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UniProtKB - Q7Z3H0 (PANKY_HUMAN)

Entry version 127 (02 Dec 2020)
Sequence version 4 (20 Dec 2017)
Previous versions | rss
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Protein

Photoreceptor ankyrin repeat protein

Gene

ANKRD33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z3H0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Photoreceptor ankyrin repeat proteinBy similarity
Alternative name(s):
Ankyrin repeat domain-containing protein 33Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD33
Synonyms:C12orf7, PANKY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000167612.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:13788, ANKRD33

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z3H0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		341405

Open Targets

More...OpenTargetsi		ENSG00000167612

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25508

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z3H0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANKRD33

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439441

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439081 – 452Photoreceptor ankyrin repeat proteinAdd BLAST452

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z3H0

PeptideAtlas

More...PeptideAtlasi		Q7Z3H0

PRoteomics IDEntifications database

More...PRIDEi		Q7Z3H0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69047 [Q7Z3H0-1]
69048 [Q7Z3H0-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167612, Expressed in placenta and 48 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z3H0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z3H0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167612, Group enriched (placenta, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131136, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z3H0, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301190

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z3H0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati94 – 123ANK 1Sequence analysisAdd BLAST30
Repeati130 – 160ANK 2Sequence analysisAdd BLAST31
Repeati164 – 193ANK 3Sequence analysisAdd BLAST30
Repeati223 – 257ANK 4Sequence analysisAdd BLAST35

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRWZ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00500000044852

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049994_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z3H0

Identification of Orthologs from Complete Genome Data

More...OMAi		VTCVASW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z3H0

TreeFam database of animal gene trees

More...TreeFami		TF332022

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: Q7Z3H0-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVQPSVTCV ASWGGIVHLE AFGDPVIVLR GAWAVPRVDC LIDTLRTPNA 
        60         70         80         90        100
SCMRKGTHLL VPCLEEEELA LHRRRLDMSE ALPCPGKETP TPGCRLGALY 
       110        120        130        140        150
WACVHNDPTQ LQAILDGGVS PEEATQVDSN GRTGLMVACY HGFQSVVALL 
       160        170        180        190        200
SHCPFLDVNQ QDKGGDTALM LAAQAGHVPL VSLLLNYYVG LDLERRDQRG 
       210        220        230        240        250
LTALMKAAMR NRCADLTAVD PVRGKTALEW AVLTDSFDTV WRIRQLLRRP 
       260        270        280        290        300
QVEQLSQHYK PEWPALSGLV AQAQAQAQVA PSLLERLQAT LSLPFAPSPQ 
       310        320        330        340        350
EGGVLDHLVT ATTSLASPFV TTACHTLCPD HPPSLGTRSK SVPELLGTAP 
       360        370        380        390        400
PPPLVPQSPP GSPQRSPWVF VPYQSPQGIL SKCLQWLQPR DSTSPRPQVP 
       410        420        430        440        450
KILLSKASSS SHQCQPKPSP SGHQSLALPL WRYQELRIEK RKQEEEARMA 

QK
Length:452
Mass (Da):49,403
Last modified:December 20, 2017 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0367E5EC638339BE
GO
Isoform 1 (identifier: Q7Z3H0-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     213-213: C → CECVATLLMAG
     347-452: GTAPPPPLVP...QEEEARMAQK → VPAEAQSFRT...EDGIGQAGNR

Show »
Length:272
Mass (Da):29,011
Checksum:i9A6C44A3D9FDA808
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VTQ6F8VTQ6_HUMAN
Photoreceptor ankyrin repeat protei...
ANKRD33
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ07991 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAQ07992 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti303G → S in CAD97893 (PubMed:17974005).Curated1
Sequence conflicti303G → S in CAE45798 (PubMed:17974005).Curated1
Isoform 1 (identifier: Q7Z3H0-1)
Sequence conflicti262G → E in CAD97893 (PubMed:17974005).Curated1
Sequence conflicti262G → E in CAE45798 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059121140Y → F. Corresponds to variant dbSNP:rs697636Ensembl.1
Natural variantiVAR_059122257Q → R1 PublicationCorresponds to variant dbSNP:rs34494292Ensembl.1
Natural variantiVAR_059123313T → N. Corresponds to variant dbSNP:rs12368048Ensembl.1
Isoform 1 (identifier: Q7Z3H0-1)
Natural variantiVAR_082795261V → ICuratedCorresponds to variant dbSNP:rs3180417Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0592651 – 135Missing in isoform 1. 1 Publication1 PublicationAdd BLAST135
Alternative sequenceiVSP_059266213C → CECVATLLMAG in isoform 1. 1 Publication1 Publication1
Alternative sequenceiVSP_059267347 – 452GTAPP…RMAQK → VPAEAQSFRTPKSGPSSLAI PGAQDREEETGGGGQNGTEV GEDGIGQAGNR in isoform 1. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK125517 mRNA Translation: BAC86190.1
BX537908 mRNA Translation: CAD97893.1
BX640656 mRNA Translation: CAE45798.1
AC025259 Genomic DNA No translation available.
BC121153 mRNA Translation: AAI21154.1
AF517112 mRNA Translation: AAQ07991.1 Different initiation.
AF517113 mRNA Translation: AAQ07992.1 Different initiation.
AF517114 mRNA Translation: AAQ07993.1
AF517115 mRNA Translation: AAQ07994.1
AF517118 mRNA Translation: AAQ07996.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44892.1 [Q7Z3H0-1]
CCDS8815.1 [Q7Z3H0-2]

NCBI Reference Sequences

More...RefSeqi		NP_001123487.1, NM_001130015.1 [Q7Z3H0-1]
NP_001291388.1, NM_001304459.1
NP_872414.3, NM_182608.3 [Q7Z3H0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301190; ENSP00000301190; ENSG00000167612 [Q7Z3H0-2]
ENST00000340970; ENSP00000344690; ENSG00000167612 [Q7Z3H0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		341405

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:341405

UCSC genome browser

More...UCSCi		uc001rzd.4, human [Q7Z3H0-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125517 mRNA Translation: BAC86190.1
BX537908 mRNA Translation: CAD97893.1
BX640656 mRNA Translation: CAE45798.1
AC025259 Genomic DNA No translation available.
BC121153 mRNA Translation: AAI21154.1
AF517112 mRNA Translation: AAQ07991.1 Different initiation.
AF517113 mRNA Translation: AAQ07992.1 Different initiation.
AF517114 mRNA Translation: AAQ07993.1
AF517115 mRNA Translation: AAQ07994.1
AF517118 mRNA Translation: AAQ07996.1
CCDSiCCDS44892.1 [Q7Z3H0-1]
CCDS8815.1 [Q7Z3H0-2]
RefSeqiNP_001123487.1, NM_001130015.1 [Q7Z3H0-1]
NP_001291388.1, NM_001304459.1
NP_872414.3, NM_182608.3 [Q7Z3H0-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131136, 15 interactors
IntActiQ7Z3H0, 11 interactors
STRINGi9606.ENSP00000301190

Polymorphism and mutation databases

BioMutaiANKRD33
DMDMi296439441

Proteomic databases

PaxDbiQ7Z3H0
PeptideAtlasiQ7Z3H0
PRIDEiQ7Z3H0
ProteomicsDBi69047 [Q7Z3H0-1]
69048 [Q7Z3H0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50682, 61 antibodies

Genome annotation databases

EnsembliENST00000301190; ENSP00000301190; ENSG00000167612 [Q7Z3H0-2]
ENST00000340970; ENSP00000344690; ENSG00000167612 [Q7Z3H0-1]
GeneIDi341405
KEGGihsa:341405
UCSCiuc001rzd.4, human [Q7Z3H0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		341405
DisGeNETi341405
EuPathDBiHostDB:ENSG00000167612.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANKRD33
HGNCiHGNC:13788, ANKRD33
HPAiENSG00000167612, Group enriched (placenta, retina)
neXtProtiNX_Q7Z3H0
OpenTargetsiENSG00000167612
PharmGKBiPA25508

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRWZ, Eukaryota
GeneTreeiENSGT00500000044852
HOGENOMiCLU_049994_0_0_1
InParanoidiQ7Z3H0
OMAiVTCVASW
PhylomeDBiQ7Z3H0
TreeFamiTF332022

Enzyme and pathway databases

PathwayCommonsiQ7Z3H0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		341405, 7 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANKRD33, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		341405
PharosiQ7Z3H0, Tdark

Protein Ontology

More...PROi		PR:Q7Z3H0
RNActiQ7Z3H0, protein

Gene expression databases

BgeeiENSG00000167612, Expressed in placenta and 48 other tissues
ExpressionAtlasiQ7Z3H0, baseline and differential
GenevisibleiQ7Z3H0, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 4 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANKY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3H0
Secondary accession number(s): Q0VAA7
, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 20, 2017
Last modified: December 2, 2020
This is version 127 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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