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Entry version 122 (22 Apr 2020)
Sequence version 2 (24 Jul 2007)
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Protein

Treslin

Gene

TICRR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Treslin
Alternative name(s):
TopBP1-interacting checkpoint and replication regulator
TopBP1-interacting, replication-stimulating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TICRR
Synonyms:C15orf42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28704 TICRR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613298 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z2Z1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
90381

Open Targets

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OpenTargetsi
ENSG00000140534

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672278

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q7Z2Z1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TICRR

Domain mapping of disease mutations (DMDM)

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DMDMi
156631024

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002966231 – 1910TreslinAdd BLAST1910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei865PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei938PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1125PhosphoserineCombined sources1
Modified residuei1134PhosphothreonineCombined sources1
Modified residuei1141PhosphoserineBy similarity1
Modified residuei1307PhosphothreonineCombined sources1
Modified residuei1413PhosphoserineCombined sources1
Modified residuei1484PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z2Z1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z2Z1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z2Z1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z2Z1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z2Z1

PeptideAtlas

More...
PeptideAtlasi
Q7Z2Z1

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z2Z1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68989 [Q7Z2Z1-1]
68990 [Q7Z2Z1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z2Z1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z2Z1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140534 Expressed in secondary oocyte and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z2Z1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z2Z1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140534 Tissue enhanced (esophagus, lymphoid tissue, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner (PubMed:20080954).

Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124706, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z2Z1, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000268138

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z2Z1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1193 – 1378Pro-richAdd BLAST186

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the treslin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFG8 Eukaryota
ENOG410Y8R6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005222

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_241727_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z2Z1

Identification of Orthologs from Complete Genome Data

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OMAi
IIKDWPR

Database of Orthologous Groups

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OrthoDBi
150355at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z2Z1

TreeFam database of animal gene trees

More...
TreeFami
TF332114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026153 Treslin
IPR032746 Treslin_N

