UniProtKB - Q7Z3K3 (POGZ_HUMAN)
Pogo transposable element with ZNF domain
POGZ
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 375 – 397 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 553 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 560 – 583 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 590 – 613 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 619 – 641 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 647 – 670 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 771 – 794 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 815 – 840 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell division Source: UniProtKB-KW
- kinetochore assembly Source: UniProtKB
- mitotic sister chromatid cohesion Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, Cell division |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7Z3K3 |
Names & Taxonomyi
Protein namesi | Recommended name: Pogo transposable element with ZNF domainAlternative name(s): Suppressor of hairy wing homolog 5 Zinc finger protein 280E Zinc finger protein 635 |
Gene namesi | Name:POGZ Synonyms:KIAA0461, SUHW5, ZNF280E, ZNF635 ORF Names:Nbla00003 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000143442.21 |
HGNCi | HGNC:18801, POGZ |
MIMi | 614787, gene |
neXtProti | NX_Q7Z3K3 |
Subcellular locationi
Nucleus
Other locations
Note: According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
White-Sutton syndrome (WHSUS)2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 817 | C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. 1 Publication | 1 | |
Mutagenesisi | 820 | C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. 1 Publication | 1 | |
Mutagenesisi | 833 | H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. 1 Publication | 1 | |
Mutagenesisi | 840 | H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. 1 Publication | 1 | |
Mutagenesisi | 1392 | S → A: Loss of phosphorylation. Loss of interaction with PSIP1; when associated with A-1396. 1 Publication | 1 | |
Mutagenesisi | 1392 | S → D: Phosphomimetic mutant. Significant increase in interaction with PSIP1; when associated with D-1396. 1 Publication | 1 | |
Mutagenesisi | 1396 | S → A: Loss of phosphorylation. Loss of interaction with PSIP1; when associated with A-1392. 1 Publication | 1 | |
Mutagenesisi | 1396 | S → D: Phosphomimetic mutant. Significant increase in interaction with PSIP1; when associated with D-1392. 1 Publication | 1 |
Keywords - Diseasei
Autism spectrum disorder, Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 23126 |
MalaCardsi | POGZ |
MIMi | 616364, phenotype |
OpenTargetsi | ENSG00000143442 |
Orphaneti | 468678, Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome |
PharmGKBi | PA38685 |
Miscellaneous databases
Pharosi | Q7Z3K3, Tbio |
Polymorphism and mutation databases
BioMutai | POGZ |
DMDMi | 143811442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047224 | 1 – 1410 | Pogo transposable element with ZNF domainAdd BLAST | 1410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 319 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 333 | PhosphoserineCombined sources | 1 | |
Cross-linki | 359 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 363 | PhosphoserineCombined sources | 1 | |
Cross-linki | 422 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 425 | PhosphoserineCombined sources | 1 | |
Modified residuei | 439 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 445 | PhosphoserineCombined sources | 1 | |
Cross-linki | 449 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 463 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 489 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 629 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 677 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 801 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 856 | PhosphoserineCombined sources | 1 | |
Cross-linki | 883 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1338 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1364 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1367 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1368 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1373 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1374 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1378 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1392 | Phosphoserine; by CK2Combined sources1 Publication | 1 | |
Modified residuei | 1394 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1396 | Phosphoserine; by CK21 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q7Z3K3 |
jPOSTi | Q7Z3K3 |
MassIVEi | Q7Z3K3 |
MaxQBi | Q7Z3K3 |
PaxDbi | Q7Z3K3 |
PeptideAtlasi | Q7Z3K3 |
PRIDEi | Q7Z3K3 |
ProteomicsDBi | 22027 69059 [Q7Z3K3-1] 69060 [Q7Z3K3-2] 69061 [Q7Z3K3-3] 69062 [Q7Z3K3-4] 69063 [Q7Z3K3-5] 7168 |
PTM databases
GlyConnecti | 2865, 1 O-Linked glycan (1 site) [Q7Z3K3-2] |
GlyGeni | Q7Z3K3, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q7Z3K3 |
PhosphoSitePlusi | Q7Z3K3 |
SwissPalmi | Q7Z3K3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143442, Expressed in kidney and 245 other tissues |
ExpressionAtlasi | Q7Z3K3, baseline and differential |
Genevisiblei | Q7Z3K3, HS |
Organism-specific databases
HPAi | ENSG00000143442, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CBX1, CBX3, MAD2L2 and CHAMP1.
Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5.
Interacts (via IBM motif) with PSIP1 isoform 1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:19244240, PubMed:25082813, PubMed:29997176).
6 PublicationsBinary interactionsi
Q7Z3K3
Protein-protein interaction databases
BioGRIDi | 116745, 137 interactors |
DIPi | DIP-38044N |
IntActi | Q7Z3K3, 153 interactors |
MINTi | Q7Z3K3 |
STRINGi | 9606.ENSP00000271715 |
Miscellaneous databases
RNActi | Q7Z3K3, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q7Z3K3 |
SMRi | Q7Z3K3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7Z3K3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1015 – 1085 | HTH CENPB-typePROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 1117 – 1323 | DDE-1Sequence analysisAdd BLAST | 207 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 810 – 850 | Required for interaction with CBX5Add BLAST | 41 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1340 – 1360 | Sequence analysisAdd BLAST | 21 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1380 – 1404 | Integrase domain-binding motif (IBM)1 PublicationAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 875 – 931 | Pro-richAdd BLAST | 57 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 375 – 397 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 553 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 560 – 583 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 590 – 613 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 619 – 641 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 647 – 670 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 771 – 794 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 815 – 840 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota KOG3105, Eukaryota |
GeneTreei | ENSGT00940000160649 |
HOGENOMi | CLU_002015_0_0_1 |
InParanoidi | Q7Z3K3 |
OMAi | RMVAWVL |
OrthoDBi | 105829at2759 |
PhylomeDBi | Q7Z3K3 |
TreeFami | TF331707 |
Family and domain databases
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR
360 370 380 390 400
TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE
410 420 430 440 450
MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV
460 470 480 490 500
PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT
510 520 530 540 550
KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE
560 570 580 590 600
NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS
610 620 630 640 650
LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN
660 670 680 690 700
KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV
710 720 730 740 750
PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR
760 770 780 790 800
QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP
810 820 830 840 850
KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL
860 870 880 890 900
TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL
910 920 930 940 950
LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP
960 970 980 990 1000
VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ
1010 1020 1030 1040 1050
RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL
1060 1070 1080 1090 1100
FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN
1110 1120 1130 1140 1150
AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV
1160 1170 1180 1190 1200
GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS
1210 1220 1230 1240 1250
DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP
1260 1270 1280 1290 1300
AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL
1310 1320 1330 1340 1350
VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI
1360 1370 1380 1390 1400
ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF
1410
EEADLDLMEI
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C238 | H7C238_HUMAN | Pogo transposable element with ZNF ... | POGZ | 60 | Annotation score: | ||
M0R2X2 | M0R2X2_HUMAN | Pogo transposable element with ZNF ... | POGZ | 109 | Annotation score: | ||
H0YCT3 | H0YCT3_HUMAN | Pogo transposable element with ZNF ... | POGZ | 316 | Annotation score: | ||
A6PW30 | A6PW30_HUMAN | Pogo transposable element with ZNF ... | POGZ | 84 | Annotation score: | ||
E9PIR8 | E9PIR8_HUMAN | Pogo transposable element with ZNF ... | POGZ | 151 | Annotation score: | ||
E9PJY9 | E9PJY9_HUMAN | Pogo transposable element with ZNF ... | POGZ | 139 | Annotation score: | ||
A0A0G2JHK5 | A0A0G2JHK5_HUMAN | Pogo transposable element with ZNF ... | POGZ | 8 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 213 | R → G in BAG63781 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 327 | I → F in BAG62060 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 503 | L → P in BAB87117 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 503 | L → P in BAE45744 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 727 | V → A in BAG63781 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 788 | N → T in CAB45136 (PubMed:10976766).Curated | 1 | |
