Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 121 (18 Sep 2019)
Sequence version 2 (31 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Endoplasmic reticulum metallopeptidase 1

Gene

ERMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi205Zinc 1; catalyticBy similarity1
Metal bindingi217Zinc 1; catalyticBy similarity1
Metal bindingi217Zinc 2; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei251Proton acceptorBy similarity1
Metal bindingi252Zinc 2; catalyticBy similarity1
Metal bindingi278Zinc 1; catalyticBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei353Transition state stabilizerBy similarity1
Metal bindingi354Zinc 2; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M28.018

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoplasmic reticulum metallopeptidase 1By similarityImported (EC:3.4.-.-Curated)
Alternative name(s):
Felix-inaBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERMP1Imported
Synonyms:FXNABy similarity, KIAA18151 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23703 ERMP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611156 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z2K6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 63CytoplasmicCuratedAdd BLAST63
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei64 – 84Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini85 – 399LumenalCuratedAdd BLAST315
Transmembranei400 – 420Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini421 – 457CytoplasmicCuratedAdd BLAST37
Transmembranei458 – 478Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini479 – 489LumenalCuratedAdd BLAST11
Transmembranei490 – 510Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini511 – 519CytoplasmicCurated9
Transmembranei520 – 540Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini541LumenalCurated1
Transmembranei542 – 562Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini563 – 579CytoplasmicCuratedAdd BLAST17
Transmembranei580 – 600Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini601 – 621LumenalCuratedAdd BLAST21
Transmembranei622 – 642Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini643 – 651CytoplasmicCurated9
Transmembranei652 – 672Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini673 – 904LumenalCuratedAdd BLAST232

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000099219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385366

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERMP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117949602

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002594921 – 904Endoplasmic reticulum metallopeptidase 1Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi182N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi204 ↔ 222By similarity
Glycosylationi730N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z2K6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z2K6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z2K6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z2K6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z2K6

PeptideAtlas

More...
PeptideAtlasi
Q7Z2K6

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z2K6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
3630
68961 [Q7Z2K6-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1205

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z2K6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z2K6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z2K6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099219 Expressed in 226 organ(s), highest expression level in palpebral conjunctiva

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z2K6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z2K6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020584

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123025, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z2K6, 54 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340427

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z2K6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M28 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2194 Eukaryota
COG2234 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230679

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z2K6

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLLMHSH

Database of Orthologous Groups

More...
OrthoDBi
248924at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z2K6

TreeFam database of animal gene trees

More...
TreeFami
TF314836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007484 Peptidase_M28

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389 Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2K6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEWGSESAAV RRHRVGVERR EGAAAAPPPE REARAQEPLV DGCSGGGRTR
60 70 80 90 100
KRSPGGSGGA SRGAGTGLSE VRAALGLALY LIALRTLVQL SLQQLVLRGA
110 120 130 140 150
AGHRGEFDAL QARDYLEHIT SIGPRTTGSP ENEILTVHYL LEQIKLIEVQ
160 170 180 190 200
SNSLHKISVD VQRPTGSFSI DFLGGFTSYY DNITNVVVKL EPRDGAQHAV
210 220 230 240 250
LANCHFDSVA NSPGASDDAV SCSVMLEVLR VLSTSSEALH HAVIFLFNGA
260 270 280 290 300
EENVLQASHG FITQHPWASL IRAFINLEAA GVGGKELVFQ TGPENPWLVQ
310 320 330 340 350
AYVSAAKHPF ASVVAQEVFQ SGIIPSDTDF RIYRDFGNIP GIDLAFIENG
360 370 380 390 400
YIYHTKYDTA DRILTDSIQR AGDNILAVLK HLATSDMLAA ASKYRHGNMV
410 420 430 440 450
FFDVLGLFVI AYPSRIGSII NYMVVMGVVL YLGKKFLQPK HKTGNYKKDF
460 470 480 490 500
LCGLGITLIS WFTSLVTVLI IAVFISLIGQ SLSWYNHFYV SVCLYGTATV
510 520 530 540 550
AKIILIHTLA KRFYYMNASA QYLGEVFFDI SLFVHCCFLV TLTYQGLCSA
560 570 580 590 600
FISAVWVAFP LLTKLCVHKD FKQHGAQGKF IAFYLLGMFI PYLYALYLIW
610 620 630 640 650
AVFEMFTPIL GRSGSEIPPD VVLASILAGC TMILSSYFIN FIYLAKSTKK
660 670 680 690 700
TMLTLTLVCA ITFLLVCSGT FFPYSSNPAN PKPKRVFLQH MTRTFHDLEG
710 720 730 740 750
NAVKRDSGIW INGFDYTGIS HITPHIPEIN DSIRAHCEEN APLCGFPWYL
760 770 780 790 800
PVHFLIRKNW YLPAPEVSPR NPPHFRLISK EQTPWDSIKL TFEATGPSHM
810 820 830 840 850
SFYVRAHKGS TLSQWSLGNG TPVTSKGGDY FVFYSHGLQA SAWQFWIEVQ
860 870 880 890 900
VSEEHPEGMV TVAIAAHYLS GEDKRSPQLD ALKEKFPDWT FPSAWVCTYD

LFVF
Length:904
Mass (Da):100,231
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A723027C53092EF
GO
Isoform 2 (identifier: Q7Z2K6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     576-904: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,151
Checksum:iB02E3CEF1788BDFB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ER77E7ER77_HUMAN
Endoplasmic reticulum metallopeptid...
ERMP1
841Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGF0A0A0C4DGF0_HUMAN
Endoplasmic reticulum metallopeptid...
ERMP1
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15604 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti575G → D in BAG52673 (PubMed:14702039).Curated1
Sequence conflicti728E → A in BAB15604 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02894544S → N. Corresponds to variant dbSNP:rs13284203Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561211 – 224Missing in isoform 2. 1 PublicationAdd BLAST224
Alternative sequenceiVSP_056122576 – 904Missing in isoform 2. 1 PublicationAdd BLAST329

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026962 mRNA Translation: BAB15604.1 Different initiation.
AK093217 mRNA Translation: BAG52673.1
AK127218 mRNA Translation: BAG54455.1
AL136980 Genomic DNA No translation available.
AL365360 Genomic DNA No translation available.
BC031630 mRNA Translation: AAH31630.2
BC136771 mRNA Translation: AAI36772.1
BC136773 mRNA Translation: AAI36774.1
AB058718 mRNA Translation: BAB47444.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34983.1 [Q7Z2K6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_079172.2, NM_024896.2 [Q7Z2K6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339450; ENSP00000340427; ENSG00000099219 [Q7Z2K6-1]
ENST00000462592; ENSP00000417160; ENSG00000099219 [Q7Z2K6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79956

UCSC genome browser

More...
UCSCi
uc003zjm.2 human [Q7Z2K6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026962 mRNA Translation: BAB15604.1 Different initiation.
AK093217 mRNA Translation: BAG52673.1
AK127218 mRNA Translation: BAG54455.1
AL136980 Genomic DNA No translation available.
AL365360 Genomic DNA No translation available.
BC031630 mRNA Translation: AAH31630.2
BC136771 mRNA Translation: AAI36772.1
BC136773 mRNA Translation: AAI36774.1
AB058718 mRNA Translation: BAB47444.2
CCDSiCCDS34983.1 [Q7Z2K6-1]
RefSeqiNP_079172.2, NM_024896.2 [Q7Z2K6-1]

3D structure databases

SMRiQ7Z2K6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123025, 42 interactors
IntActiQ7Z2K6, 54 interactors
STRINGi9606.ENSP00000340427

Protein family/group databases

MEROPSiM28.018

PTM databases

GlyConnecti1205
iPTMnetiQ7Z2K6
PhosphoSitePlusiQ7Z2K6
SwissPalmiQ7Z2K6

Polymorphism and mutation databases

BioMutaiERMP1
DMDMi117949602

Proteomic databases

EPDiQ7Z2K6
jPOSTiQ7Z2K6
MassIVEiQ7Z2K6
MaxQBiQ7Z2K6
PaxDbiQ7Z2K6
PeptideAtlasiQ7Z2K6
PRIDEiQ7Z2K6
ProteomicsDBi3630
68961 [Q7Z2K6-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q7Z2K6
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339450; ENSP00000340427; ENSG00000099219 [Q7Z2K6-1]
ENST00000462592; ENSP00000417160; ENSG00000099219 [Q7Z2K6-1]
GeneIDi79956
KEGGihsa:79956
UCSCiuc003zjm.2 human [Q7Z2K6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79956

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERMP1
HGNCiHGNC:23703 ERMP1
HPAiHPA020584
MIMi611156 gene
neXtProtiNX_Q7Z2K6
OpenTargetsiENSG00000099219
PharmGKBiPA162385366

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2194 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00530000063839
HOGENOMiHOG000230679
InParanoidiQ7Z2K6
OMAiQLLMHSH
OrthoDBi248924at2759
PhylomeDBiQ7Z2K6
TreeFamiTF314836

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79956

Pharos

More...
Pharosi
Q7Z2K6

Protein Ontology

More...
PROi
PR:Q7Z2K6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099219 Expressed in 226 organ(s), highest expression level in palpebral conjunctiva
ExpressionAtlasiQ7Z2K6 baseline and differential
GenevisibleiQ7Z2K6 HS

Family and domain databases

InterProiView protein in InterPro
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERMP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2K6
Secondary accession number(s): B2RNA4
, B3KSB1, Q8N5T5, Q9H5M1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 18, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again