PID1

Functionⁱ

Increases proliferation of preadipocytes without affecting adipocytic differentiation.1 Publication

GO - Biological processⁱ

cellular response to cytokine stimulus Source: BHF-UCL
cellular response to fatty acid Source: BHF-UCL
cellular response to interleukin-6 Source: BHF-UCL
cellular response to leptin stimulus Source: Ensembl
cellular response to tumor necrosis factor Source: BHF-UCL
energy reserve metabolic process
Source: BHF-UCL
Inferred by curatorⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
mitochondrion morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
negative regulation of ATP biosynthetic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
negative regulation of glucose import
Source: BHF-UCL
Inferred from direct assayⁱ
- "Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt."
  Zhang C.M., Chen X.H., Wang B., Liu F., Chi X., Tong M.L., Ni Y.H., Chen R.H., Guo X.R.
  Acta Pharmacol Sin 30:120-124(2009) [PubMed] [Europe PMC] [Abstract]
negative regulation of insulin receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- "Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt."
  Zhang C.M., Chen X.H., Wang B., Liu F., Chi X., Tong M.L., Ni Y.H., Chen R.H., Guo X.R.
  Acta Pharmacol Sin 30:120-124(2009) [PubMed] [Europe PMC] [Abstract]
negative regulation of protein localization to plasma membrane
Source: BHF-UCL
Inferred from direct assayⁱ
- "Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt."
  Zhang C.M., Chen X.H., Wang B., Liu F., Chi X., Tong M.L., Ni Y.H., Chen R.H., Guo X.R.
  Acta Pharmacol Sin 30:120-124(2009) [PubMed] [Europe PMC] [Abstract]
negative regulation of protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- "Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt."
  Zhang C.M., Chen X.H., Wang B., Liu F., Chi X., Tong M.L., Ni Y.H., Chen R.H., Guo X.R.
  Acta Pharmacol Sin 30:120-124(2009) [PubMed] [Europe PMC] [Abstract]
positive regulation of ATP biosynthetic process Source: BHF-UCL
positive regulation of fat cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- Ref.2
  "Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation."
  Wang B., Zhang M., Ni Y.-H., Liu F., Fan H.-Q., Fei L., Pan X.-Q., Guo M., Chen R.-H., Guo X.-R.
  Gene 379:132-140(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
positive regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
positive regulation of reactive oxygen species metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
regulation of mitochondrial fusion
Source: BHF-UCL
Inferred by curatorⁱ
- "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes."
  Zhao Y., Zhang C., Chen X., Gao C., Ji C., Chen F., Zhu C., Zhu J., Wang J., Qian L., Guo X.
  Mol Cell Biochem 340:41-48(2010) [PubMed] [Europe PMC] [Abstract]
regulation of mitochondrial membrane potential Source: BHF-UCL
regulation of reactive oxygen species metabolic process Source: BHF-UCL

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

PathwayCommonsⁱ	Q7Z2X4

PathwayCommonsⁱ

Q7Z2X4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PTB-containing, cubilin and LRP1-interacting protein Short name: P-CLI1 Alternative name(s): Phosphotyrosine interaction domain-containing protein 1 Protein NYGGF4
Gene namesⁱ	Name:PID1 Synonyms:NYGGF4, PCLI1 ORF Names:HMFN2073
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26084, PID1
MIMⁱ	612930, gene
neXtProtⁱ	NX_Q7Z2X4
VEuPathDBⁱ	HostDB:ENSG00000153823.18

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55022
Open Targets More...OpenTargetsⁱ	ENSG00000153823
PharmGKBⁱ	PA162399462

Miscellaneous databases

Pharosⁱ	Q7Z2X4, Tbio

Pharosⁱ

Q7Z2X4, Tbio

Genetic variation databases

BioMutaⁱ	PID1
DMDMⁱ	74713284

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274900	1 – 250	PTB-containing, cubilin and LRP1-interacting proteinAdd BLAST		250

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	236	PhosphoserineBy similarity		1
Modified residueⁱ	247	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7Z2X4
jPOSTⁱ	Q7Z2X4
MassIVEⁱ	Q7Z2X4
PaxDbⁱ	Q7Z2X4
PeptideAtlas More...PeptideAtlasⁱ	Q7Z2X4
PRIDEⁱ	Q7Z2X4
ProteomicsDBⁱ	68980 [Q7Z2X4-1] 68981 [Q7Z2X4-2] 68982 [Q7Z2X4-3] 68983 [Q7Z2X4-4]

PTM databases

iPTMnetⁱ	Q7Z2X4
PhosphoSitePlusⁱ	Q7Z2X4

Expressionⁱ

Tissue specificityⁱ

Expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte.1 Publication

Inductionⁱ

Up-regulated in fat of obese subjects.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000153823, Expressed in forebrain and 230 other tissues
ExpressionAtlasⁱ	Q7Z2X4, baseline and differential
Genevisibleⁱ	Q7Z2X4, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000153823, Low tissue specificity

HPAⁱ

ENSG00000153823, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Found in a complex with PID1/PCLI1, LRP1 and CUBNI.

Interacts with LRP1 and CUBN.

1 Publication

Binary interactionsⁱ

Hide details

Q7Z2X4

With	#Exp.	IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]	3	EBI-10256685,EBI-10173507
BANP [Q8N9N5]	3	EBI-10256685,EBI-744695
CBY2 [Q8NA61]	3	EBI-10256685,EBI-741724
CRX [O43186]	3	EBI-10256685,EBI-748171
GOLGA2 [Q08379]	3	EBI-10256685,EBI-618309
GOPC [Q9HD26]	3	EBI-10256685,EBI-349832
MDFI [Q99750]	3	EBI-10256685,EBI-724076
NME1 [P15531]	3	EBI-10256685,EBI-741141
NOTCH2NLA [Q7Z3S9]	3	EBI-10256685,EBI-945833
THAP1 [Q9NVV9]	3	EBI-10256685,EBI-741515

Isoform 3 [Q7Z2X4-3]

With	#Exp.	IntAct
CPSF7 - isoform 3 [Q8N684-3]	3	EBI-11953174,EBI-11523759
DNAAF6 [Q9NQM4]	3	EBI-11953174,EBI-10239299

Protein-protein interaction databases

BioGRIDⁱ	120352, 24 interactors
CORUMⁱ	Q7Z2X4
IntActⁱ	Q7Z2X4, 12 interactors
STRINGⁱ	9606.ENSP00000375907

Miscellaneous databases

RNActⁱ	Q7Z2X4, protein

RNActⁱ

Q7Z2X4, protein

Structureⁱ

3D structure databases

SMRⁱ	Q7Z2X4
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	93 – 250	PIDPROSITE-ProRule annotationAdd BLAST		158

Phylogenomic databases

eggNOGⁱ	KOG4448, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048154
HOGENOMⁱ	CLU_088811_0_0_1
InParanoidⁱ	Q7Z2X4
OMAⁱ	HAKSRTH
Database of Orthologous Groups More...OrthoDBⁱ	1145472at2759
PhylomeDBⁱ	Q7Z2X4

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13167, PTB_P-CLI1, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993, PH-like_dom_sf IPR039112, PID1 IPR039114, PID1_PTB IPR006020, PTB/PI_dom
PANTHERⁱ	PTHR16265, PTHR16265, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14719, PID_2, 1 hit
SMARTⁱ	View protein in SMART SM00462, PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179, PID, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q7Z2X4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSLPLSLPL CEDTAFLPSK CCSSHKTIKQ ARTLIMIFLA SGTHFQTMLK 
        60         70         80         90        100
SKLNVLTLKK EPLPAVIFHE PEAIELCTTT PLMKTRTHSG CKVTYLGKVS 
       110        120        130        140        150
TTGMQFLSGC TEKPVIELWK KHTLAREDVF PANALLEIRP FQVWLHHLDH 
       160        170        180        190        200
KGEATVHMDT FQVARIAYCT ADHNVSPNIF AWVYREINDD LSYQMDCHAV 
       210        220        230        240        250
ECESKLEAKK LAHAMMEAFR KTFHSMKSDG RIHSNSSSEE VSQELESDDG

Length:250

Mass (Da):28,272

Last modified:October 1, 2003 - v1

Checksum:ⁱ3C2F4AE5254D2885

GO

Isoform 2 (identifier: Q7Z2X4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-43: MFSLPLSLPL...LIMIFLASGT → MPRIAGNHLM...LHFGLPASEM

