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Entry version 168 (13 Feb 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Pogo transposable element with ZNF domain

Gene

POGZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri375 – 397C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 553C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri560 – 583C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri590 – 613C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri619 – 641C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 670C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri771 – 794C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri815 – 840C2H2-type 9PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • kinetochore assembly Source: UniProtKB
  • mitotic sister chromatid cohesion Source: UniProtKB
  • regulation of gene expression Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pogo transposable element with ZNF domain
Alternative name(s):
Suppressor of hairy wing homolog 5
Zinc finger protein 280E
Zinc finger protein 635
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POGZ
Synonyms:KIAA0461, SUHW5, ZNF280E, ZNF635
ORF Names:Nbla00003
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143442.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18801 POGZ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614787 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z3K3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in POGZ may be associated with neuropsychiatric disorders such as autism spectrum disorders (ASD), bipolar affective disorders and early dementia onset. ASD are characterized by impairments in reciprocal social interaction and communication as well as restricted and stereotyped patterns of interest and activities. ASD include forms with moderate to severe cognitive impairment and milder forms with higher cognitive ability (Asperger syndrome).1 Publication
White-Sutton syndrome (WHSUS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by developmental delay, intellectual disability, hypotonia, behavioral abnormalities, and dysmorphic facial features. Variable features include short stature, microcephaly, strabismus and hearing loss.
See also OMIM:616364

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi817C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. 1 Publication1
Mutagenesisi820C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. 1 Publication1
Mutagenesisi833H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. 1 Publication1
Mutagenesisi840H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. 1 Publication1

Keywords - Diseasei

Autism spectrum disorder, Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
23126

MalaCards human disease database

More...
MalaCardsi
POGZ
MIMi616364 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143442

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
468678 Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38685

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POGZ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811442

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472241 – 1410Pogo transposable element with ZNF domainAdd BLAST1410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333PhosphoserineCombined sources1
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei363PhosphoserineCombined sources1
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei425PhosphoserineCombined sources1
Modified residuei439PhosphothreonineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Cross-linki449Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei463PhosphothreonineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki677Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki801Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei856PhosphoserineCombined sources1
Cross-linki883Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1368PhosphothreonineCombined sources1
Modified residuei1392PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z3K3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z3K3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z3K3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z3K3

PeptideAtlas

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PeptideAtlasi
Q7Z3K3

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z3K3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69059
69060 [Q7Z3K3-2]
69061 [Q7Z3K3-3]
69062 [Q7Z3K3-4]
69063 [Q7Z3K3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z3K3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z3K3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143442 Expressed in 235 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z3K3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z3K3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006800
HPA008781

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116745, 57 interactors

Database of interacting proteins

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DIPi
DIP-38044N

Protein interaction database and analysis system

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IntActi
Q7Z3K3, 149 interactors

Molecular INTeraction database

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MINTi
Q7Z3K3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E72NMR-A370-405[»]
2N3ANMR-A1389-1404[»]
6EMPNMR-A1370-1404[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7Z3K3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z3K3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7Z3K3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1015 – 1085HTH CENPB-typePROSITE-ProRule annotationAdd BLAST71
Domaini1117 – 1323DDE-1Sequence analysisAdd BLAST207

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni810 – 850Required for interaction with CBX5Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1340 – 1360Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi875 – 931Pro-richAdd BLAST57

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri375 – 397C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 553C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri560 – 583C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri590 – 613C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri619 – 641C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 670C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri771 – 794C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri815 – 840C2H2-type 9PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
KOG3105 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000010309

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG049435

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z3K3

KEGG Orthology (KO)

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KOi
K22594

Identification of Orthologs from Complete Genome Data

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OMAi
RQIHTQD

Database of Orthologous Groups

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OrthoDBi
105829at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z3K3

