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UniProtKB - Q7Z2T5 (TRM1L_HUMAN)

Protein

TRMT1-like protein

Gene

TRMT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in motor coordination and exploratory behavior.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • tRNA (guanine-N2-)-methyltransferase activity Source: GO_Central
  • tRNA binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processBehavior, tRNA processing
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
TRMT1-like protein (EC:2.1.1.-)
Gene namesi
Name:TRMT1L
Synonyms:C1orf25, TRM1L
ORF Names:MSTP070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121486.11
HGNCiHGNC:16782 TRMT1L
MIMi611673 gene
neXtProtiNX_Q7Z2T5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121486
PharmGKBiPA25612

Polymorphism and mutation databases

BioMutaiTRMT1L
DMDMi166988174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175681 – 733TRMT1-like proteinAdd BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphothreonineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Cross-linki585Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei612PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7Z2T5
MaxQBiQ7Z2T5
PaxDbiQ7Z2T5
PeptideAtlasiQ7Z2T5
PRIDEiQ7Z2T5
ProteomicsDBi68967
68968 [Q7Z2T5-2]

PTM databases

iPTMnetiQ7Z2T5
PhosphoSitePlusiQ7Z2T5

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000121486 Expressed in 222 organ(s), highest expression level in female gonad
CleanExiHS_C1orf25
ExpressionAtlasiQ7Z2T5 baseline and differential
GenevisibleiQ7Z2T5 HS

Organism-specific databases

HPAiHPA026728

Interactioni

Protein-protein interaction databases

BioGridi123562, 46 interactors
IntActiQ7Z2T5, 19 interactors
MINTiQ7Z2T5
STRINGi9606.ENSP00000356476

Structurei

3D structure databases

ProteinModelPortaliQ7Z2T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 688Trm1 methyltransferasePROSITE-ProRule annotationAdd BLAST462

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1253 Eukaryota
COG1867 LUCA
GeneTreeiENSGT00530000063646
HOGENOMiHOG000154681
HOVERGENiHBG057055
InParanoidiQ7Z2T5
OMAiQSEGHVQ
OrthoDBiEOG091G0QDC
PhylomeDBiQ7Z2T5
TreeFamiTF300851

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002905 Trm1
IPR013087 Znf_C2H2_type
PANTHERiPTHR10631 PTHR10631, 1 hit
PfamiView protein in Pfam
PF02005 TRM, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51626 SAM_MT_TRM1, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2T5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA 
        60         70         80         90        100
SAPAPAPALA QAPALSPSLA SAPEEAKSKR HISIQRQLAD LENLAFVTDG 
       110        120        130        140        150
NFDSASSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV 
       160        170        180        190        200
EFEGYRMCIC HLPCRPVKPN IIGEQITSKM GAHYHCIICS ATITRRTDML 
       210        220        230        240        250
GHVRRHMNKG ETKSSYIAAS TAKPPKEILK EADTDVQVCP NYSIPQKTDS 
       260        270        280        290        300
YFNPKMKLNR QLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA 
       310        320        330        340        350
VKVTINDLNE NSVTLIQENC HLNKLKVVVD SKEKEKSDDI LEEGEKNLGN 
       360        370        380        390        400
IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST 
       410        420        430        440        450
DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI 
       460        470        480        490        500
EVLFAVALEH FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG 
       510        520        530        540        550
NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF LKRMLFESLH 
       560        570        580        590        600
HGLDDIQTLI KTLIFESECT PQSQFSIHAS SNVNKQEENG VFIKTTDDTT 
       610        620        630        640        650
TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK 
       660        670        680        690        700
LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ 
       710        720        730 
SESHVQSASE DTVTERVEMS VNDKAEASGC RRW
Length:733
Mass (Da):81,747
Last modified:February 5, 2008 - v2
Checksum:i364B6BD4F22D1B08
GO
Isoform 2 (identifier: Q7Z2T5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     505-733: ENPYRQLPCN...KAEASGCRRW → DYSANFVISY...VMEACLERQQ

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):43,952
Checksum:i9FD3050EE2D66CB8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RK96X6RK96_HUMAN
TRMT1-like protein
TRMT1L
212Annotation score:

