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Protein

Nik-related protein kinase

Gene

NRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei54ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q7Z2Y5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nik-related protein kinase (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000123572.16

Human Gene Nomenclature Database

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HGNCi
HGNC:25391 NRK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300791 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z2Y5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
203447

Open Targets

More...
OpenTargetsi
ENSG00000123572

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134869113

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NRK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115502506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002505111 – 1582Nik-related protein kinaseAdd BLAST1582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei1027PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1034PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z2Y5

PeptideAtlas

More...
PeptideAtlasi
Q7Z2Y5

PRoteomics IDEntifications database

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PRIDEi
Q7Z2Y5

ProteomicsDB human proteome resource

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ProteomicsDBi
68985
68986 [Q7Z2Y5-2]
68987 [Q7Z2Y5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z2Y5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z2Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000123572 Expressed in 139 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

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CleanExi
HS_NRK

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z2Y5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z2Y5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017238

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000438378

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z2Y5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z2Y5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST289
Domaini1209 – 1552CNHPROSITE-ProRule annotationAdd BLAST344

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili725 – 759Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi402 – 570Gln-richAdd BLAST169
Compositional biasi917 – 979Asp-richAdd BLAST63

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0587 Eukaryota
ENOG410YEAG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161533

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080612

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z2Y5

KEGG Orthology (KO)

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KOi
K16313

Identification of Orthologs from Complete Genome Data

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OMAi
YEDTYDH

Database of Orthologous Groups

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OrthoDBi
EOG091G00RS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z2Y5

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF
60 70 80 90 100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY
110 120 130 140 150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK
160 170 180 190 200
EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA
210 220 230 240 250
QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM
260 270 280 290 300
AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF
310 320 330 340 350
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE
360 370 380 390 400
AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE
410 420 430 440 450
PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ
460 470 480 490 500
AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK
510 520 530 540 550
QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL
560 570 580 590 600
EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL
610 620 630 640 650
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA
660 670 680 690 700
PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS
710 720 730 740 750
PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE
760 770 780 790 800
DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH
810 820 830 840 850
VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR
860 870 880 890 900
RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF
910 920 930 940 950
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN
960 970 980 990 1000
GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS
1010 1020 1030 1040 1050
CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI
1060 1070 1080 1090 1100
GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE
1110 1120 1130 1140 1150
YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP
1160 1170 1180 1190 1200
SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL
1210 1220 1230 1240 1250
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF
1260 1270 1280 1290 1300
RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK
1310 1320 1330 1340 1350
TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST
1360 1370 1380 1390 1400
AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL
1410 1420 1430 1440 1450
KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK
1460 1470 1480 1490 1500
NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI
1510 1520 1530 1540 1550
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD
1560 1570 1580
KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV
Length:1,582
Mass (Da):178,479
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9C56860C8AEBFF3
GO
Isoform 2 (identifier: Q7Z2Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-338: IIKKRQ → MFFSFV

Note: No experimental confirmation available.
Show »
Length:1,250
Mass (Da):140,606
Checksum:i5ACDF85130EFEC4D
GO
Isoform 3 (identifier: Q7Z2Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
     189-1582: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,368
Checksum:i702BC65F8A2DE6ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H049F5H049_HUMAN
Nik-related protein kinase
NRK
355Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z1I7B7Z1I7_HUMAN
Nik-related protein kinase
NRK
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152D → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti522G → S in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti572E → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti705R → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti1138S → P in CAD98108 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040951355Q → H1 PublicationCorresponds to variant dbSNP:rs55862725Ensembl.1
Natural variantiVAR_033908358V → M1 PublicationCorresponds to variant dbSNP:rs209373Ensembl.1
Natural variantiVAR_040952424S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040953426P → A1 PublicationCorresponds to variant dbSNP:rs55635933Ensembl.1
Natural variantiVAR_040954579E → G1 PublicationCorresponds to variant dbSNP:rs56350428Ensembl.1
Natural variantiVAR_040955679E → G1 PublicationCorresponds to variant dbSNP:rs35115195Ensembl.1
Natural variantiVAR_051653727R → H. Corresponds to variant dbSNP:rs33936206Ensembl.1
Natural variantiVAR_040956880I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764355898Ensembl.1
Natural variantiVAR_040957971D → G1 PublicationCorresponds to variant dbSNP:rs35334892Ensembl.1
Natural variantiVAR_033909993A → E. Corresponds to variant dbSNP:rs16984889Ensembl.1
Natural variantiVAR_0409581106P → S1 PublicationCorresponds to variant dbSNP:rs35393519Ensembl.1
Natural variantiVAR_0409591121A → P1 PublicationCorresponds to variant dbSNP:rs35720774Ensembl.1
Natural variantiVAR_0409601276H → L1 PublicationCorresponds to variant dbSNP:rs35942881Ensembl.1
Natural variantiVAR_0409611471G → A1 PublicationCorresponds to variant dbSNP:rs34232354Ensembl.1
Natural variantiVAR_0409621472M → L1 PublicationCorresponds to variant dbSNP:rs35609510Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0206541 – 332Missing in isoform 2. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_020655164 – 188GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_020656189 – 1582Missing in isoform 3. 1 PublicationAdd BLAST1394
Alternative sequenceiVSP_020657333 – 338IIKKRQ → MFFSFV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX538345 mRNA Translation: CAD98108.1
Z68339 Genomic DNA No translation available.
Z69734 Genomic DNA No translation available.
Z70274 Genomic DNA No translation available.
Z83850 Genomic DNA No translation available.
BC108702 mRNA Translation: AAI08703.1
AK131549 mRNA Translation: BAD18683.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS65305.1 [Q7Z2Y5-1]

NCBI Reference Sequences

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RefSeqi
NP_940867.2, NM_198465.3 [Q7Z2Y5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.209527

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000243300; ENSP00000434830; ENSG00000123572 [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
203447

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:203447

UCSC genome browser

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UCSCi
uc065ans.1 human [Q7Z2Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA Translation: CAD98108.1
Z68339 Genomic DNA No translation available.
Z69734 Genomic DNA No translation available.
Z70274 Genomic DNA No translation available.
Z83850 Genomic DNA No translation available.
BC108702 mRNA Translation: AAI08703.1
AK131549 mRNA Translation: BAD18683.1
CCDSiCCDS65305.1 [Q7Z2Y5-1]
RefSeqiNP_940867.2, NM_198465.3 [Q7Z2Y5-1]
UniGeneiHs.209527

3D structure databases

ProteinModelPortaliQ7Z2Y5
SMRiQ7Z2Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000438378

PTM databases

iPTMnetiQ7Z2Y5
PhosphoSitePlusiQ7Z2Y5

Polymorphism and mutation databases

BioMutaiNRK
DMDMi115502506

Proteomic databases

PaxDbiQ7Z2Y5
PeptideAtlasiQ7Z2Y5
PRIDEiQ7Z2Y5
ProteomicsDBi68985
68986 [Q7Z2Y5-2]
68987 [Q7Z2Y5-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
203447
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243300; ENSP00000434830; ENSG00000123572 [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3]
GeneIDi203447
KEGGihsa:203447
UCSCiuc065ans.1 human [Q7Z2Y5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
203447
DisGeNETi203447
EuPathDBiHostDB:ENSG00000123572.16

GeneCards: human genes, protein and diseases

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GeneCardsi
NRK

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0028465
HGNCiHGNC:25391 NRK
HPAiHPA017238
MIMi300791 gene
neXtProtiNX_Q7Z2Y5
OpenTargetsiENSG00000123572
PharmGKBiPA134869113

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0587 Eukaryota
ENOG410YEAG LUCA
GeneTreeiENSGT00940000161533
HOVERGENiHBG080612
InParanoidiQ7Z2Y5
KOiK16313
OMAiYEDTYDH
OrthoDBiEOG091G00RS
PhylomeDBiQ7Z2Y5

Enzyme and pathway databases

SignaLinkiQ7Z2Y5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NRK human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NRK_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
203447

Protein Ontology

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PROi
PR:Q7Z2Y5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123572 Expressed in 139 organ(s), highest expression level in metanephros
CleanExiHS_NRK
ExpressionAtlasiQ7Z2Y5 baseline and differential
GenevisibleiQ7Z2Y5 HS

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2Y5
Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: December 5, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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