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UniProtKB - Q7Z319 (Q7Z319_HUMAN)
Protein
Submitted name:
MAP kinase-interacting serine/threonine-protein kinase 1
Gene
MKNK1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- protein kinase activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: MAP kinase-interacting serine/threonine-protein kinase 1ImportedSubmitted name: Uncharacterized protein DKFZp686E14208Imported |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7110, MKNK1 |
VEuPathDBi | HostDB:ENSG00000079277 |
Expressioni
Gene expression databases
Bgeei | ENSG00000079277, Expressed in body of pancreas and 237 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 238 | Protein kinaseInterPro annotationAdd BLAST | 238 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 310 – 329 | DisorderedSequence analysisAdd BLAST | 20 |
Phylogenomic databases
GeneTreei | ENSGT00940000162886 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
Q7Z319-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKSMPSKSS RNKQGTVGVG CFERWRRCIS VRETSSILAH IQKQKHFNER
60 70 80 90 100
EASRVVRDVA AALDFLHTKG IAHRDLKPEN ILCESPEKVS PVKICDFDLG
110 120 130 140 150
SGMKLNNSCT PITTPELTTP CGSAEYMAPE VVEVFTDQAT FYDKRCDLWS
160 170 180 190 200
LGVVLYIMLS GYPPFVGHCG ADCGWDRGEV CRVCQNKLFE SIQEGKYEFP
210 220 230 240 250
DKDWAHISSE AKDLISKLLV RDAKQRLSAA QVLQHPWVQG QAPEKGLPTP
260 270 280 290 300
QVLQRNSSTM DLTLFAAEAI ALNRQLSQHE ENELAEEPEA LADGLCSMKL
310 320
SPPCKSRLAR RRALAQAGRG EDRSPPTAL
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BUB5 | MKNK1_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 MNK1 | 465 | Annotation score: | ||
E9PIA0 | E9PIA0_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 166 | Annotation score: | ||
A0A499FJN1 | A0A499FJN1_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 412 | Annotation score: | ||
A0A499FJS1 | A0A499FJS1_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 335 | Annotation score: | ||
A0A499FIS5 | A0A499FIS5_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 453 | Annotation score: | ||
E9PSE0 | E9PSE0_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 88 | Annotation score: | ||
E9PMM8 | E9PMM8_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 106 | Annotation score: | ||
E9PLE7 | E9PLE7_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 89 | Annotation score: | ||
E9PN34 | E9PN34_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 79 | Annotation score: | ||
E9PQ26 | E9PQ26_HUMAN | MAP kinase-interacting serine/threo... | MKNK1 | 44 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136373 Genomic DNA No translation available. KF459523 Genomic DNA No translation available. KF495933 Genomic DNA No translation available. BX538193 mRNA Translation: CAD98062.1 |
RefSeqi | XP_006711076.1, XM_006711013.1 XP_006711077.1, XM_006711014.1 XP_006711078.1, XM_006711015.1 XP_016858153.1, XM_017002664.1 |
Genome annotation databases
Ensembli | ENST00000341183; ENSP00000339573; ENSG00000079277 |
GeneIDi | 8569 |
UCSCi | uc057get.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136373 Genomic DNA No translation available. KF459523 Genomic DNA No translation available. KF495933 Genomic DNA No translation available. BX538193 mRNA Translation: CAD98062.1 |
RefSeqi | XP_006711076.1, XM_006711013.1 XP_006711077.1, XM_006711014.1 XP_006711078.1, XM_006711015.1 XP_016858153.1, XM_017002664.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 69000 |
Protocols and materials databases
Antibodypediai | 32808, 574 antibodies from 33 providers |
DNASUi | 8569 |
Genome annotation databases
Ensembli | ENST00000341183; ENSP00000339573; ENSG00000079277 |
GeneIDi | 8569 |
UCSCi | uc057get.1, human |
Organism-specific databases
CTDi | 8569 |
HGNCi | HGNC:7110, MKNK1 |
OpenTargetsi | ENSG00000079277 |
VEuPathDBi | HostDB:ENSG00000079277 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162886 |
Miscellaneous databases
BioGRID-ORCSi | 8569, 135 hits in 1082 CRISPR screens |
ChiTaRSi | MKNK1, human |
GenomeRNAii | 8569 |
Gene expression databases
Bgeei | ENSG00000079277, Expressed in body of pancreas and 237 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7Z319_HUMAN | |
Accessioni | Q7Z319Primary (citable) accession number: Q7Z319 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2003 |
Last sequence update: | October 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |