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Protein

Coiled-coil domain-containing protein 186

Gene

CCDC186

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 186
Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC186
Synonyms:C10orf118
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165813.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24349 CCDC186

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z3E2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134904295

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC186

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152997

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898232 – 898Coiled-coil domain-containing protein 186Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei740PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z3E2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z3E2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z3E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z3E2

PeptideAtlas

More...
PeptideAtlasi
Q7Z3E2

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z3E2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69040

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z3E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z3E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165813 Expressed in 201 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_C10orf118

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z3E2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z3E2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014569
HPA018019

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120401, 16 interactors

Database of interacting proteins

More...
DIPi
DIP-47298N

Protein interaction database and analysis system

More...
IntActi
Q7Z3E2, 11 interactors

Molecular INTeraction database

More...
MINTi
Q7Z3E2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358293

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7Z3E2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z3E2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili201 – 712Sequence analysisAdd BLAST512
Coiled coili759 – 803Sequence analysisAdd BLAST45
Coiled coili855 – 894Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi710 – 747Ser-richAdd BLAST38

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0992 Eukaryota
ENOG4110CGV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00720000108851

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081202

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z3E2

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKVVQHY

Database of Orthologous Groups

More...
OrthoDBi
604365at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z3E2

TreeFam database of animal gene trees

More...
TreeFami
TF328785

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038830 CCDC186

The PANTHER Classification System

More...
PANTHERi
PTHR18911 PTHR18911, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7Z3E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD
60 70 80 90 100
KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN
110 120 130 140 150
FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI
160 170 180 190 200
SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD
210 220 230 240 250
KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT
260 270 280 290 300
IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK
310 320 330 340 350
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI
360 370 380 390 400
KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK
410 420 430 440 450
AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN
460 470 480 490 500
ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT
510 520 530 540 550
LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL
560 570 580 590 600
QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA
610 620 630 640 650
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE
660 670 680 690 700
EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ
710 720 730 740 750
ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV
760 770 780 790 800
DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII
810 820 830 840 850
QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL
860 870 880 890
EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT
Length:898
Mass (Da):103,687
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E8A9BD547C82D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7V5H0Y7V5_HUMAN
Coiled-coil domain-containing prote...
CCDC186
436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFU7A0A0C4DFU7_HUMAN
Coiled-coil domain-containing prote...
CCDC186
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH70368 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 212.Curated
The sequence AAM44457 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 792.Curated
The sequence AAM44457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91480 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03926 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74 – 76GGG → IRH in AAM44457 (PubMed:14996095).Curated3
Sequence conflicti209I → T in AAH70368 (PubMed:15489334).Curated1
Sequence conflicti614D → I in BAA91480 (PubMed:14702039).Curated1
Sequence conflicti745G → E in CAD39031 (PubMed:17974005).Curated1
Sequence conflicti857Q → L in CAD97928 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02304785T → I2 PublicationsCorresponds to variant dbSNP:rs1061159Ensembl.1
Natural variantiVAR_023048179R → Q1 PublicationCorresponds to variant dbSNP:rs12782946Ensembl.1
Natural variantiVAR_023049271Q → K3 PublicationsCorresponds to variant dbSNP:rs7095762Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL834368 mRNA Translation: CAD39031.2
BX537964 mRNA Translation: CAD97928.1
BC070368 mRNA Translation: AAH70368.1 Sequence problems.
BC103499 mRNA Translation: AAI03500.1
BC105632 mRNA Translation: AAI05633.1
BC152306 mRNA Translation: AAI52307.1
AF273054 mRNA Translation: AAM44457.1 Sequence problems.
AK001050 mRNA Translation: BAA91480.1 Different initiation.
AK092620 mRNA Translation: BAC03926.1 Sequence problems.
BK001329 mRNA Translation: DAA01463.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7587.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308758.1, NM_001321829.1
NP_060487.2, NM_018017.3
NP_694981.1, NM_153249.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.159066
Hs.603328
Hs.732218

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369287; ENSP00000358293; ENSG00000165813
ENST00000648613; ENSP00000498136; ENSG00000165813

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55088

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55088

UCSC genome browser

More...
UCSCi
uc001lbb.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834368 mRNA Translation: CAD39031.2
BX537964 mRNA Translation: CAD97928.1
BC070368 mRNA Translation: AAH70368.1 Sequence problems.
BC103499 mRNA Translation: AAI03500.1
BC105632 mRNA Translation: AAI05633.1
BC152306 mRNA Translation: AAI52307.1
AF273054 mRNA Translation: AAM44457.1 Sequence problems.
AK001050 mRNA Translation: BAA91480.1 Different initiation.
AK092620 mRNA Translation: BAC03926.1 Sequence problems.
BK001329 mRNA Translation: DAA01463.1
CCDSiCCDS7587.1
RefSeqiNP_001308758.1, NM_001321829.1
NP_060487.2, NM_018017.3
NP_694981.1, NM_153249.1
UniGeneiHs.159066
Hs.603328
Hs.732218

3D structure databases

ProteinModelPortaliQ7Z3E2
SMRiQ7Z3E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120401, 16 interactors
DIPiDIP-47298N
IntActiQ7Z3E2, 11 interactors
MINTiQ7Z3E2
STRINGi9606.ENSP00000358293

PTM databases

iPTMnetiQ7Z3E2
PhosphoSitePlusiQ7Z3E2

Polymorphism and mutation databases

BioMutaiCCDC186
DMDMi71152997

Proteomic databases

EPDiQ7Z3E2
jPOSTiQ7Z3E2
MaxQBiQ7Z3E2
PaxDbiQ7Z3E2
PeptideAtlasiQ7Z3E2
PRIDEiQ7Z3E2
ProteomicsDBi69040

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55088
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369287; ENSP00000358293; ENSG00000165813
ENST00000648613; ENSP00000498136; ENSG00000165813
GeneIDi55088
KEGGihsa:55088
UCSCiuc001lbb.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55088
EuPathDBiHostDB:ENSG00000165813.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC186
HGNCiHGNC:24349 CCDC186
HPAiHPA014569
HPA018019
neXtProtiNX_Q7Z3E2
OpenTargetsiENSG00000165813
PharmGKBiPA134904295

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0992 Eukaryota
ENOG4110CGV LUCA
GeneTreeiENSGT00720000108851
HOVERGENiHBG081202
InParanoidiQ7Z3E2
OMAiSKVVQHY
OrthoDBi604365at2759
PhylomeDBiQ7Z3E2
TreeFamiTF328785

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC186 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C10orf118

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55088

Protein Ontology

More...
PROi
PR:Q7Z3E2

Gene expression databases

BgeeiENSG00000165813 Expressed in 201 organ(s), highest expression level in sperm
CleanExiHS_C10orf118
ExpressionAtlasiQ7Z3E2 baseline and differential
GenevisibleiQ7Z3E2 HS

Family and domain databases

InterProiView protein in InterPro
IPR038830 CCDC186
PANTHERiPTHR18911 PTHR18911, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC186_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6
, Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: January 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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