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Protein

39S ribosomal protein L21, mitochondrial

Gene

MRPL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L21, mitochondrial
Short name:
L21mt
Short name:
MRP-L21
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL21m1 Publication
Gene namesi
Name:MRPL21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197345.12
HGNCiHGNC:14479 MRPL21
MIMi611834 gene
neXtProtiNX_Q7Z2W9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197345
PharmGKBiPA30951

Polymorphism and mutation databases

BioMutaiMRPL21
DMDMi229462820

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000025244240 – 20539S ribosomal protein L21, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ7Z2W9
MaxQBiQ7Z2W9
PaxDbiQ7Z2W9
PeptideAtlasiQ7Z2W9
PRIDEiQ7Z2W9
ProteomicsDBi68979

PTM databases

iPTMnetiQ7Z2W9
PhosphoSitePlusiQ7Z2W9

Expressioni

Gene expression databases

BgeeiENSG00000197345 Expressed in 195 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL21
ExpressionAtlasiQ7Z2W9 baseline and differential
GenevisibleiQ7Z2W9 HS

Organism-specific databases

HPAiHPA051657

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi128594, 54 interactors
CORUMiQ7Z2W9
IntActiQ7Z2W9, 17 interactors
MINTiQ7Z2W9
STRINGi9606.ENSP00000354580

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7Z2W9
SMRiQ7Z2W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1686 Eukaryota
ENOG4111TX4 LUCA
GeneTreeiENSGT00390000005535
HOGENOMiHOG000022586
HOVERGENiHBG083573
InParanoidiQ7Z2W9
KOiK02888
OMAiWPPNIGD
OrthoDBiEOG091G0VBY
PhylomeDBiQ7Z2W9
TreeFamiTF324867

Family and domain databases

InterProiView protein in InterPro
IPR036164 L21-like_sf
IPR028909 L21p-like
IPR001787 Ribosomal_L21
PANTHERiPTHR21349 PTHR21349, 1 hit
PfamiView protein in Pfam
PF00829 Ribosomal_L21p, 1 hit
SUPFAMiSSF141091 SSF141091, 1 hit
TIGRFAMsiTIGR00061 L21, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY
60 70 80 90 100
VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH
110 120 130 140 150
FASRQWKVTS EDLILIGNEL DLACGERIRL EKVLLVGADN FTLLGKPLLG
160 170 180 190 200
KDLVRVEATV IEKTESWPRI IMRFRKRKNF KKKRIVTTPQ TVLRINSIEI

APCLL
Length:205
Mass (Da):22,815
Last modified:May 5, 2009 - v2
Checksum:iB4AF172AB0C1E5FB
GO
Isoform 2 (identifier: Q7Z2W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,746
Checksum:iF25AEBA02DCFD41C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUY0H3BUY0_HUMAN
39S ribosomal protein L21, mitochon...
MRPL21
195Annotation score:
F5H7V8F5H7V8_HUMAN
39S ribosomal protein L21, mitochon...
MRPL21
150Annotation score:
F5H3L0F5H3L0_HUMAN
39S ribosomal protein L21, mitochon...
MRPL21
36Annotation score:
F5H4R5F5H4R5_HUMAN
39S ribosomal protein L21, mitochon...
MRPL21
49Annotation score:

Sequence cautioni

The sequence AAH55088 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0456331 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000808 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74724.1
BC055088 mRNA Translation: AAH55088.1 Different initiation.
BM915440 mRNA No translation available.
CCDSiCCDS44662.1 [Q7Z2W9-2]
CCDS8186.1 [Q7Z2W9-1]
RefSeqiNP_852615.1, NM_181514.1 [Q7Z2W9-1]
NP_852616.1, NM_181515.1 [Q7Z2W9-2]
UniGeneiHs.503047

Genome annotation databases

EnsembliENST00000362034; ENSP00000354580; ENSG00000197345 [Q7Z2W9-1]
ENST00000450904; ENSP00000389400; ENSG00000197345 [Q7Z2W9-2]
GeneIDi219927
KEGGihsa:219927
UCSCiuc001ooh.4 human [Q7Z2W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000808 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74724.1
BC055088 mRNA Translation: AAH55088.1 Different initiation.
BM915440 mRNA No translation available.
CCDSiCCDS44662.1 [Q7Z2W9-2]
CCDS8186.1 [Q7Z2W9-1]
RefSeqiNP_852615.1, NM_181514.1 [Q7Z2W9-1]
NP_852616.1, NM_181515.1 [Q7Z2W9-2]
UniGeneiHs.503047

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40S1-205[»]
3J9Melectron microscopy3.50S1-205[»]
5OOLelectron microscopy3.06S1-205[»]
5OOMelectron microscopy3.03S1-205[»]
ProteinModelPortaliQ7Z2W9
SMRiQ7Z2W9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128594, 54 interactors
CORUMiQ7Z2W9
IntActiQ7Z2W9, 17 interactors
MINTiQ7Z2W9
STRINGi9606.ENSP00000354580

PTM databases

iPTMnetiQ7Z2W9
PhosphoSitePlusiQ7Z2W9

Polymorphism and mutation databases

BioMutaiMRPL21
DMDMi229462820

Proteomic databases

EPDiQ7Z2W9
MaxQBiQ7Z2W9
PaxDbiQ7Z2W9
PeptideAtlasiQ7Z2W9
PRIDEiQ7Z2W9
ProteomicsDBi68979

Protocols and materials databases

DNASUi219927
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362034; ENSP00000354580; ENSG00000197345 [Q7Z2W9-1]
ENST00000450904; ENSP00000389400; ENSG00000197345 [Q7Z2W9-2]
GeneIDi219927
KEGGihsa:219927
UCSCiuc001ooh.4 human [Q7Z2W9-1]

Organism-specific databases

CTDi219927
EuPathDBiHostDB:ENSG00000197345.12
GeneCardsiMRPL21
HGNCiHGNC:14479 MRPL21
HPAiHPA051657
MIMi611834 gene
neXtProtiNX_Q7Z2W9
OpenTargetsiENSG00000197345
PharmGKBiPA30951
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1686 Eukaryota
ENOG4111TX4 LUCA
GeneTreeiENSGT00390000005535
HOGENOMiHOG000022586
HOVERGENiHBG083573
InParanoidiQ7Z2W9
KOiK02888
OMAiWPPNIGD
OrthoDBiEOG091G0VBY
PhylomeDBiQ7Z2W9
TreeFamiTF324867

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL21 human
GenomeRNAii219927
PROiPR:Q7Z2W9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197345 Expressed in 195 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL21
ExpressionAtlasiQ7Z2W9 baseline and differential
GenevisibleiQ7Z2W9 HS

Family and domain databases

InterProiView protein in InterPro
IPR036164 L21-like_sf
IPR028909 L21p-like
IPR001787 Ribosomal_L21
PANTHERiPTHR21349 PTHR21349, 1 hit
PfamiView protein in Pfam
PF00829 Ribosomal_L21p, 1 hit
SUPFAMiSSF141091 SSF141091, 1 hit
TIGRFAMsiTIGR00061 L21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM21_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2W9
Secondary accession number(s): A6NKU0, C9JPR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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