Sequence cautioni

The sequence AAH39738 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ13590 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156R → G in BAC11302 (PubMed:14702039).Curated1
Sequence conflicti319N → S in BAD18605 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310421 – 156Missing in isoform 2. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_031043505 – 733ENPYR…GCRRW → DYSANFVISYTGFPFVNRQD IRKTHIDSCLVTVMEACLER QQ in isoform 2. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288399 mRNA Translation: AAG60618.1
AK074936 mRNA Translation: BAC11302.1
AK074993 mRNA Translation: BAC11341.1
AK131460 mRNA Translation: BAD18605.1
AL109865 Genomic DNA No translation available.
AL136133 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91190.1
BC039738 mRNA Translation: AAH39738.1 Sequence problems.
BC045535 mRNA Translation: AAH45535.1
AF163261 mRNA Translation: AAQ13590.1 Different initiation.
CCDSiCCDS1366.1 [Q7Z2T5-1]
RefSeqiNP_001189352.1, NM_001202423.1
NP_112196.3, NM_030934.4 [Q7Z2T5-1]
UniGeneiHs.107149

Genome annotation databases

EnsembliENST00000367506; ENSP00000356476; ENSG00000121486 [Q7Z2T5-1]
GeneIDi81627
KEGGihsa:81627
UCSCiuc001grf.5 human [Q7Z2T5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288399 mRNA Translation: AAG60618.1
AK074936 mRNA Translation: BAC11302.1
AK074993 mRNA Translation: BAC11341.1
AK131460 mRNA Translation: BAD18605.1
AL109865 Genomic DNA No translation available.
AL136133 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91190.1
BC039738 mRNA Translation: AAH39738.1 Sequence problems.
BC045535 mRNA Translation: AAH45535.1
AF163261 mRNA Translation: AAQ13590.1 Different initiation.
CCDSiCCDS1366.1 [Q7Z2T5-1]
RefSeqiNP_001189352.1, NM_001202423.1
NP_112196.3, NM_030934.4 [Q7Z2T5-1]
UniGeneiHs.107149

3D structure databases

ProteinModelPortaliQ7Z2T5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123562, 46 interactors
IntActiQ7Z2T5, 19 interactors
MINTiQ7Z2T5
STRINGi9606.ENSP00000356476

PTM databases

iPTMnetiQ7Z2T5
PhosphoSitePlusiQ7Z2T5

Polymorphism and mutation databases

BioMutaiTRMT1L
DMDMi166988174

Proteomic databases

EPDiQ7Z2T5
MaxQBiQ7Z2T5
PaxDbiQ7Z2T5
PeptideAtlasiQ7Z2T5
PRIDEiQ7Z2T5
ProteomicsDBi68967
68968 [Q7Z2T5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367506; ENSP00000356476; ENSG00000121486 [Q7Z2T5-1]
GeneIDi81627
KEGGihsa:81627
UCSCiuc001grf.5 human [Q7Z2T5-1]

Organism-specific databases

CTDi81627
EuPathDBiHostDB:ENSG00000121486.11
GeneCardsiTRMT1L
H-InvDBiHIX0001421
HGNCiHGNC:16782 TRMT1L
HPAiHPA026728
MIMi611673 gene
neXtProtiNX_Q7Z2T5
OpenTargetsiENSG00000121486
PharmGKBiPA25612
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1253 Eukaryota
COG1867 LUCA
GeneTreeiENSGT00530000063646
HOGENOMiHOG000154681
HOVERGENiHBG057055
InParanoidiQ7Z2T5
OMAiQSEGHVQ
OrthoDBiEOG091G0QDC
PhylomeDBiQ7Z2T5
TreeFamiTF300851

Miscellaneous databases

ChiTaRSiTRMT1L human
GenomeRNAii81627
PROiPR:Q7Z2T5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121486 Expressed in 222 organ(s), highest expression level in female gonad
CleanExiHS_C1orf25
ExpressionAtlasiQ7Z2T5 baseline and differential
GenevisibleiQ7Z2T5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002905 Trm1
IPR013087 Znf_C2H2_type
PANTHERiPTHR10631 PTHR10631, 1 hit
PfamiView protein in Pfam
PF02005 TRM, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51626 SAM_MT_TRM1, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRM1L_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2T5
Secondary accession number(s): Q5TEN0
, Q6ZMX0, Q8IWH5, Q8NC68, Q9BZQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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