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Protein

Neuronal growth regulator 1

Gene

NEGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal growth regulator 1
Alternative name(s):
IgLON family member 4
Gene namesi
Name:NEGR1
Synonyms:IGLON4
ORF Names:UNQ2433/PRO4993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000172260.13
HGNCiHGNC:17302 NEGR1
MIMi613173 gene
neXtProtiNX_Q7Z3B1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi257194
OpenTargetsiENSG00000172260
PharmGKBiPA134862452

Polymorphism and mutation databases

BioMutaiNEGR1
DMDMi88984537

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37By similarityAdd BLAST37
ChainiPRO_000001503738 – 324Neuronal growth regulator 1Add BLAST287
PropeptideiPRO_0000015038325 – 354Removed in mature formCuratedAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 118PROSITE-ProRule annotation
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 203PROSITE-ProRule annotation
Modified residuei187PhosphotyrosineBy similarity1
Disulfide bondi245 ↔ 297PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi324GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z3B1
MaxQBiQ7Z3B1
PaxDbiQ7Z3B1
PeptideAtlasiQ7Z3B1
PRIDEiQ7Z3B1
ProteomicsDBi69021

PTM databases

GlyConnecti1555
iPTMnetiQ7Z3B1
PhosphoSitePlusiQ7Z3B1

Expressioni

Gene expression databases

BgeeiENSG00000172260 Expressed in 194 organ(s), highest expression level in occipital lobe
CleanExiHS_NEGR1
GenevisibleiQ7Z3B1 HS

Organism-specific databases

HPAiHPA011894

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi129205, 6 interactors
IntActiQ7Z3B1, 4 interactors
STRINGi9606.ENSP00000350364

Structurei

3D structure databases

ProteinModelPortaliQ7Z3B1
SMRiQ7Z3B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 134Ig-like C2-type 1Add BLAST97
Domaini139 – 221Ig-like C2-type 2Add BLAST83
Domaini225 – 313Ig-like C2-type 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJE Eukaryota
ENOG4110TBP LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ7Z3B1
KOiK06775
OMAiTKSSEMY
OrthoDBiEOG091G0B5D
PhylomeDBiQ7Z3B1
TreeFamiTF351104

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z3B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMMLLVQGA CCSNQWLAAV LLSLCCLLPS CLPAGQSVDF PWAAVDNMMV
60 70 80 90 100
RKGDTAVLRC YLEDGASKGA WLNRSSIIFA GGDKWSVDPR VSISTLNKRD
110 120 130 140 150
YSLQIQNVDV TDDGPYTCSV QTQHTPRTMQ VHLTVQVPPK IYDISNDMTV
160 170 180 190 200
NEGTNVTLTC LATGKPEPSI SWRHISPSAK PFENGQYLDI YGITRDQAGE
210 220 230 240 250
YECSAENDVS FPDVRKVKVV VNFAPTIQEI KSGTVTPGRS GLIRCEGAGV
260 270 280 290 300
PPPAFEWYKG EKKLFNGQQG IIIQNFSTRS ILTVTNVTQE HFGNYTCVAA
310 320 330 340 350
NKLGTTNASL PLNPPSTAQY GITGSADVLF SCWYLVLTLS SFTSIFYLKN

AILQ
Length:354
Mass (Da):38,719
Last modified:February 21, 2006 - v3
Checksum:i41B05D00224CF34A
GO
Isoform 2 (identifier: Q7Z3B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):24,733
Checksum:i61EBC9E93977B520
GO