« Hide

        10         20         30         40         50
MPRIAGNHLM LEESRTCSSP ELLDGVWPCQ PLHFGLPASE MHFQTMLKSK 
        60         70         80         90        100
LNVLTLKKEP LPAVIFHEPE AIELCTTTPL MKTRTHSGCK VTYLGKVSTT 
       110        120        130        140        150
GMQFLSGCTE KPVIELWKKH TLAREDVFPA NALLEIRPFQ VWLHHLDHKG 
       160        170        180        190        200
EATVHMDTFQ VARIAYCTAD HNVSPNIFAW VYREINDDLS YQMDCHAVEC 
       210        220        230        240 
ESKLEAKKLA HAMMEAFRKT FHSMKSDGRI HSNSSSEEVS QELESDDG

Show »

Length:248

Mass (Da):28,121

Checksum:ⁱD4D89783A12B71D3

GO

Isoform 3 (identifier: Q7Z2X4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.
83-92: MKTRTHSGCK → MWQPATERLQ

« Hide

        10         20         30         40         50
MWQPATERLQ VTYLGKVSTT GMQFLSGCTE KPVIELWKKH TLAREDVFPA 
        60         70         80         90        100
NALLEIRPFQ VWLHHLDHKG EATVHMDTFQ VARIAYCTAD HNVSPNIFAW 
       110        120        130        140        150
VYREINDDLS YQMDCHAVEC ESKLEAKKLA HAMMEAFRKT FHSMKSDGRI 
       160 
HSNSSSEEVS QELESDDG

Show »

Length:168

Mass (Da):19,285

Checksum:ⁱ5A8DBD3D2B54E512

GO

Isoform 4 (identifier: Q7Z2X4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-43: MFSLPLSLPLCEDTAFLPSKCCSSHKTIKQARTLIMIFLASGT → MWQPATERLQ

« Hide

        10         20         30         40         50
MWQPATERLQ HFQTMLKSKL NVLTLKKEPL PAVIFHEPEA IELCTTTPLM 
        60         70         80         90        100
KTRTHSGCKV TYLGKVSTTG MQFLSGCTEK PVIELWKKHT LAREDVFPAN 
       110        120        130        140        150
ALLEIRPFQV WLHHLDHKGE ATVHMDTFQV ARIAYCTADH NVSPNIFAWV 
       160        170        180        190        200
YREINDDLSY QMDCHAVECE SKLEAKKLAH AMMEAFRKTF HSMKSDGRIH 
       210 
SNSSSEEVSQ ELESDDG

Show »

Length:217

Mass (Da):24,829

Checksum:ⁱ247256CD547081F5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5H314	F5H314_HUMAN		PTB-containing, cubilin and LRP1-in... PTB-containing, cubilin and LRP1-interacting protein	PID1	41	Annotation score:

Sequence cautionⁱ

The sequence BAD38656 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismⁱ

Some sequences seem to have a duplication of exon 2.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030361	43	T → THFQTMLKSKLNVLTLKKEP LPAVIFHEPEAIELCTTTPL MKTRTHSGCK in variant with duplicated exon 2.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_022909	1 – 82	Missing in isoform 3. 1 PublicationAdd BLAST	82
Alternative sequenceⁱVSP_022910	1 – 43	MFSLP…LASGT → MPRIAGNHLMLEESRTCSSP ELLDGVWPCQPLHFGLPASE M in isoform 2. 1 PublicationAdd BLAST	43
Alternative sequenceⁱVSP_022911	1 – 43	MFSLP…LASGT → MWQPATERLQ in isoform 4. 2 PublicationsAdd BLAST	43
Alternative sequenceⁱVSP_022912	83 – 92	MKTRTHSGCK → MWQPATERLQ in isoform 3. 1 Publication	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB075874 mRNA Translation: BAD38656.1 Different initiation. AY317148 mRNA Translation: AAP79437.1 AK000708 mRNA Translation: BAA91333.1 AK096636 mRNA Translation: BAG53344.1 AK125359 mRNA Translation: BAC86145.1 CH471063 Genomic DNA Translation: EAW70891.1 BC040164 mRNA Translation: AAH40164.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2471.1 [Q7Z2X4-2] CCDS42830.1 [Q7Z2X4-4] CCDS82577.1 [Q7Z2X4-1] CCDS82578.1 [Q7Z2X4-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001094288.1, NM_001100818.1 [Q7Z2X4-4] NP_001317085.1, NM_001330156.1 [Q7Z2X4-1] NP_001317086.1, NM_001330157.1 [Q7Z2X4-3] NP_060403.3, NM_017933.4 [Q7Z2X4-2]