Sequence conflicti | 888 | K → E in BAB87117 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 888 | K → E in BAE45744 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 933 | A → V in CAD97850 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1026 | E → G in CAD97850 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1078 | R → W in BAB87117 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 1078 | R → W in BAE45744 (PubMed:12880961).Curated | 1 | |
Sequence conflicti | 1092 – 1107 | TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117 (PubMed:12880961).CuratedAdd BLAST | 16 | |
Sequence conflicti | 1092 – 1107 | TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744 (PubMed:12880961).CuratedAdd BLAST | 16 | |
Sequence conflicti | 1248 | T → A in BAG63781 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1304 | W → R in CAD97850 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073179 | 1040 | E → K Probable disease-associated variant found in patients with ASD. 1 Publication | 1 | |
Natural variantiVAR_031476 | 1365 | E → D. Corresponds to variant dbSNP:rs35198305EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010185 | 42 – 94 | Missing in isoform 2, isoform 3 and isoform 7. 3 PublicationsAdd BLAST | 53 | |
Alternative sequenceiVSP_030150 | 96 – 190 | Missing in isoform 5. CuratedAdd BLAST | 95 | |
Alternative sequenceiVSP_046785 | 287 – 295 | Missing in isoform 6 and isoform 7. 1 Publication | 9 | |
Alternative sequenceiVSP_010187 | 360 – 363 | VTSS → GTIT in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_010188 | 364 – 1410 | Missing in isoform 4. 1 PublicationAdd BLAST | 1047 | |
Alternative sequenceiVSP_010186 | 593 | Q → QPYFPSYVTQ in isoform 3. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1] ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5] ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2] ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6] ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3] ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7] |
GeneIDi | 23126 |
KEGGi | hsa:23126 |
UCSCi | uc001eyd.2, human [Q7Z3K3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E72 | NMR | - | A | 370-405 | [»] | |
2N3A | NMR | - | A | 1389-1404 | [»] | |
6EMP | NMR | - | A | 1370-1404 | [»] | |
BMRBi | Q7Z3K3 | |||||
SMRi | Q7Z3K3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116745, 137 interactors |
DIPi | DIP-38044N |
IntActi | Q7Z3K3, 153 interactors |
MINTi | Q7Z3K3 |
STRINGi | 9606.ENSP00000271715 |
PTM databases
GlyConnecti | 2865, 1 O-Linked glycan (1 site) [Q7Z3K3-2] |
GlyGeni | Q7Z3K3, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q7Z3K3 |
PhosphoSitePlusi | Q7Z3K3 |
SwissPalmi | Q7Z3K3 |
Polymorphism and mutation databases
BioMutai | POGZ |
DMDMi | 143811442 |
Proteomic databases
EPDi | Q7Z3K3 |
jPOSTi | Q7Z3K3 |
MassIVEi | Q7Z3K3 |
MaxQBi | Q7Z3K3 |
PaxDbi | Q7Z3K3 |
PeptideAtlasi | Q7Z3K3 |
PRIDEi | Q7Z3K3 |
ProteomicsDBi | 22027 69059 [Q7Z3K3-1] 69060 [Q7Z3K3-2] 69061 [Q7Z3K3-3] 69062 [Q7Z3K3-4] 69063 [Q7Z3K3-5] 7168 |
Protocols and materials databases
Antibodypediai | 1872, 136 antibodies |
DNASUi | 23126 |
Genome annotation databases
Ensembli | ENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1] ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5] ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2] ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6] ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3] ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7] |
GeneIDi | 23126 |
KEGGi | hsa:23126 |
UCSCi | uc001eyd.2, human [Q7Z3K3-1] |
Organism-specific databases
CTDi | 23126 |
DisGeNETi | 23126 |
EuPathDBi | HostDB:ENSG00000143442.21 |
GeneCardsi | POGZ |
HGNCi | HGNC:18801, POGZ |
HPAi | ENSG00000143442, Low tissue specificity |
MalaCardsi | POGZ |
MIMi | 614787, gene 616364, phenotype |
neXtProti | NX_Q7Z3K3 |
OpenTargetsi | ENSG00000143442 |
Orphaneti | 468678, Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome |
PharmGKBi | PA38685 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota KOG3105, Eukaryota |
GeneTreei | ENSGT00940000160649 |
HOGENOMi | CLU_002015_0_0_1 |
InParanoidi | Q7Z3K3 |
OMAi | RMVAWVL |
OrthoDBi | 105829at2759 |
PhylomeDBi | Q7Z3K3 |
TreeFami | TF331707 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z3K3 |
Miscellaneous databases
BioGRID-ORCSi | 23126, 222 hits in 846 CRISPR screens |
ChiTaRSi | POGZ, human |
EvolutionaryTracei | Q7Z3K3 |
GeneWikii | POGZ |
GenomeRNAii | 23126 |
Pharosi | Q7Z3K3, Tbio |
PROi | PR:Q7Z3K3 |
RNActi | Q7Z3K3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143442, Expressed in kidney and 245 other tissues |
ExpressionAtlasi | Q7Z3K3, baseline and differential |
Genevisiblei | Q7Z3K3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POGZ_HUMAN | |
Accessioni | Q7Z3K3Primary (citable) accession number: Q7Z3K3 Secondary accession number(s): B4DTP8 Q9Y4X7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations