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Entry version 137 (13 Feb 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Transient receptor potential cation channel subfamily M member 8

Gene

TRPM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.4 Publications

Miscellaneous

The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.
Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.

Caution

The 192-residue sequence submitted as AAS45276 has been confirmed by the authors of PubMed:22128173 to be incorrect as translation starts from a downstream methionine.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Sensory transduction, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3295583 TRP channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.5.7 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 8
Alternative name(s):
Long transient receptor potential channel 6
Short name:
LTrpC-6
Short name:
LTrpC6
Transient receptor potential p8
Short name:
Trp-p8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPM8
Synonyms:LTRPC6, TRPP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144481.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17961 TRPM8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606678 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z2W7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 691CytoplasmicSequence analysisAdd BLAST691
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei692 – 712Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini713 – 734ExtracellularSequence analysisAdd BLAST22
Transmembranei735 – 755Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini756 – 759CytoplasmicSequence analysis4
Transmembranei760 – 780Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini781 – 794ExtracellularSequence analysisAdd BLAST14
Transmembranei795 – 815Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini816 – 829CytoplasmicSequence analysisAdd BLAST14
Transmembranei830 – 850Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini851 – 958ExtracellularSequence analysisAdd BLAST108
Transmembranei959 – 979Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini980 – 1104CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi821N → Q: No effect on glycosylation or ability to form functional channels. 1 Publication1
Mutagenesisi934N → Q: Abolishes glycosylation. 1 Publication1
Mutagenesisi946H → N: No effect on glycosylation or channel activity. 1 Publication1
Mutagenesisi1089L → P: Abolishes multimerization and channel activity. Reduces cell surface expression. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79054

Open Targets

More...
OpenTargetsi
ENSG00000144481

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38270

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075319

Drug and drug target database

More...
DrugBanki
DB00825 Menthol

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
500

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPM8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811469

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153331 – 1104Transient receptor potential cation channel subfamily M member 8Add BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi934N-linked (GlcNAc...) (complex) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z2W7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z2W7

PeptideAtlas

More...
PeptideAtlasi
Q7Z2W7

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z2W7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68976
68977 [Q7Z2W7-2]
68978 [Q7Z2W7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z2W7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z2W7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144481 Expressed in 67 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z2W7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z2W7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (By similarity). Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius. Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity (PubMed:25559186). Interacts (via N-terminus and C-terminus domains) with TCAF2 isoform 2; the interaction inhibits TRPM8 channel activity (PubMed:25559186).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122512, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z2W7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323926

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q7Z2W7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7Z2W7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni187 – 195Epitope; activates specific cytotoxic T lymphocytes9

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1071 – 1104Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil region is required for multimerization.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INBX Eukaryota
ENOG4110YBY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160270

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213866

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100888

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z2W7

KEGG Orthology (KO)

More...
KOi
K04983

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIMDDFT

Database of Orthologous Groups

More...
OrthoDBi
738147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z2W7

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR029603 TRPM8

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF9 PTHR13800:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2W7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFRAARLSM RNRRNDTLDS TRTLYSSASR STDLSYSESD LVNFIQANFK
60 70 80 90 100
KRECVFFTKD SKATENVCKC GYAQSQHMEG TQINQSEKWN YKKHTKEFPT
110 120 130 140 150
DAFGDIQFET LGKKGKYIRL SCDTDAEILY ELLTQHWHLK TPNLVISVTG
160 170 180 190 200
GAKNFALKPR MRKIFSRLIY IAQSKGAWIL TGGTHYGLMK YIGEVVRDNT
210 220 230 240 250
ISRSSEENIV AIGIAAWGMV SNRDTLIRNC DAEGYFLAQY LMDDFTRDPL
260 270 280 290 300
YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTI QDSNYGGKIP
310 320 330 340 350
IVCFAQGGGK ETLKAINTSI KNKIPCVVVE GSGQIADVIA SLVEVEDALT
360 370 380 390 400
SSAVKEKLVR FLPRTVSRLP EEETESWIKW LKEILECSHL LTVIKMEEAG
410 420 430 440 450
DEIVSNAISY ALYKAFSTSE QDKDNWNGQL KLLLEWNQLD LANDEIFTND
460 470 480 490 500
RRWESADLQE VMFTALIKDR PKFVRLFLEN GLNLRKFLTH DVLTELFSNH
510 520 530 540 550
FSTLVYRNLQ IAKNSYNDAL LTFVWKLVAN FRRGFRKEDR NGRDEMDIEL
560 570 580 590 600
HDVSPITRHP LQALFIWAIL QNKKELSKVI WEQTRGCTLA ALGASKLLKT
610 620 630 640 650
LAKVKNDINA AGESEELANE YETRAVELFT ECYSSDEDLA EQLLVYSCEA
660 670 680 690 700
WGGSNCLELA VEATDQHFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF
710 720 730 740 750
IIPLVGCGFV SFRKKPVDKH KKLLWYYVAF FTSPFVVFSW NVVFYIAFLL
760 770 780 790 800
LFAYVLLMDF HSVPHPPELV LYSLVFVLFC DEVRQWYVNG VNYFTDLWNV
810 820 830 840 850
MDTLGLFYFI AGIVFRLHSS NKSSLYSGRV IFCLDYIIFT LRLIHIFTVS
860 870 880 890 900
RNLGPKIIML QRMLIDVFFF LFLFAVWMVA FGVARQGILR QNEQRWRWIF
910 920 930 940 950
RSVIYEPYLA MFGQVPSDVD GTTYDFAHCT FTGNESKPLC VELDEHNLPR
960 970 980 990 1000
FPEWITIPLV CIYMLSTNIL LVNLLVAMFG YTVGTVQENN DQVWKFQRYF
1010 1020 1030 1040 1050
LVQEYCSRLN IPFPFIVFAY FYMVVKKCFK CCCKEKNMES SVCCFKNEDN
1060 1070 1080 1090 1100
ETLAWEGVMK ENYLVKINTK ANDTSEEMRH RFRQLDTKLN DLKGLLKEIA

NKIK
Length:1,104
Mass (Da):127,685
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D88F5081EDFA632
GO
Isoform 2 (identifier: Q7Z2W7-2) [UniParc]FASTAAdd to basket
Also known as: sTRPM8-18, sM8-18

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     234-242: GYFLAQYLM → VPVGQEEVC
     243-1104: Missing.

Show »
Length:54
Mass (Da):5,940
Checksum:i5DB74DAF67EBDCED
GO
Isoform 3 (identifier: Q7Z2W7-3) [UniParc]FASTAAdd to basket
Also known as: sTRPM8-6, sM8-6

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     234-242: GYFLAQYLM → VPVGQEEVC
     243-1104: Missing.

Show »
Length:165
Mass (Da):18,655
Checksum:i1EC4CEA05A33B6B6
GO
Isoform 4 (identifier: Q7Z2W7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MS → MQ
     3-314: Missing.
     675-784: Missing.

Note: No experimental confirmation available.
Show »
Length:682
Mass (Da):79,096
Checksum:iADF16E630E91F0EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSV2A0A0A0MSV2_HUMAN
Transient receptor potential cation...
TRPM8
753Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7P0H0Y7P0_HUMAN
Transient receptor potential cation...
TRPM8
376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZP4H7BZP4_HUMAN
Transient receptor potential cation...
TRPM8
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD55F8WD55_HUMAN
Transient receptor potential cation...
TRPM8
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFT0A0A0C4DFT0_HUMAN
Transient receptor potential cation...
TRPM8 hCG_2012695
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01135 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAS45276 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58T → I in AAM10446 (PubMed:11325849).Curated1
Sequence conflicti693W → R in BAB86335 (Ref. 7) Curated1
Sequence conflicti795T → A in AAP92167 (PubMed:16174775).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052383247R → T. Corresponds to variant dbSNP:rs13004520Ensembl.1
Natural variantiVAR_052384251Y → C. Corresponds to variant dbSNP:rs17868387Ensembl.1
Natural variantiVAR_059837419S → N. Corresponds to variant dbSNP:rs7593557Ensembl.1
Natural variantiVAR_052385462M → T. Corresponds to variant dbSNP:rs28902173Ensembl.1
Natural variantiVAR_052386732T → I. Corresponds to variant dbSNP:rs17862932Ensembl.1
Natural variantiVAR_052387821N → S. Corresponds to variant dbSNP:rs28902201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0532681 – 188Missing in isoform 2. 2 PublicationsAdd BLAST188
Alternative sequenceiVSP_0123301 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_0545051 – 2MS → MQ in isoform 4. 1 Publication2
Alternative sequenceiVSP_0545063 – 314Missing in isoform 4. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_012332234 – 242GYFLAQYLM → VPVGQEEVC in isoform 2 and isoform 3. 2 Publications9
Alternative sequenceiVSP_012333243 – 1104Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST862
Alternative sequenceiVSP_054507675 – 784Missing in isoform 4. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY090109 mRNA Translation: AAM10446.1
AY328400 mRNA Translation: AAP92167.1
DQ139309 mRNA Translation: AAZ73614.1
AY532375 mRNA Translation: AAS45275.1
AY532376 mRNA Translation: AAS45276.1 Different initiation.
AC005538 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71068.1
BC001135 mRNA Translation: AAH01135.1 Different initiation.
BC126342 mRNA Translation: AAI26343.1
AB061779 mRNA Translation: BAB86335.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33407.1 [Q7Z2W7-1]

NCBI Reference Sequences

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RefSeqi
NP_076985.4, NM_024080.4 [Q7Z2W7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.366053

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324695; ENSP00000323926; ENSG00000144481 [Q7Z2W7-1]
ENST00000409625; ENSP00000386771; ENSG00000144481 [Q7Z2W7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79054

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79054

UCSC genome browser

More...
UCSCi
uc002vvi.4 human [Q7Z2W7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY090109 mRNA Translation: AAM10446.1
AY328400 mRNA Translation: AAP92167.1
DQ139309 mRNA Translation: AAZ73614.1
AY532375 mRNA Translation: AAS45275.1
AY532376 mRNA Translation: AAS45276.1 Different initiation.
AC005538 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71068.1
BC001135 mRNA Translation: AAH01135.1 Different initiation.
BC126342 mRNA Translation: AAI26343.1
AB061779 mRNA Translation: BAB86335.1
CCDSiCCDS33407.1 [Q7Z2W7-1]
RefSeqiNP_076985.4, NM_024080.4 [Q7Z2W7-1]
UniGeneiHs.366053

3D structure databases

ProteinModelPortaliQ7Z2W7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122512, 13 interactors
IntActiQ7Z2W7, 1 interactor
STRINGi9606.ENSP00000323926

Chemistry databases

BindingDBiQ7Z2W7
ChEMBLiCHEMBL1075319
DrugBankiDB00825 Menthol
GuidetoPHARMACOLOGYi500

Protein family/group databases

TCDBi1.A.4.5.7 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ7Z2W7
PhosphoSitePlusiQ7Z2W7

Polymorphism and mutation databases

BioMutaiTRPM8
DMDMi143811469

Proteomic databases

EPDiQ7Z2W7
PaxDbiQ7Z2W7
PeptideAtlasiQ7Z2W7
PRIDEiQ7Z2W7
ProteomicsDBi68976
68977 [Q7Z2W7-2]
68978 [Q7Z2W7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79054
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324695; ENSP00000323926; ENSG00000144481 [Q7Z2W7-1]
ENST00000409625; ENSP00000386771; ENSG00000144481 [Q7Z2W7-3]
GeneIDi79054
KEGGihsa:79054
UCSCiuc002vvi.4 human [Q7Z2W7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79054
DisGeNETi79054
EuPathDBiHostDB:ENSG00000144481.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRPM8
HGNCiHGNC:17961 TRPM8
MIMi606678 gene
neXtProtiNX_Q7Z2W7
OpenTargetsiENSG00000144481
PharmGKBiPA38270

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INBX Eukaryota
ENOG4110YBY LUCA
GeneTreeiENSGT00940000160270
HOGENOMiHOG000213866
HOVERGENiHBG100888
InParanoidiQ7Z2W7
KOiK04983
OMAiYIMDDFT
OrthoDBi738147at2759
PhylomeDBiQ7Z2W7
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRPM8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79054

Protein Ontology

More...
PROi
PR:Q7Z2W7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144481 Expressed in 67 organ(s), highest expression level in liver
ExpressionAtlasiQ7Z2W7 baseline and differential
GenevisibleiQ7Z2W7 HS

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029603 TRPM8
PANTHERiPTHR13800:SF9 PTHR13800:SF9, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2W7
Secondary accession number(s): A0AVG2
, Q3YFM7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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