Genome annotation databases

Ensemblⁱ	ENST00000354069; ENSP00000283937; ENSG00000153823 [Q7Z2X4-1] ENST00000392054; ENSP00000375907; ENSG00000153823 [Q7Z2X4-2] ENST00000392055; ENSP00000375908; ENSG00000153823 [Q7Z2X4-4] ENST00000409462; ENSP00000386826; ENSG00000153823 [Q7Z2X4-3]
GeneIDⁱ	55022
KEGGⁱ	hsa:55022
UCSC genome browser More...UCSCⁱ	uc002vpr.5, human [Q7Z2X4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z2X4-3	PID1 isoform 2		PONAB		168	UniRef100_A0A2J8SHR1
PID domain-containing protein		RHIRO		168
PID domain-containing protein		CEBCI		168
Phosphotyrosine interaction domain containing 1		PANTR		168
PID domain-containing protein		CERAT		168
+9
Q7Z2X4-4	Phosphotyrosine interaction domain containing 1		PANTR		217	UniRef100_K7DGI2
Uncharacterized protein FLJ20701 (Fragment)		HUMAN		158
PTB-containing, cubilin and LRP1-interacting protein isoform 2		MACMU		217
PID domain-containing protein		RHIRO		217
PID domain-containing protein		CEBCI		217
+19

Protein	Similar proteins		Species	Score	Length	Source
Q7Z2X4	PID1 isoform 6		PANTR		250	UniRef90_Q7Z2X4
PID1 isoform 6		PONAB		250
Phosphotyrosine interaction domain containing 1		GORGO		250
PID domain-containing protein		RHIRO		250
PID domain-containing protein		RHIBE		250
+32
Q7Z2X4-2	PID domain-containing protein		PROCO		248	UniRef90_Q7Z2X4-2
PID domain-containing protein		RHIRO		248
PID domain-containing protein		RHIBE		248
PID1 isoform 3		PONAB		248
PID domain-containing protein		CERAT		248
+15
Q7Z2X4-3	PID domain-containing protein		MACFA		174	UniRef90_A0A2K5VXY2
PID domain-containing protein		CEBCI		205
Phosphotyrosine interaction domain containing 1		PANTR		181
PID domain-containing protein		PANPA		181
PID domain-containing protein		AOTNA		168
+16
Q7Z2X4-4	Phosphotyrosine interaction domain containing 1		PANTR		217	UniRef90_K7DGI2
Uncharacterized protein FLJ20701 (Fragment)		HUMAN		158
PTB-containing, cubilin and LRP1-interacting protein isoform 2		MACMU		217
PID domain-containing protein		RHIRO		217
PID domain-containing protein		CEBCI		217
+19

Protein	Similar proteins		Species	Score	Length	Source
Q7Z2X4	PID domain-containing protein		CEBCI		250	UniRef50_Q7Z2X4
PID domain-containing protein		AOTNA		250
PID1 isoform 6		PONAB		250
PID domain-containing protein		RHIRO		250
PID domain-containing protein		RHIBE		250
+44
Q7Z2X4-2	PID domain-containing protein		PROCO		248	UniRef50_Q7Z2X4-2
PID domain-containing protein		RHIRO		248
PID domain-containing protein		RHIBE		248
PID domain-containing protein		PAPAN		248
PID1 isoform 3		PONAB		248
+72
Q7Z2X4-3	Ab1-119		RAT		245	UniRef50_Q7TPA0
PTB-containing, cubilin and LRP1-interacting protein-like		SCLFO		208
PID domain-containing protein		Paramormyrops kingsleyae		168
PID domain-containing protein		CEBCI		205
Phosphotyrosine interaction domain containing 1		PANTR		181
+154

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB075874 mRNA Translation: BAD38656.1 Different initiation. AY317148 mRNA Translation: AAP79437.1 AK000708 mRNA Translation: BAA91333.1 AK096636 mRNA Translation: BAG53344.1 AK125359 mRNA Translation: BAC86145.1 CH471063 Genomic DNA Translation: EAW70891.1 BC040164 mRNA Translation: AAH40164.1
CCDSⁱ	CCDS2471.1 [Q7Z2X4-2] CCDS42830.1 [Q7Z2X4-4] CCDS82577.1 [Q7Z2X4-1] CCDS82578.1 [Q7Z2X4-3]
RefSeqⁱ	NP_001094288.1, NM_001100818.1 [Q7Z2X4-4] NP_001317085.1, NM_001330156.1 [Q7Z2X4-1] NP_001317086.1, NM_001330157.1 [Q7Z2X4-3] NP_060403.3, NM_017933.4 [Q7Z2X4-2]

3D structure databases

SMRⁱ	Q7Z2X4
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	120352, 24 interactors
CORUMⁱ	Q7Z2X4
IntActⁱ	Q7Z2X4, 12 interactors
STRINGⁱ	9606.ENSP00000375907

PTM databases

iPTMnetⁱ	Q7Z2X4
PhosphoSitePlusⁱ	Q7Z2X4

Genetic variation databases

BioMutaⁱ	PID1
DMDMⁱ	74713284

Proteomic databases

EPDⁱ	Q7Z2X4
jPOSTⁱ	Q7Z2X4
MassIVEⁱ	Q7Z2X4
PaxDbⁱ	Q7Z2X4
PeptideAtlasⁱ	Q7Z2X4
PRIDEⁱ	Q7Z2X4
ProteomicsDBⁱ	68980 [Q7Z2X4-1] 68981 [Q7Z2X4-2] 68982 [Q7Z2X4-3] 68983 [Q7Z2X4-4]

Protocols and materials databases

Antibodypediaⁱ	34394, 113 antibodies

Antibodypediaⁱ

34394, 113 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000354069; ENSP00000283937; ENSG00000153823 [Q7Z2X4-1] ENST00000392054; ENSP00000375907; ENSG00000153823 [Q7Z2X4-2] ENST00000392055; ENSP00000375908; ENSG00000153823 [Q7Z2X4-4] ENST00000409462; ENSP00000386826; ENSG00000153823 [Q7Z2X4-3]
GeneIDⁱ	55022
KEGGⁱ	hsa:55022
UCSCⁱ	uc002vpr.5, human [Q7Z2X4-1]

Organism-specific databases

CTDⁱ	55022
DisGeNETⁱ	55022
GeneCardsⁱ	PID1
HGNCⁱ	HGNC:26084, PID1
HPAⁱ	ENSG00000153823, Low tissue specificity
MIMⁱ	612930, gene
neXtProtⁱ	NX_Q7Z2X4
OpenTargetsⁱ	ENSG00000153823
PharmGKBⁱ	PA162399462
VEuPathDBⁱ	HostDB:ENSG00000153823.18
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4448, Eukaryota
GeneTreeⁱ	ENSGT00510000048154
HOGENOMⁱ	CLU_088811_0_0_1
InParanoidⁱ	Q7Z2X4
OMAⁱ	HAKSRTH
OrthoDBⁱ	1145472at2759
PhylomeDBⁱ	Q7Z2X4

Enzyme and pathway databases

PathwayCommonsⁱ	Q7Z2X4

PathwayCommonsⁱ

Q7Z2X4

Miscellaneous databases

BioGRID-ORCSⁱ	55022, 2 hits in 879 CRISPR screens
ChiTaRSⁱ	PID1, human
GenomeRNAiⁱ	55022
Pharosⁱ	Q7Z2X4, Tbio
Protein Ontology More...PROⁱ	PR:Q7Z2X4
RNActⁱ	Q7Z2X4, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153823, Expressed in forebrain and 230 other tissues
ExpressionAtlasⁱ	Q7Z2X4, baseline and differential
Genevisibleⁱ	Q7Z2X4, HS

Family and domain databases

CDDⁱ	cd13167, PTB_P-CLI1, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993, PH-like_dom_sf IPR039112, PID1 IPR039114, PID1_PTB IPR006020, PTB/PI_dom
PANTHERⁱ	PTHR16265, PTHR16265, 1 hit
Pfamⁱ	View protein in Pfam PF14719, PID_2, 1 hit
SMARTⁱ	View protein in SMART SM00462, PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179, PID, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCLI1_HUMAN
Accessionⁱ	Q7Z2X4Primary (citable) accession number: Q7Z2X4 Secondary accession number(s): B3KU82 , Q68CJ2, Q6ZUS3, Q8IXL0, Q9NWP6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	October 1, 2003
	Last modified:	February 10, 2021
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants

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UniProtKB - Q7Z2X4 (PCLI1_HUMAN)

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PTB-containing, cubilin and LRP1-interacting protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Other locations

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Organism-specific databases

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Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q7Z2X4

Isoform 3 [Q7Z2X4-3]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Protocols and materials databases

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Enzyme and pathway databases

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<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