TreeFam database of animal gene trees

More...
TreeFami
TF331707

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00674 CENPB, 1 hit
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR
360 370 380 390 400
TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE
410 420 430 440 450
MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV
460 470 480 490 500
PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT
510 520 530 540 550
KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE
560 570 580 590 600
NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS
610 620 630 640 650
LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN
660 670 680 690 700
KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV
710 720 730 740 750
PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR
760 770 780 790 800
QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP
810 820 830 840 850
KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL
860 870 880 890 900
TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL
910 920 930 940 950
LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP
960 970 980 990 1000
VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ
1010 1020 1030 1040 1050
RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL
1060 1070 1080 1090 1100
FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN
1110 1120 1130 1140 1150
AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV
1160 1170 1180 1190 1200
GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS
1210 1220 1230 1240 1250
DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP
1260 1270 1280 1290 1300
AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL
1310 1320 1330 1340 1350
VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI
1360 1370 1380 1390 1400
ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF
1410
EEADLDLMEI
Length:1,410
Mass (Da):155,344
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58F672EDCD57CCD8
GO
Isoform 2 (identifier: Q7Z3K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.

Note: No experimental confirmation available.
Show »
Length:1,357
Mass (Da):150,130
Checksum:i3EC92965C8E95A98
GO
Isoform 3 (identifier: Q7Z3K3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     593-593: Q → QPYFPSYVTQ

Note: No experimental confirmation available.
Show »
Length:1,366
Mass (Da):151,213
Checksum:iC88635F4469B70AA
GO
Isoform 4 (identifier: Q7Z3K3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-363: VTSS → GTIT
     364-1410: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):37,882
Checksum:iE4CA34C166CC3E78
GO
Isoform 5 (identifier: Q7Z3K3-5) [UniParc]FASTAAdd to basket
Also known as: CRA_e

The sequence of this isoform differs from the canonical sequence as follows:
     96-190: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,315
Mass (Da):145,295
Checksum:i457D70CDC875B81C
GO
Isoform 6 (identifier: Q7Z3K3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-295: Missing.

Show »
Length:1,401
Mass (Da):154,492
Checksum:i99537C2A84842376
GO
Isoform 7 (identifier: Q7Z3K3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     287-295: Missing.

Show »
Length:1,348
Mass (Da):149,278
Checksum:i0016C4CF1C9CB146
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCT3H0YCT3_HUMAN
Pogo transposable element with ZNF ...
POGZ
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2X2M0R2X2_HUMAN
Pogo transposable element with ZNF ...
POGZ
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJY9E9PJY9_HUMAN
Pogo transposable element with ZNF ...
POGZ
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIR8E9PIR8_HUMAN
Pogo transposable element with ZNF ...
POGZ
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PW30A6PW30_HUMAN
Pogo transposable element with ZNF ...
POGZ
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C238H7C238_HUMAN
Pogo transposable element with ZNF ...
POGZ
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JHK5A0A0G2JHK5_HUMAN
Pogo transposable element with ZNF ...
POGZ
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE45744 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213R → G in BAG63781 (PubMed:14702039).Curated1
Sequence conflicti327I → F in BAG62060 (PubMed:14702039).Curated1
Sequence conflicti503L → P in BAB87117 (PubMed:12880961).Curated1
Sequence conflicti503L → P in BAE45744 (PubMed:12880961).Curated1
Sequence conflicti727V → A in BAG63781 (PubMed:14702039).Curated1
Sequence conflicti788N → T in CAB45136 (PubMed:10976766).Curated1
Sequence conflicti888K → E in BAB87117 (PubMed:12880961).Curated1
Sequence conflicti888K → E in BAE45744 (PubMed:12880961).Curated1
Sequence conflicti933A → V in CAD97850 (PubMed:17974005).Curated1
Sequence conflicti1026E → G in CAD97850 (PubMed:17974005).Curated1
Sequence conflicti1078R → W in BAB87117 (PubMed:12880961).Curated1
Sequence conflicti1078R → W in BAE45744 (PubMed:12880961).Curated1
Sequence conflicti1092 – 1107TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117 (PubMed:12880961).CuratedAdd BLAST16
Sequence conflicti1092 – 1107TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744 (PubMed:12880961).CuratedAdd BLAST16
Sequence conflicti1248T → A in BAG63781 (PubMed:14702039).Curated1
Sequence conflicti1304W → R in CAD97850 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0731791040E → K Probable disease-associated mutation found in patients with ASD. 1 Publication1
Natural variantiVAR_0314761365E → D. Corresponds to variant dbSNP:rs35198305Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01018542 – 94Missing in isoform 2, isoform 3 and isoform 7. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_03015096 – 190Missing in isoform 5. CuratedAdd BLAST95
Alternative sequenceiVSP_046785287 – 295Missing in isoform 6 and isoform 7. 1 Publication9
Alternative sequenceiVSP_010187360 – 363VTSS → GTIT in isoform 4. 1 Publication4
Alternative sequenceiVSP_010188364 – 1410Missing in isoform 4. 1 PublicationAdd BLAST1047
Alternative sequenceiVSP_010186593Q → QPYFPSYVTQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX537838 mRNA Translation: CAD97850.1
AK300307 mRNA Translation: BAG62060.1
AK302501 mRNA Translation: BAG63781.1
AL589764 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53440.1
AB037911 mRNA Translation: BAB87117.1
AB075477 mRNA Translation: BAE45744.1 Different initiation.
AJ242979 mRNA Translation: CAB45136.1
BC057773 mRNA Translation: AAH57773.1
AB007930 mRNA Translation: BAA32306.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44222.2 [Q7Z3K3-5]
CCDS53365.1 [Q7Z3K3-7]
CCDS53366.1 [Q7Z3K3-6]
CCDS997.1 [Q7Z3K3-1]
CCDS998.1 [Q7Z3K3-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00075

