NRK

Functionⁱ

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	54	ATPPROSITE-ProRule annotation		1
Active siteⁱ	177	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	31 – 39	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase kinase kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of JNKK activity Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
neuron projection morphogenesis Source: GO_Central
parturition Source: Ensembl
regulation of apoptotic process Source: GO_Central
regulation of mitotic cell cycle Source: GO_Central
regulation of spongiotrophoblast cell proliferation Source: Ensembl
stress-activated protein kinase signaling cascade Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q7Z2Y5

SignaLinkⁱ

Q7Z2Y5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nik-related protein kinase (EC:2.7.11.1)
Gene namesⁱ	Name:NRK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123572.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25391 NRK
MIMⁱ	300791 gene
neXtProtⁱ	NX_Q7Z2Y5

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	203447
Open Targets More...OpenTargetsⁱ	ENSG00000123572
PharmGKBⁱ	PA134869113

Polymorphism and mutation databases

BioMutaⁱ	NRK
DMDMⁱ	115502506

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000250511	1 – 1582	Nik-related protein kinaseAdd BLAST		1582

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	852	PhosphoserineCombined sources	1
Modified residueⁱ	855	PhosphoserineCombined sources	1
Modified residueⁱ	1027	PhosphoserineCombined sources	1
Modified residueⁱ	1031	PhosphoserineCombined sources	1
Modified residueⁱ	1034	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q7Z2Y5
PeptideAtlas More...PeptideAtlasⁱ	Q7Z2Y5
PRIDEⁱ	Q7Z2Y5
ProteomicsDBⁱ	68985 68986 [Q7Z2Y5-2] 68987 [Q7Z2Y5-3]

PTM databases

iPTMnetⁱ	Q7Z2Y5
PhosphoSitePlusⁱ	Q7Z2Y5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000123572
CleanExⁱ	HS_NRK
ExpressionAtlasⁱ	Q7Z2Y5 baseline and differential
Genevisibleⁱ	Q7Z2Y5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017238

HPAⁱ

HPA017238

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000438378

STRINGⁱ

9606.ENSP00000438378

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z2Y5
SMRⁱ	Q7Z2Y5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 313	Protein kinasePROSITE-ProRule annotationAdd BLAST		289
Domainⁱ	1209 – 1552	CNHPROSITE-ProRule annotationAdd BLAST		344

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	725 – 759	Sequence analysisAdd BLAST		35

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	402 – 570	Gln-richAdd BLAST		169
Compositional biasⁱ	917 – 979	Asp-richAdd BLAST		63

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0587 Eukaryota ENOG410YEAG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148966
HOVERGENⁱ	HBG080612
InParanoidⁱ	Q7Z2Y5
KEGG Orthology (KO) More...KOⁱ	K16313
OMAⁱ	EDIFNQH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00RS
PhylomeDBⁱ	Q7Z2Y5

Family and domain databases

InterProⁱ	View protein in InterPro IPR001180 CNH_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00780 CNH, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00036 CNH, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50219 CNH, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF 
        60         70         80         90        100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY 
       110        120        130        140        150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK 
       160        170        180        190        200
EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA 
       210        220        230        240        250
QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM 
       260        270        280        290        300
AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 
       310        320        330        340        350
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE 
       360        370        380        390        400
AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE 
       410        420        430        440        450
PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ 
       460        470        480        490        500
AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK 
       510        520        530        540        550
QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL 
       560        570        580        590        600
EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL 
       610        620        630        640        650
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA 
       660        670        680        690        700
PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS 
       710        720        730        740        750
PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE 
       760        770        780        790        800
DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH 
       810        820        830        840        850
VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR 
       860        870        880        890        900
RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF 
       910        920        930        940        950
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN 
       960        970        980        990       1000
GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS 
      1010       1020       1030       1040       1050
CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI 
      1060       1070       1080       1090       1100
GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE 
      1110       1120       1130       1140       1150
YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP 
      1160       1170       1180       1190       1200
SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL 
      1210       1220       1230       1240       1250
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF 
      1260       1270       1280       1290       1300
RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK 
      1310       1320       1330       1340       1350
TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST 
      1360       1370       1380       1390       1400
AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL 
      1410       1420       1430       1440       1450
KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK 
      1460       1470       1480       1490       1500
NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI 
      1510       1520       1530       1540       1550
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD 
      1560       1570       1580 
KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV

Length:1,582

Mass (Da):178,479

Last modified:October 3, 2006 - v2

Checksum:ⁱC9C56860C8AEBFF3

GO

Isoform 2 (identifier: Q7Z2Y5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-332: Missing.
333-338: IIKKRQ → MFFSFV

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        10         20         30         40         50
MFFSFVKKGI PLIFEREEAI KEQYTVRRFR GPSCTHELLR LPTSSRCRPL 
        60         70         80         90        100
RVLHGEPSQP RWLPDREEPQ VQALQQLQGA ARVFMPLQAL DSAPKPLKGQ 
       110        120        130        140        150
AQAPQRLQGA ARVFMPLQAQ VKAKASKPLQ MQIKAPPRLR RAARVLMPLQ 
       160        170        180        190        200
AQVRAPRLLQ VQSQVSKKQQ AQTQTSEPQD LDQVPEEFQG QDQVPEQQRQ 
       210        220        230        240        250
GQAPEQQQRH NQVPEQELEQ NQAPEQPEVQ EQAAEPAQAE TEAEEPESLR 
       260        270        280        290        300
VNAQVFLPLL SQDHHVLLPL HLDTQVLIPV EGQTEGSPQA QAWTLEPPQA 
       310        320        330        340        350
IGSVQALIEG LSRDLLRAPN SNNSKPLGPL QTLMENLSSN RFYSQPEQAR 
       360        370        380        390        400
EKKSKVSTLR QALAKRLSPK RFRAKSSWRP EKLELSDLEA RRQRRQRRWE 
       410        420        430        440        450
DIFNQHEEEL RQVDKDKEDE SSDNDEVFHS IQAEVQIEPL KPYISNPKKI 
       460        470        480        490        500
EVQERSPSVP NNQDHAHHVK FSSSVPQRSL LEQAQKPIDI RQRSSQNRQN 
       510        520        530        540        550
WLAASESSSE EESPVTGRRS QSSPPYSTID QKLLVDIHVP DGFKVGKISP 
       560        570        580        590        600
PVYLTNEWVG YNALSEIFRN DWLTPAPVIQ PPEEDGDYVE LYDASADTDG 
       610        620        630        640        650
DDDDESNDTF EDTYDHANGN DDLDNQVDQA NDVCKDHDDD NNKFVDDVNN 
       660        670        680        690        700
NYYEAPSCPR ASYGRDGSCK QDGYDGSRGK EEAYRGYGSH TANRSHGGSA 
       710        720        730        740        750
ASEDNAAIGD QEEHAANIGS ERRGSEGDGG KGVVRTSEES GALGLNGEEN 
       760        770        780        790        800
CSETDGPGLK RPASQDFEYL QEEPGGGNEA SNAIDSGAAP SAPDHESDNK 
       810        820        830        840        850
DISESSTQSD FSANHSSPSK GSGMSADANF ASAILYAGFV EVPEESPKQP 
       860        870        880        890        900
SEVNVNPLYV SPACKKPLIH MYEKEFTSEI CCGSLWGVNL LLGTRSNLYL 
       910        920        930        940        950
MDRSGKADIT KLIRRRPFRQ IQVLEPLNLL ITISGHKNRL RVYHLTWLRN 
       960        970        980        990       1000
KILNNDPESK RRQEEMLKTE EACKAIDKLT GCEHFSVLQH EETTYIAIAL 
      1010       1020       1030       1040       1050
KSSIHLYAWA PKSFDESTAI KVCIDQSADS EGDYMSYQAY IRILAKIQAA 
      1060       1070       1080       1090       1100
DPVNRFKRPD ELLHLLKLKV FPTLDHKPVT VDLAIGSEKR LKIFFSSADG 
      1110       1120       1130       1140       1150
YHLIDAESEV MSDVTLPKNP LEIIIPQNII ILPDCLGIGM MLTFNAEALS 
      1160       1170       1180       1190       1200
VEANEQLFKK ILEMWKDIPS SIAFECTQRT TGWGQKAIEV RSLQSRVLES 
      1210       1220       1230       1240       1250
ELKRRSIKKL RFLCTRGDKL FFTSTLRNHH SRVYFMTLGK LEELQSNYDV

Note: No experimental confirmation available.

Show »

Length:1,250

Mass (Da):140,606

Checksum:ⁱ5ACDF85130EFEC4D

GO

Isoform 3 (identifier: Q7Z2Y5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
189-1582: Missing.

« Hide

        10         20         30         40         50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF 
        60         70         80         90        100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY 
       110        120        130        140        150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK 
       160        170        180 
EDWIAYICRE ILQPKVIFLG TGCSDSSLKK ELCLKHQN

Note: No experimental confirmation available.

Show »

Length:188

Mass (Da):21,368

Checksum:ⁱ702BC65F8A2DE6ED

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	152	D → G in CAD98108 (PubMed:17974005).Curated	1
Sequence conflictⁱ	522	G → S in CAD98108 (PubMed:17974005).Curated	1
Sequence conflictⁱ	572	E → G in CAD98108 (PubMed:17974005).Curated	1
Sequence conflictⁱ	705	R → G in CAD98108 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1138	S → P in CAD98108 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040951	355	Q → H1 PublicationCorresponds to variant dbSNP:rs55862725Ensembl.	1
Natural variantⁱVAR_033908	358	V → M1 PublicationCorresponds to variant dbSNP:rs209373Ensembl.	1
Natural variantⁱVAR_040952	424	S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040953	426	P → A1 PublicationCorresponds to variant dbSNP:rs55635933Ensembl.	1
Natural variantⁱVAR_040954	579	E → G1 PublicationCorresponds to variant dbSNP:rs56350428Ensembl.	1
Natural variantⁱVAR_040955	679	E → G1 PublicationCorresponds to variant dbSNP:rs35115195Ensembl.	1
Natural variantⁱVAR_051653	727	R → H. Corresponds to variant dbSNP:rs33936206Ensembl.	1
Natural variantⁱVAR_040956	880	I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764355898Ensembl.	1
Natural variantⁱVAR_040957	971	D → G1 PublicationCorresponds to variant dbSNP:rs35334892Ensembl.	1
Natural variantⁱVAR_033909	993	A → E. Corresponds to variant dbSNP:rs16984889Ensembl.	1
Natural variantⁱVAR_040958	1106	P → S1 PublicationCorresponds to variant dbSNP:rs35393519Ensembl.	1
Natural variantⁱVAR_040959	1121	A → P1 PublicationCorresponds to variant dbSNP:rs35720774Ensembl.	1
Natural variantⁱVAR_040960	1276	H → L1 PublicationCorresponds to variant dbSNP:rs35942881Ensembl.	1
Natural variantⁱVAR_040961	1471	G → A1 PublicationCorresponds to variant dbSNP:rs34232354Ensembl.	1
Natural variantⁱVAR_040962	1472	M → L1 PublicationCorresponds to variant dbSNP:rs35609510Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_020654	1 – 332	Missing in isoform 2. 1 PublicationAdd BLAST	332
Alternative sequenceⁱVSP_020655	164 – 188	GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationAdd BLAST	25
Alternative sequenceⁱVSP_020656	189 – 1582	Missing in isoform 3. 1 PublicationAdd BLAST	1394
Alternative sequenceⁱVSP_020657	333 – 338	IIKKRQ → MFFSFV in isoform 2. 1 Publication	6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX538345 mRNA Translation: CAD98108.1 Z68339 Genomic DNA No translation available. Z69734 Genomic DNA No translation available. Z70274 Genomic DNA No translation available. Z83850 Genomic DNA No translation available. BC108702 mRNA Translation: AAI08703.1 AK131549 mRNA Translation: BAD18683.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS65305.1 [Q7Z2Y5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_940867.2, NM_198465.3 [Q7Z2Y5-1]
UniGeneⁱ	Hs.209527

Genome annotation databases

Ensemblⁱ	ENST00000243300; ENSP00000434830; ENSG00000123572 [Q7Z2Y5-1] ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3]
GeneIDⁱ	203447
KEGGⁱ	hsa:203447
UCSC genome browser More...UCSCⁱ	uc065ans.1 human [Q7Z2Y5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length
Q7Z2Y5	UPI0005D0019C		HUMAN		1527
Uncharacterized protein		MACMU		1586
UPI00083BB14E		RHIBE		143
Uncharacterized protein		MACFA		1585
UPI00027F690A		PAPAN		1583
+37
Q7Z2Y5-3	NRK isoform 2		PANTR		188
NRK isoform 4		PONAB		188
Nik related kinase		PANPA		188
Nik related kinase		GORGO		188
Nik related kinase		SAIBB		188
+13

Protein	Similar proteins		Species	Score	Length
Q7Z2Y5	UPI0005D0019C		HUMAN		1527
Uncharacterized protein		MACMU		1586
UPI00083BB14E		RHIBE		143
Uncharacterized protein		MACFA		1585
UPI0007DBD931		PANTR		1583
+133
Q7Z2Y5-2	UPI00083C79F9		RHIBE		1245
UPI0004E4862C		RAT		1271
NRK isoform 4		PANTR		1252
Nik-related protein kinase		CRIGR		1315
nik-related protein kinase		DIPOR		1534
+1
Q7Z2Y5-3	Nik related kinase		MACMU		188
Uncharacterized protein		CERAT		188
Nik related kinase		PAPAN		188
Nik related kinase		MANLE		188
Nik related kinase		MACFA		188
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX538345 mRNA Translation: CAD98108.1 Z68339 Genomic DNA No translation available. Z69734 Genomic DNA No translation available. Z70274 Genomic DNA No translation available. Z83850 Genomic DNA No translation available. BC108702 mRNA Translation: AAI08703.1 AK131549 mRNA Translation: BAD18683.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS65305.1 [Q7Z2Y5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_940867.2, NM_198465.3 [Q7Z2Y5-1]
UniGeneⁱ	Hs.209527

3D structure databases

ProteinModelPortalⁱ	Q7Z2Y5
SMRⁱ	Q7Z2Y5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000438378

STRINGⁱ

9606.ENSP00000438378

PTM databases

iPTMnetⁱ	Q7Z2Y5
PhosphoSitePlusⁱ	Q7Z2Y5

Polymorphism and mutation databases

BioMutaⁱ	NRK
DMDMⁱ	115502506

Proteomic databases

PaxDbⁱ	Q7Z2Y5
PeptideAtlas More...PeptideAtlasⁱ	Q7Z2Y5
PRIDEⁱ	Q7Z2Y5
ProteomicsDBⁱ	68985 68986 [Q7Z2Y5-2] 68987 [Q7Z2Y5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	203447
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000243300; ENSP00000434830; ENSG00000123572 [Q7Z2Y5-1] ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3]
GeneIDⁱ	203447
KEGGⁱ	hsa:203447
UCSC genome browser More...UCSCⁱ	uc065ans.1 human [Q7Z2Y5-1]

Organism-specific databases

CTDⁱ	203447
DisGeNET More...DisGeNETⁱ	203447
EuPathDBⁱ	HostDB:ENSG00000123572.16
GeneCardsⁱ	NRK
H-InvDBⁱ	HIX0028465
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25391 NRK
Human Protein Atlas More...HPAⁱ	HPA017238
MIMⁱ	300791 gene
neXtProtⁱ	NX_Q7Z2Y5
Open Targets More...OpenTargetsⁱ	ENSG00000123572
PharmGKBⁱ	PA134869113
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0587 Eukaryota ENOG410YEAG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148966
HOVERGENⁱ	HBG080612
InParanoidⁱ	Q7Z2Y5
KEGG Orthology (KO) More...KOⁱ	K16313
OMAⁱ	EDIFNQH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00RS
PhylomeDBⁱ	Q7Z2Y5

Enzyme and pathway databases

SignaLinkⁱ	Q7Z2Y5

SignaLinkⁱ

Q7Z2Y5

Miscellaneous databases

ChiTaRSⁱ	NRK human
GeneWikiⁱ	NRK_(gene)
GenomeRNAiⁱ	203447
Protein Ontology More...PROⁱ	PR:Q7Z2Y5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123572
CleanExⁱ	HS_NRK
ExpressionAtlasⁱ	Q7Z2Y5 baseline and differential
Genevisibleⁱ	Q7Z2Y5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001180 CNH_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00780 CNH, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00036 CNH, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50219 CNH, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRK_HUMAN
Accessionⁱ	Q7Z2Y5Primary (citable) accession number: Q7Z2Y5 Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	October 3, 2006
	Last modified:	June 20, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q7Z2Y5 (NRK_HUMAN)

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Nik-related protein kinase

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Functionⁱ

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Pathology & Biotechⁱ

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