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Protein

Highly divergent homeobox

Gene

HDX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi3 – 63Homeobox 1PROSITE-ProRule annotationAdd BLAST61
DNA bindingi435 – 498Homeobox 2PROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Highly divergent homeobox
Gene namesi
Name:HDX
Synonyms:CXorf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000165259.13
HGNCiHGNC:26411 HDX
MIMi300994 gene
neXtProtiNX_Q7Z353

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165259
PharmGKBiPA162390630

Polymorphism and mutation databases

BioMutaiHDX
DMDMi74762426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994871 – 690Highly divergent homeoboxAdd BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7Z353
PaxDbiQ7Z353
PeptideAtlasiQ7Z353
PRIDEiQ7Z353
ProteomicsDBi69008
69009 [Q7Z353-2]

PTM databases

iPTMnetiQ7Z353
PhosphoSitePlusiQ7Z353

Expressioni

Gene expression databases

BgeeiENSG00000165259
CleanExiHS_HDX
ExpressionAtlasiQ7Z353 baseline and differential
GenevisibleiQ7Z353 HS

Organism-specific databases

HPAiHPA047189

Interactioni

Protein-protein interaction databases

BioGridi126559, 5 interactors
IntActiQ7Z353, 15 interactors
STRINGi9606.ENSP00000297977

Structurei

Secondary structure

1690
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi444 – 454Combined sources11
Turni455 – 459Combined sources5
Helixi463 – 476Combined sources14
Helixi480 – 497Combined sources18

3D structure databases

ProteinModelPortaliQ7Z353
SMRiQ7Z353
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z353

Family & Domainsi

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiENOG410IE54 Eukaryota
ENOG4110JHR LUCA
GeneTreeiENSGT00390000008591
HOGENOMiHOG000112876
HOVERGENiHBG095615
InParanoidiQ7Z353
OMAiQRSYKPE
OrthoDBiEOG091G031B
PhylomeDBiQ7Z353
TreeFamiTF330998

Family and domain databases

CDDicd00086 homeodomain, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT
60 70 80 90 100
WVGNKRRKMS SKNSESGTAT TGTSLSAPDI TVRNVVNIAR PSSQQSSWTS
110 120 130 140 150
ANNDVIVTGI YSPASSSSRQ GTNKHTDTQI TEAHKIPIQK TATKNDTEFQ
160 170 180 190 200
LHIPVQRQVA HCKNASLLLG EKTIILSRQT SVLNAGNSVF NHAKKNYGNS
210 220 230 240 250
SVQASEMTVP QKPSVCHRPC KIEPVGIQRS YKPEHTGPAL HNLCGQKPTI
260 270 280 290 300
RDPYCRTQNL EIREVFSLAV SDYPQRILGG NAPQKPSSAE GNCLSIAMET
310 320 330 340 350
GDAEDEYARE EELASMRAQI PSYSRFYESG SSLRAENQST TLPGPGRNMP
360 370 380 390 400
NSQMVNIRDM SDNVLYQNRN YHLTPRTSLH TASSTMYSNT NPLRSNFSPH
410 420 430 440 450
FASSNQLRLS QNQNNYQISG NLTVPWITGC SRKRALQDRT QFSDRDLATL
460 470 480 490 500
KKYWDNGMTS LGSVCREKIE AVATELNVDC EIVRTWIGNR RRKYRLMGIE
510 520 530 540 550
VPPPRGGPAD FSEQPESGSL SALTPGEEAG PEVGEDNDRN DEVSICLSEG
560 570 580 590 600
SSQEEPNEVV PNDARAHKEE DHHAVTTDNV KIEIIDDEES DMISNSEVEQ
610 620 630 640 650
VNSFLDYKNE EVKFIENELE IQKQKYFKLQ TFVRSLILAM KADDKEQQQA
660 670 680 690
LLSDLPPELE EMDFNHASLE PDDTSFSVSS LSEKNVSESL
Length:690
Mass (Da):77,206
Last modified:October 1, 2003 - v1
Checksum:i572AA4D182400736
GO
Isoform 2 (identifier: Q7Z353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:632
Mass (Da):70,225
Checksum:iC1ACD1B97E5F95C2
GO

Sequence cautioni

The sequence CAI42095 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034827193A → T. Corresponds to variant dbSNP:rs35653454Ensembl.1
Natural variantiVAR_034828397F → S2 PublicationsCorresponds to variant dbSNP:rs35161124Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0277081 – 58Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055240 mRNA Translation: BAB70886.1
BX538112 mRNA Translation: CAD98024.1
AK290050 mRNA Translation: BAF82739.1
AL035552, AL022160 Genomic DNA Translation: CAI42056.1
AL022160 Genomic DNA Translation: CAI42095.1 Sequence problems.
AL022160, AL035552 Genomic DNA Translation: CAI42096.1
CH471104 Genomic DNA Translation: EAW98572.1
CH471104 Genomic DNA Translation: EAW98573.1
BC101720 mRNA Translation: AAI01721.1
BC101722 mRNA Translation: AAI01723.1
BC143522 mRNA Translation: AAI43523.1
CCDSiCCDS35342.1 [Q7Z353-1]
CCDS55456.1 [Q7Z353-2]
RefSeqiNP_001170949.1, NM_001177478.1 [Q7Z353-2]
NP_001170950.1, NM_001177479.1 [Q7Z353-1]
NP_653258.2, NM_144657.4 [Q7Z353-1]
XP_006724682.1, XM_006724619.1 [Q7Z353-2]
XP_011529165.1, XM_011530863.2 [Q7Z353-1]
XP_011529166.1, XM_011530864.1 [Q7Z353-1]
XP_016884763.1, XM_017029274.1 [Q7Z353-1]
UniGeneiHs.559546

Genome annotation databases

EnsembliENST00000297977; ENSP00000297977; ENSG00000165259 [Q7Z353-1]
ENST00000373177; ENSP00000362272; ENSG00000165259 [Q7Z353-1]
ENST00000506585; ENSP00000423670; ENSG00000165259 [Q7Z353-2]
GeneIDi139324
KEGGihsa:139324
UCSCiuc004eek.3 human [Q7Z353-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHDX_HUMAN
AccessioniPrimary (citable) accession number: Q7Z353
Secondary accession number(s): A8K1Y5
, B7ZL18, Q5JZB4, Q96NK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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