UniProtKB - Q7Z3K3 (POGZ_HUMAN)
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- BLAST>sp|Q7Z3K3|POGZ_HUMAN Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2 MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTVSVSQQPVSAPVPIAAHAS VAGHLSTSTTVSSSGAQNSDSTKKTLVTLIANNNAGNPLVQQGGQPLILTQNPAPGLGTM VTQPVLRPVQVMQNANHVTSSPVASQPIFITTQGFPVRNVRPVQNAMNQVGIVLNVQQGQ TVRPITLVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTMPVRPTTNTFTTVIPATLTIRST VPQSQSQQTKSTPSTSTTPTATQPTSLGQLAVQSPGQSNQTTNPKLAPSFPSPPAVSIAS FVTVKRPGVTGENSNEVAKLVNTLNTIPSLGQSPGPVVVSNNSSAHGSQRTSGPESSMKV TSSIPVFDLQDGGRKICPRCNAQFRVTEALRGHMCYCCPEMVEYQKKGKSLDSEPSVPSA AKPPSPEKTAPVASTPSSTPIPALSPPTKVPEPNENVGDAVQTKLIMLVDDFYYGRDGGK VAQLTNFPKVATSFRCPHCTKRLKNNIRFMNHMKHHVELDQQNGEVDGHTICQHCYRQFS TPFQLQCHLENVHSPYESTTKCKICEWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSS LYSEVDVHFRMIHEDTRHLLCPYCLKVFKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAK DKIEHKLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPRTVPVSSNDTPPSALQEAAPLTS SMDPLPVFLYPPVQRSIQKRAVRKMSVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYST CCSRAYANHMINNHVPRKSPKYLALFKNSVSGIKLACTSCTFVTSVGDAMAKHLVFNPSH RSSSILPRGLTWIAHSRHGQTRDRVHDRNVKNMYPPPSFPTNKAATVKSAGATPAEPEEL LTPLAPALPSPASTATPPPTPTHPQALALPPLATEGAECLNVDDQDEGSPVTQEPELASG GGGSGGVGKKEQLSVKKLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEG KYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLEGGFKISYEWAVRFMLRHH LTPHARRAVAHTLPKDVAENAGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSD DRKENALQTVGTGEPWCDVVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKESGYS DDEIMELWSTRVWQKHTACQRSKGMLVMDCHRTHLSEEVLAMLSASSTLPAVVPAGCSSK IQPLDVCIKRTVKNFLHKKWKEQAREMADTACDSDVLLQLVLVWLGEVLGVIGDCPELVQ RSFLVASVLPGPDGNINSPTRNADMQEELIASLEEQLKLSGEHSESSTPRPRSSPEETIE PESLHQLFEGESETESFYGFEEADLDLMEI
- Align
Protein
Pogo transposable element with ZNF domain
Gene
POGZ
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.14"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."
Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C.
Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH CBX1; CBX3 AND CBX5, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-817; CYS-820; HIS-833 AND HIS-840.
Regions
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 375 – 397 | C2H2-type 1; atypicalPROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 23 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 494 – 516 | C2H2-type 2PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 23 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 530 – 553 | C2H2-type 3PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 560 – 583 | C2H2-type 4PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 590 – 613 | C2H2-type 5PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 619 – 641 | C2H2-type 6PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 23 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 647 – 670 | C2H2-type 7PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 771 – 794 | C2H2-type 8PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 815 – 840 | C2H2-type 9PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 26 |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- cell division Source: UniProtKB-KW
- kinetochore assembly Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- mitotic sister chromatid cohesion Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division |
| Ligand | Metal-binding, Zinc |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Pogo transposable element with ZNF domainAlternative name(s): Suppressor of hairy wing homolog 5 Zinc finger protein 280E Zinc finger protein 635 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:POGZ Synonyms:KIAA0461, SUHW5, ZNF280E, ZNF635 ORF Names:Nbla00003 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Eukaryotic Pathogen Database Resources More...EuPathDBi | HostDB:ENSG00000143442.21 |
Human Gene Nomenclature Database More...HGNCi | HGNC:18801 POGZ |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 614787 gene |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q7Z3K3 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Nucleus
Other locations
Note: According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).1 Publication- Ref.11"Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ."
Bartholomeeusen K., Christ F., Hendrix J., Rain J.C., Emiliani S., Benarous R., Debyser Z., Gijsbers R., De Rijck J.
J. Biol. Chem. 284:11467-11477(2009) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PSIP1.
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- nucleoplasm Source: HPA
- nucleus Source: HPA
Other locations
- cytoplasm Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Chromosome, Cytoplasm, Nucleus<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei
Defects in POGZ may be associated with neuropsychiatric disorders such as autism spectrum disorders (ASD), bipolar affective disorders and early dementia onset. ASD are characterized by impairments in reciprocal social interaction and communication as well as restricted and stereotyped patterns of interest and activities. ASD include forms with moderate to severe cognitive impairment and milder forms with higher cognitive ability (Asperger syndrome).1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.23"A case of autism spectrum disorder arising from a de novo missense mutation in POGZ."
Fukai R., Hiraki Y., Yofune H., Tsurusaki Y., Nakashima M., Saitsu H., Tanaka F., Miyake N., Matsumoto N.
