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Entry version 163 (16 Oct 2019)
Sequence version 3 (10 Feb 2009)
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Protein

Zinc finger CCCH-type antiviral protein 1

Gene

ZC3HAV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Temperature dependencei

Thermostable.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri73 – 86C3H1-type 1PROSITE-ProRule annotationAdd BLAST14
Zinc fingeri88 – 110C3H1-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 193C3H1-type 4PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processAntiviral defense, Immunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6802952 Signaling by BRAF and RAF fusions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH-type antiviral protein 1
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 131 Publication
Short name:
ARTD131 Publication
Inactive Poly [ADP-ribose] polymerase 13Curated
Short name:
PARP131 Publication
Zinc finger CCCH domain-containing protein 2
Zinc finger antiviral protein
Short name:
ZAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3HAV1Imported
Synonyms:ZC3HDC2
ORF Names:PRO1677
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23721 ZC3HAV1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607312 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z2W4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi810H → N: No effect on the structural inability to bind NAD(+); when associated with Y-830. 1 Publication1
Mutagenesisi830N → Y: No effect on the structural inability to bind NAD(+); when associated with N-810. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
56829

Open Targets

More...
OpenTargetsi
ENSG00000105939

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944289

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z2W4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3HAV1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
223634727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113432 – 902Zinc finger CCCH-type antiviral protein 1Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei257Phosphoserine; by GSK3-betaCombined sources1
Modified residuei263Phosphoserine; by GSK3-betaBy similarity1
Modified residuei267Phosphoserine; by GSK3-betaBy similarity1
Modified residuei271Phosphoserine; by GSK3-betaCombined sources1
Modified residuei273PhosphothreonineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei327PhosphoserineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei393PhosphothreonineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei554PhosphothreonineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Isoform 3 (identifier: Q7Z2W4-3)
Modified residuei572PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z2W4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z2W4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z2W4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z2W4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z2W4

PeptideAtlas

More...
PeptideAtlasi
Q7Z2W4

PRoteomics IDEntifications database

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PRIDEi
Q7Z2W4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
68971 [Q7Z2W4-1]
68972 [Q7Z2W4-2]
68973 [Q7Z2W4-3]
68974 [Q7Z2W4-4]
68975 [Q7Z2W4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z2W4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z2W4

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q7Z2W4

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q7Z2W4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By type I interferon (IFN) and viruses. Isoform 2 is up-regulated by 3'-PPP-RNA.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105939 Expressed in 216 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z2W4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z2W4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047818
HPA059096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity.

Interacts with EXOSC5 (By similarity).

Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By similarity).

Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A.

Interacts with PARN in an RNA-independent manner.

Interacts with XRN1 in an RNA-dependent manner. Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an RNA-dependent manner.

Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DDX58O957864EBI-922559,EBI-995350

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121203, 195 interactors

Database of interacting proteins

More...
DIPi
DIP-37896N

Protein interaction database and analysis system

More...
IntActi
Q7Z2W4, 132 interactors

Molecular INTeraction database

More...
MINTi
Q7Z2W4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000242351

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1902
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z2W4

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7Z2W4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini594 – 681WWEPROSITE-ProRule annotationAdd BLAST88
Domaini716 – 902PARP catalyticPROSITE-ProRule annotationAdd BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 254N-terminal domainAdd BLAST253
Regioni224 – 254Binding to EXOSC5By similarityAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi69 – 76Nuclear localization signalBy similarity8
Motifi285 – 292Nuclear export signalBy similarity8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs (PubMed:20451500). Contains a divergent PARP homology ADP-ribosyltransferase domain which lacks the structural requirements for NAD[+] binding (PubMed:25635049). It is therefore inactive (PubMed:25043379, PubMed:25635049).3 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 86C3H1-type 1PROSITE-ProRule annotationAdd BLAST14
Zinc fingeri88 – 110C3H1-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 193C3H1-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEI4 Eukaryota
ENOG410ZFB8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162001

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z2W4

KEGG Orthology (KO)

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KOi
K15259

Database of Orthologous Groups

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OrthoDBi
782733at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z2W4

TreeFam database of animal gene trees

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TreeFami
TF338389

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR036388 WH-like_DNA-bd_sf
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR041360 ZAP_HTH
IPR040954 Znf-CCCH_8
IPR000571 Znf_CCCH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18606 HTH_53, 1 hit
PF00644 PARP, 1 hit
PF02825 WWE, 1 hit
PF18633 zf-CCCH_8, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF117839 SSF117839, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit
PS50103 ZF_C3H1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2W4-1) [UniParc]FASTAAdd to basket
Also known as: ZAPL

