The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q7Z3Q1 (S46A3_HUMAN)
Protein
Solute carrier family 46 member 3
Gene
SLC46A3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: FlyBase
GO - Biological processi
- transmembrane transport Source: GO_Central
- vacuolar transmembrane transport Source: FlyBase
Enzyme and pathway databases
PathwayCommonsi | Q7Z3Q1 |
SignaLinki | Q7Z3Q1 |
Protein family/group databases
TCDBi | 2.A.1.50.3, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 46 member 3 |
Gene namesi | Name:SLC46A3 ORF Names:FKSG16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27501, SLC46A3 |
neXtProti | NX_Q7Z3Q1 |
VEuPathDBi | HostDB:ENSG00000139508 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- integral component of lysosomal membrane Source: FlyBase
Other locations
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 73 | ExtracellularSequence analysisAdd BLAST | 48 | |
Transmembranei | 74 – 94 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 101 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 102 – 124 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 125 – 133 | ExtracellularSequence analysis | 9 | |
Transmembranei | 134 – 156 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 157 – 170 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 192 – 197 | ExtracellularSequence analysis | 6 | |
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 261 | CytoplasmicSequence analysisAdd BLAST | 43 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 294 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 295 – 315 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 316 – 324 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 325 – 345 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 346 – 347 | ExtracellularSequence analysis | 2 | |
Transmembranei | 348 – 368 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 369 – 382 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 383 – 403 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 404 – 415 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 416 – 436 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 437 – 461 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 283537 |
OpenTargetsi | ENSG00000139508 |
PharmGKBi | PA162403791 |
Miscellaneous databases
Pharosi | Q7Z3Q1, Tbio |
Genetic variation databases
BioMutai | SLC46A3 |
DMDMi | 74723295 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000307253 | 26 – 461 | Solute carrier family 46 member 3Add BLAST | 436 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q7Z3Q1 |
jPOSTi | Q7Z3Q1 |
MassIVEi | Q7Z3Q1 |
MaxQBi | Q7Z3Q1 |
PaxDbi | Q7Z3Q1 |
PeptideAtlasi | Q7Z3Q1 |
PRIDEi | Q7Z3Q1 |
ProteomicsDBi | 69070 [Q7Z3Q1-1] 69071 [Q7Z3Q1-2] 69072 [Q7Z3Q1-3] |
PTM databases
GlyGeni | Q7Z3Q1, 3 sites |
iPTMneti | Q7Z3Q1 |
PhosphoSitePlusi | Q7Z3Q1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139508, Expressed in adrenal tissue and 212 other tissues |
ExpressionAtlasi | Q7Z3Q1, baseline and differential |
Genevisiblei | Q7Z3Q1, HS |
Organism-specific databases
HPAi | ENSG00000139508, Tissue enhanced (intestine, liver) |
Interactioni
Binary interactionsi
Isoform 2 [Q7Z3Q1-2]
With | #Exp. | IntAct |
---|---|---|
CD79A [P11912] | 3 | EBI-18074862,EBI-7797864 |
Protein-protein interaction databases
BioGRIDi | 129597, 5 interactors |
IntActi | Q7Z3Q1, 2 interactors |
MINTi | Q7Z3Q1 |
STRINGi | 9606.ENSP00000370192 |
Miscellaneous databases
RNActi | Q7Z3Q1, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2816, Eukaryota |
GeneTreei | ENSGT00950000183096 |
HOGENOMi | CLU_028365_1_1_1 |
InParanoidi | Q7Z3Q1 |
OMAi | YCMEDIY |
OrthoDBi | 763423at2759 |
PhylomeDBi | Q7Z3Q1 |
TreeFami | TF315701 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q7Z3Q1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKILFVEPAI FLSAFAMTLT GPLTTQYVYR RIWEETGNYT FSSDSNISEC
60 70 80 90 100
EKNKSSPIFA FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR
110 120 130 140 150
KFPMILSSVG ALATSVWLCL LCYFAFPFQL LIASTFIGAF CGNYTTFWGA
160 170 180 190 200
CFAYIVDQCK EHKQKTIRIA IIDFLLGLVT GLTGLSSGYF IRELGFEWSF
210 220 230 240 250
LIIAVSLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN LFYRTYMLFK
260 270 280 290 300
NASGKRRFLL CLLLFTVITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG
310 320 330 340 350
SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMA MTAFASTTLM
360 370 380 390 400
MFLARVPFLF TIVPFSVLRS MLSKVVRSTE QGTLFACIAF LETLGGVTAV
410 420 430 440 450
STFNGIYSAT VAWYPGFTFL LSAGLLLLPA ISLCVVKCTS WNEGSYELLI
460
QEESSEDASD R
Sequence cautioni
The sequence BAC85896 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | V → I in AAH68556 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 126 | F → L in AAL18405 (Ref. 1) Curated | 1 | |
Sequence conflicti | 140 | F → I in AAL18405 (Ref. 1) Curated | 1 | |
Sequence conflicti | 159 | C → F in AAH36662 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028648 | 1 – 75 | Missing in isoform 3. 1 PublicationAdd BLAST | 75 | |
Alternative sequenceiVSP_028649 | 461 | R → RAC in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF315594 mRNA Translation: AAL18405.1 AK124604 mRNA Translation: BAC85896.1 Frameshift. BX537565 mRNA Translation: CAD97783.1 AL359454 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08436.1 CH471075 Genomic DNA Translation: EAX08438.1 BC036662 mRNA Translation: AAH36662.1 BC060850 mRNA Translation: AAH60850.1 BC068556 mRNA Translation: AAH68556.1 |
CCDSi | CCDS45021.1 [Q7Z3Q1-2] CCDS9332.1 [Q7Z3Q1-1] |
RefSeqi | NP_001129391.1, NM_001135919.1 [Q7Z3Q1-2] NP_001334889.1, NM_001347960.1 [Q7Z3Q1-1] NP_861450.1, NM_181785.3 [Q7Z3Q1-1] XP_005266418.1, XM_005266361.2 [Q7Z3Q1-2] |
Genome annotation databases
Ensembli | ENST00000266943.11; ENSP00000266943.7; ENSG00000139508.15 ENST00000380814.4; ENSP00000370192.4; ENSG00000139508.15 [Q7Z3Q1-2] |
GeneIDi | 283537 |
KEGGi | hsa:283537 |
MANE-Selecti | ENST00000266943.11; ENSP00000266943.7; NM_181785.4; NP_861450.1 |
UCSCi | uc001ush.4, human [Q7Z3Q1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF315594 mRNA Translation: AAL18405.1 AK124604 mRNA Translation: BAC85896.1 Frameshift. BX537565 mRNA Translation: CAD97783.1 AL359454 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08436.1 CH471075 Genomic DNA Translation: EAX08438.1 BC036662 mRNA Translation: AAH36662.1 BC060850 mRNA Translation: AAH60850.1 BC068556 mRNA Translation: AAH68556.1 |
CCDSi | CCDS45021.1 [Q7Z3Q1-2] CCDS9332.1 [Q7Z3Q1-1] |
RefSeqi | NP_001129391.1, NM_001135919.1 [Q7Z3Q1-2] NP_001334889.1, NM_001347960.1 [Q7Z3Q1-1] NP_861450.1, NM_181785.3 [Q7Z3Q1-1] XP_005266418.1, XM_005266361.2 [Q7Z3Q1-2] |
3D structure databases
AlphaFoldDBi | Q7Z3Q1 |
SMRi | Q7Z3Q1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129597, 5 interactors |
IntActi | Q7Z3Q1, 2 interactors |
MINTi | Q7Z3Q1 |
STRINGi | 9606.ENSP00000370192 |
Protein family/group databases
TCDBi | 2.A.1.50.3, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q7Z3Q1, 3 sites |
iPTMneti | Q7Z3Q1 |
PhosphoSitePlusi | Q7Z3Q1 |
Genetic variation databases
BioMutai | SLC46A3 |
DMDMi | 74723295 |
Proteomic databases
EPDi | Q7Z3Q1 |
jPOSTi | Q7Z3Q1 |
MassIVEi | Q7Z3Q1 |
MaxQBi | Q7Z3Q1 |
PaxDbi | Q7Z3Q1 |
PeptideAtlasi | Q7Z3Q1 |
PRIDEi | Q7Z3Q1 |
ProteomicsDBi | 69070 [Q7Z3Q1-1] 69071 [Q7Z3Q1-2] 69072 [Q7Z3Q1-3] |
Protocols and materials databases
Antibodypediai | 7527, 62 antibodies from 17 providers |
DNASUi | 283537 |
Genome annotation databases
Ensembli | ENST00000266943.11; ENSP00000266943.7; ENSG00000139508.15 ENST00000380814.4; ENSP00000370192.4; ENSG00000139508.15 [Q7Z3Q1-2] |
GeneIDi | 283537 |
KEGGi | hsa:283537 |
MANE-Selecti | ENST00000266943.11; ENSP00000266943.7; NM_181785.4; NP_861450.1 |
UCSCi | uc001ush.4, human [Q7Z3Q1-1] |
Organism-specific databases
CTDi | 283537 |
DisGeNETi | 283537 |
GeneCardsi | SLC46A3 |
HGNCi | HGNC:27501, SLC46A3 |
HPAi | ENSG00000139508, Tissue enhanced (intestine, liver) |
neXtProti | NX_Q7Z3Q1 |
OpenTargetsi | ENSG00000139508 |
PharmGKBi | PA162403791 |
VEuPathDBi | HostDB:ENSG00000139508 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2816, Eukaryota |
GeneTreei | ENSGT00950000183096 |
HOGENOMi | CLU_028365_1_1_1 |
InParanoidi | Q7Z3Q1 |
OMAi | YCMEDIY |
OrthoDBi | 763423at2759 |
PhylomeDBi | Q7Z3Q1 |
TreeFami | TF315701 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z3Q1 |
SignaLinki | Q7Z3Q1 |
Miscellaneous databases
BioGRID-ORCSi | 283537, 9 hits in 1069 CRISPR screens |
ChiTaRSi | SLC46A3, human |
GenomeRNAii | 283537 |
Pharosi | Q7Z3Q1, Tbio |
PROi | PR:Q7Z3Q1 |
RNActi | Q7Z3Q1, protein |
Gene expression databases
Bgeei | ENSG00000139508, Expressed in adrenal tissue and 212 other tissues |
ExpressionAtlasi | Q7Z3Q1, baseline and differential |
Genevisiblei | Q7Z3Q1, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S46A3_HUMAN | |
Accessioni | Q7Z3Q1Primary (citable) accession number: Q7Z3Q1 Secondary accession number(s): Q3ZCV8 Q96QA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families