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UniProtKB - Q7Z3K3 (POGZ_HUMAN)

Entry version 168 (13 Feb 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Pogo transposable element with ZNF domain

Gene

POGZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri375 – 397C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 553C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri560 – 583C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri590 – 613C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri619 – 641C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 670C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri771 – 794C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri815 – 840C2H2-type 9PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • kinetochore assembly Source: UniProtKB
  • mitotic sister chromatid cohesion Source: UniProtKB
  • regulation of gene expression Source: GO_Central
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pogo transposable element with ZNF domain
Alternative name(s):
Suppressor of hairy wing homolog 5
Zinc finger protein 280E
Zinc finger protein 635
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POGZ
Synonyms:KIAA0461, SUHW5, ZNF280E, ZNF635
ORF Names:Nbla00003
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000143442.21

Human Gene Nomenclature Database

More...HGNCi		HGNC:18801 POGZ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614787 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z3K3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in POGZ may be associated with neuropsychiatric disorders such as autism spectrum disorders (ASD), bipolar affective disorders and early dementia onset. ASD are characterized by impairments in reciprocal social interaction and communication as well as restricted and stereotyped patterns of interest and activities. ASD include forms with moderate to severe cognitive impairment and milder forms with higher cognitive ability (Asperger syndrome).1 Publication
White-Sutton syndrome (WHSUS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by developmental delay, intellectual disability, hypotonia, behavioral abnormalities, and dysmorphic facial features. Variable features include short stature, microcephaly, strabismus and hearing loss.
See also OMIM:616364

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi817C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. 1 Publication1
Mutagenesisi820C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. 1 Publication1
Mutagenesisi833H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. 1 Publication1
Mutagenesisi840H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. 1 Publication1

Keywords - Diseasei

Autism spectrum disorder, Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		23126

MalaCards human disease database

More...MalaCardsi		POGZ
MIMi616364 phenotype

Open Targets

More...OpenTargetsi		ENSG00000143442

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		468678 Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38685

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POGZ

Domain mapping of disease mutations (DMDM)

More...DMDMi		143811442

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472241 – 1410Pogo transposable element with ZNF domainAdd BLAST1410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333PhosphoserineCombined sources1
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei363PhosphoserineCombined sources1
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei425PhosphoserineCombined sources1
Modified residuei439PhosphothreonineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Cross-linki449Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei463PhosphothreonineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki677Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki801Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei856PhosphoserineCombined sources1
Cross-linki883Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1368PhosphothreonineCombined sources1
Modified residuei1392PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z3K3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z3K3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z3K3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z3K3

PeptideAtlas

More...PeptideAtlasi		Q7Z3K3

PRoteomics IDEntifications database

More...PRIDEi		Q7Z3K3

ProteomicsDB human proteome resource

More...ProteomicsDBi		69059
69060 [Q7Z3K3-2]
69061 [Q7Z3K3-3]
69062 [Q7Z3K3-4]
69063 [Q7Z3K3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z3K3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z3K3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143442 Expressed in 235 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z3K3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z3K3 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA006800
HPA008781

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116745, 57 interactors

Database of interacting proteins

More...DIPi		DIP-38044N

Protein interaction database and analysis system

More...IntActi		Q7Z3K3, 149 interactors

Molecular INTeraction database

More...MINTi		Q7Z3K3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000271715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E72NMR-A370-405[»]
2N3ANMR-A1389-1404[»]
6EMPNMR-A1370-1404[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q7Z3K3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z3K3

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q7Z3K3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1015 – 1085HTH CENPB-typePROSITE-ProRule annotationAdd BLAST71
Domaini1117 – 1323DDE-1Sequence analysisAdd BLAST207

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni810 – 850Required for interaction with CBX5Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1340 – 1360Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi875 – 931Pro-richAdd BLAST57

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri375 – 397C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 553C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri560 – 583C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri590 – 613C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri619 – 641C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 670C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri771 – 794C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri815 – 840C2H2-type 9PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
KOG3105 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000010309