NCBI Reference Sequences

More...
RefSeqi
NP_001181866.1, NM_001194937.1 [Q7Z3K3-6]
NP_001181867.1, NM_001194938.1 [Q7Z3K3-7]
NP_055915.2, NM_015100.3 [Q7Z3K3-1]
NP_665739.3, NM_145796.3 [Q7Z3K3-5]
NP_997054.1, NM_207171.2 [Q7Z3K3-2]
XP_005245056.1, XM_005244999.2 [Q7Z3K3-1]
XP_005245057.1, XM_005245000.4 [Q7Z3K3-1]
XP_005245058.1, XM_005245001.2 [Q7Z3K3-1]
XP_005245062.1, XM_005245005.1 [Q7Z3K3-2]
XP_005245063.1, XM_005245006.4 [Q7Z3K3-2]
XP_016856234.1, XM_017000745.1 [Q7Z3K3-6]
XP_016856235.1, XM_017000746.1 [Q7Z3K3-6]
XP_016856237.1, XM_017000748.1 [Q7Z3K3-2]
XP_016856238.1, XM_017000749.1 [Q7Z3K3-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.489873

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1]
ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5]
ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2]
ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6]
ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3]
ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23126

UCSC genome browser

More...
UCSCi
uc001eyd.2 human [Q7Z3K3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537838 mRNA Translation: CAD97850.1
AK300307 mRNA Translation: BAG62060.1
AK302501 mRNA Translation: BAG63781.1
AL589764 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53440.1
AB037911 mRNA Translation: BAB87117.1
AB075477 mRNA Translation: BAE45744.1 Different initiation.
AJ242979 mRNA Translation: CAB45136.1
BC057773 mRNA Translation: AAH57773.1
AB007930 mRNA Translation: BAA32306.1
CCDSiCCDS44222.2 [Q7Z3K3-5]
CCDS53365.1 [Q7Z3K3-7]
CCDS53366.1 [Q7Z3K3-6]
CCDS997.1 [Q7Z3K3-1]
CCDS998.1 [Q7Z3K3-2]
PIRiT00075
RefSeqiNP_001181866.1, NM_001194937.1 [Q7Z3K3-6]
NP_001181867.1, NM_001194938.1 [Q7Z3K3-7]
NP_055915.2, NM_015100.3 [Q7Z3K3-1]
NP_665739.3, NM_145796.3 [Q7Z3K3-5]
NP_997054.1, NM_207171.2 [Q7Z3K3-2]
XP_005245056.1, XM_005244999.2 [Q7Z3K3-1]
XP_005245057.1, XM_005245000.4 [Q7Z3K3-1]
XP_005245058.1, XM_005245001.2 [Q7Z3K3-1]
XP_005245062.1, XM_005245005.1 [Q7Z3K3-2]
XP_005245063.1, XM_005245006.4 [Q7Z3K3-2]
XP_016856234.1, XM_017000745.1 [Q7Z3K3-6]
XP_016856235.1, XM_017000746.1 [Q7Z3K3-6]
XP_016856237.1, XM_017000748.1 [Q7Z3K3-2]
XP_016856238.1, XM_017000749.1 [Q7Z3K3-2]
UniGeneiHs.489873

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E72NMR-A370-405[»]
2N3ANMR-A1389-1404[»]
6EMPNMR-A1370-1404[»]
ProteinModelPortaliQ7Z3K3
