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Entry version 155 (17 Jun 2020)
Sequence version 2 (31 Oct 2003)
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Protein

Nucleoporin p54

Gene

NUP54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-9609690 HCMV Early Events
R-HSA-9610379 HCMV Late Events

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin p54
Alternative name(s):
54 kDa nucleoporin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138750.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17359 NUP54

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607607 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z3B4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000138750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31853

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z3B4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUP54

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048741 – 507Nucleoporin p54Add BLAST507

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z3B4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z3B4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z3B4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z3B4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z3B4

PeptideAtlas

More...
PeptideAtlasi
Q7Z3B4

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z3B4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5071
69024 [Q7Z3B4-1]
69025 [Q7Z3B4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z3B4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z3B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138750 Expressed in intestine and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z3B4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z3B4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138750 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58.

Interacts with NUTF2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q7Z3B4
With#Exp.IntAct
AGR2 [O95994]3EBI-741048,EBI-712648
AP1B1 - isoform C [Q10567-3]3EBI-741048,EBI-11978055
AP2B1 - isoform 2 [P63010-2]3EBI-741048,EBI-11529439
BPIFA1 [Q9NP55]3EBI-741048,EBI-953896
C14orf119 [Q9NWQ9]5EBI-741048,EBI-725606
C1orf109 [Q9NX04]5EBI-741048,EBI-8643161
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-741048,EBI-10175300
CDC23 [Q9UJX2]3EBI-741048,EBI-396137
CENPH [Q9H3R5]3EBI-741048,EBI-1003700
DCTN3 - isoform 2 [O75935-2]3EBI-741048,EBI-12091947
EFHC1 [Q5JVL4]3EBI-741048,EBI-743105
EIF3F [O00303]3EBI-741048,EBI-711990
EURL - isoform 3 [Q9NYK6-3]3EBI-741048,EBI-13371226
EXOC1 [Q9NV70]4EBI-741048,EBI-1045313
EXOC8 [Q8IYI6]3EBI-741048,EBI-742102
HAUS1 [Q96CS2]3EBI-741048,EBI-2514791
HAUS8 [Q9BT25]3EBI-741048,EBI-2558143
HGS [O14964]7EBI-741048,EBI-740220
HOMER1 [Q86YM7]3EBI-741048,EBI-746815
IFT20 [Q8IY31]3EBI-741048,EBI-744203
IFT20 - isoform 3 [Q8IY31-3]5EBI-741048,EBI-9091197
KRT15 [P19012]4EBI-741048,EBI-739566
KRT27 [Q7Z3Y8]3EBI-741048,EBI-3044087
KRT33B [Q14525]3EBI-741048,EBI-1049638
NFKBID [Q8NI38]3EBI-741048,EBI-10271199
NUP58 [Q9BVL2]9EBI-741048,EBI-2811583
NUP62 [P37198]12EBI-741048,EBI-347978
NUTF2 [P61970]3EBI-741048,EBI-591778
OIP5 [O43482]3EBI-741048,EBI-536879
PKNOX2 [Q96KN3]3EBI-741048,EBI-2692890
SERTAD3 [Q9UJW9]3EBI-741048,EBI-748621
SMYD3 [Q9H7B4]3EBI-741048,EBI-347919
SOHLH1 [Q5JUK2]3EBI-741048,EBI-12288855
SPG21 [Q9NZD8]3EBI-741048,EBI-742688
TACC3 [Q9Y6A5]3EBI-741048,EBI-2554984
TCHP [Q9BT92]3EBI-741048,EBI-740781
TEKT1 [Q969V4]3EBI-741048,EBI-10180409
TEX12 [Q9BXU0]3EBI-741048,EBI-12090309
TPM3 [P06753]6EBI-741048,EBI-355607
VPS37C [A5D8V6]3EBI-741048,EBI-2559305
ZWINT [O95229]3EBI-741048,EBI-1001132
PA [Q67020] from Influenza A virus (A/WSN/1933(H1N1)).2EBI-741048,EBI-11514477

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119759, 69 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-873 Nuclear pore complex

Protein interaction database and analysis system

More...
IntActi
Q7Z3B4, 76 interactors

Molecular INTeraction database

More...
MINTi
Q7Z3B4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264883

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z3B4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z3B4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 612
Repeati25 – 2622
Repeati28 – 2932
Repeati53 – 5442
Repeati61 – 6252
Repeati63 – 6462
Repeati67 – 6872
Repeati87 – 8882
Repeati444 – 44592

