UniProtKB - Q7Z3H4 (SAMD7_HUMAN)
Protein
Sterile alpha motif domain-containing protein 7
Gene
SAMD7
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.By similarity
GO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q7Z3H4 |
Names & Taxonomyi
Protein namesi | Recommended name: Sterile alpha motif domain-containing protein 7Short name: SAM domain-containing protein 7 |
Gene namesi | Name:SAMD7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25394, SAMD7 |
neXtProti | NX_Q7Z3H4 |
VEuPathDBi | HostDB:ENSG00000187033.9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 344658 |
OpenTargetsi | ENSG00000187033 |
PharmGKBi | PA134861212 |
Miscellaneous databases
Pharosi | Q7Z3H4, Tdark |
Genetic variation databases
BioMutai | SAMD7 |
DMDMi | 74713382 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263102 | 1 – 446 | Sterile alpha motif domain-containing protein 7Add BLAST | 446 |
Proteomic databases
MassIVEi | Q7Z3H4 |
PaxDbi | Q7Z3H4 |
PeptideAtlasi | Q7Z3H4 |
PRIDEi | Q7Z3H4 |
ProteomicsDBi | 69051 |
PTM databases
iPTMneti | Q7Z3H4 |
PhosphoSitePlusi | Q7Z3H4 |
Expressioni
Tissue specificityi
Expressed in the retina (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000187033, Expressed in tonsil and 4 other tissues |
ExpressionAtlasi | Q7Z3H4, baseline and differential |
Organism-specific databases
HPAi | ENSG00000187033, Tissue enriched (retina) |
Interactioni
Binary interactionsi
Hide detailsQ7Z3H4
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 131314, 13 interactors |
IntActi | Q7Z3H4, 12 interactors |
STRINGi | 9606.ENSP00000391299 |
Miscellaneous databases
RNActi | Q7Z3H4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 327 – 392 | SAMPROSITE-ProRule annotationAdd BLAST | 66 |
Phylogenomic databases
eggNOGi | KOG3829, Eukaryota |
GeneTreei | ENSGT00940000160075 |
HOGENOMi | CLU_046957_0_0_1 |
InParanoidi | Q7Z3H4 |
OMAi | DLHFHRS |
OrthoDBi | 622508at2759 |
PhylomeDBi | Q7Z3H4 |
TreeFami | TF331299 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7Z3H4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVNPLLTPT GQQTIPLIPS PFGPPTVDRD VLPSTVAPTD PRQFCVPSQF
60 70 80 90 100
GSSVLPNTNM ANVLSSRIYP GWGILPPESI KAVARRNEMI QRHHTARTEM
110 120 130 140 150
EMYAIYQQRR MEKINPKGLA GLGIPFLYGS SVPAAPAAYH GRSMLPAGDL
160 170 180 190 200
HFHRSTLRNL QGNPMLAATA PHFEESWGQR CRRLRKNTGN QKALDSDAES
210 220 230 240 250
SKSQAEEKIL GQTHAVPYEE DHYAKDPDIE APSNQKSSET NEKPTTALAN
260 270 280 290 300
TCGELEPTHR KPWGSHTTTL KAKAWDDGKE EASEQIFATC DEKNGVCPPV
310 320 330 340 350
PRPSLPGTHA LVTIGGNLSL DEDIQKWTVD DVHSFIRSLP GCSDYAQVFK
360 370 380 390 400
DHAIDGETLP LLTEEHLRGT MGLKLGPALK IQSQVSQHVG SMFYKKTLSF
410 420 430 440
PIRQAFDQPA DTSPLLDPNS WSDTMNIFCP QDTIIPKGIE RGSMRN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WDF1 | F8WDF1_HUMAN | Sterile alpha motif domain-containi... | SAMD7 | 98 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029586 | 220 | E → D. Corresponds to variant dbSNP:rs10513680Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX537903 mRNA Translation: CAD97889.1 BC117339 mRNA Translation: AAI17340.1 |
CCDSi | CCDS3209.1 |
RefSeqi | NP_001291295.1, NM_001304366.1 NP_872416.1, NM_182610.3 |
Genome annotation databases
Ensembli | ENST00000335556; ENSP00000334668; ENSG00000187033 ENST00000428432; ENSP00000391299; ENSG00000187033 |
GeneIDi | 344658 |
KEGGi | hsa:344658 |
UCSCi | uc003fgd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX537903 mRNA Translation: CAD97889.1 BC117339 mRNA Translation: AAI17340.1 |
CCDSi | CCDS3209.1 |
RefSeqi | NP_001291295.1, NM_001304366.1 NP_872416.1, NM_182610.3 |
3D structure databases
SMRi | Q7Z3H4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131314, 13 interactors |
IntActi | Q7Z3H4, 12 interactors |
STRINGi | 9606.ENSP00000391299 |
PTM databases
iPTMneti | Q7Z3H4 |
PhosphoSitePlusi | Q7Z3H4 |
Genetic variation databases
BioMutai | SAMD7 |
DMDMi | 74713382 |
Proteomic databases
MassIVEi | Q7Z3H4 |
PaxDbi | Q7Z3H4 |
PeptideAtlasi | Q7Z3H4 |
PRIDEi | Q7Z3H4 |
ProteomicsDBi | 69051 |
Protocols and materials databases
Antibodypediai | 51043, 142 antibodies |
DNASUi | 344658 |
Genome annotation databases
Ensembli | ENST00000335556; ENSP00000334668; ENSG00000187033 ENST00000428432; ENSP00000391299; ENSG00000187033 |
GeneIDi | 344658 |
KEGGi | hsa:344658 |
UCSCi | uc003fgd.4, human |
Organism-specific databases
CTDi | 344658 |
DisGeNETi | 344658 |
GeneCardsi | SAMD7 |
HGNCi | HGNC:25394, SAMD7 |
HPAi | ENSG00000187033, Tissue enriched (retina) |
neXtProti | NX_Q7Z3H4 |
OpenTargetsi | ENSG00000187033 |
PharmGKBi | PA134861212 |
VEuPathDBi | HostDB:ENSG00000187033.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3829, Eukaryota |
GeneTreei | ENSGT00940000160075 |
HOGENOMi | CLU_046957_0_0_1 |
InParanoidi | Q7Z3H4 |
OMAi | DLHFHRS |
OrthoDBi | 622508at2759 |
PhylomeDBi | Q7Z3H4 |
TreeFami | TF331299 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z3H4 |
Miscellaneous databases
BioGRID-ORCSi | 344658, 5 hits in 980 CRISPR screens |
GenomeRNAii | 344658 |
Pharosi | Q7Z3H4, Tdark |
PROi | PR:Q7Z3H4 |
RNActi | Q7Z3H4, protein |
Gene expression databases
Bgeei | ENSG00000187033, Expressed in tonsil and 4 other tissues |
ExpressionAtlasi | Q7Z3H4, baseline and differential |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SAMD7_HUMAN | |
Accessioni | Q7Z3H4Primary (citable) accession number: Q7Z3H4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports