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Protein

Treslin

Gene

TICRR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.1 Publication

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Treslin
Alternative name(s):
TopBP1-interacting checkpoint and replication regulator
TopBP1-interacting, replication-stimulating protein
Gene namesi
Name:TICRR
Synonyms:C15orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140534.13
HGNCiHGNC:28704 TICRR
MIMi613298 gene
neXtProtiNX_Q7Z2Z1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90381
OpenTargetsiENSG00000140534
PharmGKBiPA142672278

Polymorphism and mutation databases

BioMutaiTICRR
DMDMi156631024

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002966231 – 1910TreslinAdd BLAST1910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei292PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei865PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei938PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1125PhosphoserineCombined sources1
Modified residuei1134PhosphothreonineCombined sources1
Modified residuei1141PhosphoserineBy similarity1
Modified residuei1307PhosphothreonineCombined sources1
Modified residuei1413PhosphoserineCombined sources1
Modified residuei1484PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z2Z1
MaxQBiQ7Z2Z1
PaxDbiQ7Z2Z1
PeptideAtlasiQ7Z2Z1
PRIDEiQ7Z2Z1
ProteomicsDBi68989
68990 [Q7Z2Z1-2]

PTM databases

iPTMnetiQ7Z2Z1
PhosphoSitePlusiQ7Z2Z1

Expressioni

Gene expression databases

BgeeiENSG00000140534 Expressed in 98 organ(s), highest expression level in secondary oocyte
CleanExiHS_C15orf42
ExpressionAtlasiQ7Z2Z1 baseline and differential
GenevisibleiQ7Z2Z1 HS

Organism-specific databases

HPAiHPA046746
HPA049454

Interactioni

Subunit structurei

Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner (PubMed:20080954). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891).2 Publications

Protein-protein interaction databases

BioGridi124706, 4 interactors
IntActiQ7Z2Z1, 2 interactors
STRINGi9606.ENSP00000268138

Structurei

3D structure databases

ProteinModelPortaliQ7Z2Z1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1193 – 1378Pro-richAdd BLAST186

Sequence similaritiesi

Belongs to the treslin family.Curated

Phylogenomic databases

eggNOGiENOG410IFG8 Eukaryota
ENOG410Y8R6 LUCA
GeneTreeiENSGT00390000005222
HOVERGENiHBG101933
InParanoidiQ7Z2Z1
OMAiELEGVCQ
OrthoDBiEOG091G0WBD
PhylomeDBiQ7Z2Z1
TreeFamiTF332114

