UniProtKB - Q7Z2T5 (TRM1L_HUMAN)
Protein
TRMT1-like protein
Gene
TRMT1L
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in motor coordination and exploratory behavior.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 184 – 206 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- tRNA (guanine-N2-)-methyltransferase activity Source: GO_Central
- tRNA binding Source: UniProtKB-KW
GO - Biological processi
- behavior Source: UniProtKB-KW
- tRNA N2-guanine methylation Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, RNA-binding, Transferase, tRNA-binding |
Biological process | Behavior, tRNA processing |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7Z2T5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TRMT1L Synonyms:C1orf25, TRM1L ORF Names:MSTP070 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16782, TRMT1L |
MIMi | 611673, gene |
neXtProti | NX_Q7Z2T5 |
VEuPathDBi | HostDB:ENSG00000121486.11 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000121486 |
PharmGKBi | PA25612 |
Miscellaneous databases
Pharosi | Q7Z2T5, Tdark |
Genetic variation databases
BioMutai | TRMT1L |
DMDMi | 166988174 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317568 | 1 – 733 | TRMT1-like proteinAdd BLAST | 733 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Cross-linki | 585 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 612 | PhosphoserineCombined sources | 1 | |
Modified residuei | 707 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q7Z2T5 |
jPOSTi | Q7Z2T5 |
MassIVEi | Q7Z2T5 |
MaxQBi | Q7Z2T5 |
PaxDbi | Q7Z2T5 |
PeptideAtlasi | Q7Z2T5 |
PRIDEi | Q7Z2T5 |
ProteomicsDBi | 68967 [Q7Z2T5-1] 68968 [Q7Z2T5-2] |
PTM databases
iPTMneti | Q7Z2T5 |
MetOSitei | Q7Z2T5 |
PhosphoSitePlusi | Q7Z2T5 |
SwissPalmi | Q7Z2T5 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000121486, Expressed in female gonad and 235 other tissues |
ExpressionAtlasi | Q7Z2T5, baseline and differential |
Genevisiblei | Q7Z2T5, HS |
Organism-specific databases
HPAi | ENSG00000121486, Low tissue specificity |
Interactioni
Binary interactionsi
Q7Z2T5
With | #Exp. | IntAct |
---|---|---|
GTF2B [Q00403] | 3 | EBI-1237316,EBI-389564 |
Protein-protein interaction databases
BioGRIDi | 123562, 83 interactors |
IntActi | Q7Z2T5, 36 interactors |
MINTi | Q7Z2T5 |
STRINGi | 9606.ENSP00000356476 |
Miscellaneous databases
RNActi | Q7Z2T5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 227 – 688 | Trm1 methyltransferasePROSITE-ProRule annotationAdd BLAST | 462 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.PROSITE-ProRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 184 – 206 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1253, Eukaryota |
GeneTreei | ENSGT00530000063646 |
HOGENOMi | CLU_010862_3_0_1 |
InParanoidi | Q7Z2T5 |
OMAi | HPAFYYS |
OrthoDBi | 1414511at2759 |
PhylomeDBi | Q7Z2T5 |
TreeFami | TF300851 |
Family and domain databases
Gene3Di | 3.30.56.70, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR002905, Trm1 IPR042296, tRNA_met_Trm1_C IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10631, PTHR10631, 1 hit |
Pfami | View protein in Pfam PF02005, TRM, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51626, SAM_MT_TRM1, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z2T5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA
60 70 80 90 100
SAPAPAPALA QAPALSPSLA SAPEEAKSKR HISIQRQLAD LENLAFVTDG
110 120 130 140 150
NFDSASSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV
160 170 180 190 200
EFEGYRMCIC HLPCRPVKPN IIGEQITSKM GAHYHCIICS ATITRRTDML
210 220 230 240 250
GHVRRHMNKG ETKSSYIAAS TAKPPKEILK EADTDVQVCP NYSIPQKTDS
260 270 280 290 300
YFNPKMKLNR QLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA
310 320 330 340 350
VKVTINDLNE NSVTLIQENC HLNKLKVVVD SKEKEKSDDI LEEGEKNLGN
360 370 380 390 400
IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST
410 420 430 440 450
DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI
460 470 480 490 500
EVLFAVALEH FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG
510 520 530 540 550
NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF LKRMLFESLH
560 570 580 590 600
HGLDDIQTLI KTLIFESECT PQSQFSIHAS SNVNKQEENG VFIKTTDDTT
610 620 630 640 650
TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK
660 670 680 690 700
LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ
710 720 730
SESHVQSASE DTVTERVEMS VNDKAEASGC RRW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RK96 | X6RK96_HUMAN | TRMT1-like protein | TRMT1L | 212 | Annotation score: |
Sequence cautioni
The sequence AAH39738 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ13590 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 156 | R → G in BAC11302 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 319 | N → S in BAD18605 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031042 | 1 – 156 | Missing in isoform 2. 1 PublicationAdd BLAST | 156 | |
Alternative sequenceiVSP_031043 | 505 – 733 | ENPYR…GCRRW → DYSANFVISYTGFPFVNRQD IRKTHIDSCLVTVMEACLER QQ in isoform 2. 1 PublicationAdd BLAST | 229 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF288399 mRNA Translation: AAG60618.1 AK074936 mRNA Translation: BAC11302.1 AK074993 mRNA Translation: BAC11341.1 AK131460 mRNA Translation: BAD18605.1 AL109865 Genomic DNA No translation available. AL136133 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91190.1 BC039738 mRNA Translation: AAH39738.1 Sequence problems. BC045535 mRNA Translation: AAH45535.1 AF163261 mRNA Translation: AAQ13590.1 Different initiation. |
CCDSi | CCDS1366.1 [Q7Z2T5-1] |
RefSeqi | NP_001189352.1, NM_001202423.1 NP_112196.3, NM_030934.4 [Q7Z2T5-1] |
Genome annotation databases
Ensembli | ENST00000367506; ENSP00000356476; ENSG00000121486 [Q7Z2T5-1] |
GeneIDi | 81627 |
KEGGi | hsa:81627 |
UCSCi | uc001grf.5, human [Q7Z2T5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF288399 mRNA Translation: AAG60618.1 AK074936 mRNA Translation: BAC11302.1 AK074993 mRNA Translation: BAC11341.1 AK131460 mRNA Translation: BAD18605.1 AL109865 Genomic DNA No translation available. AL136133 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91190.1 BC039738 mRNA Translation: AAH39738.1 Sequence problems. BC045535 mRNA Translation: AAH45535.1 AF163261 mRNA Translation: AAQ13590.1 Different initiation. |
CCDSi | CCDS1366.1 [Q7Z2T5-1] |
RefSeqi | NP_001189352.1, NM_001202423.1 NP_112196.3, NM_030934.4 [Q7Z2T5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123562, 83 interactors |
IntActi | Q7Z2T5, 36 interactors |
MINTi | Q7Z2T5 |
STRINGi | 9606.ENSP00000356476 |
PTM databases
iPTMneti | Q7Z2T5 |
MetOSitei | Q7Z2T5 |
PhosphoSitePlusi | Q7Z2T5 |
SwissPalmi | Q7Z2T5 |
Genetic variation databases
BioMutai | TRMT1L |
DMDMi | 166988174 |
Proteomic databases
EPDi | Q7Z2T5 |
jPOSTi | Q7Z2T5 |
MassIVEi | Q7Z2T5 |
MaxQBi | Q7Z2T5 |
PaxDbi | Q7Z2T5 |
PeptideAtlasi | Q7Z2T5 |
PRIDEi | Q7Z2T5 |
ProteomicsDBi | 68967 [Q7Z2T5-1] 68968 [Q7Z2T5-2] |
Protocols and materials databases
Antibodypediai | 20610, 86 antibodies |
Genome annotation databases
Ensembli | ENST00000367506; ENSP00000356476; ENSG00000121486 [Q7Z2T5-1] |
GeneIDi | 81627 |
KEGGi | hsa:81627 |
UCSCi | uc001grf.5, human [Q7Z2T5-1] |
Organism-specific databases
CTDi | 81627 |
GeneCardsi | TRMT1L |
HGNCi | HGNC:16782, TRMT1L |
HPAi | ENSG00000121486, Low tissue specificity |
MIMi | 611673, gene |
neXtProti | NX_Q7Z2T5 |
OpenTargetsi | ENSG00000121486 |
PharmGKBi | PA25612 |
VEuPathDBi | HostDB:ENSG00000121486.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1253, Eukaryota |
GeneTreei | ENSGT00530000063646 |
HOGENOMi | CLU_010862_3_0_1 |
InParanoidi | Q7Z2T5 |
OMAi | HPAFYYS |
OrthoDBi | 1414511at2759 |
PhylomeDBi | Q7Z2T5 |
TreeFami | TF300851 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z2T5 |
Miscellaneous databases
BioGRID-ORCSi | 81627, 4 hits in 994 CRISPR screens |
ChiTaRSi | TRMT1L, human |
GenomeRNAii | 81627 |
Pharosi | Q7Z2T5, Tdark |
PROi | PR:Q7Z2T5 |
RNActi | Q7Z2T5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121486, Expressed in female gonad and 235 other tissues |
ExpressionAtlasi | Q7Z2T5, baseline and differential |
Genevisiblei | Q7Z2T5, HS |
Family and domain databases
Gene3Di | 3.30.56.70, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR002905, Trm1 IPR042296, tRNA_met_Trm1_C IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10631, PTHR10631, 1 hit |
Pfami | View protein in Pfam PF02005, TRM, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51626, SAM_MT_TRM1, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRM1L_HUMAN | |
Accessioni | Q7Z2T5Primary (citable) accession number: Q7Z2T5 Secondary accession number(s): Q5TEN0 Q9BZQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families