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Protein

Autophagy-related protein 9A

Gene

ATG9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • autophagosome assembly Source: MGI
  • autophagy of mitochondrion Source: GO_Central
  • late nucleophagy Source: GO_Central
  • protein localization to phagophore assembly site Source: GO_Central
  • protein transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1632852 Macroautophagy

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
mATG9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG9A
Synonyms:APG9L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198925.10

Human Gene Nomenclature Database

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HGNCi
HGNC:22408 ATG9A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612204 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z3C6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 66CytoplasmicBy similarityAdd BLAST65
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 131LumenalBy similarityAdd BLAST44
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 289CytoplasmicBy similarityAdd BLAST137
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 371LumenalBy similarityAdd BLAST61
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 400CytoplasmicBy similarity8
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 473LumenalBy similarityAdd BLAST52
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 839CytoplasmicBy similarityAdd BLAST345

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79065

Open Targets

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OpenTargetsi
ENSG00000198925

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134931318

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ATG9A

Domain mapping of disease mutations (DMDM)

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DMDMi
296439428

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198202 – 839Autophagy-related protein 9AAdd BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei16PhosphoserineBy similarity1
Modified residuei18PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei656PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z3C6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z3C6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z3C6

PeptideAtlas

More...
PeptideAtlasi
Q7Z3C6

PRoteomics IDEntifications database

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PRIDEi
Q7Z3C6

ProteomicsDB human proteome resource

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ProteomicsDBi
69026
69027 [Q7Z3C6-2]
69028 [Q7Z3C6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z3C6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z3C6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198925 Expressed in 212 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_ATG9A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z3C6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z3C6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA059551

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SUPT20H.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122518, 54 interactors

Protein interaction database and analysis system

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IntActi
Q7Z3C6, 64 interactors

Molecular INTeraction database

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MINTi
Q7Z3C6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355173

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z3C6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2173 Eukaryota
ENOG410XQBE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014839

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050539

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z3C6

KEGG Orthology (KO)

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KOi
K17907

Identification of Orthologs from Complete Genome Data

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OMAi
AWMSAGK

Database of Orthologous Groups

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OrthoDBi
EOG091G01WQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z3C6

TreeFam database of animal gene trees

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TreeFami
TF313665

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007241 Autophagy-rel_prot_9

The PANTHER Classification System

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PANTHERi
PTHR13038 PTHR13038, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04109 APG9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE
510 520 530 540 550
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT EASVYQQAED
560 570 580 590 600
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP
610 620 630 640 650
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS
660 670 680 690 700
ALRSFSPLQP GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE
710 720 730 740 750
YASTEMSLHA LYMHQLHKQQ AQAEPERHVW HRRESDESGE SAPDEGGEGA
760 770 780 790 800
RAPQSIPRSA SYPCAAPRPG APETTALHGG FQRRYGGITD PGTVPRVPSH
810 820 830
FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV
Length:839
Mass (Da):94,447
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69BE087CA550DC42
GO
Isoform 2 (identifier: Q7Z3C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:778
Mass (Da):87,379
Checksum:iDBF1B239460D7250
GO
Isoform 3 (identifier: Q7Z3C6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-528: NAHRSQTRDE...CSFAQMDVRQ → VHFGRVAEPH...ADRGLSVPAS
     529-839: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:528
Mass (Da):60,694
Checksum:iFB9BEBBFA794B352
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JD65C9JD65_HUMAN
Autophagy-related protein 9
ATG9A
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKV7C9JKV7_HUMAN
Autophagy-related protein 9
ATG9A
169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDK4C9JDK4_HUMAN
Autophagy-related protein 9
ATG9A
172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYZ9C9IYZ9_HUMAN
Autophagy-related protein 9
ATG9A
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JS65C9JS65_HUMAN
Autophagy-related protein 9
ATG9A
93Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JX27C9JX27_HUMAN
Autophagy-related protein 9
ATG9A
131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1G6H7C1G6_HUMAN
Autophagy-related protein 9
ATG9A
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFV2C9JFV2_HUMAN
Autophagy-related protein 9
ATG9A
97Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXG2C9JXG2_HUMAN
Autophagy-related protein 9
ATG9A
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3I6F2Z3I6_HUMAN
Autophagy-related protein 9A
ATG9A
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15246 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55119 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39H → R in CAD97944 (PubMed:17974005).Curated1
Sequence conflicti300L → P in CAD97944 (PubMed:17974005).Curated1
Sequence conflicti381A → T in AAH65534 (PubMed:15489334).Curated1
Sequence conflicti519C → R in CAD98061 (PubMed:17974005).Curated1
Sequence conflicti567W → R in CAD98061 (PubMed:17974005).Curated1
Sequence conflicti669H → N in BAB15246 (PubMed:14702039).Curated1
Sequence conflicti765A → V in CAD97944 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021835592S → G2 PublicationsCorresponds to variant dbSNP:rs2276635Ensembl.1
Natural variantiVAR_055534659Q → H. Corresponds to variant dbSNP:rs2276634Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0133961 – 61Missing in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_013397455 – 528NAHRS…MDVRQ → VHFGRVAEPHCHTPHPHLLP APTGPGDYRLLPKLHRGGRW CGRYLLLCSDGCSPAWSSPV AICWADRGLSVPAS in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_013398529 – 839Missing in isoform 3. 1 PublicationAdd BLAST311

