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Protein

Nik-related protein kinase

Gene

NRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ7Z2Y5

Names & Taxonomyi

Protein namesi
Recommended name:
Nik-related protein kinase (EC:2.7.11.1)
Gene namesi
Name:NRK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000123572.16
HGNCiHGNC:25391 NRK
MIMi300791 gene
neXtProtiNX_Q7Z2Y5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi203447
OpenTargetsiENSG00000123572
PharmGKBiPA134869113

Polymorphism and mutation databases

BioMutaiNRK
DMDMi115502506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505111 – 1582Nik-related protein kinaseAdd BLAST1582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei1027PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1034PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z2Y5
PeptideAtlasiQ7Z2Y5
PRIDEiQ7Z2Y5
ProteomicsDBi68985
68986 [Q7Z2Y5-2]
68987 [Q7Z2Y5-3]

PTM databases

iPTMnetiQ7Z2Y5
PhosphoSitePlusiQ7Z2Y5

Expressioni

Gene expression databases

BgeeiENSG00000123572 Expressed in 139 organ(s), highest expression level in metanephros
CleanExiHS_NRK
ExpressionAtlasiQ7Z2Y5 baseline and differential
GenevisibleiQ7Z2Y5 HS

Organism-specific databases

HPAiHPA017238

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000438378

Structurei

3D structure databases

ProteinModelPortaliQ7Z2Y5
SMRiQ7Z2Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST289
Domaini1209 – 1552CNHPROSITE-ProRule annotationAdd BLAST344

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili725 – 759Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi402 – 570Gln-richAdd BLAST169
Compositional biasi917 – 979Asp-richAdd BLAST63

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0587 Eukaryota
ENOG410YEAG LUCA
GeneTreeiENSGT00920000148966
HOVERGENiHBG080612
InParanoidiQ7Z2Y5
KOiK16313
OMAiEDIFNQH
OrthoDBiEOG091G00RS
PhylomeDBiQ7Z2Y5

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF
60 70 80 90 100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY
110 120 130 140 150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK
160 170 180 190 200
EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA
210 220 230 240 250
QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM
260 270 280 290 300
AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF
310 320 330 340 350
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE
360 370 380 390 400
AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE
410 420 430 440 450
PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ
460 470 480 490 500
AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK
510 520 530 540 550
QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL
560 570 580 590 600
EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL
610 620 630 640 650
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA
660 670 680 690 700
PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS
710 720 730 740 750
PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE
760 770 780 790 800
DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH
810 820 830 840 850
VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR
860 870 880 890 900
RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF
910 920 930 940 950
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN
960 970 980 990 1000
GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS
1010 1020 1030 1040 1050
CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI
1060 1070 1080 1090 1100
GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE
1110 1120 1130 1140 1150
YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP
1160 1170 1180 1190 1200
SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL
1210 1220 1230 1240 1250
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF
1260 1270 1280 1290 1300
RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK
1310 1320 1330 1340 1350
TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST
1360 1370 1380 1390 1400
AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL
1410 1420 1430 1440 1450
KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK
1460 1470 1480 1490 1500
NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI
1510 1520 1530 1540 1550
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD
1560 1570 1580
KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV
Length:1,582
Mass (Da):178,479
Last modified:October 3, 2006 - v2
Checksum:iC9C56860C8AEBFF3
GO
Isoform 2 (identifier: Q7Z2Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-338: IIKKRQ → MFFSFV

Note: No experimental confirmation available.
Show »
Length:1,250
Mass (Da):140,606
Checksum:i5ACDF85130EFEC4D
GO
Isoform 3 (identifier: Q7Z2Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
     189-1582: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,368
Checksum:i702BC65F8A2DE6ED
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H049F5H049_HUMAN
Nik-related protein kinase
NRK
355Annotation score:
B7Z1I7B7Z1I7_HUMAN
Nik-related protein kinase
NRK
163Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152D → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti522G → S in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti572E → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti705R → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti1138S → P in CAD98108 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040951355Q → H1 PublicationCorresponds to variant dbSNP:rs55862725Ensembl.1
Natural variantiVAR_033908358V → M1 PublicationCorresponds to variant dbSNP:rs209373Ensembl.1
Natural variantiVAR_040952424S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040953426P → A1 PublicationCorresponds to variant dbSNP:rs55635933Ensembl.1
Natural variantiVAR_040954579E → G1 PublicationCorresponds to variant dbSNP:rs56350428Ensembl.1
Natural variantiVAR_040955679E → G1 PublicationCorresponds to variant dbSNP:rs35115195Ensembl.1
Natural variantiVAR_051653727R → H. Corresponds to variant dbSNP:rs33936206Ensembl.1
Natural variantiVAR_040956880I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764355898Ensembl.1
Natural variantiVAR_040957971D → G1 PublicationCorresponds to variant dbSNP:rs35334892Ensembl.1
Natural variantiVAR_033909993A → E. Corresponds to variant dbSNP:rs16984889Ensembl.1
Natural variantiVAR_0409581106P → S1 PublicationCorresponds to variant dbSNP:rs35393519Ensembl.1
Natural variantiVAR_0409591121A → P1 PublicationCorresponds to variant dbSNP:rs35720774Ensembl.1
Natural variantiVAR_0409601276H → L1 PublicationCorresponds to variant dbSNP:rs35942881Ensembl.1
Natural variantiVAR_0409611471G → A1 PublicationCorresponds to variant dbSNP:rs34232354Ensembl.1
Natural variantiVAR_0409621472M → L1 PublicationCorresponds to variant dbSNP:rs35609510Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0206541 – 332Missing in isoform 2. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_020655164 – 188GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_020656189 – 1582Missing in isoform 3. 1 PublicationAdd BLAST1394
Alternative sequenceiVSP_020657333 – 338IIKKRQ → MFFSFV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA Translation: CAD98108.1
Z68339 Genomic DNA No translation available.
Z69734 Genomic DNA No translation available.
Z70274 Genomic DNA No translation available.
Z83850 Genomic DNA No translation available.
BC108702 mRNA Translation: AAI08703.1
AK131549 mRNA Translation: BAD18683.1
CCDSiCCDS65305.1 [Q7Z2Y5-1]
RefSeqiNP_940867.2, NM_198465.3 [Q7Z2Y5-1]
UniGeneiHs.209527

Genome annotation databases

EnsembliENST00000243300; ENSP00000434830; ENSG00000123572 [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3]
GeneIDi203447
KEGGihsa:203447
UCSCiuc065ans.1 human [Q7Z2Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA Translation: CAD98108.1
Z68339 Genomic DNA No translation available.
Z69734 Genomic DNA No translation available.
Z70274 Genomic DNA No translation available.
Z83850 Genomic DNA No translation available.
BC108702 mRNA Translation: AAI08703.1
AK131549 mRNA Translation: BAD18683.1
CCDSiCCDS65305.1 [Q7Z2Y5-1]
RefSeqiNP_940867.2, NM_198465.3 [Q7Z2Y5-1]
UniGeneiHs.209527

3D structure databases

ProteinModelPortaliQ7Z2Y5
SMRiQ7Z2Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000438378

PTM databases

iPTMnetiQ7Z2Y5
PhosphoSitePlusiQ7Z2Y5

Polymorphism and mutation databases

BioMutaiNRK
DMDMi115502506

Proteomic databases

PaxDbiQ7Z2Y5
PeptideAtlasiQ7Z2Y5
PRIDEiQ7Z2Y5
ProteomicsDBi68985
68986 [Q7Z2Y5-2]
68987 [Q7Z2Y5-3]

Protocols and materials databases

DNASUi203447
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243300; ENSP00000434830; ENSG00000123572 [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3]
GeneIDi203447
KEGGihsa:203447
UCSCiuc065ans.1 human [Q7Z2Y5-1]

Organism-specific databases

CTDi203447
DisGeNETi203447
EuPathDBiHostDB:ENSG00000123572.16
GeneCardsiNRK
H-InvDBiHIX0028465
HGNCiHGNC:25391 NRK
HPAiHPA017238
MIMi300791 gene
neXtProtiNX_Q7Z2Y5
OpenTargetsiENSG00000123572
PharmGKBiPA134869113
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0587 Eukaryota
ENOG410YEAG LUCA
GeneTreeiENSGT00920000148966
HOVERGENiHBG080612
InParanoidiQ7Z2Y5
KOiK16313
OMAiEDIFNQH
OrthoDBiEOG091G00RS
PhylomeDBiQ7Z2Y5

Enzyme and pathway databases

SignaLinkiQ7Z2Y5

Miscellaneous databases

ChiTaRSiNRK human
GeneWikiiNRK_(gene)
GenomeRNAii203447
PROiPR:Q7Z2Y5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123572 Expressed in 139 organ(s), highest expression level in metanephros
CleanExiHS_NRK
ExpressionAtlasiQ7Z2Y5 baseline and differential
GenevisibleiQ7Z2Y5 HS

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRK_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2Y5
Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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