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Entry version 132 (07 Oct 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Protein mono-ADP-ribosyltransferase TIPARP

Gene

TIPARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ADP-ribosyltransferase activity is inhibited by PJ34; inhibition is however not specific to TIPARP and other PARP-domain containing proteins are also inhibited by PJ34 (PubMed:30373764). Partially inhibited by KU0058948 (PubMed:30373764).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri237 – 264C3H1-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z3E1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mono-ADP-ribosyltransferase TIPARPCurated (EC:2.4.2.-3 Publications)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 141 Publication
Short name:
ARTD141 Publication
Poly [ADP-ribose] polymerase 71 Publication
Short name:
PARP-71 Publication
TCDD-inducible poly [ADP-ribose] polymerase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIPARP1 PublicationImported
Synonyms:PARP71 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163659.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23696, TIPARP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612480, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z3E1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39C → A: Slight reduction of auto-mono-ADP-ribosylation. 2 Publications1
Mutagenesisi41K → A: Partial relocalization to the cytoplasm. 1 Publication1
Mutagenesisi243C → A: Relocalization to the cytosol. 2 Publications1
Mutagenesisi532H → A: Abolishes ADP-ribosyltransferase activity. 2 Publications1
Mutagenesisi564Y → A: Abolishes ADP-ribosyltransferase activity. 1 Publication1
Mutagenesisi631I → A: Does not affect ADP-ribosyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
25976

Open Targets

More...
OpenTargetsi
ENSG00000163659

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885396

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z3E1, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2380188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIPARP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002478351 – 657Protein mono-ADP-ribosyltransferase TIPARPAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39ADP-ribosylcysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-mono-ADP-ribosylated.1 Publication

Keywords - PTMi

ADP-ribosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z3E1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z3E1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z3E1

PeptideAtlas

More...
PeptideAtlasi
Q7Z3E1

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z3E1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69039

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z3E1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z3E1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163659, Expressed in tibia and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z3E1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z3E1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163659, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AHR.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117460, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q7Z3E1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420612

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z3E1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z3E1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini332 – 410WWEPROSITE-ProRule annotationAdd BLAST79
Domaini449 – 657PARP catalyticPROSITE-ProRule annotationAdd BLAST209

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi41 – 47Nuclear localization signal1 Publication7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 264C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQXA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155368

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z3E1

KEGG Orthology (KO)

More...
KOi
K15259

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNPDNDR

Database of Orthologous Groups

More...
OrthoDBi
782733at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z3E1

TreeFam database of animal gene trees

More...
TreeFami
TF328965

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
IPR000571, Znf_CCCH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00644, PARP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51059, PARP_CATALYTIC, 1 hit
PS50918, WWE, 1 hit
PS50103, ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q7Z3E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT
60 70 80 90 100
GTLRSLRPIL NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC
110 120 130 140 150
PPAENNMSVL IPDRTNVGDQ IPEAHPSTEA PERVVPIQDH SFPSETLSGT
160 170 180 190 200
VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK VIDYVPGIFQ ENSFTIQYIL
210 220 230 240 250
DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI EICMDFLQGT
260 270 280 290 300
CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR
310 320 330 340 350
MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF
360 370 380 390 400
CRDHFGWREY PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK
410 420 430 440 450
RRPLFRSCFI LLPYLQTLGG VPTQAPPPLE ATSSSQIICP DGVTSANFYP
460 470 480 490 500
ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN
510 520 530 540 550
QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD GICKHNFDPR
560 570 580 590 600
VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS
610 620 630 640 650
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE

VSNTVSI
Length:657
Mass (Da):76,227
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E63E311F1B36CEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5K7H7C5K7_HUMAN
Poly [ADP-ribose] polymerase
TIPARP
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9W1G5E9W1_HUMAN
Protein mono-ADP-ribosyltransferase...
TIPARP hCG_27716
654Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXM5C9JXM5_HUMAN
Protein mono-ADP-ribosyltransferase...
TIPARP hCG_27716
506Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43K → E in CAH18441 (PubMed:17974005).Curated1
Sequence conflicti582G → R in CAH18441 (PubMed:17974005).Curated1
Sequence conflicti633V → A in CAH18441 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027155406R → S1 PublicationCorresponds to variant dbSNP:rs17854621Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL080156 mRNA Translation: CAB45747.2
BX537965 mRNA Translation: CAD97929.1
CR749647 mRNA Translation: CAH18441.1
CH471052 Genomic DNA Translation: EAW78725.1
CH471052 Genomic DNA Translation: EAW78728.1
BC050350 mRNA Translation: AAH50350.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3177.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T12540

NCBI Reference Sequences

More...
RefSeqi
NP_001171646.1, NM_001184717.1
NP_001171647.1, NM_001184718.1
NP_056323.2, NM_015508.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295924; ENSP00000295924; ENSG00000163659
ENST00000461166; ENSP00000420612; ENSG00000163659
ENST00000486483; ENSP00000418757; ENSG00000163659
ENST00000542783; ENSP00000438345; ENSG00000163659

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25976

UCSC genome browser

More...
UCSCi
uc003fav.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA Translation: CAB45747.2
BX537965 mRNA Translation: CAD97929.1
CR749647 mRNA Translation: CAH18441.1
CH471052 Genomic DNA Translation: EAW78725.1
CH471052 Genomic DNA Translation: EAW78728.1
BC050350 mRNA Translation: AAH50350.2
CCDSiCCDS3177.1
PIRiT12540
RefSeqiNP_001171646.1, NM_001184717.1
NP_001171647.1, NM_001184718.1
NP_056323.2, NM_015508.4

3D structure databases

SMRiQ7Z3E1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117460, 1 interactor
IntActiQ7Z3E1, 2 interactors
STRINGi9606.ENSP00000420612

Chemistry databases

ChEMBLiCHEMBL2380188

PTM databases

iPTMnetiQ7Z3E1
PhosphoSitePlusiQ7Z3E1

Polymorphism and mutation databases

BioMutaiTIPARP
DMDMi74723283

Proteomic databases

EPDiQ7Z3E1
MassIVEiQ7Z3E1
PaxDbiQ7Z3E1
PeptideAtlasiQ7Z3E1
PRIDEiQ7Z3E1
ProteomicsDBi69039

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33637, 83 antibodies

The DNASU plasmid repository

More...
DNASUi
25976

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659
ENST00000461166; ENSP00000420612; ENSG00000163659
ENST00000486483; ENSP00000418757; ENSG00000163659
ENST00000542783; ENSP00000438345; ENSG00000163659
GeneIDi25976
KEGGihsa:25976
UCSCiuc003fav.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25976
DisGeNETi25976
EuPathDBiHostDB:ENSG00000163659.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TIPARP
HGNCiHGNC:23696, TIPARP
HPAiENSG00000163659, Low tissue specificity
MIMi612480, gene
neXtProtiNX_Q7Z3E1
OpenTargetsiENSG00000163659
PharmGKBiPA134885396

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QQXA, Eukaryota
GeneTreeiENSGT00940000155368
InParanoidiQ7Z3E1
KOiK15259
OMAiCNPDNDR
OrthoDBi782733at2759
PhylomeDBiQ7Z3E1
TreeFamiTF328965

Enzyme and pathway databases

PathwayCommonsiQ7Z3E1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
25976, 155 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TIPARP, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TIPARP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25976
PharosiQ7Z3E1, Tbio

Protein Ontology

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PROi
PR:Q7Z3E1
RNActiQ7Z3E1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163659, Expressed in tibia and 237 other tissues
ExpressionAtlasiQ7Z3E1, baseline and differential
GenevisibleiQ7Z3E1, HS

Family and domain databases

InterProiView protein in InterPro
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
IPR000571, Znf_CCCH
PfamiView protein in Pfam
PF00644, PARP, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059, PARP_CATALYTIC, 1 hit
PS50918, WWE, 1 hit
PS50103, ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARPT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3E1
Secondary accession number(s): D3DNK6
, Q68CY9, Q86VP4, Q9Y4P7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: October 7, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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