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Protein

Nucleoporin p54

Gene

NUP54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin p54
Alternative name(s):
54 kDa nucleoporin
Gene namesi
Name:NUP54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138750.14
HGNCiHGNC:17359 NUP54
MIMi607607 gene
neXtProtiNX_Q7Z3B4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138750
PharmGKBiPA31853

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048741 – 507Nucleoporin p54Add BLAST507

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ7Z3B4
MaxQBiQ7Z3B4
PaxDbiQ7Z3B4
PeptideAtlasiQ7Z3B4
PRIDEiQ7Z3B4
ProteomicsDBi69024
69025 [Q7Z3B4-2]

PTM databases

iPTMnetiQ7Z3B4
PhosphoSitePlusiQ7Z3B4

Expressioni

Gene expression databases

BgeeiENSG00000138750
CleanExiHS_NUP54
ExpressionAtlasiQ7Z3B4 baseline and differential
GenevisibleiQ7Z3B4 HS

Organism-specific databases

HPAiHPA035929
HPA058122

Interactioni

Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119759, 49 interactors
IntActiQ7Z3B4, 55 interactors
MINTiQ7Z3B4
STRINGi9606.ENSP00000264883

Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi454 – 456Combined sources3
Helixi457 – 487Combined sources31
Helixi488 – 490Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JNUX-ray1.44A/B/C/D453-491[»]
4JNVX-ray1.85A/B/C/D453-491[»]
4JO7X-ray1.75B/D/F/H453-491[»]
4JO9X-ray2.50A/C453-491[»]
5IJNelectron microscopy21.40F/L/R/X1-507[»]
5IJOelectron microscopy21.40F/L/R/X1-507[»]
ProteinModelPortaliQ7Z3B4
SMRiQ7Z3B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 612
Repeati25 – 2622
Repeati28 – 2932
Repeati53 – 5442
Repeati61 – 6252
Repeati63 – 6462
Repeati67 – 6872
Repeati87 – 8882
Repeati444 – 44592

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 4459 X 2 AA repeats of F-GAdd BLAST441

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 89Gly-richAdd BLAST84
Compositional biasi30 – 99Thr-richAdd BLAST70
Compositional biasi93 – 97Poly-Gln5
Compositional biasi205 – 208Poly-Gln4

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP54 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3091 Eukaryota
ENOG410XPU5 LUCA
GeneTreeiENSGT00390000013620
HOGENOMiHOG000046583
HOVERGENiHBG052698
InParanoidiQ7Z3B4
KOiK14308
OMAiWNQLQAY
OrthoDBiEOG091G0BAH
PhylomeDBiQ7Z3B4
TreeFamiTF320237

Family and domain databases

InterProiView protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom
PANTHERiPTHR13000 PTHR13000, 1 hit
PfamiView protein in Pfam
PF13874 Nup54, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3B4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT
60 70 80 90 100
GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGGF NTQQQQQTTL
110 120 130 140 150
GGLFSQPTQA PTQSNQLINT ASALSAPTLL GDERDAILAK WNQLQAFWGT
160 170 180 190 200
GKGYFNNNIP PVEFTQENPF CRFKAVGYSC MPSNKDEDGL VVLVFNKKET
210 220 230 240 250
EIRSQQQQLV ESLHKVLGGN QTLTVNVEGT KTLPDDQTEV VIYVVERSPN
260 270 280 290 300
GTSRRVPATT LYAHFEQANI KTQLQQLGVT LSMTRTELSP AQIKQLLQNP
310 320 330 340 350
PAGVDPIIWE QAKVDNPDSE KLIPVPMVGF KELLRRLKVQ DQMTKQHQTR
360 370 380 390 400
LDIISEDISE LQKNQTTSVA KIAQYKRKLM DLSHRTLQVL IKQEIQRKSG
410 420 430 440 450
YAIQADEEQL RVQLDTIQGE LNAPTQFKGR LNELMSQIRM QNHFGAVRSE
460 470 480 490 500
ERYYIDADLL REIKQHLKQQ QEGLSHLISI IKDDLEDIKL VEHGLNETIH

IRGGVFS
Length:507
Mass (Da):55,435
Last modified:October 31, 2003 - v2
Checksum:iB5D235E01F1FE467
GO
Isoform 2 (identifier: Q7Z3B4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: Missing.
     353-388: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):33,180
Checksum:i442CA17A5CBC6D3E
GO
Isoform 3 (identifier: Q7Z3B4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-99: GLFGGTQNKGFGFGTGFGTTTGTSTGLGTGLGTGLGFGGFNTQQQQQTT → A

Note: No experimental confirmation available.
Show »
Length:459
Mass (Da):50,775
Checksum:iD35813EFEA5AC035
GO

Sequence cautioni

The sequence BAA91735 differs from that shown. Reason: Frameshift at position 479.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 25AGGF → GWV in AAF67488 (PubMed:10931946).Curated4
Sequence conflicti226N → S in BAA91735 (PubMed:14702039).Curated1
Sequence conflicti265 – 277FEQAN…QLQQL → LNKPYKNTIAAT in AAF67488 (PubMed:10931946).CuratedAdd BLAST13
Sequence conflicti322L → V in AAF67488 (PubMed:10931946).Curated1
Sequence conflicti363K → T in AAF67488 (PubMed:10931946).Curated1
Sequence conflicti433E → G in AAF67488 (PubMed:10931946).Curated1
Sequence conflicti507S → G in CAD97957 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0087401 – 180Missing in isoform 2. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_05435551 – 99GLFGG…QQQTT → A in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_008741353 – 388Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157322 mRNA Translation: AAF67488.1
AK001517 mRNA Translation: BAA91735.1 Frameshift.
AK300036 mRNA Translation: BAG61847.1
AK315160 mRNA Translation: BAG37604.1
BX538002 mRNA Translation: CAD97957.1
AC110795 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05777.1
CCDSiCCDS3576.1 [Q7Z3B4-1]
CCDS63998.1 [Q7Z3B4-3]
RefSeqiNP_001265532.1, NM_001278603.1 [Q7Z3B4-3]
NP_059122.2, NM_017426.3 [Q7Z3B4-1]
UniGeneiHs.430435

Genome annotation databases

EnsembliENST00000264883; ENSP00000264883; ENSG00000138750 [Q7Z3B4-1]
ENST00000514987; ENSP00000421304; ENSG00000138750 [Q7Z3B4-3]
GeneIDi53371
KEGGihsa:53371
UCSCiuc003hjs.5 human [Q7Z3B4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNUP54_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3B4
Secondary accession number(s): B2RCK7
, B4DT35, Q96EA7, Q9NVL5, Q9P0I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: June 20, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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