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5 – 4459 X 2 AA repeats of F-GAdd BLAST441

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 89Gly-richAdd BLAST84
Compositional biasi30 – 99Thr-richAdd BLAST70
Compositional biasi93 – 97Poly-Gln5
Compositional biasi205 – 208Poly-Gln4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP54 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3091 Eukaryota
ENOG410XPU5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033371_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z3B4

KEGG Orthology (KO)

More...
KOi
K14308

Identification of Orthologs from Complete Genome Data

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OMAi
CRRKHLV

Database of Orthologous Groups

More...
OrthoDBi
1506658at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z3B4

TreeFam database of animal gene trees

More...
TreeFami
TF320237

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom
IPR040985 Nup54_C

The PANTHER Classification System

More...
PANTHERi
PTHR13000 PTHR13000, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13874 Nup54, 1 hit
PF18437 Nup54_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z3B4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT
60 70 80 90 100
GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGGF NTQQQQQTTL
110 120 130 140 150
GGLFSQPTQA PTQSNQLINT ASALSAPTLL GDERDAILAK WNQLQAFWGT
160 170 180 190 200
GKGYFNNNIP PVEFTQENPF CRFKAVGYSC MPSNKDEDGL VVLVFNKKET
210 220 230 240 250
EIRSQQQQLV ESLHKVLGGN QTLTVNVEGT KTLPDDQTEV VIYVVERSPN
260 270 280 290 300
GTSRRVPATT LYAHFEQANI KTQLQQLGVT LSMTRTELSP AQIKQLLQNP
310 320 330 340 350
PAGVDPIIWE QAKVDNPDSE KLIPVPMVGF KELLRRLKVQ DQMTKQHQTR
360 370 380 390 400
LDIISEDISE LQKNQTTSVA KIAQYKRKLM DLSHRTLQVL IKQEIQRKSG
410 420 430 440 450
YAIQADEEQL RVQLDTIQGE LNAPTQFKGR LNELMSQIRM QNHFGAVRSE
460 470 480 490 500
ERYYIDADLL REIKQHLKQQ QEGLSHLISI IKDDLEDIKL VEHGLNETIH

IRGGVFS
Length:507
Mass (Da):55,435
Last modified:October 31, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5D235E01F1FE467
GO
Isoform 2 (identifier: Q7Z3B4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: Missing.
     353-388: Missing.

Show »
Length:291
Mass (Da):33,180
Checksum:i442CA17A5CBC6D3E
GO
Isoform 3 (identifier: Q7Z3B4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-99: GLFGGTQNKGFGFGTGFGTTTGTSTGLGTGLGTGLGFGGFNTQQQQQTT → A

Show »
Length:459
Mass (Da):50,775
Checksum:iD35813EFEA5AC035
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBF7D6RBF7_HUMAN
Nucleoporin p54
NUP54
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAH0D6RAH0_HUMAN
Nucleoporin p54
NUP54
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB65D6RB65_HUMAN
Nucleoporin p54
NUP54
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFI8D6RFI8_HUMAN
Nucleoporin p54
NUP54
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91735 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22 – 25AGGF → GWV in AAF67488 (PubMed:10931946).Curated4
Sequence conflicti226N → S in BAA91735 (PubMed:14702039).Curated1
Sequence conflicti265 – 277FEQAN…QLQQL → LNKPYKNTIAAT in AAF67488 (PubMed:10931946).CuratedAdd BLAST13
Sequence conflicti322L → V in AAF67488 (PubMed:10931946).Curated1
Sequence conflicti363K → T in AAF67488 (PubMed:10931946).Curated1
Sequence conflicti433E → G in AAF67488 (PubMed:10931946).Curated1
Sequence conflicti507S → G in CAD97957 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0087401 – 180Missing in isoform 2. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_05435551 – 99GLFGG…QQQTT → A in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_008741353 – 388Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF157322 mRNA Translation: AAF67488.1
AK001517 mRNA Translation: BAA91735.1 Frameshift.
AK300036 mRNA Translation: BAG61847.1
AK315160 mRNA Translation: BAG37604.1
BX538002 mRNA Translation: CAD97957.1
AC110795 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05777.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3576.1 [Q7Z3B4-1]
CCDS63998.1 [Q7Z3B4-3]

