UniProtKB - Q7Z2X4 (PCLI1_HUMAN)
Protein
PTB-containing, cubilin and LRP1-interacting protein
Gene
PID1
Organism
Homo sapiens (Human)
Status
Functioni
Increases proliferation of preadipocytes without affecting adipocytic differentiation.1 Publication
GO - Biological processi
- cellular response to cytokine stimulus Source: BHF-UCL
- cellular response to fatty acid Source: BHF-UCL
- cellular response to interleukin-6 Source: BHF-UCL
- cellular response to leptin stimulus Source: Ensembl
- cellular response to tumor necrosis factor Source: BHF-UCL
- energy reserve metabolic process Source: BHF-UCL
- mitochondrion morphogenesis Source: BHF-UCL
- negative regulation of ATP biosynthetic process Source: BHF-UCL
- negative regulation of glucose import Source: BHF-UCL
- negative regulation of insulin receptor signaling pathway Source: BHF-UCL
- negative regulation of protein localization to plasma membrane Source: BHF-UCL
- negative regulation of protein phosphorylation Source: BHF-UCL
- positive regulation of ATP biosynthetic process Source: BHF-UCL
- positive regulation of fat cell proliferation Source: BHF-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of mitochondrial fusion Source: BHF-UCL
- regulation of mitochondrial membrane potential Source: BHF-UCL
- regulation of reactive oxygen species metabolic process Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | Q7Z2X4 |
Names & Taxonomyi
Protein namesi | Recommended name: PTB-containing, cubilin and LRP1-interacting proteinShort name: P-CLI1 Alternative name(s): Phosphotyrosine interaction domain-containing protein 1 Protein NYGGF4 |
Gene namesi | Name:PID1 Synonyms:NYGGF4, PCLI1 ORF Names:HMFN2073 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153823.18 |
HGNCi | HGNC:26084, PID1 |
MIMi | 612930, gene |
neXtProti | NX_Q7Z2X4 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55022 |
OpenTargetsi | ENSG00000153823 |
PharmGKBi | PA162399462 |
Miscellaneous databases
Pharosi | Q7Z2X4, Tbio |
Polymorphism and mutation databases
BioMutai | PID1 |
DMDMi | 74713284 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274900 | 1 – 250 | PTB-containing, cubilin and LRP1-interacting proteinAdd BLAST | 250 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 236 | PhosphoserineBy similarity | 1 | |
Modified residuei | 247 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q7Z2X4 |
jPOSTi | Q7Z2X4 |
MassIVEi | Q7Z2X4 |
PaxDbi | Q7Z2X4 |
PeptideAtlasi | Q7Z2X4 |
PRIDEi | Q7Z2X4 |
ProteomicsDBi | 68980 [Q7Z2X4-1] 68981 [Q7Z2X4-2] 68982 [Q7Z2X4-3] 68983 [Q7Z2X4-4] |
PTM databases
iPTMneti | Q7Z2X4 |
PhosphoSitePlusi | Q7Z2X4 |
Expressioni
Tissue specificityi
Expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte.1 Publication
Inductioni
Up-regulated in fat of obese subjects.1 Publication
Gene expression databases
Bgeei | ENSG00000153823, Expressed in forebrain and 230 other tissues |
ExpressionAtlasi | Q7Z2X4, baseline and differential |
Genevisiblei | Q7Z2X4, HS |
Organism-specific databases
HPAi | ENSG00000153823, Low tissue specificity |
Interactioni
Subunit structurei
Found in a complex with PID1/PCLI1, LRP1 and CUBNI.
Interacts with LRP1 and CUBN.
