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Protein

LysM and putative peptidoglycan-binding domain-containing protein 3

Gene

LYSMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LysM and putative peptidoglycan-binding domain-containing protein 3
Gene namesi
Name:LYSMD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000176018.12
HGNCiHGNC:26969 LYSMD3
neXtProtiNX_Q7Z3D4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 217ExtracellularSequence analysisAdd BLAST217
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 306CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116068
OpenTargetsiENSG00000176018
PharmGKBiPA142671495

Polymorphism and mutation databases

BioMutaiLYSMD3
DMDMi114150022

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002480071 – 306LysM and putative peptidoglycan-binding domain-containing protein 3Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z3D4
MaxQBiQ7Z3D4
PaxDbiQ7Z3D4
PeptideAtlasiQ7Z3D4
PRIDEiQ7Z3D4
ProteomicsDBi69029
69030 [Q7Z3D4-2]
69031 [Q7Z3D4-3]

PTM databases

iPTMnetiQ7Z3D4
PhosphoSitePlusiQ7Z3D4

Expressioni

Gene expression databases

BgeeiENSG00000176018 Expressed in 199 organ(s), highest expression level in liver
CleanExiHS_LYSMD3
ExpressionAtlasiQ7Z3D4 baseline and differential
GenevisibleiQ7Z3D4 HS

Organism-specific databases

HPAiHPA018024

Interactioni

Protein-protein interaction databases

BioGridi125469, 2 interactors
IntActiQ7Z3D4, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7Z3D4
SMRiQ7Z3D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 109LysMPROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2850 Eukaryota
ENOG4112BYV LUCA
GeneTreeiENSGT00530000063803
HOGENOMiHOG000237338
HOVERGENiHBG081944
InParanoidiQ7Z3D4
OMAiCTDTKRE
OrthoDBiEOG091G0Q9I
PhylomeDBiQ7Z3D4
TreeFamiTF326271

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF01476 LysM, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3D4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGRHQNRSF PLPGVQSSGQ VHAFGNCSDS DILEEDAEVY ELRSRGKEKV
60 70 80 90 100
RRSTSRDRLD DIIVLTKDIQ EGDTLNAIAL QYCCTVADIK RVNNLISDQD
110 120 130 140 150
FFALRSIKIP VKKFSSLTET LCPPKGRQTS RHSSVQYSSE QQEILPANDS
160 170 180 190 200
LAYSDSAGSF LKEVDRDIEQ IVKCTDNKRE NLNEVVSALT AQQMRFEPDN
210 220 230 240 250
KNTQRKDPYY GADWGIGWWT AVVIMLIVGI ITPVFYLLYY EILAKVDVSH
260 270 280 290 300
HSTVDSSHLH SKITPPSQQR EMENGIVPTK GIHFSQQDDH KLYSQDSQSP

AAQQET
Length:306
Mass (Da):34,538
Last modified:September 5, 2006 - v2
Checksum:iDBCEAF17C2ADC42D
GO
Isoform 2 (identifier: Q7Z3D4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-127: ADIKRVNNLI...TETLCPPKGR → YQNSSKKVQF...LFRTTGNFAS
     128-306: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,332
Checksum:i4456DA8A8860BD20
GO
Isoform 3 (identifier: Q7Z3D4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-150: VADIKRVNNL...QQEILPANDS → LRWMLVIIQQ...HLLLNRKHSN
     151-306: Missing.

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):17,482
Checksum:i7B15B60DE19239A8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9N8G5E9N8_HUMAN
HCG37164, isoform CRA_c
LYSMD3 hCG_37164
90Annotation score:

Sequence cautioni

The sequence CAD97936 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02012586 – 150VADIK…PANDS → LRWMLVIIQQWTLHIYIQKS HPHHSREKWKMELCQLKEYI SANKMIINCIVKILSHLLLN RKHSN in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_02012687 – 127ADIKR…PPKGR → YQNSSKKVQFLDRNTLSSKR KTDFTSFICSILFRTTGNFA S in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_020127128 – 306Missing in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_020128151 – 306Missing in isoform 3. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137315 mRNA Translation: CAB70692.1
BX537972 mRNA Translation: CAD97936.1 Different initiation.
CR933624 mRNA Translation: CAI45934.1
BC058027 mRNA Translation: AAH58027.1
CCDSiCCDS43338.1 [Q7Z3D4-1]
CCDS68911.1 [Q7Z3D4-2]
PIRiT46287
RefSeqiNP_001273741.1, NM_001286812.1 [Q7Z3D4-2]
NP_938014.1, NM_198273.2 [Q7Z3D4-1]
XP_005248478.1, XM_005248421.4 [Q7Z3D4-1]
UniGeneiHs.136235

Genome annotation databases

EnsembliENST00000315948; ENSP00000314518; ENSG00000176018 [Q7Z3D4-1]
ENST00000500869; ENSP00000427020; ENSG00000176018 [Q7Z3D4-3]
ENST00000509384; ENSP00000427683; ENSG00000176018 [Q7Z3D4-2]
GeneIDi116068
KEGGihsa:116068
UCSCiuc003kjr.5 human [Q7Z3D4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137315 mRNA Translation: CAB70692.1
BX537972 mRNA Translation: CAD97936.1 Different initiation.
CR933624 mRNA Translation: CAI45934.1
BC058027 mRNA Translation: AAH58027.1
CCDSiCCDS43338.1 [Q7Z3D4-1]
CCDS68911.1 [Q7Z3D4-2]
PIRiT46287
RefSeqiNP_001273741.1, NM_001286812.1 [Q7Z3D4-2]
NP_938014.1, NM_198273.2 [Q7Z3D4-1]
XP_005248478.1, XM_005248421.4 [Q7Z3D4-1]
UniGeneiHs.136235

3D structure databases

ProteinModelPortaliQ7Z3D4
SMRiQ7Z3D4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125469, 2 interactors
IntActiQ7Z3D4, 2 interactors

PTM databases

iPTMnetiQ7Z3D4
PhosphoSitePlusiQ7Z3D4

Polymorphism and mutation databases

BioMutaiLYSMD3
DMDMi114150022

Proteomic databases

EPDiQ7Z3D4
MaxQBiQ7Z3D4
PaxDbiQ7Z3D4
PeptideAtlasiQ7Z3D4
PRIDEiQ7Z3D4
ProteomicsDBi69029
69030 [Q7Z3D4-2]
69031 [Q7Z3D4-3]

Protocols and materials databases

DNASUi116068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315948; ENSP00000314518; ENSG00000176018 [Q7Z3D4-1]
ENST00000500869; ENSP00000427020; ENSG00000176018 [Q7Z3D4-3]
ENST00000509384; ENSP00000427683; ENSG00000176018 [Q7Z3D4-2]
GeneIDi116068
KEGGihsa:116068
UCSCiuc003kjr.5 human [Q7Z3D4-1]

Organism-specific databases

CTDi116068
DisGeNETi116068
EuPathDBiHostDB:ENSG00000176018.12
GeneCardsiLYSMD3
HGNCiHGNC:26969 LYSMD3
HPAiHPA018024
neXtProtiNX_Q7Z3D4
OpenTargetsiENSG00000176018
PharmGKBiPA142671495
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2850 Eukaryota
ENOG4112BYV LUCA
GeneTreeiENSGT00530000063803
HOGENOMiHOG000237338
HOVERGENiHBG081944
InParanoidiQ7Z3D4
OMAiCTDTKRE
OrthoDBiEOG091G0Q9I
PhylomeDBiQ7Z3D4
TreeFamiTF326271

Miscellaneous databases

GeneWikiiLYSMD3
GenomeRNAii116068
PROiPR:Q7Z3D4

Gene expression databases

BgeeiENSG00000176018 Expressed in 199 organ(s), highest expression level in liver
CleanExiHS_LYSMD3
ExpressionAtlasiQ7Z3D4 baseline and differential
GenevisibleiQ7Z3D4 HS

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF01476 LysM, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYSM3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3D4
Secondary accession number(s): Q5H9U0, Q6PEK0, Q9NTE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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