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL833865 mRNA Translation: CAD38723.1
BX537984 mRNA Translation: CAD97944.1
BX538192 mRNA Translation: CAD98061.1
BX538198 mRNA Translation: CAD98064.1
AC068946 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70706.1
BC001098 mRNA Translation: AAH01098.2
BC021202 mRNA Translation: AAH21202.2
BC065534 mRNA Translation: AAH65534.1
AK021732 mRNA Translation: BAB13882.1 Different initiation.
AK027448 mRNA Translation: BAB55119.1 Different initiation.
AK025822 mRNA Translation: BAB15246.1 Different initiation.
BK004018 mRNA Translation: DAA05199.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42820.1 [Q7Z3C6-1]

NCBI Reference Sequences

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RefSeqi
NP_001070666.1, NM_001077198.2 [Q7Z3C6-1]
NP_076990.4, NM_024085.4 [Q7Z3C6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.323363

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361242; ENSP00000355173; ENSG00000198925 [Q7Z3C6-1]
ENST00000396761; ENSP00000379983; ENSG00000198925 [Q7Z3C6-1]
ENST00000409033; ENSP00000386482; ENSG00000198925 [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925 [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925 [Q7Z3C6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79065

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79065

UCSC genome browser

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UCSCi
uc002vke.3 human [Q7Z3C6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833865 mRNA Translation: CAD38723.1
BX537984 mRNA Translation: CAD97944.1
BX538192 mRNA Translation: CAD98061.1
BX538198 mRNA Translation: CAD98064.1
AC068946 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70706.1
BC001098 mRNA Translation: AAH01098.2
BC021202 mRNA Translation: AAH21202.2
BC065534 mRNA Translation: AAH65534.1
AK021732 mRNA Translation: BAB13882.1 Different initiation.
AK027448 mRNA Translation: BAB55119.1 Different initiation.
AK025822 mRNA Translation: BAB15246.1 Different initiation.
BK004018 mRNA Translation: DAA05199.1
CCDSiCCDS42820.1 [Q7Z3C6-1]
RefSeqiNP_001070666.1, NM_001077198.2 [Q7Z3C6-1]
NP_076990.4, NM_024085.4 [Q7Z3C6-1]
UniGeneiHs.323363

3D structure databases

ProteinModelPortaliQ7Z3C6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122518, 54 interactors
IntActiQ7Z3C6, 64 interactors
MINTiQ7Z3C6
STRINGi9606.ENSP00000355173

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiQ7Z3C6
PhosphoSitePlusiQ7Z3C6

Polymorphism and mutation databases

BioMutaiATG9A
DMDMi296439428

Proteomic databases

EPDiQ7Z3C6
MaxQBiQ7Z3C6
PaxDbiQ7Z3C6
PeptideAtlasiQ7Z3C6
PRIDEiQ7Z3C6
ProteomicsDBi69026
69027 [Q7Z3C6-2]
69028 [Q7Z3C6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79065
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361242; ENSP00000355173; ENSG00000198925 [Q7Z3C6-1]
ENST00000396761; ENSP00000379983; ENSG00000198925 [Q7Z3C6-1]
ENST00000409033; ENSP00000386482; ENSG00000198925 [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925 [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925 [Q7Z3C6-1]
GeneIDi79065
KEGGihsa:79065
UCSCiuc002vke.3 human [Q7Z3C6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79065
DisGeNETi79065
EuPathDBiHostDB:ENSG00000198925.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ATG9A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002853
HIX0077803
HGNCiHGNC:22408 ATG9A
HPAiHPA059551
MIMi612204 gene
neXtProtiNX_Q7Z3C6
OpenTargetsiENSG00000198925
PharmGKBiPA134931318

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2173 Eukaryota
ENOG410XQBE LUCA
GeneTreeiENSGT00390000014839
HOVERGENiHBG050539
InParanoidiQ7Z3C6
KOiK17907
OMAiAWMSAGK
OrthoDBiEOG091G01WQ
PhylomeDBiQ7Z3C6
TreeFamiTF313665

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATG9A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATG9A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79065

Protein Ontology

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PROi
PR:Q7Z3C6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198925 Expressed in 212 organ(s), highest expression level in testis
CleanExiHS_ATG9A
ExpressionAtlasiQ7Z3C6 baseline and differential
GenevisibleiQ7Z3C6 HS

Family and domain databases

InterProiView protein in InterPro
IPR007241 Autophagy-rel_prot_9
PANTHERiPTHR13038 PTHR13038, 1 hit
PfamiView protein in Pfam
PF04109 APG9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG9A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3C6
Secondary accession number(s): Q3ZAQ6
, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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