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Protein

Solute carrier family 46 member 3

Gene

SLC46A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Protein family/group databases

TCDBi2.A.1.50.3 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 46 member 3
Gene namesi
Name:SLC46A3
ORF Names:FKSG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139508.14
HGNCiHGNC:27501 SLC46A3
neXtProtiNX_Q7Z3Q1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 73ExtracellularSequence analysisAdd BLAST48
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 101CytoplasmicSequence analysis7
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Topological domaini125 – 133ExtracellularSequence analysis9
Transmembranei134 – 156HelicalSequence analysisAdd BLAST23
Topological domaini157 – 170CytoplasmicSequence analysisAdd BLAST14
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 197ExtracellularSequence analysis6
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 261CytoplasmicSequence analysisAdd BLAST43
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 294ExtracellularSequence analysisAdd BLAST12
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 324CytoplasmicSequence analysis9
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 347ExtracellularSequence analysis2
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 382CytoplasmicSequence analysisAdd BLAST14
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Topological domaini404 – 415ExtracellularSequence analysisAdd BLAST12
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 461CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139508
PharmGKBiPA162403791

Polymorphism and mutation databases

BioMutaiSLC46A3
DMDMi74723295

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000030725326 – 461Solute carrier family 46 member 3Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ7Z3Q1
MaxQBiQ7Z3Q1
PaxDbiQ7Z3Q1
PeptideAtlasiQ7Z3Q1
PRIDEiQ7Z3Q1
ProteomicsDBi69070
69071 [Q7Z3Q1-2]
69072 [Q7Z3Q1-3]

PTM databases

iPTMnetiQ7Z3Q1
PhosphoSitePlusiQ7Z3Q1

Expressioni

Gene expression databases

BgeeiENSG00000139508 Expressed in 200 organ(s), highest expression level in adrenal tissue
CleanExiHS_SLC46A3
ExpressionAtlasiQ7Z3Q1 baseline and differential
GenevisibleiQ7Z3Q1 HS

Organism-specific databases

HPAiHPA039930

Interactioni

Protein-protein interaction databases

BioGridi129597, 1 interactor
IntActiQ7Z3Q1, 1 interactor
STRINGi9606.ENSP00000370192

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816 Eukaryota
ENOG410ZVCA LUCA
GeneTreeiENSGT00530000063076
HOGENOMiHOG000074207
HOVERGENiHBG108453
InParanoidiQ7Z3Q1
KOiK20840
OMAiYCMEDIY
OrthoDBiEOG091G08MP
PhylomeDBiQ7Z3Q1
TreeFamiTF315701

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z3Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKILFVEPAI FLSAFAMTLT GPLTTQYVYR RIWEETGNYT FSSDSNISEC
60 70 80 90 100
EKNKSSPIFA FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR
110 120 130 140 150
KFPMILSSVG ALATSVWLCL LCYFAFPFQL LIASTFIGAF CGNYTTFWGA
160 170 180 190 200
CFAYIVDQCK EHKQKTIRIA IIDFLLGLVT GLTGLSSGYF IRELGFEWSF
210 220 230 240 250
LIIAVSLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN LFYRTYMLFK
260 270 280 290 300
NASGKRRFLL CLLLFTVITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG
310 320 330 340 350
SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMA MTAFASTTLM
360 370 380 390 400
MFLARVPFLF TIVPFSVLRS MLSKVVRSTE QGTLFACIAF LETLGGVTAV
410 420 430 440 450
STFNGIYSAT VAWYPGFTFL LSAGLLLLPA ISLCVVKCTS WNEGSYELLI
460
QEESSEDASD R
Length:461
Mass (Da):51,519
Last modified:October 1, 2003 - v1
Checksum:iCF1227F889055DE5
GO
Isoform 2 (identifier: Q7Z3Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-461: R → RAC

Show »
Length:463
Mass (Da):51,694
Checksum:i13C80F1227F88905
GO
Isoform 3 (identifier: Q7Z3Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:386
Mass (Da):42,830
Checksum:i4988E4603352A282
GO