The PANTHER Classification System

More...
PANTHERi
PTHR21556 PTHR21556, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15292 Treslin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2Z1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACCHKVMLL LDTAGGAARH SRVRRAALRL LTYLSCRFGL ARVHWAFKFF
60 70 80 90 100
DSQGARSRPS RVSDFRELGS RSWEDFEEEL EARLEDRAHL PGPAPRATHT
110 120 130 140 150
HGALMETLLD YQWDRPEITS PTKPILRSSG RRLLDVESEA KEAEAALGGL
160 170 180 190 200
VNAVFLLAPC PHSQRELLQF VSGCEAQAQR LPPTPKQVME KLLPKRVREV
210 220 230 240 250
MVARKITFYW VDTTEWSKLW ESPDHLGYWT VCELLHHGGG TVLPSESFSW
260 270 280 290 300
DFAQAGEMLL RSGIKLSSEP HLSPWISMLP TDATLNRLLY NSPEYEASFP
310 320 330 340 350
RMEGMLFLPV EAGKEIQETW TVTLEPLAMH QRHFQKPVRI FLKGSVAQWS
360 370 380 390 400
LPTSSTLGTD SWMLGSPEES TATQRLLFQQ LVSRLTAEEL HLVADVDPGE
410 420 430 440 450
GRPPITGVIS PLSASAMILT VCRTKEAEFQ RHVLQTAVAD SPRDTASLFS
460 470 480 490 500
DVVDSILNQT HDSLADTASA ASPVPEWAQQ ELGHTTPWSP AVVEKWFPFC
510 520 530 540 550
NISGASSDLM ESFGLLQAAS ANKEESSKTE GELIHCLAEL YQRKSREEST
560 570 580 590 600
IAHQEDSKKK RGVPRTPVRQ KMNTMCRSLK MLNVARLNVK AQKLHPDGSP
610 620 630 640 650
DVAGEKGIQK IPSGRTVDKL EDRGRTLRSS KPKDFKTEEE LLSYIRENYQ
660 670 680 690 700
KTVATGEIML YACARNMIST VKMFLKSKGT KELEVNCLNQ VKSSLLKTSK
710 720 730 740 750
SLRQNLGKKL DKEDKVRECQ LQVFLRLEMC LQCPSINEST DDMEQVVEEV
760 770 780 790 800
TDLLRMVCLT EDSAYLAEFL EEILRLYIDS IPKTLGNLYN SLGFVIPQKL
810 820 830 840 850
AGVLPTDFFS DDSMTQENKS PLLSVPFLSS ARRSVSGSPE SDELQELRTR
860 870 880 890 900
SAKKRRKNAL IRHKSIAEVS QNLRQIEIPK VSKRATKKEN SHPAPQQPSQ
910 920 930 940 950
PVKDTVQEVT KVRRNLFNQE LLSPSKRSLK RGLPRSHSVS AVDGLEDKLD
960 970 980 990 1000
NFKKNKGYHK LLTKSVAETP VHKQISKRLL HRQIKGRSSD PGPDIGVVEE
1010 1020 1030 1040 1050
SPEKGDEISL RRSPRIKQLS FSRTHSASFY SVSQPKSRSV QRVHSFQQDK
1060 1070 1080 1090 1100
SDQRENSPVQ SIRSPKSLLF GAMSEMISPS EKGSARMKKR SRNTLDSEVP
1110 1120 1130 1140 1150
AAYQTPKKSH QKSLSFSKTT PRRISHTPQT PLYTPERLQK SPAKMTPTKQ
1160 1170 1180 1190 1200
AAFKESLKDS SSPGHDSPLD SKITPQKRHT QAGEGTSLET KTPRTPKRQG
1210 1220 1230 1240 1250
TQPPGFLPNC TWPHSVNSSP ESPSCPAPPT SSTAQPRREC LTPIRDPLRT
1260 1270 1280 1290 1300
PPRAAAFMGT PQNQTHQQPH VLRAARAEEP AQKLKDKAIK TPKRPGNSTV
1310 1320 1330 1340 1350
TSSPPVTPKK LFTSPLCDVS KKSPFRKSKI ECPSPGELDQ KEPQMSPSVA
1360 1370 1380 1390 1400
ASLSCPVPST PPELSQRATL DTVPPPPPSK VGKRCRKTSD PRRSIVECQP
1410 1420 1430 1440 1450
DASATPGVGT ADSPAAPTDS RDDQKGLSLS PQSPPERRGY PGPGLRSDWH
1460 1470 1480 1490 1500
ASSPLLITSD TEHVTLLSEA EHHGIGDLKS NVLSVEEGEG LRTADAEKSS
1510 1520 1530 1540 1550
LSHPGIPPSP PSCGPGSPLM PSRDVHCTTD GRQCQASAQL DNLPASAWHS
1560 1570 1580 1590 1600
TDSASPQTYE VELEMQASGL PKLRIKKIDP SSSLEAEPLS KEESSLGEES
1610 1620 1630 1640 1650
FLPALSMPRA SRSLSKPEPT YVSPPCPRLS HSTPGKSRGQ TYICQACTPT
1660 1670 1680 1690 1700
HGPSSTPSPF QTDGVPWTPS PKHSGKTTPD IIKDWPRRKR AVGCGAGSSS
1710 1720 1730 1740 1750
GRGEVGADLP GSLSLLESEG KDHGLELSIH RTPILEDFEL EGVCQLPDQS
1760 1770 1780 1790 1800
PPRNSMPKAE EASSWGQFGL SSRKRVLLAK EEADRGAKRI CDLREDSEVS
1810 1820 1830 1840 1850
KSKEGSPSWS AWQLPSTGDE EVFVSGSTPP PSCAVRSCLS ASALQALTQS
1860 1870 1880 1890 1900
PLLFQGKTPS SQSKDPRDED VDVLPSTVED SPFSRAFSRR RPISRTYTRK
1910
KLMGTWLEDL
Length:1,910
Mass (Da):210,857
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E726E5091B9FA5B
GO
Isoform 2 (identifier: Q7Z2Z1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: Missing.

Show »
Length:1,909
Mass (Da):210,786
Checksum:i01A60617B75CDB54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN97H0YN97_HUMAN
Treslin
TICRR
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11165 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG38104 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG53921 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152N → Y in DR731357 (Ref. 3) Curated1
Sequence conflicti336K → T in DR731357 (Ref. 3) Curated1
Sequence conflicti1009S → G in ADC30133 (PubMed:20116089).Curated1
Sequence conflicti1009S → G in BAG53921 (PubMed:14702039).Curated1
Sequence conflicti1344Q → L in BAG38104 (PubMed:14702039).Curated1
Sequence conflicti1373V → I in BAG53921 (PubMed:14702039).Curated1
Sequence conflicti1427L → P in BAC11165 (PubMed:14702039).Curated1
Sequence conflicti1667W → R in BAC11165 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050886287R → C1 PublicationCorresponds to variant dbSNP:rs10775247Ensembl.1
Natural variantiVAR_050887402R → W. Corresponds to variant dbSNP:rs11629584Ensembl.1
Natural variantiVAR_034631628R → C. Corresponds to variant dbSNP:rs3743372Ensembl.1
Natural variantiVAR_050888747V → A. Corresponds to variant dbSNP:rs12905387Ensembl.1
Natural variantiVAR_050889923S → C. Corresponds to variant dbSNP:rs16943377Ensembl.1
Natural variantiVAR_0508901523R → C2 PublicationsCorresponds to variant dbSNP:rs894157Ensembl.1
Natural variantiVAR_0508911718S → T1 PublicationCorresponds to variant dbSNP:rs1866928Ensembl.1
Natural variantiVAR_0508921885R → C1 PublicationCorresponds to variant dbSNP:rs3743372Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039218312Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GQ227787 mRNA Translation: ADC30133.1
AC013391 Genomic DNA No translation available.
AC013787 Genomic DNA No translation available.
DR731357 mRNA No translation available.
AK074727 mRNA Translation: BAC11165.1 Different initiation.
AK123612 mRNA Translation: BAG53921.1 Different initiation.
AK315750 mRNA Translation: BAG38104.1 Different initiation.
BX538335 mRNA Translation: CAD98102.1
BC002881 mRNA Translation: AAH02881.2
BC033209 mRNA Translation: AAH33209.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10352.2 [Q7Z2Z1-1]
CCDS76791.1 [Q7Z2Z1-2]

NCBI Reference Sequences

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RefSeqi
NP_001294954.1, NM_001308025.1 [Q7Z2Z1-2]
NP_689472.3, NM_152259.3 [Q7Z2Z1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268138; ENSP00000268138; ENSG00000140534 [Q7Z2Z1-1]
ENST00000560985; ENSP00000453306; ENSG00000140534 [Q7Z2Z1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
90381

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:90381

UCSC genome browser

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UCSCi
uc002boe.4 human [Q7Z2Z1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ227787 mRNA Translation: ADC30133.1
AC013391 Genomic DNA No translation available.
AC013787 Genomic DNA No translation available.
DR731357 mRNA No translation available.
AK074727 mRNA Translation: BAC11165.1 Different initiation.
AK123612 mRNA Translation: BAG53921.1 Different initiation.
AK315750 mRNA Translation: BAG38104.1 Different initiation.
BX538335 mRNA Translation: CAD98102.1
BC002881 mRNA Translation: AAH02881.2
BC033209 mRNA Translation: AAH33209.2
CCDSiCCDS10352.2 [Q7Z2Z1-1]
CCDS76791.1 [Q7Z2Z1-2]
RefSeqiNP_001294954.1, NM_001308025.1 [Q7Z2Z1-2]
NP_689472.3, NM_152259.3 [Q7Z2Z1-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124706, 11 interactors
IntActiQ7Z2Z1, 5 interactors
STRINGi9606.ENSP00000268138

PTM databases

iPTMnetiQ7Z2Z1
PhosphoSitePlusiQ7Z2Z1

Polymorphism and mutation databases

BioMutaiTICRR
DMDMi156631024

Proteomic databases

EPDiQ7Z2Z1
jPOSTiQ7Z2Z1
MassIVEiQ7Z2Z1
MaxQBiQ7Z2Z1
PaxDbiQ7Z2Z1
PeptideAtlasiQ7Z2Z1
PRIDEiQ7Z2Z1
ProteomicsDBi68989 [Q7Z2Z1-1]
68990 [Q7Z2Z1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
64736 34 antibodies

Genome annotation databases

EnsembliENST00000268138; ENSP00000268138; ENSG00000140534 [Q7Z2Z1-1]
ENST00000560985; ENSP00000453306; ENSG00000140534 [Q7Z2Z1-2]
GeneIDi90381
KEGGihsa:90381
UCSCiuc002boe.4 human [Q7Z2Z1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
90381
DisGeNETi90381

GeneCards: human genes, protein and diseases

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GeneCardsi
TICRR
HGNCiHGNC:28704 TICRR
HPAiENSG00000140534 Tissue enhanced (esophagus, lymphoid tissue, tongue)
MIMi613298 gene
neXtProtiNX_Q7Z2Z1
OpenTargetsiENSG00000140534
PharmGKBiPA142672278

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFG8 Eukaryota
ENOG410Y8R6 LUCA
GeneTreeiENSGT00390000005222
HOGENOMiCLU_241727_0_0_1
InParanoidiQ7Z2Z1
OMAiIIKDWPR
OrthoDBi150355at2759
PhylomeDBiQ7Z2Z1
TreeFamiTF332114

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TICRR human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90381
PharosiQ7Z2Z1 Tbio

Protein Ontology

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PROi
PR:Q7Z2Z1
RNActiQ7Z2Z1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000140534 Expressed in secondary oocyte and 97 other tissues
ExpressionAtlasiQ7Z2Z1 baseline and differential
GenevisibleiQ7Z2Z1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026153 Treslin
IPR032746 Treslin_N
PANTHERiPTHR21556 PTHR21556, 1 hit
PfamiView protein in Pfam
PF15292 Treslin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTICRR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2Z1
Secondary accession number(s): B2RE07
, B3KVV9, D3IUT4, Q8N4X8, Q8NCH6, Q9BU55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 22, 2020
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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