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UniProtKB - Q7Z2D5 (PLPR4_HUMAN)

Entry version 130 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Phospholipid phosphatase-related protein type 4

Gene

PLPPR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.4, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z2D5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-419408, Lysosphingolipid and LPA receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4Curated (EC:3.1.3.4)
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 11 Publication
Lipid phosphate phosphatase-related protein type 41 Publication
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLPPR4Imported
Synonyms:KIAA04551 Publication, LPPR41 Publication, PHP11 Publication, PRG11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000117600.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:23496, PLPPR4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607813, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z2D5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi252H → K: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9890

Open Targets

More...OpenTargetsi		ENSG00000117600

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z2D5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLPPR4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174361 – 763Phospholipid phosphatase-related protein type 4Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei346PhosphoserineBy similarity1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei385PhosphoserineBy similarity1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei438PhosphoserineBy similarity1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei461PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei606PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z2D5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z2D5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z2D5

PeptideAtlas

More...PeptideAtlasi		Q7Z2D5

PRoteomics IDEntifications database

More...PRIDEi		Q7Z2D5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17424
68943 [Q7Z2D5-1]
68944 [Q7Z2D5-2]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		PLPPR4

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7Z2D5, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z2D5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z2D5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117600, Expressed in dorsolateral prefrontal cortex and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z2D5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z2D5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117600, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115220, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359204

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z2D5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi695 – 698Poly-His4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PA-phosphatase related phosphoesterase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3030, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021458_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z2D5

KEGG Orthology (KO)

More...KOi		K19582

Identification of Orthologs from Complete Genome Data

More...OMAi		GPSITIM

Database of Orthologous Groups

More...OrthoDBi		1621899at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z2D5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028684, LPPR4
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase
IPR043216, PLPP

The PANTHER Classification System

More...PANTHERi		PTHR10165, PTHR10165, 1 hit
PTHR10165:SF13, PTHR10165:SF13, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01569, PAP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00014, acidPPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48317, SSF48317, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z2D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS 
        60         70         80         90        100
AKERPKGKVI KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG 
       110        120        130        140        150
FSCYDRSLSM PYIEPTQEAI PFLMLLSLAF AGPAITIMVG EGILYCCLSK 
       160        170        180        190        200
RRNGVGLEPN INAGGCNFNS FLRRAVRFVG VHVFGLCSTA LITDIIQLST 
       210        220        230        240        250
GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV INSGRKSFPS 
       260        270        280        290        300
QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ 
       310        320        330        340        350
YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL 
       360        370        380        390        400
NQDPNRLLSA KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT 
       410        420        430        440        450
PRSPMGKENM VTFSNTLPRA NTPSVEDPVR RNASIHASMD SARSKQLLTQ 
       460        470        480        490        500
WKNKNESRKL SLQVIEPEPG QSPPRSIEMR SSSEPSRVGV NGDHHGPGNQ 
       510        520        530        540        550
YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET QENISTSPKS 
       560        570        580        590        600
SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST 
       610        620        630        640        650
VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK 
       660        670        680        690        700
APEKGSLRQT YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI 
       710        720        730        740        750
TTIRVTPVEG SEIGSETLSI SSSRDSTLRR KGNIILIPER SNSPENTRNI 
       760 
FYKGTSPTRA YKD
Length:763
Mass (Da):82,983
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0401DD5073EBE71
GO
Isoform 2 (identifier: Q7Z2D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-577: SARAKWLKAAEKTVACNRSNSQPRIM → RVSSKAAPRTLKAARSPALAPSAIKP
     578-763: Missing.

Show »
Length:577
Mass (Da):62,148
Checksum:iBB77A61AD5A407E2
GO
Isoform 3 (identifier: Q7Z2D5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-322: Missing.

Show »
Length:705
Mass (Da):76,554
Checksum:i9ED8A85F8A8A419E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W4VSQ3W4VSQ3_HUMAN
Phospholipid phosphatase-related pr...
PLPPR4
605Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32300 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW72991 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18A → S in BAB71245 (PubMed:14702039).Curated1
Sequence conflicti718L → R in CAD39052 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0506182Q → K. Corresponds to variant dbSNP:rs712896Ensembl.1
Natural variantiVAR_05061932A → V. Corresponds to variant dbSNP:rs35285687Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046784265 – 322Missing in isoform 3. CuratedAdd BLAST58
Alternative sequenceiVSP_030950552 – 577SARAK…QPRIM → RVSSKAAPRTLKAARSPALA PSAIKP in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_030951578 – 763Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF541281 mRNA Translation: AAP57770.1
AY304518 mRNA Translation: AAP72155.1
AB007924 mRNA Translation: BAA32300.3 Different initiation.
AK056665 mRNA Translation: BAB71245.1
AK291369 mRNA Translation: BAF84058.1
AL136147 Genomic DNA No translation available.
AL139425 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72991.1 Sequence problems.
CH471097 Genomic DNA Translation: EAW72992.1
AF357013 mRNA Translation: AAO85400.1
AL834390 mRNA Translation: CAD39052.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53347.1 [Q7Z2D5-3]
CCDS757.1 [Q7Z2D5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001159724.1, NM_001166252.1 [Q7Z2D5-3]
NP_055654.2, NM_014839.4 [Q7Z2D5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370185; ENSP00000359204; ENSG00000117600 [Q7Z2D5-1]
ENST00000457765; ENSP00000394913; ENSG00000117600 [Q7Z2D5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9890