1 PublicationBinary interactionsi
Hide detailsQ7Z2X4
Isoform 3 [Q7Z2X4-3]
With | #Exp. | IntAct |
---|---|---|
CPSF7 - isoform 3 [Q8N684-3] | 3 | EBI-11953174,EBI-11523759 |
DNAAF6 [Q9NQM4] | 3 | EBI-11953174,EBI-10239299 |
Protein-protein interaction databases
BioGRIDi | 120352, 24 interactors |
CORUMi | Q7Z2X4 |
IntActi | Q7Z2X4, 12 interactors |
STRINGi | 9606.ENSP00000375907 |
Miscellaneous databases
RNActi | Q7Z2X4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 93 – 250 | PIDPROSITE-ProRule annotationAdd BLAST | 158 |
Phylogenomic databases
eggNOGi | KOG4448, Eukaryota |
GeneTreei | ENSGT00510000048154 |
HOGENOMi | CLU_088811_0_0_1 |
InParanoidi | Q7Z2X4 |
OMAi | HAKSRTH |
OrthoDBi | 1145472at2759 |
PhylomeDBi | Q7Z2X4 |
Family and domain databases
CDDi | cd13167, PTB_P-CLI1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR039112, PID1 IPR039114, PID1_PTB IPR006020, PTB/PI_dom |
PANTHERi | PTHR16265, PTHR16265, 1 hit |
Pfami | View protein in Pfam PF14719, PID_2, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z2X4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFSLPLSLPL CEDTAFLPSK CCSSHKTIKQ ARTLIMIFLA SGTHFQTMLK
60 70 80 90 100
SKLNVLTLKK EPLPAVIFHE PEAIELCTTT PLMKTRTHSG CKVTYLGKVS
110 120 130 140 150
TTGMQFLSGC TEKPVIELWK KHTLAREDVF PANALLEIRP FQVWLHHLDH
160 170 180 190 200
KGEATVHMDT FQVARIAYCT ADHNVSPNIF AWVYREINDD LSYQMDCHAV
210 220 230 240 250
ECESKLEAKK LAHAMMEAFR KTFHSMKSDG RIHSNSSSEE VSQELESDDG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H314 | F5H314_HUMAN | PTB-containing, cubilin and LRP1-in... | PID1 | 41 | Annotation score: |
Sequence cautioni
The sequence BAD38656 differs from that shown. Reason: Erroneous initiation.Curated
Polymorphismi
Some sequences seem to have a duplication of exon 2.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030361 | 43 | T → THFQTMLKSKLNVLTLKKEP LPAVIFHEPEAIELCTTTPL MKTRTHSGCK in variant with duplicated exon 2. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022909 | 1 – 82 | Missing in isoform 3. 1 PublicationAdd BLAST | 82 | |
Alternative sequenceiVSP_022910 | 1 – 43 | MFSLP…LASGT → MPRIAGNHLMLEESRTCSSP ELLDGVWPCQPLHFGLPASE M in isoform 2. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_022911 | 1 – 43 | MFSLP…LASGT → MWQPATERLQ in isoform 4. 2 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_022912 | 83 – 92 | MKTRTHSGCK → MWQPATERLQ in isoform 3. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075874 mRNA Translation: BAD38656.1 Different initiation. AY317148 mRNA Translation: AAP79437.1 AK000708 mRNA Translation: BAA91333.1 AK096636 mRNA Translation: BAG53344.1 AK125359 mRNA Translation: BAC86145.1 CH471063 Genomic DNA Translation: EAW70891.1 BC040164 mRNA Translation: AAH40164.1 |
CCDSi | CCDS2471.1 [Q7Z2X4-2] CCDS42830.1 [Q7Z2X4-4] CCDS82577.1 [Q7Z2X4-1] CCDS82578.1 [Q7Z2X4-3] |
RefSeqi | NP_001094288.1, NM_001100818.1 [Q7Z2X4-4] NP_001317085.1, NM_001330156.1 [Q7Z2X4-1] NP_001317086.1, NM_001330157.1 [Q7Z2X4-3] NP_060403.3, NM_017933.4 [Q7Z2X4-2] |
Genome annotation databases
Ensembli | ENST00000354069; ENSP00000283937; ENSG00000153823 [Q7Z2X4-1] ENST00000392054; ENSP00000375907; ENSG00000153823 [Q7Z2X4-2] ENST00000392055; ENSP00000375908; ENSG00000153823 [Q7Z2X4-4] ENST00000409462; ENSP00000386826; ENSG00000153823 [Q7Z2X4-3] |
