We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q7Z2Y5 (NRK_HUMAN)
Protein
Nik-related protein kinase
Gene
NRK
Organism
Homo sapiens (Human)
Status
Functioni
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 177 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 39 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- actin cytoskeleton reorganization Source: GO_Central
- intracellular signal transduction Source: GO_Central
- MAPK cascade Source: GO_Central
- neuron projection morphogenesis Source: GO_Central
- protein phosphorylation Source: GO_Central
- regulation of MAPK cascade Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q7Z2Y5 |
SignaLinki | Q7Z2Y5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:NRK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25391, NRK |
MIMi | 300791, gene |
neXtProti | NX_Q7Z2Y5 |
VEuPathDBi | HostDB:ENSG00000123572 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 203447 |
OpenTargetsi | ENSG00000123572 |
PharmGKBi | PA134869113 |
Miscellaneous databases
Pharosi | Q7Z2Y5, Tdark |
Genetic variation databases
BioMutai | NRK |
DMDMi | 115502506 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250511 | 1 – 1582 | Nik-related protein kinaseAdd BLAST | 1582 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 852 | PhosphoserineCombined sources | 1 | |
Modified residuei | 855 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1027 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1031 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1034 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q7Z2Y5 |
MassIVEi | Q7Z2Y5 |
PaxDbi | Q7Z2Y5 |
PeptideAtlasi | Q7Z2Y5 |
PRIDEi | Q7Z2Y5 |
ProteomicsDBi | 68985 [Q7Z2Y5-1] 68986 [Q7Z2Y5-2] 68987 [Q7Z2Y5-3] |
PTM databases
GlyGeni | Q7Z2Y5, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q7Z2Y5 |
PhosphoSitePlusi | Q7Z2Y5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123572, Expressed in metanephros and 153 other tissues |
ExpressionAtlasi | Q7Z2Y5, baseline and differential |
Genevisiblei | Q7Z2Y5, HS |
Organism-specific databases
HPAi | ENSG00000123572, Tissue enhanced (adrenal gland, ovary, placenta) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128472, 3 interactors |
STRINGi | 9606.ENSP00000434830 |
Miscellaneous databases
RNActi | Q7Z2Y5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 313 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 289 | |
Domaini | 1209 – 1552 | CNHPROSITE-ProRule annotationAdd BLAST | 344 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 492 – 579 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 783 – 859 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 926 – 1156 | DisorderedSequence analysisAdd BLAST | 231 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 725 – 759 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 492 – 514 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 522 – 560 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 783 – 813 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 820 – 859 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 926 – 942 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 943 – 977 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1003 – 1019 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1039 – 1065 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1136 – 1156 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0587, Eukaryota |
GeneTreei | ENSGT00940000161533 |
HOGENOMi | CLU_001831_2_0_1 |
InParanoidi | Q7Z2Y5 |
OrthoDBi | 533537at2759 |
PhylomeDBi | Q7Z2Y5 |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF
60 70 80 90 100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY
110 120 130 140 150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK
160 170 180 190 200
EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA
210 220 230 240 250
QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM
260 270 280 290 300
AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF
310 320 330 340 350
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE
360 370 380 390 400
AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE
410 420 430 440 450
PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ
460 470 480 490 500
AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK
510 520 530 540 550
QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL
560 570 580 590 600
EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL
610 620 630 640 650
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA
660 670 680 690 700
PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS
710 720 730 740 750
PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE
760 770 780 790 800
DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH
810 820 830 840 850
VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR
860 870 880 890 900
RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF
910 920 930 940 950
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN
960 970 980 990 1000
GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS
1010 1020 1030 1040 1050
CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI
1060 1070 1080 1090 1100
GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE
1110 1120 1130 1140 1150
YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP
1160 1170 1180 1190 1200
SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL
1210 1220 1230 1240 1250
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF
1260 1270 1280 1290 1300
RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK
1310 1320 1330 1340 1350
TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST
1360 1370 1380 1390 1400
AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL
1410 1420 1430 1440 1450
KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK
1460 1470 1480 1490 1500
NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI
1510 1520 1530 1540 1550
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD
1560 1570 1580
KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H049 | F5H049_HUMAN | Nik-related protein kinase | NRK | 355 | Annotation score: | ||
B7Z1I7 | B7Z1I7_HUMAN | Nik-related protein kinase | NRK | 163 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | D → G in CAD98108 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 522 | G → S in CAD98108 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 572 | E → G in CAD98108 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 705 | R → G in CAD98108 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1138 | S → P in CAD98108 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040951 | 355 | Q → H1 PublicationCorresponds to variant dbSNP:rs55862725Ensembl. | 1 | |
Natural variantiVAR_033908 | 358 | V → M1 PublicationCorresponds to variant dbSNP:rs209373Ensembl. | 1 | |
Natural variantiVAR_040952 | 424 | S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040953 | 426 | P → A1 PublicationCorresponds to variant dbSNP:rs55635933Ensembl. | 1 | |
Natural variantiVAR_040954 | 579 | E → G1 PublicationCorresponds to variant dbSNP:rs56350428Ensembl. | 1 | |
Natural variantiVAR_040955 | 679 | E → G1 PublicationCorresponds to variant dbSNP:rs35115195Ensembl. | 1 | |
Natural variantiVAR_051653 | 727 | R → H. Corresponds to variant dbSNP:rs33936206Ensembl. | 1 | |
Natural variantiVAR_040956 | 880 | I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764355898Ensembl. | 1 | |
Natural variantiVAR_040957 | 971 | D → G1 PublicationCorresponds to variant dbSNP:rs35334892Ensembl. | 1 | |
Natural variantiVAR_033909 | 993 | A → E. Corresponds to variant dbSNP:rs16984889Ensembl. | 1 | |
Natural variantiVAR_040958 | 1106 | P → S1 PublicationCorresponds to variant dbSNP:rs35393519Ensembl. | 1 | |
Natural variantiVAR_040959 | 1121 | A → P1 PublicationCorresponds to variant dbSNP:rs35720774Ensembl. | 1 | |
Natural variantiVAR_040960 | 1276 | H → L1 PublicationCorresponds to variant dbSNP:rs35942881Ensembl. | 1 | |
Natural variantiVAR_040961 | 1471 | G → A1 PublicationCorresponds to variant dbSNP:rs34232354Ensembl. | 1 | |
Natural variantiVAR_040962 | 1472 | M → L1 PublicationCorresponds to variant dbSNP:rs35609510Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020654 | 1 – 332 | Missing in isoform 2. 1 PublicationAdd BLAST | 332 | |
Alternative sequenceiVSP_020655 | 164 – 188 | GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_020656 | 189 – 1582 | Missing in isoform 3. 1 PublicationAdd BLAST | 1394 | |
Alternative sequenceiVSP_020657 | 333 – 338 | IIKKRQ → MFFSFV in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX538345 mRNA Translation: CAD98108.1 Z68339 Genomic DNA No translation available. Z69734 Genomic DNA No translation available. Z70274 Genomic DNA No translation available. Z83850 Genomic DNA No translation available. BC108702 mRNA Translation: AAI08703.1 AK131549 mRNA Translation: BAD18683.1 |
CCDSi | CCDS65305.1 [Q7Z2Y5-1] |
RefSeqi | NP_940867.2, NM_198465.3 [Q7Z2Y5-1] |
Genome annotation databases
Ensembli | ENST00000243300; ENSP00000434830; ENSG00000123572 ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3] |
GeneIDi | 203447 |
KEGGi | hsa:203447 |
MANE-Selecti | ENST00000243300.14; ENSP00000434830.1; NM_198465.4; NP_940867.2 |
UCSCi | uc065ans.1, human [Q7Z2Y5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX538345 mRNA Translation: CAD98108.1 Z68339 Genomic DNA No translation available. Z69734 Genomic DNA No translation available. Z70274 Genomic DNA No translation available. Z83850 Genomic DNA No translation available. BC108702 mRNA Translation: AAI08703.1 AK131549 mRNA Translation: BAD18683.1 |
CCDSi | CCDS65305.1 [Q7Z2Y5-1] |
RefSeqi | NP_940867.2, NM_198465.3 [Q7Z2Y5-1] |
3D structure databases
SMRi | Q7Z2Y5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128472, 3 interactors |
STRINGi | 9606.ENSP00000434830 |
PTM databases
GlyGeni | Q7Z2Y5, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q7Z2Y5 |
PhosphoSitePlusi | Q7Z2Y5 |
Genetic variation databases
BioMutai | NRK |
DMDMi | 115502506 |
Proteomic databases
jPOSTi | Q7Z2Y5 |
MassIVEi | Q7Z2Y5 |
PaxDbi | Q7Z2Y5 |
PeptideAtlasi | Q7Z2Y5 |
PRIDEi | Q7Z2Y5 |
ProteomicsDBi | 68985 [Q7Z2Y5-1] 68986 [Q7Z2Y5-2] 68987 [Q7Z2Y5-3] |
Protocols and materials databases
Antibodypediai | 2074, 65 antibodies from 21 providers |
DNASUi | 203447 |
Genome annotation databases
Ensembli | ENST00000243300; ENSP00000434830; ENSG00000123572 ENST00000536164; ENSP00000438785; ENSG00000123572 [Q7Z2Y5-3] |
GeneIDi | 203447 |
KEGGi | hsa:203447 |
MANE-Selecti | ENST00000243300.14; ENSP00000434830.1; NM_198465.4; NP_940867.2 |
UCSCi | uc065ans.1, human [Q7Z2Y5-1] |
Organism-specific databases
CTDi | 203447 |
DisGeNETi | 203447 |
GeneCardsi | NRK |
HGNCi | HGNC:25391, NRK |
HPAi | ENSG00000123572, Tissue enhanced (adrenal gland, ovary, placenta) |
MIMi | 300791, gene |
neXtProti | NX_Q7Z2Y5 |
OpenTargetsi | ENSG00000123572 |
PharmGKBi | PA134869113 |
VEuPathDBi | HostDB:ENSG00000123572 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0587, Eukaryota |
GeneTreei | ENSGT00940000161533 |
HOGENOMi | CLU_001831_2_0_1 |
InParanoidi | Q7Z2Y5 |
OrthoDBi | 533537at2759 |
PhylomeDBi | Q7Z2Y5 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z2Y5 |
SignaLinki | Q7Z2Y5 |
Miscellaneous databases
BioGRID-ORCSi | 203447, 17 hits in 677 CRISPR screens |
ChiTaRSi | NRK, human |
GeneWikii | NRK_(gene) |
GenomeRNAii | 203447 |
Pharosi | Q7Z2Y5, Tdark |
PROi | PR:Q7Z2Y5 |
RNActi | Q7Z2Y5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123572, Expressed in metanephros and 153 other tissues |
ExpressionAtlasi | Q7Z2Y5, baseline and differential |
Genevisiblei | Q7Z2Y5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NRK_HUMAN | |
Accessioni | Q7Z2Y5Primary (citable) accession number: Q7Z2Y5 Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families