Sequence cautioni

The sequence BAC85896 differs from that shown. Reason: Frameshift at position 353.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109V → I in AAH68556 (PubMed:15489334).Curated1
Sequence conflicti126F → L in AAL18405 (Ref. 1) Curated1
Sequence conflicti140F → I in AAL18405 (Ref. 1) Curated1
Sequence conflicti159C → F in AAH36662 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0286481 – 75Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_028649461R → RAC in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315594 mRNA Translation: AAL18405.1
AK124604 mRNA Translation: BAC85896.1 Frameshift.
BX537565 mRNA Translation: CAD97783.1
AL359454 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08436.1
CH471075 Genomic DNA Translation: EAX08438.1
BC036662 mRNA Translation: AAH36662.1
BC060850 mRNA Translation: AAH60850.1
BC068556 mRNA Translation: AAH68556.1
CCDSiCCDS45021.1 [Q7Z3Q1-2]
CCDS9332.1 [Q7Z3Q1-1]
RefSeqiNP_001129391.1, NM_001135919.1 [Q7Z3Q1-2]
NP_001334889.1, NM_001347960.1 [Q7Z3Q1-1]
NP_861450.1, NM_181785.3 [Q7Z3Q1-1]
XP_005266418.1, XM_005266361.2 [Q7Z3Q1-2]
UniGeneiHs.117167

Genome annotation databases

EnsembliENST00000266943; ENSP00000266943; ENSG00000139508 [Q7Z3Q1-1]
ENST00000380814; ENSP00000370192; ENSG00000139508 [Q7Z3Q1-2]
GeneIDi283537
KEGGihsa:283537
UCSCiuc001ush.4 human [Q7Z3Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315594 mRNA Translation: AAL18405.1
AK124604 mRNA Translation: BAC85896.1 Frameshift.
BX537565 mRNA Translation: CAD97783.1
AL359454 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08436.1
CH471075 Genomic DNA Translation: EAX08438.1
BC036662 mRNA Translation: AAH36662.1
BC060850 mRNA Translation: AAH60850.1
BC068556 mRNA Translation: AAH68556.1
CCDSiCCDS45021.1 [Q7Z3Q1-2]
CCDS9332.1 [Q7Z3Q1-1]
RefSeqiNP_001129391.1, NM_001135919.1 [Q7Z3Q1-2]
NP_001334889.1, NM_001347960.1 [Q7Z3Q1-1]
NP_861450.1, NM_181785.3 [Q7Z3Q1-1]
XP_005266418.1, XM_005266361.2 [Q7Z3Q1-2]
UniGeneiHs.117167

3D structure databases

ProteinModelPortaliQ7Z3Q1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129597, 1 interactor
IntActiQ7Z3Q1, 1 interactor
STRINGi9606.ENSP00000370192

Protein family/group databases

TCDBi2.A.1.50.3 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ7Z3Q1
PhosphoSitePlusiQ7Z3Q1

Polymorphism and mutation databases

BioMutaiSLC46A3
DMDMi74723295

Proteomic databases

EPDiQ7Z3Q1
MaxQBiQ7Z3Q1
PaxDbiQ7Z3Q1
PeptideAtlasiQ7Z3Q1
PRIDEiQ7Z3Q1
ProteomicsDBi69070
69071 [Q7Z3Q1-2]
69072 [Q7Z3Q1-3]

Protocols and materials databases

DNASUi283537
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266943; ENSP00000266943; ENSG00000139508 [Q7Z3Q1-1]
ENST00000380814; ENSP00000370192; ENSG00000139508 [Q7Z3Q1-2]
GeneIDi283537
KEGGihsa:283537
UCSCiuc001ush.4 human [Q7Z3Q1-1]

Organism-specific databases

CTDi283537
EuPathDBiHostDB:ENSG00000139508.14
GeneCardsiSLC46A3
HGNCiHGNC:27501 SLC46A3
HPAiHPA039930
neXtProtiNX_Q7Z3Q1
OpenTargetsiENSG00000139508
PharmGKBiPA162403791
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2816 Eukaryota
ENOG410ZVCA LUCA
GeneTreeiENSGT00530000063076
HOGENOMiHOG000074207
HOVERGENiHBG108453
InParanoidiQ7Z3Q1
KOiK20840
OMAiYCMEDIY
OrthoDBiEOG091G08MP
PhylomeDBiQ7Z3Q1
TreeFamiTF315701

Miscellaneous databases

GenomeRNAii283537
PROiPR:Q7Z3Q1

Gene expression databases

BgeeiENSG00000139508 Expressed in 200 organ(s), highest expression level in adrenal tissue
CleanExiHS_SLC46A3
ExpressionAtlasiQ7Z3Q1 baseline and differential
GenevisibleiQ7Z3Q1 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS46A3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Q1
Secondary accession number(s): Q3ZCV8
, Q6NUK5, Q6P9B3, Q6ZVG5, Q96QA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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