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UniProtKB - Q7Z3Q1 (S46A3_HUMAN)

Entry version 130 (25 May 2022)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

Solute carrier family 46 member 3

Gene

SLC46A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z3Q1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q7Z3Q1

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.50.3, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 46 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC46A3
ORF Names:FKSG16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27501, SLC46A3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z3Q1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000139508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 73ExtracellularSequence analysisAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 101CytoplasmicSequence analysis7
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Topological domaini125 – 133ExtracellularSequence analysis9
Transmembranei134 – 156HelicalSequence analysisAdd BLAST23
Topological domaini157 – 170CytoplasmicSequence analysisAdd BLAST14
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 197ExtracellularSequence analysis6
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 261CytoplasmicSequence analysisAdd BLAST43
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 294ExtracellularSequence analysisAdd BLAST12
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 324CytoplasmicSequence analysis9
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 347ExtracellularSequence analysis2
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 382CytoplasmicSequence analysisAdd BLAST14
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Topological domaini404 – 415ExtracellularSequence analysisAdd BLAST12
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 461CytoplasmicSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		283537

Open Targets

More...OpenTargetsi		ENSG00000139508

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162403791

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z3Q1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC46A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74723295

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030725326 – 461Solute carrier family 46 member 3Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z3Q1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z3Q1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z3Q1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z3Q1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z3Q1

PeptideAtlas

More...PeptideAtlasi		Q7Z3Q1

PRoteomics IDEntifications database

More...PRIDEi		Q7Z3Q1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69070 [Q7Z3Q1-1]
69071 [Q7Z3Q1-2]
69072 [Q7Z3Q1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7Z3Q1, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z3Q1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z3Q1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000139508, Expressed in adrenal tissue and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z3Q1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z3Q1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000139508, Tissue enhanced (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129597, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z3Q1, 2 interactors

Molecular INTeraction database

More...MINTi		Q7Z3Q1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370192

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z3Q1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q7Z3Q1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z3Q1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. SLC46A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2816, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183096

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_028365_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z3Q1

Identification of Orthologs from Complete Genome Data

More...OMAi		YCMEDIY

Database of Orthologous Groups

More...OrthoDBi		763423at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z3Q1

TreeFam database of animal gene trees

More...TreeFami		TF315701

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z3Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKILFVEPAI FLSAFAMTLT GPLTTQYVYR RIWEETGNYT FSSDSNISEC 
        60         70         80         90        100
EKNKSSPIFA FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR 
       110        120        130        140        150
KFPMILSSVG ALATSVWLCL LCYFAFPFQL LIASTFIGAF CGNYTTFWGA 
       160        170        180        190        200
CFAYIVDQCK EHKQKTIRIA IIDFLLGLVT GLTGLSSGYF IRELGFEWSF 
       210        220        230        240        250
LIIAVSLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN LFYRTYMLFK 
       260        270        280        290        300
NASGKRRFLL CLLLFTVITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG 
       310        320        330        340        350
SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMA MTAFASTTLM 
       360        370        380        390        400
MFLARVPFLF TIVPFSVLRS MLSKVVRSTE QGTLFACIAF LETLGGVTAV 
       410        420        430        440        450
STFNGIYSAT VAWYPGFTFL LSAGLLLLPA ISLCVVKCTS WNEGSYELLI 
       460 
QEESSEDASD R
Length:461
Mass (Da):51,519
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF1227F889055DE5
GO
Isoform 2 (identifier: Q7Z3Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-461: R → RAC

Show »
Length:463
Mass (Da):51,694
Checksum:i13C80F1227F88905
GO
Isoform 3 (identifier: Q7Z3Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:386
Mass (Da):42,830
Checksum:i4988E4603352A282
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85896 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109V → I in AAH68556 (PubMed:15489334).Curated1
Sequence conflicti126F → L in AAL18405 (Ref. 1) Curated1
Sequence conflicti140F → I in AAL18405 (Ref. 1) Curated1
Sequence conflicti159C → F in AAH36662 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0286481 – 75Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_028649461R → RAC in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF315594 mRNA Translation: AAL18405.1
AK124604 mRNA Translation: BAC85896.1 Frameshift.
BX537565 mRNA Translation: CAD97783.1
AL359454 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08436.1
CH471075 Genomic DNA Translation: EAX08438.1
BC036662 mRNA Translation: AAH36662.1
BC060850 mRNA Translation: AAH60850.1
BC068556 mRNA Translation: AAH68556.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45021.1 [Q7Z3Q1-2]
CCDS9332.1 [Q7Z3Q1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001129391.1, NM_001135919.1 [Q7Z3Q1-2]
NP_001334889.1, NM_001347960.1 [Q7Z3Q1-1]
NP_861450.1, NM_181785.3 [Q7Z3Q1-1]
XP_005266418.1, XM_005266361.2 [Q7Z3Q1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000266943.11; ENSP00000266943.7; ENSG00000139508.15
ENST00000380814.4; ENSP00000370192.4; ENSG00000139508.15 [Q7Z3Q1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		283537

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:283537

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000266943.11; ENSP00000266943.7; NM_181785.4; NP_861450.1

UCSC genome browser

More...UCSCi		uc001ush.4, human [Q7Z3Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315594 mRNA Translation: AAL18405.1
AK124604 mRNA Translation: BAC85896.1 Frameshift.
BX537565 mRNA Translation: CAD97783.1
AL359454 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08436.1
CH471075 Genomic DNA Translation: EAX08438.1
BC036662 mRNA Translation: AAH36662.1
BC060850 mRNA Translation: AAH60850.1
BC068556 mRNA Translation: AAH68556.1
CCDSiCCDS45021.1 [Q7Z3Q1-2]
CCDS9332.1 [Q7Z3Q1-1]
RefSeqiNP_001129391.1, NM_001135919.1 [Q7Z3Q1-2]
NP_001334889.1, NM_001347960.1 [Q7Z3Q1-1]
NP_861450.1, NM_181785.3 [Q7Z3Q1-1]
XP_005266418.1, XM_005266361.2 [Q7Z3Q1-2]

3D structure databases

AlphaFoldDBiQ7Z3Q1
SMRiQ7Z3Q1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129597, 5 interactors
IntActiQ7Z3Q1, 2 interactors
MINTiQ7Z3Q1
STRINGi9606.ENSP00000370192

Protein family/group databases

TCDBi2.A.1.50.3, the major facilitator superfamily (mfs)

PTM databases

GlyGeniQ7Z3Q1, 3 sites
iPTMnetiQ7Z3Q1
PhosphoSitePlusiQ7Z3Q1

Genetic variation databases

BioMutaiSLC46A3
DMDMi74723295

Proteomic databases

EPDiQ7Z3Q1
jPOSTiQ7Z3Q1
MassIVEiQ7Z3Q1
MaxQBiQ7Z3Q1
PaxDbiQ7Z3Q1
PeptideAtlasiQ7Z3Q1
PRIDEiQ7Z3Q1
ProteomicsDBi69070 [Q7Z3Q1-1]
69071 [Q7Z3Q1-2]
69072 [Q7Z3Q1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7527, 62 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		283537

Genome annotation databases

EnsembliENST00000266943.11; ENSP00000266943.7; ENSG00000139508.15
ENST00000380814.4; ENSP00000370192.4; ENSG00000139508.15 [Q7Z3Q1-2]
GeneIDi283537
KEGGihsa:283537
MANE-SelectiENST00000266943.11; ENSP00000266943.7; NM_181785.4; NP_861450.1
UCSCiuc001ush.4, human [Q7Z3Q1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		283537
DisGeNETi283537

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC46A3
HGNCiHGNC:27501, SLC46A3
HPAiENSG00000139508, Tissue enhanced (intestine, liver)
neXtProtiNX_Q7Z3Q1
OpenTargetsiENSG00000139508
PharmGKBiPA162403791
VEuPathDBiHostDB:ENSG00000139508

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2816, Eukaryota
GeneTreeiENSGT00950000183096
HOGENOMiCLU_028365_1_1_1
InParanoidiQ7Z3Q1
OMAiYCMEDIY
OrthoDBi763423at2759
PhylomeDBiQ7Z3Q1
TreeFamiTF315701

Enzyme and pathway databases

PathwayCommonsiQ7Z3Q1
SignaLinkiQ7Z3Q1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		283537, 9 hits in 1069 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC46A3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		283537
PharosiQ7Z3Q1, Tbio

Protein Ontology

More...PROi		PR:Q7Z3Q1
RNActiQ7Z3Q1, protein

Gene expression databases

BgeeiENSG00000139508, Expressed in adrenal tissue and 212 other tissues
ExpressionAtlasiQ7Z3Q1, baseline and differential
GenevisibleiQ7Z3Q1, HS

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS46A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3Q1
Secondary accession number(s): Q3ZCV8
, Q6NUK5, Q6P9B3, Q6ZVG5, Q96QA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2003
Last modified: May 25, 2022
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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