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADPEVCCFI TKILCAHGGR MALDALLQEI ALSEPQLCEV LQVAGPDRFV
60 70 80 90 100
VLETGGEAGI TRSVVATTRA RVCRRKYCQR PCDNLHLCKL NLLGRCNYSQ
110 120 130 140 150
SERNLCKYSH EVLSEENFKV LKNHELSGLN KEELAVLLLQ SDPFFMPEIC
160 170 180 190 200
KSYKGEGRQQ ICNQQPPCSR LHICDHFTRG NCRFPNCLRS HNLMDRKVLA
210 220 230 240 250
IMREHGLNPD VVQNIQDICN SKHMQKNPPG PRAPSSHRRN MAYRARSKSR
260 270 280 290 300
DRFFQGSQEF LASASASAER SCTPSPDQIS HRASLEDAPV DDLTRKFTYL
310 320 330 340 350
GSQDRARPPS GSSKATDLGG TSQAGTSQRF LENGSQEDLL HGNPGSTYLA
360 370 380 390 400
SNSTSAPNWK SLTSWTNDQG ARRKTVFSPT LPAARSSLGS LQTPEAVTTR
410 420 430 440 450
KGTGLLSSDY RIINGKSGTQ DIQPGPLFNN NADGVATDIT STRSLNYKST
460 470 480 490 500
SSGHREISSP RIQDAGPASR DVQATGRIAD DADPRVALVN DSLSDVTSTT
510 520 530 540 550
SSRVDDHDSE EICLDHLCKG CPLNGSCSKV HFHLPYRWQM LIGKTWTDFE
560 570 580 590 600
HMETIEKGYC NPGIHLCSVG SYTINFRVMS CDSFPIRRLS TPSSVTKPAN
610 620 630 640 650
SVFTTKWIWY WKNESGTWIQ YGEEKDKRKN SNVDSSYLES LYQSCPRGVV
660 670 680 690 700
PFQAGSRNYE LSFQGMIQTN IASKTQKDVI RRPTFVPQWY VQQMKRGPDH
710 720 730 740 750
QPAKTSSVSL TATFRPQEDF CFLSSKKYKL SEIHHLHPEY VRVSEHFKAS
760 770 780 790 800
MKNFKIEKIK KIENSELLDK FTWKKSQMKE EGKLLFYATS RAYVESICSN
810 820 830 840 850
NFDSFLHETH ENKYGKGIYF AKDAIYSHKN CPYDAKNVVM FVAQVLVGKF
860 870 880 890 900
TEGNITYTSP PPQFDSCVDT RSNPSVFVIF QKDQVYPQYV IEYTEDKACV

IS
Length:902
Mass (Da):101,431
Last modified:February 10, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72AB311D23658E24
GO
Isoform 2 (identifier: Q7Z2W4-2) [UniParc]FASTAAdd to basket
Also known as: ZAPS1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     699-902: DHQPAKTSSV...YTEDKACVIS → E

Note: No experimental confirmation available.
Show »
Length:699
Mass (Da):77,903
Checksum:i372C52B7678BD888
GO
Isoform 3 (identifier: Q7Z2W4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-624: DSLSDVTSTT...SGTWIQYGEE → GKYKGKTLWA...SLKDKGASVS
     625-902: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:624
Mass (Da):67,590
Checksum:i1900A164D585DEFE
GO
Isoform 4 (identifier: Q7Z2W4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):42,115
Checksum:iF47044E719F91DFA
GO
Isoform 5 (identifier: Q7Z2W4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     699-902: DHQPAKTSSV...YTEDKACVIS → E

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,586
Checksum:iEC59CEFD5B5CB421
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6P4C9J6P4_HUMAN
Zinc finger CCCH-type antiviral pro...
ZC3HAV1
1,024Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5K1H7C5K1_HUMAN
Zinc finger CCCH-type antiviral pro...
ZC3HAV1
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245A → T in CAE11868 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018454485R → K1 PublicationCorresponds to variant dbSNP:rs2236426Ensembl.1
Natural variantiVAR_018455565H → Q2 PublicationsCorresponds to variant dbSNP:rs2297241Ensembl.1
Natural variantiVAR_054319701Q → E3 PublicationsCorresponds to variant dbSNP:rs2297236Ensembl.1
Natural variantiVAR_018456851T → I2 PublicationsCorresponds to variant dbSNP:rs3735007Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0102681 – 539Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST539
Alternative sequenceiVSP_010270491 – 624DSLSD…QYGEE → GKYKGKTLWASTFVHDIPNG SSQVVDKTTDVEKTGATGFG LTMAVKAEKDMLCTGSQSLR NLVPTTPGESTAPAQVSTLP QSPAALSSSNRAAVWGAQGQ NCTQVPVSSASELTRKTTGS AQCKSLKDKGASVS in isoform 3. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_010271625 – 902Missing in isoform 3. 1 PublicationAdd BLAST278
Alternative sequenceiVSP_010269699 – 902DHQPA…ACVIS → E in isoform 2 and isoform 5. 2 PublicationsAdd BLAST204

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF138863 mRNA Translation: AAF61195.1
AK055851 mRNA Translation: BAB71028.1
AK023350 mRNA Translation: BAB14537.1
BX571742 mRNA Translation: CAE11868.1
CH236950 Genomic DNA Translation: EAL24040.1
CH236950 Genomic DNA Translation: EAL24041.1
BC025308 mRNA Translation: AAH25308.1
BC027462 mRNA Translation: AAH27462.1
BC033105 mRNA Translation: AAH33105.1
BC040956 mRNA Translation: AAH40956.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55171.1 [Q7Z2W4-2]
CCDS5851.1 [Q7Z2W4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_064504.2, NM_020119.3 [Q7Z2W4-1]
NP_078901.3, NM_024625.3 [Q7Z2W4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242351; ENSP00000242351; ENSG00000105939 [Q7Z2W4-1]
ENST00000471652; ENSP00000419855; ENSG00000105939 [Q7Z2W4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56829

UCSC genome browser

More...
UCSCi
uc003vun.4 human [Q7Z2W4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF138863 mRNA Translation: AAF61195.1
AK055851 mRNA Translation: BAB71028.1
AK023350 mRNA Translation: BAB14537.1
BX571742 mRNA Translation: CAE11868.1
CH236950 Genomic DNA Translation: EAL24040.1
CH236950 Genomic DNA Translation: EAL24041.1
BC025308 mRNA Translation: AAH25308.1
BC027462 mRNA Translation: AAH27462.1
BC033105 mRNA Translation: AAH33105.1
BC040956 mRNA Translation: AAH40956.1
CCDSiCCDS55171.1 [Q7Z2W4-2]
CCDS5851.1 [Q7Z2W4-1]
RefSeqiNP_064504.2, NM_020119.3 [Q7Z2W4-1]
NP_078901.3, NM_024625.3 [Q7Z2W4-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X5YX-ray1.05A724-896[»]
4X52X-ray2.08A/B/C/D726-896[»]
SMRiQ7Z2W4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121203, 195 interactors
DIPiDIP-37896N
IntActiQ7Z2W4, 132 interactors
MINTiQ7Z2W4
STRINGi9606.ENSP00000242351

PTM databases

iPTMnetiQ7Z2W4
PhosphoSitePlusiQ7Z2W4
SwissPalmiQ7Z2W4

Polymorphism and mutation databases

BioMutaiZC3HAV1
DMDMi223634727

Proteomic databases

EPDiQ7Z2W4
jPOSTiQ7Z2W4
MassIVEiQ7Z2W4
MaxQBiQ7Z2W4
PaxDbiQ7Z2W4
PeptideAtlasiQ7Z2W4
PRIDEiQ7Z2W4
ProteomicsDBi68971 [Q7Z2W4-1]
68972 [Q7Z2W4-2]
68973 [Q7Z2W4-3]
68974 [Q7Z2W4-4]
68975 [Q7Z2W4-5]

Genome annotation databases

EnsembliENST00000242351; ENSP00000242351; ENSG00000105939 [Q7Z2W4-1]
ENST00000471652; ENSP00000419855; ENSG00000105939 [Q7Z2W4-2]
GeneIDi56829
KEGGihsa:56829
UCSCiuc003vun.4 human [Q7Z2W4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56829
DisGeNETi56829

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZC3HAV1
HGNCiHGNC:23721 ZC3HAV1
HPAiHPA047818
HPA059096
MIMi607312 gene
neXtProtiNX_Q7Z2W4
OpenTargetsiENSG00000105939
PharmGKBiPA134944289

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEI4 Eukaryota
ENOG410ZFB8 LUCA
GeneTreeiENSGT00940000162001
InParanoidiQ7Z2W4
KOiK15259
OrthoDBi782733at2759
PhylomeDBiQ7Z2W4
TreeFamiTF338389

Enzyme and pathway databases

ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZC3HAV1 human
EvolutionaryTraceiQ7Z2W4

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZC3HAV1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56829
PharosiQ7Z2W4
PMAP-CutDBiQ7Z2W4

Protein Ontology

More...
PROi
PR:Q7Z2W4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105939 Expressed in 216 organ(s), highest expression level in blood
ExpressionAtlasiQ7Z2W4 baseline and differential
GenevisibleiQ7Z2W4 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR036388 WH-like_DNA-bd_sf
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR041360 ZAP_HTH
IPR040954 Znf-CCCH_8
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF18606 HTH_53, 1 hit
PF00644 PARP, 1 hit
PF02825 WWE, 1 hit
PF18633 zf-CCCH_8, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit
PS50103 ZF_C3H1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCCHV_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2W4
Secondary accession number(s): A4D1R2
, A4D1S4, Q8IW57, Q8TAJ3, Q96N79, Q9H8R9, Q9P0Y7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 10, 2009
Last modified: October 16, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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