SMRiQ7Z3K3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116745, 57 interactors
DIPiDIP-38044N
IntActiQ7Z3K3, 149 interactors
MINTiQ7Z3K3
STRINGi9606.ENSP00000271715

PTM databases

iPTMnetiQ7Z3K3
PhosphoSitePlusiQ7Z3K3

Polymorphism and mutation databases

BioMutaiPOGZ
DMDMi143811442

Proteomic databases

EPDiQ7Z3K3
jPOSTiQ7Z3K3
MaxQBiQ7Z3K3
PaxDbiQ7Z3K3
PeptideAtlasiQ7Z3K3
PRIDEiQ7Z3K3
ProteomicsDBi69059
69060 [Q7Z3K3-2]
69061 [Q7Z3K3-3]
69062 [Q7Z3K3-4]
69063 [Q7Z3K3-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23126
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271715; ENSP00000271715; ENSG00000143442 [Q7Z3K3-1]
ENST00000368863; ENSP00000357856; ENSG00000143442 [Q7Z3K3-5]
ENST00000392723; ENSP00000376484; ENSG00000143442 [Q7Z3K3-2]
ENST00000409503; ENSP00000386836; ENSG00000143442 [Q7Z3K3-6]
ENST00000491586; ENSP00000418408; ENSG00000143442 [Q7Z3K3-3]
ENST00000531094; ENSP00000431259; ENSG00000143442 [Q7Z3K3-7]
GeneIDi23126
KEGGihsa:23126
UCSCiuc001eyd.2 human [Q7Z3K3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23126
DisGeNETi23126
EuPathDBiHostDB:ENSG00000143442.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POGZ
HGNCiHGNC:18801 POGZ
HPAiHPA006800
HPA008781
MalaCardsiPOGZ
MIMi614787 gene
616364 phenotype
neXtProtiNX_Q7Z3K3
OpenTargetsiENSG00000143442
Orphaneti468678 Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome
PharmGKBiPA38685

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG3105 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000160649
HOGENOMiHOG000010309
HOVERGENiHBG049435
InParanoidiQ7Z3K3
KOiK22594
OMAiRQIHTQD
OrthoDBi105829at2759
PhylomeDBiQ7Z3K3
TreeFamiTF331707

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POGZ human
EvolutionaryTraceiQ7Z3K3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
POGZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23126

Protein Ontology

More...
PROi
PR:Q7Z3K3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143442 Expressed in 235 organ(s), highest expression level in kidney
ExpressionAtlasiQ7Z3K3 baseline and differential
GenevisibleiQ7Z3K3 HS

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOGZ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3K3
Secondary accession number(s): B4DTP8
, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q8TDZ7, Q9Y4X7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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