UniProtKB - Q7Z2D5 (PLPR4_HUMAN)
Protein
2-lysophosphatidate phosphatase PLPPR4
Gene
PLPPR4
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes lysophosphatidic acid (LPA) and participates to the axonal outgrowth during development by attenuating phospholipid-induced axon collapse in neuron.1 Publication
Catalytic activityi
- EC:3.1.3.106By similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphateBy similarityThis reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- lipid phosphatase activity Source: GO_Central
- phosphatase activity Source: GO_Central
- phosphatidate phosphatase activity Source: GO_Central
GO - Biological processi
- axonogenesis Source: GO_Central
- inner ear development Source: Ensembl
- phospholipid dephosphorylation Source: GO_Central
- phospholipid metabolic process Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.4, 2681 |
PathwayCommonsi | Q7Z2D5 |
Reactomei | R-HSA-419408, Lysosphingolipid and LPA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: 2-lysophosphatidate phosphatase PLPPR4By similarity (EC:3.1.3.106By similarity)Alternative name(s): Brain-specific phosphatidic acid phosphatase-like protein 11 Publication Lipid phosphate phosphatase-related protein type 41 Publication Phospholipid phosphatase-related protein type 4Curated Plasticity-related gene 1 protein1 Publication Short name: PRG-11 Publication |
Gene namesi | Name:PLPPR4Imported Synonyms:KIAA04551 Publication, LPPR41 Publication, PHP11 Publication, PRG11 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23496, PLPPR4 |
MIMi | 607813, gene |
neXtProti | NX_Q7Z2D5 |
VEuPathDBi | HostDB:ENSG00000117600.12 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic density membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 276 – 296 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 252 | H → K: Loss of lysophosphatidic acid phosphatase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9890 |
OpenTargetsi | ENSG00000117600 |
Miscellaneous databases
Pharosi | Q7Z2D5, Tbio |
Genetic variation databases
BioMutai | PLPPR4 |
DMDMi | 74750018 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317436 | 1 – 763 | 2-lysophosphatidate phosphatase PLPPR4Add BLAST | 763 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 214 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 219 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 268 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 346 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 362 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 385 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 432 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 438 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 455 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 461 | PhosphoserineBy similarity | 1 | |
Modified residuei | 472 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 513 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 543 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 568 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 606 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q7Z2D5 |
MassIVEi | Q7Z2D5 |
PaxDbi | Q7Z2D5 |
PeptideAtlasi | Q7Z2D5 |
PRIDEi | Q7Z2D5 |
ProteomicsDBi | 17424 68943 [Q7Z2D5-1] 68944 [Q7Z2D5-2] |
PTM databases
DEPODi | PLPPR4 |
GlyGeni | Q7Z2D5, 9 sites |
iPTMneti | Q7Z2D5 |
PhosphoSitePlusi | Q7Z2D5 |
Expressioni
Tissue specificityi
Specifically expressed in neurons.1 Publication
Gene expression databases
Bgeei | ENSG00000117600, Expressed in dorsolateral prefrontal cortex and 174 other tissues |
ExpressionAtlasi | Q7Z2D5, baseline and differential |
Genevisiblei | Q7Z2D5, HS |
Organism-specific databases
HPAi | ENSG00000117600, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115220, 1 interactor |
STRINGi | 9606.ENSP00000359204 |
Miscellaneous databases
RNActi | Q7Z2D5, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 695 – 698 | Poly-His | 4 |
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000156181 |
HOGENOMi | CLU_021458_8_0_1 |
InParanoidi | Q7Z2D5 |
OMAi | GPSITIM |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q7Z2D5 |
Family and domain databases
InterProi | View protein in InterPro IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP IPR028684, PLPPR4 |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF13, PTHR10165:SF13, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z2D5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS
60 70 80 90 100
AKERPKGKVI KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG
110 120 130 140 150
FSCYDRSLSM PYIEPTQEAI PFLMLLSLAF AGPAITIMVG EGILYCCLSK
160 170 180 190 200
RRNGVGLEPN INAGGCNFNS FLRRAVRFVG VHVFGLCSTA LITDIIQLST
210 220 230 240 250
GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV INSGRKSFPS
260 270 280 290 300
QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ
310 320 330 340 350
YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL
360 370 380 390 400
NQDPNRLLSA KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT
410 420 430 440 450
PRSPMGKENM VTFSNTLPRA NTPSVEDPVR RNASIHASMD SARSKQLLTQ
460 470 480 490 500
WKNKNESRKL SLQVIEPEPG QSPPRSIEMR SSSEPSRVGV NGDHHGPGNQ
510 520 530 540 550
YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET QENISTSPKS
560 570 580 590 600
SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST
610 620 630 640 650
VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK
660 670 680 690 700
APEKGSLRQT YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI
710 720 730 740 750
TTIRVTPVEG SEIGSETLSI SSSRDSTLRR KGNIILIPER SNSPENTRNI
760
FYKGTSPTRA YKD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketW4VSQ3 | W4VSQ3_HUMAN | 2-lysophosphatidate phosphatase PLP... | PLPPR4 | 605 | Annotation score: |
Sequence cautioni
The sequence BAA32300 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW72991 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | A → S in BAB71245 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 718 | L → R in CAD39052 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050618 | 2 | Q → K. Corresponds to variant dbSNP:rs712896Ensembl. | 1 | |
Natural variantiVAR_050619 | 32 | A → V. Corresponds to variant dbSNP:rs35285687Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046784 | 265 – 322 | Missing in isoform 3. CuratedAdd BLAST | 58 | |
Alternative sequenceiVSP_030950 | 552 – 577 | SARAK…QPRIM → RVSSKAAPRTLKAARSPALA PSAIKP in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_030951 | 578 – 763 | Missing in isoform 2. 1 PublicationAdd BLAST | 186 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF541281 mRNA Translation: AAP57770.1 AY304518 mRNA Translation: AAP72155.1 AB007924 mRNA Translation: BAA32300.3 Different initiation. AK056665 mRNA Translation: BAB71245.1 AK291369 mRNA Translation: BAF84058.1 AL136147 Genomic DNA No translation available. AL139425 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72991.1 Sequence problems. CH471097 Genomic DNA Translation: EAW72992.1 AF357013 mRNA Translation: AAO85400.1 AL834390 mRNA Translation: CAD39052.1 |
CCDSi | CCDS53347.1 [Q7Z2D5-3] |
RefSeqi | NP_001159724.1, NM_001166252.1 [Q7Z2D5-3] NP_055654.2, NM_014839.4 |
Genome annotation databases
Ensembli | ENST00000370185; ENSP00000359204; ENSG00000117600 [Q7Z2D5-1] ENST00000457765; ENSP00000394913; ENSG00000117600 [Q7Z2D5-3] |
GeneIDi | 9890 |
KEGGi | hsa:9890 |
UCSCi | uc001dse.4, human [Q7Z2D5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF541281 mRNA Translation: AAP57770.1 AY304518 mRNA Translation: AAP72155.1 AB007924 mRNA Translation: BAA32300.3 Different initiation. AK056665 mRNA Translation: BAB71245.1 AK291369 mRNA Translation: BAF84058.1 AL136147 Genomic DNA No translation available. AL139425 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72991.1 Sequence problems. CH471097 Genomic DNA Translation: EAW72992.1 AF357013 mRNA Translation: AAO85400.1 AL834390 mRNA Translation: CAD39052.1 |
CCDSi | CCDS53347.1 [Q7Z2D5-3] |
RefSeqi | NP_001159724.1, NM_001166252.1 [Q7Z2D5-3] NP_055654.2, NM_014839.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115220, 1 interactor |
STRINGi | 9606.ENSP00000359204 |
PTM databases
DEPODi | PLPPR4 |
GlyGeni | Q7Z2D5, 9 sites |
iPTMneti | Q7Z2D5 |
PhosphoSitePlusi | Q7Z2D5 |
Genetic variation databases
BioMutai | PLPPR4 |
DMDMi | 74750018 |
Proteomic databases
jPOSTi | Q7Z2D5 |
MassIVEi | Q7Z2D5 |
PaxDbi | Q7Z2D5 |
PeptideAtlasi | Q7Z2D5 |
PRIDEi | Q7Z2D5 |
ProteomicsDBi | 17424 68943 [Q7Z2D5-1] 68944 [Q7Z2D5-2] |
Protocols and materials databases
Antibodypediai | 1575, 101 antibodies |
DNASUi | 9890 |
Genome annotation databases
Ensembli | ENST00000370185; ENSP00000359204; ENSG00000117600 [Q7Z2D5-1] ENST00000457765; ENSP00000394913; ENSG00000117600 [Q7Z2D5-3] |
GeneIDi | 9890 |
KEGGi | hsa:9890 |
UCSCi | uc001dse.4, human [Q7Z2D5-1] |
Organism-specific databases
CTDi | 9890 |
DisGeNETi | 9890 |
GeneCardsi | PLPPR4 |
HGNCi | HGNC:23496, PLPPR4 |
HPAi | ENSG00000117600, Tissue enriched (brain) |
MIMi | 607813, gene |
neXtProti | NX_Q7Z2D5 |
OpenTargetsi | ENSG00000117600 |
VEuPathDBi | HostDB:ENSG00000117600.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000156181 |
HOGENOMi | CLU_021458_8_0_1 |
InParanoidi | Q7Z2D5 |
OMAi | GPSITIM |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q7Z2D5 |
Enzyme and pathway databases
BRENDAi | 3.1.3.4, 2681 |
PathwayCommonsi | Q7Z2D5 |
Reactomei | R-HSA-419408, Lysosphingolipid and LPA receptors |
Miscellaneous databases
BioGRID-ORCSi | 9890, 3 hits in 843 CRISPR screens |
ChiTaRSi | PLPPR4, human |
GenomeRNAii | 9890 |
Pharosi | Q7Z2D5, Tbio |
PROi | PR:Q7Z2D5 |
RNActi | Q7Z2D5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117600, Expressed in dorsolateral prefrontal cortex and 174 other tissues |
ExpressionAtlasi | Q7Z2D5, baseline and differential |
Genevisiblei | Q7Z2D5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP IPR028684, PLPPR4 |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF13, PTHR10165:SF13, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLPR4_HUMAN | |
Accessioni | Q7Z2D5Primary (citable) accession number: Q7Z2D5 Secondary accession number(s): E7EPS1 Q96MP0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families