GeneIDi | 55022 |
KEGGi | hsa:55022 |
UCSCi | uc002vpr.5, human [Q7Z2X4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075874 mRNA Translation: BAD38656.1 Different initiation. AY317148 mRNA Translation: AAP79437.1 AK000708 mRNA Translation: BAA91333.1 AK096636 mRNA Translation: BAG53344.1 AK125359 mRNA Translation: BAC86145.1 CH471063 Genomic DNA Translation: EAW70891.1 BC040164 mRNA Translation: AAH40164.1 |
CCDSi | CCDS2471.1 [Q7Z2X4-2] CCDS42830.1 [Q7Z2X4-4] CCDS82577.1 [Q7Z2X4-1] CCDS82578.1 [Q7Z2X4-3] |
RefSeqi | NP_001094288.1, NM_001100818.1 [Q7Z2X4-4] NP_001317085.1, NM_001330156.1 [Q7Z2X4-1] NP_001317086.1, NM_001330157.1 [Q7Z2X4-3] NP_060403.3, NM_017933.4 [Q7Z2X4-2] |
3D structure databases
SMRi | Q7Z2X4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120352, 24 interactors |
CORUMi | Q7Z2X4 |
IntActi | Q7Z2X4, 12 interactors |
STRINGi | 9606.ENSP00000375907 |
PTM databases
iPTMneti | Q7Z2X4 |
PhosphoSitePlusi | Q7Z2X4 |
Polymorphism and mutation databases
BioMutai | PID1 |
DMDMi | 74713284 |
Proteomic databases
EPDi | Q7Z2X4 |
jPOSTi | Q7Z2X4 |
MassIVEi | Q7Z2X4 |
PaxDbi | Q7Z2X4 |
PeptideAtlasi | Q7Z2X4 |
PRIDEi | Q7Z2X4 |
ProteomicsDBi | 68980 [Q7Z2X4-1] 68981 [Q7Z2X4-2] 68982 [Q7Z2X4-3] 68983 [Q7Z2X4-4] |
Protocols and materials databases
Antibodypediai | 34394, 113 antibodies |
Genome annotation databases
Ensembli | ENST00000354069; ENSP00000283937; ENSG00000153823 [Q7Z2X4-1] ENST00000392054; ENSP00000375907; ENSG00000153823 [Q7Z2X4-2] ENST00000392055; ENSP00000375908; ENSG00000153823 [Q7Z2X4-4] ENST00000409462; ENSP00000386826; ENSG00000153823 [Q7Z2X4-3] |
GeneIDi | 55022 |
KEGGi | hsa:55022 |
UCSCi | uc002vpr.5, human [Q7Z2X4-1] |
Organism-specific databases
CTDi | 55022 |
DisGeNETi | 55022 |
EuPathDBi | HostDB:ENSG00000153823.18 |
GeneCardsi | PID1 |
HGNCi | HGNC:26084, PID1 |
HPAi | ENSG00000153823, Low tissue specificity |
MIMi | 612930, gene |
neXtProti | NX_Q7Z2X4 |
OpenTargetsi | ENSG00000153823 |
PharmGKBi | PA162399462 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4448, Eukaryota |
GeneTreei | ENSGT00510000048154 |
HOGENOMi | CLU_088811_0_0_1 |
InParanoidi | Q7Z2X4 |
OMAi | HAKSRTH |
OrthoDBi | 1145472at2759 |
PhylomeDBi | Q7Z2X4 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z2X4 |
Miscellaneous databases
BioGRID-ORCSi | 55022, 2 hits in 848 CRISPR screens |
ChiTaRSi | PID1, human |
GenomeRNAii | 55022 |
Pharosi | Q7Z2X4, Tbio |
PROi | PR:Q7Z2X4 |
RNActi | Q7Z2X4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153823, Expressed in forebrain and 230 other tissues |
ExpressionAtlasi | Q7Z2X4, baseline and differential |
Genevisiblei | Q7Z2X4, HS |
Family and domain databases
CDDi | cd13167, PTB_P-CLI1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR039112, PID1 IPR039114, PID1_PTB IPR006020, PTB/PI_dom |
PANTHERi | PTHR16265, PTHR16265, 1 hit |
Pfami | View protein in Pfam PF14719, PID_2, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCLI1_HUMAN | |
Accessioni | Q7Z2X4Primary (citable) accession number: Q7Z2X4 Secondary accession number(s): B3KU82 Q9NWP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations