UniProtKB - Q7Z3I7 (ZN572_HUMAN)
Protein
Zinc finger protein 572
Gene
ZNF572
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 132 – 154 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 160 – 182 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 244 – 266 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 272 – 294 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 300 – 322 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 328 – 350 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 490 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7Z3I7 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 572 |
Gene namesi | Name:ZNF572 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26758, ZNF572 |
neXtProti | NX_Q7Z3I7 |
VEuPathDBi | HostDB:ENSG00000180938.5 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: LIFEdb
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 137209 |
OpenTargetsi | ENSG00000180938 |
PharmGKBi | PA134924678 |
Miscellaneous databases
Pharosi | Q7Z3I7, Tdark |
Genetic variation databases
BioMutai | ZNF572 |
DMDMi | 74762429 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251223 | 1 – 529 | Zinc finger protein 572Add BLAST | 529 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 5 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q7Z3I7 |
MassIVEi | Q7Z3I7 |
MaxQBi | Q7Z3I7 |
PaxDbi | Q7Z3I7 |
PeptideAtlasi | Q7Z3I7 |
PRIDEi | Q7Z3I7 |
ProteomicsDBi | 69054 |
PTM databases
iPTMneti | Q7Z3I7 |
PhosphoSitePlusi | Q7Z3I7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180938, Expressed in testis and 124 other tissues |
Genevisiblei | Q7Z3I7, HS |
Organism-specific databases
HPAi | ENSG00000180938, Low tissue specificity |
Interactioni
Binary interactionsi
Q7Z3I7
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 126473, 61 interactors |
IntActi | Q7Z3I7, 69 interactors |
STRINGi | 9606.ENSP00000319305 |
Miscellaneous databases
RNActi | Q7Z3I7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 132 – 154 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 160 – 182 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 244 – 266 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 272 – 294 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 300 – 322 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 328 – 350 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 490 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162935 |
HOGENOMi | CLU_002678_10_0_1 |
InParanoidi | Q7Z3I7 |
OMAi | HEWTWKN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7Z3I7 |
TreeFami | TF341767 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
i Sequence
Sequence statusi: Complete.
Q7Z3I7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQEKKLLVS DSNSFMERES LKSPFTGDTS MNNLETVHHN NSKADKLKEK
60 70 80 90 100
PSEWSKRHRP QHYKHEDAKE MPLTWVQDEI WCHDSYESDG KSENWGNFIA
110 120 130 140 150
KEEEKPNHQE WDSGEHTNAC VQQNSSFVDR PYKCSECWKS FSNSSHLRTH
160 170 180 190 200
QRTHSGEKPY KCSECAKCFC NSSHLIQHLR MHTGEKPYQC GECGKSFSNT
210 220 230 240 250
SHLIIHERTH TGEKPYKCPE CGKRFSSSSH LIQHHRSHTG EKPYECSVCG
260 270 280 290 300
KGFSHSYVLI EHQRTHTGEK PYKCPDCGKS FSQSSSLIRH QRTHTGEKPY
310 320 330 340 350
KCLECEKSFG CNSTLIKHQR IHTGEKPYQC PECGKNFSRS SNLITHQKMH
360 370 380 390 400
TGEKSYESSE YEESLGQNCN VIEECRIQLG EKPYRCCECG KSFGLSSHLI
410 420 430 440 450
RHQRTHTGEK PYRCSECWKT FSQSSTLVIH QRTHTGEKPY KCPDCGESFS
460 470 480 490 500
QSFNLIRHRR THIGEKPYKC TSCEKCFSRS AYLSQHRKIH VEKPFESPDV
510 520
GDFPHEWTWK NCSGEMPFIS SFSVSNSSS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 480 | S → I in BAC04529 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027664 | 317 | K → T. Corresponds to variant dbSNP:rs10104558Ensembl. | 1 | |
Natural variantiVAR_027665 | 380 | G → E1 PublicationCorresponds to variant dbSNP:rs10105106Ensembl. | 1 | |
Natural variantiVAR_027666 | 448 | S → C1 PublicationCorresponds to variant dbSNP:rs10107774Ensembl. | 1 | |
Natural variantiVAR_027667 | 500 | V → I. Corresponds to variant dbSNP:rs7825375Ensembl. | 1 | |
Natural variantiVAR_035591 | 512 | C → F in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095321 mRNA Translation: BAC04529.1 BX537876 mRNA Translation: CAD97876.1 BC130515 mRNA Translation: AAI30516.1 BC130517 mRNA Translation: AAI30518.1 |
CCDSi | CCDS6354.1 |
RefSeqi | NP_689625.2, NM_152412.2 |
Genome annotation databases
Ensembli | ENST00000319286; ENSP00000319305; ENSG00000180938 |
GeneIDi | 137209 |
KEGGi | hsa:137209 |
UCSCi | uc003yrr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095321 mRNA Translation: BAC04529.1 BX537876 mRNA Translation: CAD97876.1 BC130515 mRNA Translation: AAI30516.1 BC130517 mRNA Translation: AAI30518.1 |
CCDSi | CCDS6354.1 |
RefSeqi | NP_689625.2, NM_152412.2 |
3D structure databases
SMRi | Q7Z3I7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126473, 61 interactors |
IntActi | Q7Z3I7, 69 interactors |
STRINGi | 9606.ENSP00000319305 |
PTM databases
iPTMneti | Q7Z3I7 |
PhosphoSitePlusi | Q7Z3I7 |
Genetic variation databases
BioMutai | ZNF572 |
DMDMi | 74762429 |
Proteomic databases
jPOSTi | Q7Z3I7 |
MassIVEi | Q7Z3I7 |
MaxQBi | Q7Z3I7 |
PaxDbi | Q7Z3I7 |
PeptideAtlasi | Q7Z3I7 |
PRIDEi | Q7Z3I7 |
ProteomicsDBi | 69054 |
Protocols and materials databases
Antibodypediai | 27116, 118 antibodies |
DNASUi | 137209 |
Genome annotation databases
Ensembli | ENST00000319286; ENSP00000319305; ENSG00000180938 |
GeneIDi | 137209 |
KEGGi | hsa:137209 |
UCSCi | uc003yrr.4, human |
Organism-specific databases
CTDi | 137209 |
DisGeNETi | 137209 |
GeneCardsi | ZNF572 |
HGNCi | HGNC:26758, ZNF572 |
HPAi | ENSG00000180938, Low tissue specificity |
neXtProti | NX_Q7Z3I7 |
OpenTargetsi | ENSG00000180938 |
PharmGKBi | PA134924678 |
VEuPathDBi | HostDB:ENSG00000180938.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162935 |
HOGENOMi | CLU_002678_10_0_1 |
InParanoidi | Q7Z3I7 |
OMAi | HEWTWKN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7Z3I7 |
TreeFami | TF341767 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z3I7 |
Miscellaneous databases
BioGRID-ORCSi | 137209, 9 hits in 1012 CRISPR screens |
ChiTaRSi | ZNF572, human |
GenomeRNAii | 137209 |
Pharosi | Q7Z3I7, Tdark |
PROi | PR:Q7Z3I7 |
RNActi | Q7Z3I7, protein |
Gene expression databases
Bgeei | ENSG00000180938, Expressed in testis and 124 other tissues |
Genevisiblei | Q7Z3I7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN572_HUMAN | |
Accessioni | Q7Z3I7Primary (citable) accession number: Q7Z3I7 Secondary accession number(s): A1L4E9, A1L4F1, Q8N1Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families