NCBI Reference Sequences

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RefSeqi
NP_001265532.1, NM_001278603.1 [Q7Z3B4-3]
NP_059122.2, NM_017426.3 [Q7Z3B4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264883; ENSP00000264883; ENSG00000138750 [Q7Z3B4-1]
ENST00000514987; ENSP00000421304; ENSG00000138750 [Q7Z3B4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53371

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:53371

UCSC genome browser

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UCSCi
uc003hjs.5 human [Q7Z3B4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157322 mRNA Translation: AAF67488.1
AK001517 mRNA Translation: BAA91735.1 Frameshift.
AK300036 mRNA Translation: BAG61847.1
AK315160 mRNA Translation: BAG37604.1
BX538002 mRNA Translation: CAD97957.1
AC110795 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05777.1
CCDSiCCDS3576.1 [Q7Z3B4-1]
CCDS63998.1 [Q7Z3B4-3]
RefSeqiNP_001265532.1, NM_001278603.1 [Q7Z3B4-3]
NP_059122.2, NM_017426.3 [Q7Z3B4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JNUX-ray1.44A/B/C/D453-491[»]
4JNVX-ray1.85A/B/C/D453-491[»]
4JO7X-ray1.75B/D/F/H453-491[»]
4JO9X-ray2.50A/C453-491[»]
5IJNelectron microscopy21.40F/L/R/X1-507[»]
5IJOelectron microscopy21.40F/L/R/X1-507[»]
SMRiQ7Z3B4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119759, 69 interactors
ComplexPortaliCPX-873 Nuclear pore complex
IntActiQ7Z3B4, 76 interactors
MINTiQ7Z3B4
STRINGi9606.ENSP00000264883

Protein family/group databases

TCDBi1.I.1.1.3 the nuclear pore complex (npc) family

PTM databases

iPTMnetiQ7Z3B4
PhosphoSitePlusiQ7Z3B4

Polymorphism and mutation databases

BioMutaiNUP54

Proteomic databases

EPDiQ7Z3B4
jPOSTiQ7Z3B4
MassIVEiQ7Z3B4
MaxQBiQ7Z3B4
PaxDbiQ7Z3B4
PeptideAtlasiQ7Z3B4
PRIDEiQ7Z3B4
ProteomicsDBi5071
69024 [Q7Z3B4-1]
69025 [Q7Z3B4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24771 96 antibodies

The DNASU plasmid repository

More...
DNASUi
53371

Genome annotation databases

EnsembliENST00000264883; ENSP00000264883; ENSG00000138750 [Q7Z3B4-1]
ENST00000514987; ENSP00000421304; ENSG00000138750 [Q7Z3B4-3]
GeneIDi53371
KEGGihsa:53371
UCSCiuc003hjs.5 human [Q7Z3B4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53371
EuPathDBiHostDB:ENSG00000138750.14

GeneCards: human genes, protein and diseases

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GeneCardsi
NUP54
HGNCiHGNC:17359 NUP54
HPAiENSG00000138750 Low tissue specificity
MIMi607607 gene
neXtProtiNX_Q7Z3B4
OpenTargetsiENSG00000138750
PharmGKBiPA31853

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3091 Eukaryota
ENOG410XPU5 LUCA
GeneTreeiENSGT00390000013620
HOGENOMiCLU_033371_0_0_1
InParanoidiQ7Z3B4
KOiK14308
OMAiCRRKHLV
OrthoDBi1506658at2759
PhylomeDBiQ7Z3B4
TreeFamiTF320237

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-9609690 HCMV Early Events
R-HSA-9610379 HCMV Late Events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
53371 506 hits in 792 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUP54 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NUP54

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53371
PharosiQ7Z3B4 Tbio

Protein Ontology

More...
PROi
PR:Q7Z3B4
RNActiQ7Z3B4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138750 Expressed in intestine and 224 other tissues
ExpressionAtlasiQ7Z3B4 baseline and differential
GenevisibleiQ7Z3B4 HS

Family and domain databases

InterProiView protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom
IPR040985 Nup54_C
PANTHERiPTHR13000 PTHR13000, 1 hit
PfamiView protein in Pfam
PF13874 Nup54, 1 hit
PF18437 Nup54_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z3B4
Secondary accession number(s): B2RCK7
, B4DT35, Q96EA7, Q9NVL5, Q9P0I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: June 17, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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