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Protein

Venom allergen 5

Gene
N/A
Organism
Polybia scutellaris rioplatensis (Camoati)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5
Alternative name(s):
Allergen Pol s V
Antigen 5
Short name:
Ag5
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Pol s 5
OrganismiPolybia scutellaris rioplatensis (Camoati)
Taxonomic identifieri260979 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaVespidaePolistinaeEpiponiniPolybia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. In most vespids, Antigen 5 is a potent allergen. Pol s 5 is a variant with a much lower allergenicity. It has a reduced IgE response and anaphylactic activity.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3494 Poly s 5.0101
771 Poly s 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115381 – 207Venom allergen 5Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 16By similarity
Disulfide bondi8 ↔ 105By similarity
Disulfide bondi29 ↔ 97By similarity
Disulfide bondi173 ↔ 190By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ7Z156
SMRiQ7Z156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 192SCPAdd BLAST145

Sequence similaritiesi

Belongs to the CRISP family.Curated

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NKYCNIKCSK VAHTVCQYGE STKPSSKNCN KVSITSVGVT EEEKKLIVDE
60 70 80 90 100
HNRFRQKVAQ GLETRGNPGP QPAASDMNNL VWNDELAYIA QVWANQCQFF
110 120 130 140 150
VHDKCRNTAQ YQVGQNIAYS ASTAAYPGIV SLIVLWENEV KDFNYSQGIT
160 170 180 190 200
KENFAKVGHY TQVVWAKTKE VGCGSIKYIE KGMKSHYLVC NYGPAGNYMG

QPIYTKK
Length:207
Mass (Da):23,209
Last modified:February 2, 2004 - v2
Checksum:i35E2D236344DF74C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28Missing in AAP57536 (Ref. 2) Curated1
Sequence conflicti95N → S in AAP57536 (Ref. 2) Curated1
Sequence conflicti155A → S in AAP57536 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299635 mRNA Translation: AAP57536.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299635 mRNA Translation: AAP57536.1

3D structure databases

ProteinModelPortaliQ7Z156
SMRiQ7Z156
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3494 Poly s 5.0101
771 Poly s 5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVA5_POLSR
AccessioniPrimary (citable) accession number: Q7Z156
Secondary accession number(s): P82958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 2, 2004
Last modified: October 25, 2017
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Allergens
    Nomenclature of allergens and list of entries
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