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Entry version 133 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

G protein-regulated inducer of neurite outgrowth 1

Gene

GPRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neurite outgrowth.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9022699 MECP2 regulates neuronal receptors and channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 1
Short name:
GRIN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPRIN1
Synonyms:KIAA1893
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24835 GPRIN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611239 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z2K8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000169258

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390183

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z2K8

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5266

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPRIN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434528

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002359771 – 1008G protein-regulated inducer of neurite outgrowth 1Add BLAST1008

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphothreonineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei237PhosphoserineBy similarity1
Modified residuei436PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei615PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei799PhosphoserineBy similarity1
Modified residuei877PhosphothreonineBy similarity1
Modified residuei895PhosphoserineBy similarity1
Modified residuei914PhosphoserineBy similarity1
Modified residuei993PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi999S-palmitoyl cysteineBy similarity1
Lipidationi1000S-palmitoyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z2K8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z2K8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z2K8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z2K8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z2K8

PeptideAtlas

More...
PeptideAtlasi
Q7Z2K8

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z2K8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68962 [Q7Z2K8-1]
68963 [Q7Z2K8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z2K8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z2K8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z2K8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in the central nervous system, with highest levels in spinal cord.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169258 Expressed in 93 organ(s), highest expression level in right frontal lobe

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z2K8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036478
HPA070892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with activated forms of GNAI1, GNAO1 and GNAZ.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125349, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z2K8, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305839

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z2K8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni899 – 1008Interaction with GNAO1By similarityAdd BLAST110

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJTD Eukaryota
ENOG410YQX7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162796

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112813

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z2K8

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTKAPSW

Database of Orthologous Groups

More...
OrthoDBi
612273at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z2K8

TreeFam database of animal gene trees

More...
TreeFami
TF337047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C

The PANTHER Classification System

More...
PANTHERi
PTHR15718 PTHR15718, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15235 GRIN_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z2K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTAEDPAWL QLLQKDSSPP GPRPTAFFCP QDGSLGAGSS AMRDYCPSQQ
60 70 80 90 100
KASPAPPRHT PDQSPGMESR HRSPSGAGEG ASCSDGPRGS LACPSPTCFS
110 120 130 140 150
PQESPSKETL EAHGASISGT PEATTSGKPE PVSSVKTEPK SSDDRNPMFL
160 170 180 190 200
EKMDFKSSKQ ADSTSIGKED PGSSRKADPM FTGKAEPEIL GKGDPVAPGR
210 220 230 240 250
MDPMTVRKED LGSLGKVDPL CSSKTYTVSP RKEDPGSLRK VDPVSSDKVD
260 270 280 290 300
PVFPRKEEPR YSGKEHPVSS EKVAPTSAEK VDLVLSGKRD PGPSGKADPM
310 320 330 340 350
PLESMDSAST GKTEPGLLGK LIPGSSGKNG PVSSGTGAPG SLGRLDPTCL
360 370 380 390 400
GMADPASVGN VETVPATKED SRFLGKMDPA SSGEGRPVSG HTDTTASAKT
410 420 430 440 450
DLTSLKNVDP MSSGKVDPVS LGKMDPMCSG KPELLSPGQA ERVSVGKAGT
460 470 480 490 500
VSPGKEDPVS SRREDPISAG SRKTSSEKVN PESSGKTNPV SSGPGDPRSL
510 520 530 540 550
GTAGPPSAVK AEPATGGKGD PLSSEKAGLV ASGKAAPTAS GKAEPLAVGK
560 570 580 590 600
EDPVSKGKAD AGPSGQGDSV SIGKVVSTPG KTVPVPSGKV DPVSLGKAEA
610 620 630 640 650
IPEGKVGSLP LEKGSPVTTT KADPRASGKA QPQSGGKAET KLPGQEGAAA
660 670 680 690 700
PGEAGAVCLK KETPQASEKV DPGSCRKAEP LASGKGEPVS LGKADSAPSR
710 720 730 740 750
KTESPSLGKV VPLSLEKTKP SSSSRQLDRK ALGSARSPEG ARGSEGRVEP
760 770 780 790 800
KAEPVSSTEA SSLGQKDLEA AGAERSPCPE AAAPPPGPRT RDNFTKAPSW
810 820 830 840 850
EASAPPPPRE DAGTQAGAQA CVSVAVSPMS PQDGAGGSAF SFQAAPRAPS
860 870 880 890 900
PPSRRDAGLQ VSLGAAETRS VATGPMTPQA AAPPAFPEVR VRPGSALAAA
910 920 930 940 950
VAPPEPAEPV RDVSWDEKGM TWEVYGAAME VEVLGMAIQK HLERQIEEHG
960 970 980 990 1000
RQGAPAPPPA ARAGPGRSGS VRTAPPDGAA KRPPGLFRAL LQSVRRPRCC

SRAGPTAE
Length:1,008
Mass (Da):102,399
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA4AAED9917E570E
GO
Isoform 2 (identifier: Q7Z2K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     748-798: VEPKAEPVSS...RTRDNFTKAP → QASARPVPRA...SQAPFLITGP
     799-1008: Missing.

Show »
Length:798
Mass (Da):80,948
Checksum:iB8E73BED0226E863
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67786 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231 – 238Missing in CAD38868 (PubMed:17974005).Curated8
Sequence conflicti680P → A in CAD38868 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063136121P → T1 PublicationCorresponds to variant dbSNP:rs17854765Ensembl.1
Natural variantiVAR_063137300M → V3 PublicationsCorresponds to variant dbSNP:rs6556276Ensembl.1
Natural variantiVAR_056902337G → A. Corresponds to variant dbSNP:rs10037225Ensembl.1
Natural variantiVAR_056903357S → P. Corresponds to variant dbSNP:rs34285890Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018546748 – 798VEPKA…FTKAP → QASARPVPRAAAECAPAAVL LAGGTHGRVICPHFVRPSFR PSQAPFLITGP in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_018547799 – 1008Missing in isoform 2. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB067480 mRNA Translation: BAB67786.1 Different initiation.
AC091934 Genomic DNA No translation available.
BC052950 mRNA Translation: AAH52950.1
AL834165 mRNA Translation: CAD38868.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4405.1 [Q7Z2K8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_443131.2, NM_052899.2 [Q7Z2K8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303991; ENSP00000305839; ENSG00000169258 [Q7Z2K8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114787

UCSC genome browser

More...
UCSCi
uc003meo.2 human [Q7Z2K8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067480 mRNA Translation: BAB67786.1 Different initiation.
AC091934 Genomic DNA No translation available.
BC052950 mRNA Translation: AAH52950.1
AL834165 mRNA Translation: CAD38868.1
CCDSiCCDS4405.1 [Q7Z2K8-1]
RefSeqiNP_443131.2, NM_052899.2 [Q7Z2K8-1]

3D structure databases

SMRiQ7Z2K8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125349, 23 interactors
IntActiQ7Z2K8, 13 interactors
STRINGi9606.ENSP00000305839

Chemistry databases

ChEMBLiCHEMBL5266

PTM databases

iPTMnetiQ7Z2K8
PhosphoSitePlusiQ7Z2K8
SwissPalmiQ7Z2K8

Polymorphism and mutation databases

BioMutaiGPRIN1
DMDMi296434528

Proteomic databases

EPDiQ7Z2K8
jPOSTiQ7Z2K8
MassIVEiQ7Z2K8
MaxQBiQ7Z2K8
PaxDbiQ7Z2K8
PeptideAtlasiQ7Z2K8
PRIDEiQ7Z2K8
ProteomicsDBi68962 [Q7Z2K8-1]
68963 [Q7Z2K8-2]

Genome annotation databases

EnsembliENST00000303991; ENSP00000305839; ENSG00000169258 [Q7Z2K8-1]
GeneIDi114787
KEGGihsa:114787
UCSCiuc003meo.2 human [Q7Z2K8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114787

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPRIN1
HGNCiHGNC:24835 GPRIN1
HPAiHPA036478
HPA070892
MIMi611239 gene
neXtProtiNX_Q7Z2K8
OpenTargetsiENSG00000169258
PharmGKBiPA162390183

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJTD Eukaryota
ENOG410YQX7 LUCA
GeneTreeiENSGT00940000162796
HOGENOMiHOG000112813
InParanoidiQ7Z2K8
OMAiFTKAPSW
OrthoDBi612273at2759
PhylomeDBiQ7Z2K8
TreeFamiTF337047

Enzyme and pathway databases

ReactomeiR-HSA-9022699 MECP2 regulates neuronal receptors and channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GPRIN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114787
PharosiQ7Z2K8

Protein Ontology

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PROi
PR:Q7Z2K8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169258 Expressed in 93 organ(s), highest expression level in right frontal lobe
GenevisibleiQ7Z2K8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C
PANTHERiPTHR15718 PTHR15718, 2 hits
PfamiView protein in Pfam
PF15235 GRIN_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRIN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2K8
Secondary accession number(s): C9JM70, Q8ND74, Q96PZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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