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9890

UCSC genome browser

More...UCSCi		uc001dse.4, human [Q7Z2D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541281 mRNA Translation: AAP57770.1
AY304518 mRNA Translation: AAP72155.1
AB007924 mRNA Translation: BAA32300.3 Different initiation.
AK056665 mRNA Translation: BAB71245.1
AK291369 mRNA Translation: BAF84058.1
AL136147 Genomic DNA No translation available.
AL139425 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72991.1 Sequence problems.
CH471097 Genomic DNA Translation: EAW72992.1
AF357013 mRNA Translation: AAO85400.1
AL834390 mRNA Translation: CAD39052.1
CCDSiCCDS53347.1 [Q7Z2D5-3]
CCDS757.1 [Q7Z2D5-1]
RefSeqiNP_001159724.1, NM_001166252.1 [Q7Z2D5-3]
NP_055654.2, NM_014839.4 [Q7Z2D5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115220, 1 interactor
STRINGi9606.ENSP00000359204

PTM databases

DEPODiPLPPR4
GlyGeniQ7Z2D5, 9 sites
iPTMnetiQ7Z2D5
PhosphoSitePlusiQ7Z2D5

Polymorphism and mutation databases

BioMutaiPLPPR4
DMDMi74750018

Proteomic databases

jPOSTiQ7Z2D5
MassIVEiQ7Z2D5
PaxDbiQ7Z2D5
PeptideAtlasiQ7Z2D5
PRIDEiQ7Z2D5
ProteomicsDBi17424
68943 [Q7Z2D5-1]
68944 [Q7Z2D5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1575, 101 antibodies

The DNASU plasmid repository

More...DNASUi		9890

Genome annotation databases

EnsembliENST00000370185; ENSP00000359204; ENSG00000117600 [Q7Z2D5-1]
ENST00000457765; ENSP00000394913; ENSG00000117600 [Q7Z2D5-3]
GeneIDi9890
KEGGihsa:9890
UCSCiuc001dse.4, human [Q7Z2D5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9890
DisGeNETi9890
EuPathDBiHostDB:ENSG00000117600.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLPPR4
HGNCiHGNC:23496, PLPPR4
HPAiENSG00000117600, Tissue enriched (brain)
MIMi607813, gene
neXtProtiNX_Q7Z2D5
OpenTargetsiENSG00000117600

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3030, Eukaryota
GeneTreeiENSGT00940000156181
HOGENOMiCLU_021458_8_0_1
InParanoidiQ7Z2D5
KOiK19582
OMAiGPSITIM
OrthoDBi1621899at2759
PhylomeDBiQ7Z2D5

Enzyme and pathway databases

BRENDAi3.1.3.4, 2681
PathwayCommonsiQ7Z2D5
ReactomeiR-HSA-419408, Lysosphingolipid and LPA receptors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9890, 2 hits in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLPPR4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9890
PharosiQ7Z2D5, Tbio

Protein Ontology

More...PROi		PR:Q7Z2D5
RNActiQ7Z2D5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117600, Expressed in dorsolateral prefrontal cortex and 174 other tissues
ExpressionAtlasiQ7Z2D5, baseline and differential
GenevisibleiQ7Z2D5, HS

Family and domain databases

InterProiView protein in InterPro
IPR028684, LPPR4
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase
IPR043216, PLPP
PANTHERiPTHR10165, PTHR10165, 1 hit
PTHR10165:SF13, PTHR10165:SF13, 1 hit
PfamiView protein in Pfam
PF01569, PAP2, 1 hit
SMARTiView protein in SMART
SM00014, acidPPc, 1 hit
SUPFAMiSSF48317, SSF48317, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPR4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z2D5
Secondary accession number(s): E7EPS1
, O75043, Q5T9R9, Q86XQ5, Q8N3F1, Q96MP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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