J. Hum. Genet. 60:277-279(2015) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT LYS-1040, INVOLVEMENT IN AUTISM.
White-Sutton syndrome (WHSUS)2 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More...</a></p>
Manual assertion based on experiment ini
- Ref.19"Large-scale discovery of novel genetic causes of developmental disorders."
Deciphering Developmental Disorders Study
Nature 519:223-228(2015) [PubMed] [Europe PMC] [Abstract]Cited for: INVOLVEMENT IN WHSUS. - Ref.20"POGZ truncating alleles cause syndromic intellectual disability."
White J., Beck C.R., Harel T., Posey J.E., Jhangiani S.N., Tang S., Farwell K.D., Powis Z., Mendelsohn N.J., Baker J.A., Pollack L., Mason K.J., Wierenga K.J., Arrington D.K., Hall M., Psychogios A., Fairbrother L., Walkiewicz M. , Person R.E., Niu Z., Zhang J., Rosenfeld J.A., Muzny D.M., Eng C., Beaudet A.L., Lupski J.R., Boerwinkle E., Gibbs R.A., Yang Y., Xia F., Sutton V.R.
Genome Med. 8:3-3(2016) [PubMed] [Europe PMC] [Abstract]Cited for: INVOLVEMENT IN WHSUS.
Ref.19
"Large-scale discovery of novel genetic causes of developmental disorders."
Deciphering Developmental Disorders Study
Nature 519:223-228(2015) [PubMed] [Europe PMC] [Abstract]
Deciphering Developmental Disorders Study
Nature 519:223-228(2015) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN WHSUS.
Ref.20
"POGZ truncating alleles cause syndromic intellectual disability."
White J., Beck C.R., Harel T., Posey J.E., Jhangiani S.N., Tang S., Farwell K.D., Powis Z., Mendelsohn N.J., Baker J.A., Pollack L., Mason K.J., Wierenga K.J., Arrington D.K., Hall M., Psychogios A., Fairbrother L., Walkiewicz M. , Person R.E., Niu Z., Zhang J., Rosenfeld J.A., Muzny D.M., Eng C., Beaudet A.L., Lupski J.R., Boerwinkle E., Gibbs R.A., Yang Y., Xia F., Sutton V.R.
Genome Med. 8:3-3(2016) [PubMed] [Europe PMC] [Abstract]
White J., Beck C.R., Harel T., Posey J.E., Jhangiani S.N., Tang S., Farwell K.D., Powis Z., Mendelsohn N.J., Baker J.A., Pollack L., Mason K.J., Wierenga K.J., Arrington D.K., Hall M., Psychogios A., Fairbrother L., Walkiewicz M. , Person R.E., Niu Z., Zhang J., Rosenfeld J.A., Muzny D.M., Eng C., Beaudet A.L., Lupski J.R., Boerwinkle E., Gibbs R.A., Yang Y., Xia F., Sutton V.R.
Genome Med. 8:3-3(2016) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN WHSUS.
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by developmental delay, intellectual disability, hypotonia, behavioral abnormalities, and dysmorphic facial features. Variable features include short stature, microcephaly, strabismus and hearing loss.
See also OMIM:616364Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 817 | C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 820 | C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 833 | H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 840 | H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei
Autism spectrum disorder, Disease mutation, Mental retardationOrganism-specific databases
DisGeNET More...DisGeNETi | 23126 |
MalaCards human disease database More...MalaCardsi | POGZ |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 616364 phenotype |
Open Targets More...OpenTargetsi | ENSG00000143442 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA38685 |
Polymorphism and mutation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | POGZ |
Domain mapping of disease mutations (DMDM) More...DMDMi | 143811442 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000047224 | 1 – 1410 | Pogo transposable element with ZNF domainAdd BLAST | 1410 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 319 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 333 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 359 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 363 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 422 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 425 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 439 | PhosphothreonineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 445 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 449 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 463 | PhosphothreonineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 489 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 629 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 677 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 801 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 856 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 883 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| ||
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1338 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1364 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1367 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1368 | PhosphothreonineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1392 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
Encyclopedia of Proteome Dynamics More...EPDi | Q7Z3K3 |
MaxQB - The MaxQuant DataBase More...MaxQBi | Q7Z3K3 |
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q7Z3K3 |
PeptideAtlas More...PeptideAtlasi | Q7Z3K3 |
PRoteomics IDEntifications database More...PRIDEi | Q7Z3K3 |
ProteomicsDB human proteome resource More...ProteomicsDBi | 69059 69060 [Q7Z3K3-2] 69061 [Q7Z3K3-3] 69062 [Q7Z3K3-4] 69063 [Q7Z3K3-5] |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q7Z3K3 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q7Z3K3 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000143442 |
CleanEx database of gene expression profiles More...CleanExi | HS_POGZ |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q7Z3K3 baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q7Z3K3 HS |
Organism-specific databases
Human Protein Atlas More...HPAi | HPA006800 HPA008781 |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1.4 Publications
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.6"A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
Gunther M., Laithier M., Brison O.
Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-788 (ISOFORM 1), INTERACTION WITH SP1. - Ref.11"Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ."
Bartholomeeusen K., Christ F., Hendrix J., Rain J.C., Emiliani S., Benarous R., Debyser Z., Gijsbers R., De Rijck J.
J. Biol. Chem. 284:11467-11477(2009) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PSIP1. - Ref.13"Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."
Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S., Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G., Mann M.
Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CHAMP1; MAD2L2; CBX1; CBX3 AND CBX5. - Ref.14"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."
Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C.
Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH CBX1; CBX3 AND CBX5, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-817; CYS-820; HIS-833 AND HIS-840.
<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 116745, 55 interactors |
Database of interacting proteins More...DIPi | DIP-38044N |
Protein interaction database and analysis system More...IntActi | Q7Z3K3, 148 interactors |
Molecular INTeraction database More...MINTi | Q7Z3K3 |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000271715 |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsHide details| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code ‘T’.<p><a href='/help/turn' target='_top'>More...</a></p>Turni | 378 – 380 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 387 – 397 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 11 | |
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code ‘T’.<p><a href='/help/turn' target='_top'>More...</a></p>Turni | 399 – 401 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 3 |
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q7Z3K3 |
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q7Z3K3 |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
Miscellaneous databases
Relative evolutionary importance of amino acids within a protein sequence More...EvolutionaryTracei | Q7Z3K3 |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 1015 – 1085 | HTH CENPB-typePROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 71 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 1117 – 1323 | DDE-1Sequence analysisAdd BLAST | 207 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 810 – 850 | Required for interaction with CBX5Add BLAST | 41 |
Coiled coil
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili | 1340 – 1360 | Sequence analysisAdd BLAST | 21 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 875 – 931 | Pro-richAdd BLAST | 57 |
Zinc finger
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 375 – 397 | C2H2-type 1; atypicalPROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 23 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 494 – 516 | C2H2-type 2PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 23 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 530 – 553 | C2H2-type 3PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 560 – 583 | C2H2-type 4PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 590 – 613 | C2H2-type 5PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 619 – 641 | C2H2-type 6PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 23 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 647 – 670 | C2H2-type 7PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 771 – 794 | C2H2-type 8PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 24 | |
| <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri | 815 – 840 | C2H2-type 9PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 26 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG1721 Eukaryota KOG3105 Eukaryota COG5048 LUCA |
Ensembl GeneTree More...GeneTreei | ENSGT00530000063300 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | HOG000010309 |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG049435 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q7Z3K3 |
KEGG Orthology (KO) More...KOi | K22594 |
Identification of Orthologs from Complete Genome Data More...OMAi | GLTWISH |
Database of Orthologous Groups More...OrthoDBi | EOG091G01UE |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q7Z3K3 |
TreeFam database of animal gene trees More...TreeFami | TF331707 |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfam protein domain database More...Pfami | View protein in Pfam PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM00674 CENPB, 1 hit SM00355 ZnF_C2H2, 8 hits |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF46689 SSF46689, 1 hit SSF57667 SSF57667, 2 hits |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basket
Isoform 1 (identifier: Q7Z3K3-1) [UniParc]FASTAAdd to basketAdded to basketShow »
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR
360 370 380 390 400
TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE
410 420 430 440 450
MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV
460 470 480 490 500
PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT
510 520 530 540 550
KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE
560 570 580 590 600
NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS
610 620 630 640 650
LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN
660 670 680 690 700
KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV
710 720 730 740 750
PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR
760 770 780 790 800
QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP
810 820 830 840 850
KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL
860 870 880 890 900
TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL
910 920 930 940 950
LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP
960 970 980 990 1000
VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ
1010 1020 1030 1040 1050
RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL
1060 1070 1080 1090 1100
FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN
1110 1120 1130 1140 1150
AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV
1160 1170 1180 1190 1200
GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS
1210 1220 1230 1240 1250
DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP
1260 1270 1280 1290 1300
AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL
1310 1320 1330 1340 1350
VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI
1360 1370 1380 1390 1400
ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF
1410
EEADLDLMEI
Length:1,410
Mass (Da):155,344
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i58F672EDCD57CCD8
Isoform 2 (identifier: Q7Z3K3-2) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
42-94: Missing.
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TAGNPLVQQG
60 70 80 90 100
GQPLILTQNP APGLGTMVTQ PVLRPVQVMQ NANHVTSSPV ASQPIFITTQ
110 120 130 140 150
GFPVRNVRPV QNAMNQVGIV LNVQQGQTVR PITLVPAPGT QFVKPTVGVP
160 170 180 190 200
QVFSQMTPVR PGSTMPVRPT TNTFTTVIPA TLTIRSTVPQ SQSQQTKSTP
210 220 230 240 250
STSTTPTATQ PTSLGQLAVQ SPGQSNQTTN PKLAPSFPSP PAVSIASFVT
260 270 280 290 300
VKRPGVTGEN SNEVAKLVNT LNTIPSLGQS PGPVVVSNNS SAHGSQRTSG
310 320 330 340 350
PESSMKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE
360 370 380 390 400
YQKKGKSLDS EPSVPSAAKP PSPEKTAPVA STPSSTPIPA LSPPTKVPEP
410 420 430 440 450
NENVGDAVQT KLIMLVDDFY YGRDGGKVAQ LTNFPKVATS FRCPHCTKRL
460 470 480 490 500
KNNIRFMNHM KHHVELDQQN GEVDGHTICQ HCYRQFSTPF QLQCHLENVH
510 520 530 540 550
SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ VCQYRSSLYS
560 570 580 590 600
EVDVHFRMIH EDTRHLLCPY CLKVFKNGNA FQQHYMRHQK RNVYHCNKCR
610 620 630 640 650
LQFLFAKDKI EHKLQHHKTF RKPKQLEGLK PGTKVTIRAS RGQPRTVPVS
660 670 680 690 700
SNDTPPSALQ EAAPLTSSMD PLPVFLYPPV QRSIQKRAVR KMSVMGRQTC
710 720 730 740 750
LECSFEIPDF PNHFPTYVHC SLCRYSTCCS RAYANHMINN HVPRKSPKYL
760 770 780 790 800
ALFKNSVSGI KLACTSCTFV TSVGDAMAKH LVFNPSHRSS SILPRGLTWI
810 820 830 840 850
AHSRHGQTRD RVHDRNVKNM YPPPSFPTNK AATVKSAGAT PAEPEELLTP
860 870 880 890 900
LAPALPSPAS TATPPPTPTH PQALALPPLA TEGAECLNVD DQDEGSPVTQ
910 920 930 940 950
EPELASGGGG SGGVGKKEQL SVKKLRVVLF ALCCNTEQAA EHFRNPQRRI
960 970 980 990 1000
RRWLRRFQAS QGENLEGKYL SFEAEEKLAE WVLTQREQQL PVNEETLFQK
1010 1020 1030 1040 1050
ATKIGRSLEG GFKISYEWAV RFMLRHHLTP HARRAVAHTL PKDVAENAGL
1060 1070 1080 1090 1100
FIDFVQRQIH NQDLPLSMIV AIDEISLFLD TEVLSSDDRK ENALQTVGTG
1110 1120 1130 1140 1150
EPWCDVVLAI LADGTVLPTL VFYRGQMDQP ANMPDSILLE AKESGYSDDE
1160 1170 1180 1190 1200
IMELWSTRVW QKHTACQRSK GMLVMDCHRT HLSEEVLAML SASSTLPAVV
1210 1220 1230 1240 1250
PAGCSSKIQP LDVCIKRTVK NFLHKKWKEQ AREMADTACD SDVLLQLVLV
1260 1270 1280 1290 1300
WLGEVLGVIG DCPELVQRSF LVASVLPGPD GNINSPTRNA DMQEELIASL
1310 1320 1330 1340 1350
EEQLKLSGEH SESSTPRPRS SPEETIEPES LHQLFEGESE TESFYGFEEA
DLDLMEI
Note: No experimental confirmation available.
Show »Length:1,357
Mass (Da):150,130
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i3EC92965C8E95A98
Isoform 3 (identifier: Q7Z3K3-3) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
42-94: Missing.
593-593: Q → QPYFPSYVTQ
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TAGNPLVQQG
60 70 80 90 100
GQPLILTQNP APGLGTMVTQ PVLRPVQVMQ NANHVTSSPV ASQPIFITTQ
110 120 130 140 150
GFPVRNVRPV QNAMNQVGIV LNVQQGQTVR PITLVPAPGT QFVKPTVGVP
160 170 180 190 200
QVFSQMTPVR PGSTMPVRPT TNTFTTVIPA TLTIRSTVPQ SQSQQTKSTP
210 220 230 240 250
STSTTPTATQ PTSLGQLAVQ SPGQSNQTTN PKLAPSFPSP PAVSIASFVT
260 270 280 290 300
VKRPGVTGEN SNEVAKLVNT LNTIPSLGQS PGPVVVSNNS SAHGSQRTSG
310 320 330 340 350
PESSMKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE
360 370 380 390 400
YQKKGKSLDS EPSVPSAAKP PSPEKTAPVA STPSSTPIPA LSPPTKVPEP
410 420 430 440 450
NENVGDAVQT KLIMLVDDFY YGRDGGKVAQ LTNFPKVATS FRCPHCTKRL
460 470 480 490 500
KNNIRFMNHM KHHVELDQQN GEVDGHTICQ HCYRQFSTPF QLQCHLENVH
510 520 530 540 550
SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ PYFPSYVTQV
560 570 580 590 600
CQYRSSLYSE VDVHFRMIHE DTRHLLCPYC LKVFKNGNAF QQHYMRHQKR
610 620 630 640 650
NVYHCNKCRL QFLFAKDKIE HKLQHHKTFR KPKQLEGLKP GTKVTIRASR
660 670 680 690 700
GQPRTVPVSS NDTPPSALQE AAPLTSSMDP LPVFLYPPVQ RSIQKRAVRK
710 720 730 740 750
MSVMGRQTCL ECSFEIPDFP NHFPTYVHCS LCRYSTCCSR AYANHMINNH
760 770 780 790 800
VPRKSPKYLA LFKNSVSGIK LACTSCTFVT SVGDAMAKHL VFNPSHRSSS
810 820 830 840 850
ILPRGLTWIA HSRHGQTRDR VHDRNVKNMY PPPSFPTNKA ATVKSAGATP
860 870 880 890 900
AEPEELLTPL APALPSPAST ATPPPTPTHP QALALPPLAT EGAECLNVDD
910 920 930 940 950
QDEGSPVTQE PELASGGGGS GGVGKKEQLS VKKLRVVLFA LCCNTEQAAE
960 970 980 990 1000
HFRNPQRRIR RWLRRFQASQ GENLEGKYLS FEAEEKLAEW VLTQREQQLP
1010 1020 1030 1040 1050
VNEETLFQKA TKIGRSLEGG FKISYEWAVR FMLRHHLTPH ARRAVAHTLP
1060 1070 1080 1090 1100
KDVAENAGLF IDFVQRQIHN QDLPLSMIVA IDEISLFLDT EVLSSDDRKE
1110 1120 1130 1140 1150
NALQTVGTGE PWCDVVLAIL ADGTVLPTLV FYRGQMDQPA NMPDSILLEA
1160 1170 1180 1190 1200
KESGYSDDEI MELWSTRVWQ KHTACQRSKG MLVMDCHRTH LSEEVLAMLS
1210 1220 1230 1240 1250
ASSTLPAVVP AGCSSKIQPL DVCIKRTVKN FLHKKWKEQA REMADTACDS
1260 1270 1280 1290 1300
DVLLQLVLVW LGEVLGVIGD CPELVQRSFL VASVLPGPDG NINSPTRNAD
1310 1320 1330 1340 1350
MQEELIASLE EQLKLSGEHS ESSTPRPRSS PEETIEPESL HQLFEGESET
1360
ESFYGFEEAD LDLMEI
Note: No experimental confirmation available.
Show »Length:1,366
Mass (Da):151,213
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iC88635F4469B70AA
Isoform 4 (identifier: Q7Z3K3-4) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
360-363: VTSS → GTIT
364-1410: Missing.
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR
360
TSGPESSMKG TIT
Note: No experimental confirmation available.
Show »Length:363
Mass (Da):37,882
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iE4CA34C166CC3E78
Isoform 5 (identifier: Q7Z3K3-5) [UniParc]FASTAAdd to basketAdded to basket
Also known as: CRA_e
The sequence of this isoform differs from the canonical sequence as follows:
96-190: Missing.
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAPGTQF
110 120 130 140 150
VKPTVGVPQV FSQMTPVRPG STMPVRPTTN TFTTVIPATL TIRSTVPQSQ
160 170 180 190 200
SQQTKSTPST STTPTATQPT SLGQLAVQSP GQSNQTTNPK LAPSFPSPPA
210 220 230 240 250
VSIASFVTVK RPGVTGENSN EVAKLVNTLN TIPSLGQSPG PVVVSNNSSA
260 270 280 290 300
HGSQRTSGPE SSMKVTSSIP VFDLQDGGRK ICPRCNAQFR VTEALRGHMC
310 320 330 340 350
YCCPEMVEYQ KKGKSLDSEP SVPSAAKPPS PEKTAPVAST PSSTPIPALS
360 370 380 390 400
PPTKVPEPNE NVGDAVQTKL IMLVDDFYYG RDGGKVAQLT NFPKVATSFR
410 420 430 440 450
CPHCTKRLKN NIRFMNHMKH HVELDQQNGE VDGHTICQHC YRQFSTPFQL
460 470 480 490 500
QCHLENVHSP YESTTKCKIC EWAFESEPLF LQHMKDTHKP GEMPYVCQVC
510 520 530 540 550
QYRSSLYSEV DVHFRMIHED TRHLLCPYCL KVFKNGNAFQ QHYMRHQKRN
560 570 580 590 600
VYHCNKCRLQ FLFAKDKIEH KLQHHKTFRK PKQLEGLKPG TKVTIRASRG
610 620 630 640 650
QPRTVPVSSN DTPPSALQEA APLTSSMDPL PVFLYPPVQR SIQKRAVRKM
660 670 680 690 700
SVMGRQTCLE CSFEIPDFPN HFPTYVHCSL CRYSTCCSRA YANHMINNHV
710 720 730 740 750
PRKSPKYLAL FKNSVSGIKL ACTSCTFVTS VGDAMAKHLV FNPSHRSSSI
760 770 780 790 800
LPRGLTWIAH SRHGQTRDRV HDRNVKNMYP PPSFPTNKAA TVKSAGATPA
810 820 830 840 850
EPEELLTPLA PALPSPASTA TPPPTPTHPQ ALALPPLATE GAECLNVDDQ
860 870 880 890 900
DEGSPVTQEP ELASGGGGSG GVGKKEQLSV KKLRVVLFAL CCNTEQAAEH
910 920 930 940 950
FRNPQRRIRR WLRRFQASQG ENLEGKYLSF EAEEKLAEWV LTQREQQLPV
960 970 980 990 1000
NEETLFQKAT KIGRSLEGGF KISYEWAVRF MLRHHLTPHA RRAVAHTLPK
1010 1020 1030 1040 1050
DVAENAGLFI DFVQRQIHNQ DLPLSMIVAI DEISLFLDTE VLSSDDRKEN
1060 1070 1080 1090 1100
ALQTVGTGEP WCDVVLAILA DGTVLPTLVF YRGQMDQPAN MPDSILLEAK
1110 1120 1130 1140 1150
ESGYSDDEIM ELWSTRVWQK HTACQRSKGM LVMDCHRTHL SEEVLAMLSA
1160 1170 1180 1190 1200
SSTLPAVVPA GCSSKIQPLD VCIKRTVKNF LHKKWKEQAR EMADTACDSD
1210 1220 1230 1240 1250
VLLQLVLVWL GEVLGVIGDC PELVQRSFLV ASVLPGPDGN INSPTRNADM
1260 1270 1280 1290 1300
QEELIASLEE QLKLSGEHSE SSTPRPRSSP EETIEPESLH QLFEGESETE
1310
SFYGFEEADL DLMEI
Note: Gene prediction based on EST data.
Show »Length:1,315
Mass (Da):145,295
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i457D70CDC875B81C
Isoform 6 (identifier: Q7Z3K3-6) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
287-295: Missing.
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLVSIA SFVTVKRPGV
310 320 330 340 350
TGENSNEVAK LVNTLNTIPS LGQSPGPVVV SNNSSAHGSQ RTSGPESSMK
360 370 380 390 400
VTSSIPVFDL QDGGRKICPR CNAQFRVTEA LRGHMCYCCP EMVEYQKKGK
410 420 430 440 450
SLDSEPSVPS AAKPPSPEKT APVASTPSST PIPALSPPTK VPEPNENVGD
460 470 480 490 500
AVQTKLIMLV DDFYYGRDGG KVAQLTNFPK VATSFRCPHC TKRLKNNIRF
510 520 530 540 550
MNHMKHHVEL DQQNGEVDGH TICQHCYRQF STPFQLQCHL ENVHSPYEST
560 570 580 590 600
TKCKICEWAF ESEPLFLQHM KDTHKPGEMP YVCQVCQYRS SLYSEVDVHF
610 620 630 640 650
RMIHEDTRHL LCPYCLKVFK NGNAFQQHYM RHQKRNVYHC NKCRLQFLFA
660 670 680 690 700
KDKIEHKLQH HKTFRKPKQL EGLKPGTKVT IRASRGQPRT VPVSSNDTPP
710 720 730 740 750
SALQEAAPLT SSMDPLPVFL YPPVQRSIQK RAVRKMSVMG RQTCLECSFE
760 770 780 790 800
IPDFPNHFPT YVHCSLCRYS TCCSRAYANH MINNHVPRKS PKYLALFKNS
810 820 830 840 850
VSGIKLACTS CTFVTSVGDA MAKHLVFNPS HRSSSILPRG LTWIAHSRHG
860 870 880 890 900
QTRDRVHDRN VKNMYPPPSF PTNKAATVKS AGATPAEPEE LLTPLAPALP
910 920 930 940 950
SPASTATPPP TPTHPQALAL PPLATEGAEC LNVDDQDEGS PVTQEPELAS
960 970 980 990 1000
GGGGSGGVGK KEQLSVKKLR VVLFALCCNT EQAAEHFRNP QRRIRRWLRR
1010 1020 1030 1040 1050
FQASQGENLE GKYLSFEAEE KLAEWVLTQR EQQLPVNEET LFQKATKIGR
1060 1070 1080 1090 1100
SLEGGFKISY EWAVRFMLRH HLTPHARRAV AHTLPKDVAE NAGLFIDFVQ
1110 1120 1130 1140 1150
RQIHNQDLPL SMIVAIDEIS LFLDTEVLSS DDRKENALQT VGTGEPWCDV
1160 1170 1180 1190 1200
VLAILADGTV LPTLVFYRGQ MDQPANMPDS ILLEAKESGY SDDEIMELWS
1210 1220 1230 1240 1250
TRVWQKHTAC QRSKGMLVMD CHRTHLSEEV LAMLSASSTL PAVVPAGCSS
1260 1270 1280 1290 1300
KIQPLDVCIK RTVKNFLHKK WKEQAREMAD TACDSDVLLQ LVLVWLGEVL
1310 1320 1330 1340 1350
GVIGDCPELV QRSFLVASVL PGPDGNINSP TRNADMQEEL IASLEEQLKL
1360 1370 1380 1390 1400
SGEHSESSTP RPRSSPEETI EPESLHQLFE GESETESFYG FEEADLDLME
I
Length:1,401
Mass (Da):154,492
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i99537C2A84842376
Isoform 7 (identifier: Q7Z3K3-7) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
42-94: Missing.
287-295: Missing.
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TAGNPLVQQG
60 70 80 90 100
GQPLILTQNP APGLGTMVTQ PVLRPVQVMQ NANHVTSSPV ASQPIFITTQ
110 120 130 140 150
GFPVRNVRPV QNAMNQVGIV LNVQQGQTVR PITLVPAPGT QFVKPTVGVP
160 170 180 190 200
QVFSQMTPVR PGSTMPVRPT TNTFTTVIPA TLTIRSTVPQ SQSQQTKSTP
210 220 230 240 250
STSTTPTATQ PTSLGQLAVQ SPGQSNQTTN PKLVSIASFV TVKRPGVTGE
260 270 280 290 300
NSNEVAKLVN TLNTIPSLGQ SPGPVVVSNN SSAHGSQRTS GPESSMKVTS
310 320 330 340 350
SIPVFDLQDG GRKICPRCNA QFRVTEALRG HMCYCCPEMV EYQKKGKSLD
360 370 380 390 400
SEPSVPSAAK PPSPEKTAPV ASTPSSTPIP ALSPPTKVPE PNENVGDAVQ
410 420 430 440 450
TKLIMLVDDF YYGRDGGKVA QLTNFPKVAT SFRCPHCTKR LKNNIRFMNH
460 470 480 490 500
MKHHVELDQQ NGEVDGHTIC QHCYRQFSTP FQLQCHLENV HSPYESTTKC
510 520 530 540 550
KICEWAFESE PLFLQHMKDT HKPGEMPYVC QVCQYRSSLY SEVDVHFRMI
560 570 580 590 600
HEDTRHLLCP YCLKVFKNGN AFQQHYMRHQ KRNVYHCNKC RLQFLFAKDK
610 620 630 640 650
IEHKLQHHKT FRKPKQLEGL KPGTKVTIRA SRGQPRTVPV SSNDTPPSAL
660 670 680 690 700
QEAAPLTSSM DPLPVFLYPP VQRSIQKRAV RKMSVMGRQT CLECSFEIPD
710 720 730 740 750
FPNHFPTYVH CSLCRYSTCC SRAYANHMIN NHVPRKSPKY LALFKNSVSG
760 770 780 790 800
IKLACTSCTF VTSVGDAMAK HLVFNPSHRS SSILPRGLTW IAHSRHGQTR
810 820 830 840 850
DRVHDRNVKN MYPPPSFPTN KAATVKSAGA TPAEPEELLT PLAPALPSPA
860 870 880 890 900
STATPPPTPT HPQALALPPL ATEGAECLNV DDQDEGSPVT QEPELASGGG
910 920 930 940 950
GSGGVGKKEQ LSVKKLRVVL FALCCNTEQA AEHFRNPQRR IRRWLRRFQA
960 970 980 990 1000
SQGENLEGKY LSFEAEEKLA EWVLTQREQQ LPVNEETLFQ KATKIGRSLE
1010 1020 1030 1040 1050
GGFKISYEWA VRFMLRHHLT PHARRAVAHT LPKDVAENAG LFIDFVQRQI
1060 1070 1080 1090 1100
HNQDLPLSMI VAIDEISLFL DTEVLSSDDR KENALQTVGT GEPWCDVVLA
1110 1120 1130 1140 1150
ILADGTVLPT LVFYRGQMDQ PANMPDSILL EAKESGYSDD EIMELWSTRV
1160 1170 1180 1190 1200
WQKHTACQRS KGMLVMDCHR THLSEEVLAM LSASSTLPAV VPAGCSSKIQ
1210 1220 1230 1240 1250
PLDVCIKRTV KNFLHKKWKE QAREMADTAC DSDVLLQLVL VWLGEVLGVI
1260 1270 1280 1290 1300
GDCPELVQRS FLVASVLPGP DGNINSPTRN ADMQEELIAS LEEQLKLSGE
1310 1320 1330 1340
HSESSTPRPR SSPEETIEPE SLHQLFEGES ETESFYGFEE ADLDLMEI
Length:1,348
Mass (Da):149,278
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i0016C4CF1C9CB146
<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
The sequence BAE45744 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI16808 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI16810 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 213 | R → G in BAG63781 (PubMed:14702039).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 327 | I → F in BAG62060 (PubMed:14702039).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 503 | L → P in BAB87117 (PubMed:12880961).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 503 | L → P in BAE45744 (PubMed:12880961).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 727 | V → A in BAG63781 (PubMed:14702039).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 788 | N → T in CAB45136 (PubMed:10976766).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 888 | K → E in BAB87117 (PubMed:12880961).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 888 | K → E in BAE45744 (PubMed:12880961).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 933 | A → V in CAD97850 (PubMed:17974005).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1026 | E → G in CAD97850 (PubMed:17974005).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1078 | R → W in BAB87117 (PubMed:12880961).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1078 | R → W in BAE45744 (PubMed:12880961).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1092 – 1107 | TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117 (PubMed:12880961).CuratedAdd BLAST | 16 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1092 – 1107 | TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744 (PubMed:12880961).CuratedAdd BLAST | 16 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1248 | T → A in BAG63781 (PubMed:14702039).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1304 | W → R in CAD97850 (PubMed:17974005).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073179 | 1040 | E → K Probable disease-associated mutation found in patients with ASD. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031476 | 1365 | E → D. Corresponds to variant dbSNP:rs35198305Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010185 | 42 – 94 | Missing in isoform 2, isoform 3 and isoform 7. 3 Publications <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 53 | |
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030150 | 96 – 190 | Missing in isoform 5. CuratedAdd BLAST | 95 | |
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046785 | 287 – 295 | Missing in isoform 6 and isoform 7. 1 Publication <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 9 | |
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010187 | 360 – 363 | VTSS → GTIT in isoform 4. 1 Publication <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 4 | |
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010188 | 364 – 1410 | Missing in isoform 4. 1 Publication <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 1047 | |
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010186 | 593 | Q → QPYFPSYVTQ in isoform 3. 1 Publication <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 1 |
Sequence databases
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1] ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5] ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2] ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6] ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3] ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 23126 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:23126 |
UCSC genome browser More...UCSCi | uc001eyd.2 human [Q7Z3K3-1] |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi
Alternative splicing, Polymorphism<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
| Protein | Similar proteins | Species | Score | Length | |
|---|---|---|---|---|---|
| Q7Z3K3 | POGZ isoform 2 | 1410 | |||
| UPI000048A91D | 1010 | ||||
| POGZ isoform 17 (Fragment) | 151 | ||||