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG049435

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z3K3

KEGG Orthology (KO)

More...KOi		K22594

Identification of Orthologs from Complete Genome Data

More...OMAi		RQIHTQD

Database of Orthologous Groups

More...OrthoDBi		105829at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z3K3

TreeFam database of animal gene trees

More...TreeFami		TF331707

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00674 CENPB, 1 hit
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS 
        60         70         80         90        100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV 
       110        120        130        140        150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI 
       160        170        180        190        200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV 
       210        220        230        240        250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK 
       260        270        280        290        300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS 
       310        320        330        340        350
FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR 
       360        370        380        390        400
TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE 
       410        420        430        440        450
MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV 
       460        470        480        490        500
PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT 
       510        520        530        540        550
KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE 
       560        570        580        590        600
NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS 
       610        620        630        640        650
LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN 
       660        670        680        690        700
KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV 
       710        720        730        740        750
PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR 
       760        770        780        790        800
QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP 
       810        820        830        840        850
KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL 
       860        870        880        890        900
TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL 
       910        920        930        940        950
LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP 
       960        970        980        990       1000
VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ 
      1010       1020       1030       1040       1050
RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL 
      1060       1070       1080       1090       1100
FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN 
      1110       1120       1130       1140       1150
AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV 
      1160       1170       1180       1190       1200
GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS 
      1210       1220       1230       1240       1250
DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP 
      1260       1270       1280       1290       1300
AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL 
      1310       1320       1330       1340       1350
VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI 
      1360       1370       1380       1390       1400
ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF 
      1410
EEADLDLMEI
Length:1,410
Mass (Da):155,344
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58F672EDCD57CCD8
GO
Isoform 2 (identifier: Q7Z3K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.

Note: No experimental confirmation available.
Show »
Length:1,357
Mass (Da):150,130
Checksum:i3EC92965C8E95A98
GO
Isoform 3 (identifier: Q7Z3K3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     593-593: Q → QPYFPSYVTQ

Note: No experimental confirmation available.
Show »
Length:1,366
Mass (Da):151,213
Checksum:iC88635F4469B70AA
GO
Isoform 4 (identifier: Q7Z3K3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-363: VTSS → GTIT
     364-1410: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):37,882
Checksum:iE4CA34C166CC3E78
GO
Isoform 5 (identifier: Q7Z3K3-5) [UniParc]FASTAAdd to basket
Also known as: CRA_e

The sequence of this isoform differs from the canonical sequence as follows:
     96-190: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,315
Mass (Da):145,295
Checksum:i457D70CDC875B81C
GO
Isoform 6 (identifier: Q7Z3K3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-295: Missing.

Show »
Length:1,401
Mass (Da):154,492
Checksum:i99537C2A84842376
GO
Isoform 7 (identifier: Q7Z3K3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     287-295: Missing.

Show »
Length:1,348
Mass (Da):149,278
Checksum:i0016C4CF1C9CB146
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCT3H0YCT3_HUMAN
Pogo transposable element with ZNF ...
POGZ
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2X2M0R2X2_HUMAN
Pogo transposable element with ZNF ...
POGZ
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJY9E9PJY9_HUMAN
Pogo transposable element with ZNF ...
POGZ
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIR8E9PIR8_HUMAN
Pogo transposable element with ZNF ...
POGZ
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PW30A6PW30_HUMAN
Pogo transposable element with ZNF ...
POGZ
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C238H7C238_HUMAN
Pogo transposable element with ZNF ...
POGZ
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JHK5A0A0G2JHK5_HUMAN
Pogo transposable element with ZNF ...
POGZ
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE45744 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213R → G in BAG63781 (PubMed:14702039).Curated1
Sequence conflicti327I → F in BAG62060 (PubMed:14702039).Curated1
Sequence conflicti503L → P in BAB87117 (PubMed:12880961).Curated1
Sequence conflicti503L → P in BAE45744 (PubMed:12880961).Curated1
Sequence conflicti727V → A in BAG63781 (PubMed:14702039).Curated1
Sequence conflicti788N → T in CAB45136 (PubMed:10976766).Curated1
Sequence conflicti888K → E in BAB87117 (PubMed:12880961).Curated1
Sequence conflicti888K → E in BAE45744 (PubMed:12880961).Curated1
Sequence conflicti933A → V in CAD97850 (PubMed:17974005).Curated1
Sequence conflicti1026E → G in CAD97850 (PubMed:17974005).Curated1
Sequence conflicti1078R → W in BAB87117 (PubMed:12880961).Curated1
Sequence conflicti1078R → W in BAE45744 (PubMed:12880961).Curated1
Sequence conflicti1092 – 1107TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117 (PubMed:12880961).CuratedAdd BLAST16
Sequence conflicti1092 – 1107TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744 (PubMed:12880961).CuratedAdd BLAST16
Sequence conflicti1248T → A in BAG63781 (PubMed:14702039).Curated1
Sequence conflicti1304W → R in CAD97850 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0731791040E → K Probable disease-associated mutation found in patients with ASD. 1 Publication1
Natural variantiVAR_0314761365E → D. Corresponds to variant dbSNP:rs35198305Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01018542 – 94Missing in isoform 2, isoform 3 and isoform 7. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_03015096 – 190Missing in isoform 5. CuratedAdd BLAST95
Alternative sequenceiVSP_046785287 – 295Missing in isoform 6 and isoform 7. 1 Publication9
Alternative sequenceiVSP_010187360 – 363VTSS → GTIT in isoform 4. 1 Publication4
Alternative sequenceiVSP_010188364 – 1410Missing in isoform 4. 1 PublicationAdd BLAST1047
Alternative sequenceiVSP_010186593Q → QPYFPSYVTQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX537838 mRNA Translation: CAD97850.1
AK300307 mRNA Translation: BAG62060.1
AK302501 mRNA Translation: BAG63781.1
AL589764 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53440.1
AB037911 mRNA Translation: BAB87117.1
AB075477 mRNA Translation: BAE45744.1 Different initiation.
AJ242979 mRNA Translation: CAB45136.1
BC057773 mRNA Translation: AAH57773.1
AB007930 mRNA Translation: BAA32306.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44222.2 [Q7Z3K3-5]
CCDS53365.1 [Q7Z3K3-7]
CCDS53366.1 [Q7Z3K3-6]
CCDS997.1 [Q7Z3K3-1]
CCDS998.1 [Q7Z3K3-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T00075

NCBI Reference Sequences

More...RefSeqi		NP_001181866.1, NM_001194937.1 [Q7Z3K3-6]
NP_001181867.1, NM_001194938.1 [Q7Z3K3-7]
NP_055915.2, NM_015100.3 [Q7Z3K3-1]
NP_665739.3, NM_145796.3 [Q7Z3K3-5]
NP_997054.1, NM_207171.2 [Q7Z3K3-2]
XP_005245056.1, XM_005244999.2 [Q7Z3K3-1]
XP_005245057.1, XM_005245000.4 [Q7Z3K3-1]
XP_005245058.1, XM_005245001.2 [Q7Z3K3-1]
XP_005245062.1, XM_005245005.1 [Q7Z3K3-2]
XP_005245063.1, XM_005245006.4 [Q7Z3K3-2]
XP_016856234.1, XM_017000745.1 [Q7Z3K3-6]
XP_016856235.1, XM_017000746.1 [Q7Z3K3-6]
XP_016856237.1, XM_017000748.1 [Q7Z3K3-2]
XP_016856238.1, XM_017000749.1 [Q7Z3K3-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.489873

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1]
ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5]
ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2]
ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6]
ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3]
ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23126

UCSC genome browser

More...UCSCi		uc001eyd.2 human [Q7Z3K3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537838 mRNA Translation: CAD97850.1
AK300307 mRNA Translation: BAG62060.1
AK302501 mRNA Translation: BAG63781.1
AL589764 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53440.1
AB037911 mRNA Translation: BAB87117.1
AB075477 mRNA Translation: BAE45744.1 Different initiation.
AJ242979 mRNA Translation: CAB45136.1
BC057773 mRNA Translation: AAH57773.1
AB007930 mRNA Translation: BAA32306.1
CCDSiCCDS44222.2 [Q7Z3K3-5]
CCDS53365.1 [Q7Z3K3-7]
CCDS53366.1 [Q7Z3K3-6]
CCDS997.1 [Q7Z3K3-1]
CCDS998.1 [Q7Z3K3-2]
PIRiT00075
RefSeqiNP_001181866.1, NM_001194937.1 [Q7Z3K3-6]
NP_001181867.1, NM_001194938.1 [Q7Z3K3-7]
NP_055915.2, NM_015100.3 [Q7Z3K3-1]
NP_665739.3, NM_145796.3 [Q7Z3K3-5]
NP_997054.1, NM_207171.2 [Q7Z3K3-2]
XP_005245056.1, XM_005244999.2 [Q7Z3K3-1]
XP_005245057.1, XM_005245000.4 [Q7Z3K3-1]
XP_005245058.1, XM_005245001.2 [Q7Z3K3-1]
XP_005245062.1, XM_005245005.1 [Q7Z3K3-2]
XP_005245063.1, XM_005245006.4 [Q7Z3K3-2]
XP_016856234.1, XM_017000745.1 [Q7Z3K3-6]
XP_016856235.1, XM_017000746.1 [Q7Z3K3-6]
XP_016856237.1, XM_017000748.1 [Q7Z3K3-2]
XP_016856238.1, XM_017000749.1 [Q7Z3K3-2]
UniGeneiHs.489873

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E72NMR-A370-405[»]
2N3ANMR-A1389-1404[»]
6EMPNMR-A1370-1404[»]
ProteinModelPortaliQ7Z3K3
SMRiQ7Z3K3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116745, 57 interactors
DIPiDIP-38044N
IntActiQ7Z3K3, 149 interactors
MINTiQ7Z3K3
STRINGi9606.ENSP00000271715

PTM databases

iPTMnetiQ7Z3K3
PhosphoSitePlusiQ7Z3K3

Polymorphism and mutation databases

BioMutaiPOGZ
DMDMi143811442

Proteomic databases

EPDiQ7Z3K3
jPOSTiQ7Z3K3
MaxQBiQ7Z3K3
PaxDbiQ7Z3K3
PeptideAtlasiQ7Z3K3
PRIDEiQ7Z3K3
ProteomicsDBi69059
69060 [Q7Z3K3-2]
69061 [Q7Z3K3-3]
69062 [Q7Z3K3-4]
69063 [Q7Z3K3-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		23126
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1]
ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5]
ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2]
ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6]
ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3]
ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7]
GeneIDi23126
KEGGihsa:23126
UCSCiuc001eyd.2 human [Q7Z3K3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23126
DisGeNETi23126
EuPathDBiHostDB:ENSG00000143442.21

GeneCards: human genes, protein and diseases

More...GeneCardsi		POGZ
HGNCiHGNC:18801 POGZ
HPAiHPA006800
HPA008781
MalaCardsiPOGZ
MIMi614787 gene
616364 phenotype
neXtProtiNX_Q7Z3K3
OpenTargetsiENSG00000143442
Orphaneti468678 Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome
PharmGKBiPA38685

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG3105 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000160649
HOGENOMiHOG000010309
HOVERGENiHBG049435
InParanoidiQ7Z3K3
KOiK22594
OMAiRQIHTQD
OrthoDBi105829at2759
PhylomeDBiQ7Z3K3
TreeFamiTF331707

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POGZ human
EvolutionaryTraceiQ7Z3K3

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POGZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23126

Protein Ontology

More...PROi		PR:Q7Z3K3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143442 Expressed in 235 organ(s), highest expression level in kidney
ExpressionAtlasiQ7Z3K3 baseline and differential
GenevisibleiQ7Z3K3 HS

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOGZ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3K3
Secondary accession number(s): B4DTP8
, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q8TDZ7, Q9Y4X7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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