Sequence cautioni

The sequence AAQ88499 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169S → F in BAC03858 (PubMed:14702039).Curated1
Sequence conflicti208D → A (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563131 – 128Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538014 mRNA Translation: CAD97961.1
AY358132 mRNA Translation: AAQ88499.1 Different initiation.
AK092307 mRNA Translation: BAC03858.1
AL359821 Genomic DNA No translation available.
AL627317 Genomic DNA No translation available.
AL354949 Genomic DNA No translation available.
AL645724 Genomic DNA No translation available.
AL356600 Genomic DNA No translation available.
AL355590 Genomic DNA No translation available.
AL365362 Genomic DNA No translation available.
AL391239 Genomic DNA No translation available.
AL513349 Genomic DNA No translation available.
AL645767 Genomic DNA No translation available.
BC036771 mRNA Translation: AAH36771.1
CCDSiCCDS661.1 [Q7Z3B1-1]
RefSeqiNP_776169.2, NM_173808.2 [Q7Z3B1-1]
UniGeneiHs.146542

Genome annotation databases

EnsembliENST00000306821; ENSP00000305938; ENSG00000172260 [Q7Z3B1-2]
ENST00000357731; ENSP00000350364; ENSG00000172260 [Q7Z3B1-1]
GeneIDi257194
KEGGihsa:257194
UCSCiuc001dfv.4 human [Q7Z3B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538014 mRNA Translation: CAD97961.1
AY358132 mRNA Translation: AAQ88499.1 Different initiation.
AK092307 mRNA Translation: BAC03858.1
AL359821 Genomic DNA No translation available.
AL627317 Genomic DNA No translation available.
AL354949 Genomic DNA No translation available.
AL645724 Genomic DNA No translation available.
AL356600 Genomic DNA No translation available.
AL355590 Genomic DNA No translation available.
AL365362 Genomic DNA No translation available.
AL391239 Genomic DNA No translation available.
AL513349 Genomic DNA No translation available.
AL645767 Genomic DNA No translation available.
BC036771 mRNA Translation: AAH36771.1
CCDSiCCDS661.1 [Q7Z3B1-1]
RefSeqiNP_776169.2, NM_173808.2 [Q7Z3B1-1]
UniGeneiHs.146542

3D structure databases

ProteinModelPortaliQ7Z3B1
SMRiQ7Z3B1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129205, 6 interactors
IntActiQ7Z3B1, 4 interactors
STRINGi9606.ENSP00000350364

PTM databases

GlyConnecti1555
iPTMnetiQ7Z3B1
PhosphoSitePlusiQ7Z3B1

Polymorphism and mutation databases

BioMutaiNEGR1
DMDMi88984537

Proteomic databases

EPDiQ7Z3B1
MaxQBiQ7Z3B1
PaxDbiQ7Z3B1
PeptideAtlasiQ7Z3B1
PRIDEiQ7Z3B1
ProteomicsDBi69021

Protocols and materials databases

DNASUi257194
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306821; ENSP00000305938; ENSG00000172260 [Q7Z3B1-2]
ENST00000357731; ENSP00000350364; ENSG00000172260 [Q7Z3B1-1]
GeneIDi257194
KEGGihsa:257194
UCSCiuc001dfv.4 human [Q7Z3B1-1]

Organism-specific databases

CTDi257194
DisGeNETi257194
EuPathDBiHostDB:ENSG00000172260.13
GeneCardsiNEGR1
HGNCiHGNC:17302 NEGR1
HPAiHPA011894
MIMi613173 gene
neXtProtiNX_Q7Z3B1
OpenTargetsiENSG00000172260
PharmGKBiPA134862452
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJE Eukaryota
ENOG4110TBP LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ7Z3B1
KOiK06775
OMAiTKSSEMY
OrthoDBiEOG091G0B5D
PhylomeDBiQ7Z3B1
TreeFamiTF351104

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiNEGR1 human
GeneWikiiNEGR1
GenomeRNAii257194
PROiPR:Q7Z3B1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172260 Expressed in 194 organ(s), highest expression level in occipital lobe
CleanExiHS_NEGR1
GenevisibleiQ7Z3B1 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNEGR1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3B1
Secondary accession number(s): Q5VT21
, Q6UY06, Q8N440, Q8NAQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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