| POGZ isoform 8 | 1458 | ||||
| Pogo transposable element with ZNF domain (Fragment) | 151 | ||||
| +4 | |||||
| Protein | Similar proteins | Species | Score | Length | |
|---|---|---|---|---|---|
| Q7Z3K3 | POGZ isoform 2 | 1410 | |||
| UPI000048A91D | 1010 | ||||
| POGZ isoform 17 (Fragment) | 151 | ||||
| Pogo transposable element derived with ZNF domain | 1540 | ||||
| Pogo transposable element with ZNF domain | 1421 | ||||
| +391 | |||||
| Q7Z3K3-5 | Pogo transposable element derived with ZNF domain | 1316 | |||
| POGZ isoform 7 | 1424 | ||||
| UPI0004ED4F6A | 1365 | ||||
| pogo transposable element with ZNF domain isoform X3 | 1360 | ||||
| UPI00053FEF09 | 1360 | ||||
| +24 | |||||
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
3D structure databases
| Select the link destinations: Protein Data Bank Europe More...PDBeiProtein Data Bank RCSB More...RCSB PDBiProtein Data Bank Japan More...PDBjiLinks Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 2E72 | NMR | - | A | 370-405 | [»] | |
| 2N3A | NMR | - | A | 1389-1404 | [»] | |
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q7Z3K3 | |||||
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q7Z3K3 | |||||
Database of comparative protein structure models More...ModBasei | Search... | |||||
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... | |||||
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 116745, 55 interactors |
Database of interacting proteins More...DIPi | DIP-38044N |
Protein interaction database and analysis system More...IntActi | Q7Z3K3, 148 interactors |
Molecular INTeraction database More...MINTi | Q7Z3K3 |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000271715 |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q7Z3K3 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q7Z3K3 |
Polymorphism and mutation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | POGZ |
Domain mapping of disease mutations (DMDM) More...DMDMi | 143811442 |
Proteomic databases
Encyclopedia of Proteome Dynamics More...EPDi | Q7Z3K3 |
MaxQB - The MaxQuant DataBase More...MaxQBi | Q7Z3K3 |
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q7Z3K3 |
PeptideAtlas More...PeptideAtlasi | Q7Z3K3 |
PRoteomics IDEntifications database More...PRIDEi | Q7Z3K3 |
ProteomicsDB human proteome resource More...ProteomicsDBi | 69059 69060 [Q7Z3K3-2] 69061 [Q7Z3K3-3] 69062 [Q7Z3K3-4] 69063 [Q7Z3K3-5] |
Protocols and materials databases
The DNASU plasmid repository More...DNASUi | 23126 |
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1] ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5] ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2] ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6] ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3] ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 23126 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:23126 |
UCSC genome browser More...UCSCi | uc001eyd.2 human [Q7Z3K3-1] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 23126 |
DisGeNET More...DisGeNETi | 23126 |
Eukaryotic Pathogen Database Resources More...EuPathDBi | HostDB:ENSG00000143442.21 |
GeneCards: human genes, protein and diseases More...GeneCardsi | POGZ |
Human Gene Nomenclature Database More...HGNCi | HGNC:18801 POGZ |
Human Protein Atlas More...HPAi | HPA006800 HPA008781 |
MalaCards human disease database More...MalaCardsi | POGZ |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 614787 gene 616364 phenotype |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q7Z3K3 |
Open Targets More...OpenTargetsi | ENSG00000143442 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA38685 |
Human Unidentified Gene-Encoded large proteins database More...HUGEi | Search... |
GenAtlas: human gene database More...GenAtlasi | Search... |
Phylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG1721 Eukaryota KOG3105 Eukaryota COG5048 LUCA |
Ensembl GeneTree More...GeneTreei | ENSGT00530000063300 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | HOG000010309 |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG049435 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q7Z3K3 |
KEGG Orthology (KO) More...KOi | K22594 |
Identification of Orthologs from Complete Genome Data More...OMAi | GLTWISH |
Database of Orthologous Groups More...OrthoDBi | EOG091G01UE |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q7Z3K3 |
TreeFam database of animal gene trees More...TreeFami | TF331707 |
Miscellaneous databases
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data More...ChiTaRSi | POGZ human |
Relative evolutionary importance of amino acids within a protein sequence More...EvolutionaryTracei | Q7Z3K3 |
The Gene Wiki collection of pages on human genes and proteins More...GeneWikii | POGZ |
Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens More...GenomeRNAii | 23126 |
Protein Ontology More...PROi | PR:Q7Z3K3 |
The Stanford Online Universal Resource for Clones and ESTs More...SOURCEi | Search... |
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000143442 |
CleanEx database of gene expression profiles More...CleanExi | HS_POGZ |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q7Z3K3 baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q7Z3K3 HS |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfam protein domain database More...Pfami | View protein in Pfam PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM00674 CENPB, 1 hit SM00355 ZnF_C2H2, 8 hits |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF46689 SSF46689, 1 hit SSF57667 SSF57667, 2 hits |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | POGZ_HUMAN | |
| <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | Q7Z3K3Primary (citable) accession number: Q7Z3K3 Secondary accession number(s): B4DTP8 , B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q8TDZ7, Q9Y4X7 | |
| <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
| Last sequence update: | April 3, 2007 | |
| Last modified: | July 18, 2018 | |
| This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
| <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references