Family and domain databases

InterProiView protein in InterPro
IPR026153 Treslin
IPR032746 Treslin_N
PANTHERiPTHR21556 PTHR21556, 1 hit
PfamiView protein in Pfam
PF15292 Treslin_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q7Z2Z1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACCHKVMLL LDTAGGAARH SRVRRAALRL LTYLSCRFGL ARVHWAFKFF
60 70 80 90 100
DSQGARSRPS RVSDFRELGS RSWEDFEEEL EARLEDRAHL PGPAPRATHT
110 120 130 140 150
HGALMETLLD YQWDRPEITS PTKPILRSSG RRLLDVESEA KEAEAALGGL
160 170 180 190 200
VNAVFLLAPC PHSQRELLQF VSGCEAQAQR LPPTPKQVME KLLPKRVREV
210 220 230 240 250
MVARKITFYW VDTTEWSKLW ESPDHLGYWT VCELLHHGGG TVLPSESFSW
260 270 280 290 300
DFAQAGEMLL RSGIKLSSEP HLSPWISMLP TDATLNRLLY NSPEYEASFP
310 320 330 340 350
RMEGMLFLPV EAGKEIQETW TVTLEPLAMH QRHFQKPVRI FLKGSVAQWS
360 370 380 390 400
LPTSSTLGTD SWMLGSPEES TATQRLLFQQ LVSRLTAEEL HLVADVDPGE
410 420 430 440 450
GRPPITGVIS PLSASAMILT VCRTKEAEFQ RHVLQTAVAD SPRDTASLFS
460 470 480 490 500
DVVDSILNQT HDSLADTASA ASPVPEWAQQ ELGHTTPWSP AVVEKWFPFC
510 520 530 540 550
NISGASSDLM ESFGLLQAAS ANKEESSKTE GELIHCLAEL YQRKSREEST
560 570 580 590 600
IAHQEDSKKK RGVPRTPVRQ KMNTMCRSLK MLNVARLNVK AQKLHPDGSP
610 620 630 640 650
DVAGEKGIQK IPSGRTVDKL EDRGRTLRSS KPKDFKTEEE LLSYIRENYQ
660 670 680 690 700
KTVATGEIML YACARNMIST VKMFLKSKGT KELEVNCLNQ VKSSLLKTSK
710 720 730 740 750
SLRQNLGKKL DKEDKVRECQ LQVFLRLEMC LQCPSINEST DDMEQVVEEV
760 770 780 790 800
TDLLRMVCLT EDSAYLAEFL EEILRLYIDS IPKTLGNLYN SLGFVIPQKL
810 820 830 840 850
AGVLPTDFFS DDSMTQENKS PLLSVPFLSS ARRSVSGSPE SDELQELRTR
860 870 880 890 900
SAKKRRKNAL IRHKSIAEVS QNLRQIEIPK VSKRATKKEN SHPAPQQPSQ
910 920 930 940 950
PVKDTVQEVT KVRRNLFNQE LLSPSKRSLK RGLPRSHSVS AVDGLEDKLD
960 970 980 990 1000
NFKKNKGYHK LLTKSVAETP VHKQISKRLL HRQIKGRSSD PGPDIGVVEE
1010 1020 1030 1040 1050
SPEKGDEISL RRSPRIKQLS FSRTHSASFY SVSQPKSRSV QRVHSFQQDK
1060 1070 1080 1090 1100
SDQRENSPVQ SIRSPKSLLF GAMSEMISPS EKGSARMKKR SRNTLDSEVP
1110 1120 1130 1140 1150
AAYQTPKKSH QKSLSFSKTT PRRISHTPQT PLYTPERLQK SPAKMTPTKQ
1160 1170 1180 1190 1200
AAFKESLKDS SSPGHDSPLD SKITPQKRHT QAGEGTSLET KTPRTPKRQG
1210 1220 1230 1240 1250
TQPPGFLPNC TWPHSVNSSP ESPSCPAPPT SSTAQPRREC LTPIRDPLRT
1260 1270 1280 1290 1300
PPRAAAFMGT PQNQTHQQPH VLRAARAEEP AQKLKDKAIK TPKRPGNSTV
1310 1320 1330 1340 1350
TSSPPVTPKK LFTSPLCDVS KKSPFRKSKI ECPSPGELDQ KEPQMSPSVA
1360 1370 1380 1390 1400
ASLSCPVPST PPELSQRATL DTVPPPPPSK VGKRCRKTSD PRRSIVECQP
1410 1420 1430 1440 1450
DASATPGVGT ADSPAAPTDS RDDQKGLSLS PQSPPERRGY PGPGLRSDWH
1460 1470 1480 1490 1500
ASSPLLITSD TEHVTLLSEA EHHGIGDLKS NVLSVEEGEG LRTADAEKSS
1510 1520 1530 1540 1550
LSHPGIPPSP PSCGPGSPLM PSRDVHCTTD GRQCQASAQL DNLPASAWHS
1560 1570 1580 1590 1600
TDSASPQTYE VELEMQASGL PKLRIKKIDP SSSLEAEPLS KEESSLGEES
1610 1620 1630 1640 1650
FLPALSMPRA SRSLSKPEPT YVSPPCPRLS HSTPGKSRGQ TYICQACTPT
1660 1670 1680 1690 1700
HGPSSTPSPF QTDGVPWTPS PKHSGKTTPD IIKDWPRRKR AVGCGAGSSS
1710 1720 1730 1740 1750
GRGEVGADLP GSLSLLESEG KDHGLELSIH RTPILEDFEL EGVCQLPDQS
1760 1770 1780 1790 1800
PPRNSMPKAE EASSWGQFGL SSRKRVLLAK EEADRGAKRI CDLREDSEVS
1810 1820 1830 1840 1850
KSKEGSPSWS AWQLPSTGDE EVFVSGSTPP PSCAVRSCLS ASALQALTQS
1860 1870 1880 1890 1900
PLLFQGKTPS SQSKDPRDED VDVLPSTVED SPFSRAFSRR RPISRTYTRK
1910
KLMGTWLEDL
Length:1,910
Mass (Da):210,857
Last modified:July 24, 2007 - v2
Checksum:i3E726E5091B9FA5B
GO
Isoform 2 (identifier: Q7Z2Z1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: Missing.

Show »
Length:1,909
Mass (Da):210,786
Checksum:i01A60617B75CDB54
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN97H0YN97_HUMAN
Treslin
TICRR
214Annotation score:

Sequence cautioni

The sequence BAC11165 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG38104 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG53921 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152N → Y in DR731357 (Ref. 3) Curated1
Sequence conflicti336K → T in DR731357 (Ref. 3) Curated1
Sequence conflicti1009S → G in ADC30133 (PubMed:20116089).Curated1
Sequence conflicti1009S → G in BAG53921 (PubMed:14702039).Curated1
Sequence conflicti1344Q → L in BAG38104 (PubMed:14702039).Curated1
Sequence conflicti1373V → I in BAG53921 (PubMed:14702039).Curated1
Sequence conflicti1427L → P in BAC11165 (PubMed:14702039).Curated1
Sequence conflicti1667W → R in BAC11165 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050886287R → C1 PublicationCorresponds to variant dbSNP:rs10775247Ensembl.1
Natural variantiVAR_050887402R → W. Corresponds to variant dbSNP:rs11629584Ensembl.1
Natural variantiVAR_034631628R → C. Corresponds to variant dbSNP:rs3743372Ensembl.1
Natural variantiVAR_050888747V → A. Corresponds to variant dbSNP:rs12905387Ensembl.1
Natural variantiVAR_050889923S → C. Corresponds to variant dbSNP:rs16943377Ensembl.1
Natural variantiVAR_0508901523R → C2 PublicationsCorresponds to variant dbSNP:rs894157Ensembl.1
Natural variantiVAR_0508911718S → T1 PublicationCorresponds to variant dbSNP:rs1866928Ensembl.1
Natural variantiVAR_0508921885R → C1 PublicationCorresponds to variant dbSNP:rs3743372Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039218312Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ227787 mRNA Translation: ADC30133.1
AC013391 Genomic DNA No translation available.
AC013787 Genomic DNA No translation available.
DR731357 mRNA No translation available.
AK074727 mRNA Translation: BAC11165.1 Different initiation.
AK123612 mRNA Translation: BAG53921.1 Different initiation.
AK315750 mRNA Translation: BAG38104.1 Different initiation.
BX538335 mRNA Translation: CAD98102.1
BC002881 mRNA Translation: AAH02881.2
BC033209 mRNA Translation: AAH33209.2
CCDSiCCDS10352.2 [Q7Z2Z1-1]
CCDS76791.1 [Q7Z2Z1-2]
RefSeqiNP_001294954.1, NM_001308025.1 [Q7Z2Z1-2]
NP_689472.3, NM_152259.3 [Q7Z2Z1-1]
UniGeneiHs.441708

Genome annotation databases

EnsembliENST00000268138; ENSP00000268138; ENSG00000140534 [Q7Z2Z1-1]
ENST00000560985; ENSP00000453306; ENSG00000140534 [Q7Z2Z1-2]
GeneIDi90381
KEGGihsa:90381
UCSCiuc002boe.4 human [Q7Z2Z1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTICRR_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2Z1
Secondary accession number(s): B2RE07
, B3KVV9, D3IUT4, Q8N4X8, Q8NCH6, Q9BU55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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