XP_016855387.1, XM_016999898.1
XP_016858537.1, XM_017003048.1
XP_016858538.1, XM_017003049.1
XP_016858539.1, XM_017003050.1
XP_016858540.1, XM_017003051.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000362074; ENSP00000354929; ENSG00000264343 [Q7Z3S9-1]
ENST00000579793; ENSP00000476330; ENSG00000264343 [Q7Z3S9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388677

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388677

UCSC genome browser

More...UCSCi		uc031utx.2, human [Q7Z3S9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075065 mRNA Translation: BAC11381.1 Different initiation.
BX537434 mRNA Translation: CAD97676.1
AL592307 Genomic DNA Translation: CAH73993.1
AL592307 Genomic DNA Translation: CAH73994.1
BC010154 mRNA Translation: AAH10154.3
BC019835 mRNA Translation: AAH19835.1
BC065219 mRNA Translation: AAH65219.2
BC084572 mRNA Translation: AAH84572.1 Different initiation.
BC090943 mRNA Translation: AAH90943.1
CCDSiCCDS72880.1 [Q7Z3S9-1]
RefSeqiNP_982283.2, NM_203458.4 [Q7Z3S9-1]
XP_006711766.1, XM_006711703.3
XP_006726418.1, XM_006726355.3
XP_016855384.1, XM_016999895.1
XP_016855385.1, XM_016999896.1
XP_016855386.1, XM_016999897.1
XP_016855387.1, XM_016999898.1
XP_016858537.1, XM_017003048.1
XP_016858538.1, XM_017003049.1
XP_016858539.1, XM_017003050.1
XP_016858540.1, XM_017003051.1

3D structure databases

SMRiQ7Z3S9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132802, 363 interactors
DIPiDIP-47315N
IntActiQ7Z3S9, 251 interactors
STRINGi9606.ENSP00000464060

PTM databases

GlyGeniQ7Z3S9, 1 site

Genetic variation databases

BioMutaiNOTCH2NL
DMDMi74750065

Proteomic databases

EPDiQ7Z3S9
jPOSTiQ7Z3S9
MassIVEiQ7Z3S9
MaxQBiQ7Z3S9
PaxDbiQ7Z3S9
PeptideAtlasiQ7Z3S9
PRIDEiQ7Z3S9
ProteomicsDBi69079 [Q7Z3S9-1]
69080 [Q7Z3S9-2]
69081 [Q7Z3S9-3]
TopDownProteomicsiQ7Z3S9-3 [Q7Z3S9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72493, 61 antibodies

The DNASU plasmid repository

More...DNASUi		388677

Genome annotation databases

EnsembliENST00000362074; ENSP00000354929; ENSG00000264343 [Q7Z3S9-1]
ENST00000579793; ENSP00000476330; ENSG00000264343 [Q7Z3S9-2]
GeneIDi388677
KEGGihsa:388677
UCSCiuc031utx.2, human [Q7Z3S9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388677
DisGeNETi388677

GeneCards: human genes, protein and diseases

More...GeneCardsi		NOTCH2NLA
HGNCiHGNC:31862, NOTCH2NLA
HPAiENSG00000264343, Tissue enhanced (blood)
MIMi618023, gene
neXtProtiNX_Q7Z3S9
OpenTargetsiENSG00000264343
PharmGKBiPA134983899
VEuPathDBiHostDB:ENSG00000264343.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000167308
HOGENOMiCLU_004826_3_0_1
InParanoidiQ7Z3S9
OMAiRAGPCHQ
OrthoDBi1033311at2759
PhylomeDBiQ7Z3S9

Enzyme and pathway databases

PathwayCommonsiQ7Z3S9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100996717, 0 hits in 4 CRISPR screens
100996763, 0 hits in 4 CRISPR screens
388677, 510 hits in 910 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NOTCH2NLB, human
PharosiQ7Z3S9, Tdark

Protein Ontology

More...PROi		PR:Q7Z3S9
RNActiQ7Z3S9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000264343, Expressed in colon and 114 other tissues
ExpressionAtlasiQ7Z3S9, baseline and differential
GenevisibleiQ7Z3S9, HS

Family and domain databases

InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
PfamiView protein in Pfam
PF00008, EGF, 3 hits
PF07645, EGF_CA, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 5 hits
SM00179, EGF_CA, 4 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNT2NA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3S9
Secondary accession number(s): Q5BKT8
, Q5VTG9, Q5XG84, Q6P192, Q8NC23, Q8WUQ9, Q96FY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2003
Last modified: April 7, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again