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Protein

Coiled-coil domain-containing protein 186

Gene

CCDC186

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 186
Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2
Gene namesi
Name:CCDC186
Synonyms:C10orf118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165813.16
HGNCiHGNC:24349 CCDC186
neXtProtiNX_Q7Z3E2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165813
PharmGKBiPA134904295

Polymorphism and mutation databases

BioMutaiC10orf118
DMDMi71152997

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000898232 – 898Coiled-coil domain-containing protein 186Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z3E2
MaxQBiQ7Z3E2
PaxDbiQ7Z3E2
PeptideAtlasiQ7Z3E2
PRIDEiQ7Z3E2
ProteomicsDBi69040

PTM databases

iPTMnetiQ7Z3E2
PhosphoSitePlusiQ7Z3E2

Expressioni

Gene expression databases

BgeeiENSG00000165813 Expressed in 201 organ(s), highest expression level in sperm
CleanExiHS_C10orf118
ExpressionAtlasiQ7Z3E2 baseline and differential
GenevisibleiQ7Z3E2 HS

Organism-specific databases

HPAiHPA014569
HPA018019

Interactioni

Protein-protein interaction databases

BioGridi120401, 15 interactors
DIPiDIP-47298N
IntActiQ7Z3E2, 11 interactors
MINTiQ7Z3E2
STRINGi9606.ENSP00000358293

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E2
SMRiQ7Z3E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 712Sequence analysisAdd BLAST512
Coiled coili759 – 803Sequence analysisAdd BLAST45
Coiled coili855 – 894Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi710 – 747Ser-richAdd BLAST38

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0992 Eukaryota
ENOG4110CGV LUCA
GeneTreeiENSGT00720000108851
HOVERGENiHBG081202
InParanoidiQ7Z3E2
OMAiMKYVRGE
OrthoDBiEOG091G05JM
PhylomeDBiQ7Z3E2
TreeFamiTF328785

Family and domain databases

InterProiView protein in InterPro
IPR038830 CCDC186
PANTHERiPTHR18911 PTHR18911, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7Z3E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD
60 70 80 90 100
KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN
110 120 130 140 150
FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI
160 170 180 190 200
SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD
210 220 230 240 250
KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT
260 270 280 290 300
IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK
310 320 330 340 350
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI
360 370 380 390 400
KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK
410 420 430 440 450
AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN
460 470 480 490 500
ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT
510 520 530 540 550
LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL
560 570 580 590 600
QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA
610 620 630 640 650
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE
660 670 680 690 700
EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ
710 720 730 740 750
ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV
760 770 780 790 800
DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII
810 820 830 840 850
QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL
860 870 880 890
EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT
Length:898
Mass (Da):103,687
Last modified:July 19, 2005 - v2
Checksum:i47E8A9BD547C82D3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7V5H0Y7V5_HUMAN
Coiled-coil domain-containing prote...
CCDC186
436Annotation score:
A0A0C4DFU7A0A0C4DFU7_HUMAN
Coiled-coil domain-containing prote...
CCDC186
211Annotation score:

Sequence cautioni

The sequence AAH70368 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 212.Curated
The sequence AAM44457 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 792.Curated
The sequence AAM44457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91480 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03926 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 76GGG → IRH in AAM44457 (PubMed:14996095).Curated3
Sequence conflicti209I → T in AAH70368 (PubMed:15489334).Curated1
Sequence conflicti614D → I in BAA91480 (PubMed:14702039).Curated1
Sequence conflicti745G → E in CAD39031 (PubMed:17974005).Curated1
Sequence conflicti857Q → L in CAD97928 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02304785T → I2 PublicationsCorresponds to variant dbSNP:rs1061159Ensembl.1
Natural variantiVAR_023048179R → Q1 PublicationCorresponds to variant dbSNP:rs12782946Ensembl.1
Natural variantiVAR_023049271Q → K3 PublicationsCorresponds to variant dbSNP:rs7095762Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834368 mRNA Translation: CAD39031.2
BX537964 mRNA Translation: CAD97928.1
BC070368 mRNA Translation: AAH70368.1 Sequence problems.
BC103499 mRNA Translation: AAI03500.1
BC105632 mRNA Translation: AAI05633.1
BC152306 mRNA Translation: AAI52307.1
AF273054 mRNA Translation: AAM44457.1 Sequence problems.
AK001050 mRNA Translation: BAA91480.1 Different initiation.
AK092620 mRNA Translation: BAC03926.1 Sequence problems.
BK001329 mRNA Translation: DAA01463.1
CCDSiCCDS7587.1
RefSeqiNP_001308758.1, NM_001321829.1
NP_060487.2, NM_018017.3
NP_694981.1, NM_153249.1
UniGeneiHs.159066
Hs.603328
Hs.732218

Genome annotation databases

EnsembliENST00000369287; ENSP00000358293; ENSG00000165813
GeneIDi55088
KEGGihsa:55088
UCSCiuc001lbb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834368 mRNA Translation: CAD39031.2
BX537964 mRNA Translation: CAD97928.1
BC070368 mRNA Translation: AAH70368.1 Sequence problems.
BC103499 mRNA Translation: AAI03500.1
BC105632 mRNA Translation: AAI05633.1
BC152306 mRNA Translation: AAI52307.1
AF273054 mRNA Translation: AAM44457.1 Sequence problems.
AK001050 mRNA Translation: BAA91480.1 Different initiation.
AK092620 mRNA Translation: BAC03926.1 Sequence problems.
BK001329 mRNA Translation: DAA01463.1
CCDSiCCDS7587.1
RefSeqiNP_001308758.1, NM_001321829.1
NP_060487.2, NM_018017.3
NP_694981.1, NM_153249.1
UniGeneiHs.159066
Hs.603328
Hs.732218

3D structure databases

ProteinModelPortaliQ7Z3E2
SMRiQ7Z3E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120401, 15 interactors
DIPiDIP-47298N
IntActiQ7Z3E2, 11 interactors
MINTiQ7Z3E2
STRINGi9606.ENSP00000358293

PTM databases

iPTMnetiQ7Z3E2
PhosphoSitePlusiQ7Z3E2

Polymorphism and mutation databases

BioMutaiC10orf118
DMDMi71152997

Proteomic databases

EPDiQ7Z3E2
MaxQBiQ7Z3E2
PaxDbiQ7Z3E2
PeptideAtlasiQ7Z3E2
PRIDEiQ7Z3E2
ProteomicsDBi69040

Protocols and materials databases

DNASUi55088
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369287; ENSP00000358293; ENSG00000165813
GeneIDi55088
KEGGihsa:55088
UCSCiuc001lbb.2 human

Organism-specific databases

CTDi55088
EuPathDBiHostDB:ENSG00000165813.16
GeneCardsiCCDC186
HGNCiHGNC:24349 CCDC186
HPAiHPA014569
HPA018019
neXtProtiNX_Q7Z3E2
OpenTargetsiENSG00000165813
PharmGKBiPA134904295
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0992 Eukaryota
ENOG4110CGV LUCA
GeneTreeiENSGT00720000108851
HOVERGENiHBG081202
InParanoidiQ7Z3E2
OMAiMKYVRGE
OrthoDBiEOG091G05JM
PhylomeDBiQ7Z3E2
TreeFamiTF328785

Miscellaneous databases

ChiTaRSiCCDC186 human
GeneWikiiC10orf118
GenomeRNAii55088
PROiPR:Q7Z3E2

Gene expression databases

BgeeiENSG00000165813 Expressed in 201 organ(s), highest expression level in sperm
CleanExiHS_C10orf118
ExpressionAtlasiQ7Z3E2 baseline and differential
GenevisibleiQ7Z3E2 HS

Family and domain databases

InterProiView protein in InterPro
IPR038830 CCDC186
PANTHERiPTHR18911 PTHR18911, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC186_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6
, Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 12, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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