UniProtKB - Q7Z269 (SP4_POLDO)
Protein
Venom serine protease
Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 75 | Charge relay systemBy similarity | 1 | |
Active sitei | 126 | Charge relay systemBy similarity | 1 | |
Active sitei | 220 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Protein family/group databases
MEROPSi | S01.492 |
Names & Taxonomyi
Protein namesi | |
Organismi | Polistes dominula (European paper wasp) (Vespa dominula) |
Taxonomic identifieri | 743375 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Polistinae › Polistini › Polistes |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.By similarity
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3437, Pol d 4.0101 587, Pol d 4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5000090673 | 20 – 277 | Venom serine proteaseAdd BLAST | 258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 60 ↔ 76 | PROSITE-ProRule annotation | ||
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 192 ↔ 207 | PROSITE-ProRule annotation | ||
Disulfide bondi | 216 ↔ 246 | PROSITE-ProRule annotation | ||
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinExpressioni
Tissue specificityi
Expressed by the venom duct.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 269 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 236 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7Z269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNCGKIILLF ITIIGVAKSR EENCKCGWDN PSRIVNGVET EINEFPMVAR
60 70 80 90 100
LIYPSPGMYC GGTIITPQHI VTAAHCLQKY KRTNYTGIHV VVGEHDYTTD
110 120 130 140 150
TETNVTKRYT IAEVTIHPNY NSHNNDIAIV KTNERFEYSM KVGPVCLPFN
160 170 180 190 200
YMTRNLTNET VTALGWGKLR YNGQNSKVLR KVDLHVITRE QCETHYGAAI
210 220 230 240 250
ANANLLCTFD VGRDACQNDS GGPILWRSPT TDNLILVGVV NFGRTCADDA
260 270
PGGNARVTSF MEFIHNATIG ETYCKAD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY285998 mRNA Translation: AAP37412.1 |
RefSeqi | NP_001310266.1, NM_001323337.1 |
Genome annotation databases
GeneIDi | 107070494 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY285998 mRNA Translation: AAP37412.1 |
RefSeqi | NP_001310266.1, NM_001323337.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
Allergomei | 3437, Pol d 4.0101 587, Pol d 4 |
MEROPSi | S01.492 |
Genome annotation databases
GeneIDi | 107070494 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SP4_POLDO | |
Accessioni | Q7Z269Primary (citable) accession number: Q7Z269 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | October 1, 2003 | |
Last modified: | August 12, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Documents
- SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries - Peptidase families
Classification of peptidase families and list of entries