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Protein

TCDD-inducible poly [ADP-ribose] polymerase

Gene

TIPARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 264C3H1-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

  • enhancer binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
TCDD-inducible poly [ADP-ribose] polymerase (EC:2.4.2.30)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 14
Short name:
ARTD14
Poly [ADP-ribose] polymerase 7
Short name:
PARP-7
Gene namesi
Name:TIPARP
Synonyms:PARP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163659.12
HGNCiHGNC:23696 TIPARP
MIMi612480 gene
neXtProtiNX_Q7Z3E1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi25976
OpenTargetsiENSG00000163659
PharmGKBiPA134885396

Chemistry databases

ChEMBLiCHEMBL2380188

Polymorphism and mutation databases

BioMutaiTIPARP
DMDMi74723283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478351 – 657TCDD-inducible poly [ADP-ribose] polymeraseAdd BLAST657

Proteomic databases

EPDiQ7Z3E1
PaxDbiQ7Z3E1
PeptideAtlasiQ7Z3E1
PRIDEiQ7Z3E1
ProteomicsDBi69039

PTM databases

iPTMnetiQ7Z3E1
PhosphoSitePlusiQ7Z3E1

Expressioni

Gene expression databases

BgeeiENSG00000163659 Expressed in 224 organ(s), highest expression level in tibia
CleanExiHS_TIPARP
ExpressionAtlasiQ7Z3E1 baseline and differential
GenevisibleiQ7Z3E1 HS

Organism-specific databases

HPAiHPA036796

Interactioni

Protein-protein interaction databases

BioGridi117460, 1 interactor
IntActiQ7Z3E1, 1 interactor
STRINGi9606.ENSP00000295924

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E1
SMRiQ7Z3E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 410WWEPROSITE-ProRule annotationAdd BLAST79
Domaini449 – 657PARP catalyticPROSITE-ProRule annotationAdd BLAST209

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 264C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIZH Eukaryota
ENOG410YI58 LUCA
GeneTreeiENSGT00760000119084
HOVERGENiHBG082109
InParanoidiQ7Z3E1
KOiK15259
OMAiDDFSCQM
OrthoDBiEOG091G14UY
PhylomeDBiQ7Z3E1
TreeFamiTF328965

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF00644 PARP, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit
PS50103 ZF_C3H1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q7Z3E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT
60 70 80 90 100
GTLRSLRPIL NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC
110 120 130 140 150
PPAENNMSVL IPDRTNVGDQ IPEAHPSTEA PERVVPIQDH SFPSETLSGT
160 170 180 190 200
VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK VIDYVPGIFQ ENSFTIQYIL
210 220 230 240 250
DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI EICMDFLQGT
260 270 280 290 300
CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR
310 320 330 340 350
MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF
360 370 380 390 400
CRDHFGWREY PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK
410 420 430 440 450
RRPLFRSCFI LLPYLQTLGG VPTQAPPPLE ATSSSQIICP DGVTSANFYP
460 470 480 490 500
ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN
510 520 530 540 550
QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD GICKHNFDPR
560 570 580 590 600
VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS
610 620 630 640 650
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE

VSNTVSI
Length:657
Mass (Da):76,227
Last modified:October 1, 2003 - v1
Checksum:i1E63E311F1B36CEB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5K7H7C5K7_HUMAN
Poly [ADP-ribose] polymerase
TIPARP
360Annotation score:
G5E9W1G5E9W1_HUMAN
TCDD-inducible poly [ADP-ribose] po...
TIPARP hCG_27716
654Annotation score:
C9JXM5C9JXM5_HUMAN
TCDD-inducible poly [ADP-ribose] po...
TIPARP hCG_27716
506Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43K → E in CAH18441 (PubMed:17974005).Curated1
Sequence conflicti582G → R in CAH18441 (PubMed:17974005).Curated1
Sequence conflicti633V → A in CAH18441 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027155406R → S1 PublicationCorresponds to variant dbSNP:rs17854621Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA Translation: CAB45747.2
BX537965 mRNA Translation: CAD97929.1
CR749647 mRNA Translation: CAH18441.1
CH471052 Genomic DNA Translation: EAW78725.1
CH471052 Genomic DNA Translation: EAW78728.1
BC050350 mRNA Translation: AAH50350.2
CCDSiCCDS3177.1
PIRiT12540
RefSeqiNP_001171646.1, NM_001184717.1
NP_001171647.1, NM_001184718.1
NP_056323.2, NM_015508.4
UniGeneiHs.744050

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659
ENST00000461166; ENSP00000420612; ENSG00000163659
ENST00000486483; ENSP00000418757; ENSG00000163659
ENST00000542783; ENSP00000438345; ENSG00000163659
GeneIDi25976
KEGGihsa:25976
UCSCiuc003fav.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA Translation: CAB45747.2
BX537965 mRNA Translation: CAD97929.1
CR749647 mRNA Translation: CAH18441.1
CH471052 Genomic DNA Translation: EAW78725.1
CH471052 Genomic DNA Translation: EAW78728.1
BC050350 mRNA Translation: AAH50350.2
CCDSiCCDS3177.1
PIRiT12540
RefSeqiNP_001171646.1, NM_001184717.1
NP_001171647.1, NM_001184718.1
NP_056323.2, NM_015508.4
UniGeneiHs.744050

3D structure databases

ProteinModelPortaliQ7Z3E1
SMRiQ7Z3E1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117460, 1 interactor
IntActiQ7Z3E1, 1 interactor
STRINGi9606.ENSP00000295924

Chemistry databases

ChEMBLiCHEMBL2380188

PTM databases

iPTMnetiQ7Z3E1
PhosphoSitePlusiQ7Z3E1

Polymorphism and mutation databases

BioMutaiTIPARP
DMDMi74723283

Proteomic databases

EPDiQ7Z3E1
PaxDbiQ7Z3E1
PeptideAtlasiQ7Z3E1
PRIDEiQ7Z3E1
ProteomicsDBi69039

Protocols and materials databases

DNASUi25976
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659
ENST00000461166; ENSP00000420612; ENSG00000163659
ENST00000486483; ENSP00000418757; ENSG00000163659
ENST00000542783; ENSP00000438345; ENSG00000163659
GeneIDi25976
KEGGihsa:25976
UCSCiuc003fav.4 human

Organism-specific databases

CTDi25976
DisGeNETi25976
EuPathDBiHostDB:ENSG00000163659.12
GeneCardsiTIPARP
HGNCiHGNC:23696 TIPARP
HPAiHPA036796
MIMi612480 gene
neXtProtiNX_Q7Z3E1
OpenTargetsiENSG00000163659
PharmGKBiPA134885396
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZH Eukaryota
ENOG410YI58 LUCA
GeneTreeiENSGT00760000119084
HOVERGENiHBG082109
InParanoidiQ7Z3E1
KOiK15259
OMAiDDFSCQM
OrthoDBiEOG091G14UY
PhylomeDBiQ7Z3E1
TreeFamiTF328965

Miscellaneous databases

ChiTaRSiTIPARP human
GeneWikiiTIPARP
GenomeRNAii25976
PROiPR:Q7Z3E1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163659 Expressed in 224 organ(s), highest expression level in tibia
CleanExiHS_TIPARP
ExpressionAtlasiQ7Z3E1 baseline and differential
GenevisibleiQ7Z3E1 HS

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF00644 PARP, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit
PS50103 ZF_C3H1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPARPT_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E1
Secondary accession number(s): D3DNK6
, Q68CY9, Q86VP4, Q9Y4P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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