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Protein

Iota-conotoxin-like r11c

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Causes circular motion, convulsions, copious urination, rigid paralysis and death upon intracranial injection into mice. Causes unbalanced swimming, swimming in diagonal and vertical motion and death, when injected intraperitoneally into goldfish. L-Leu and D-Leu forms are active on both nerve and muscle.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like r11c
Alternative name(s):
R11.4
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri1409 RXIC precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000026244820 – 35Add BLAST16
ChainiPRO_000003510037 – 79Iota-conotoxin-like r11cAdd BLAST43
PropeptideiPRO_000003510180Removed by a carboxypeptidase1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384-hydroxyproline; partial1 Publication1
Disulfide bondi41 ↔ 55By similarity
Modified residuei474-hydroxyproline; partial1 Publication1
Disulfide bondi48 ↔ 58By similarity
Disulfide bondi54 ↔ 63By similarity
Disulfide bondi57 ↔ 72By similarity
Modified residuei654-hydroxyproline1 Publication1
Modified residuei78D-leucine1 Publication1

Post-translational modificationi

The natural D-Leu form of the peptide is more potent than the synthetic L-Leu form.

Keywords - PTMi

Cleavage on pair of basic residues, D-amino acid, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7Z096
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z096-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLCLTFLLV LMILASVTGE KSSKHTLSRA ARVKNRGPSF CKADEKPCKY
60 70 80
HADCCNCCLG GICKPSTSWI GCSTNVFLTR
Length:80
Mass (Da):8,744
Last modified:November 28, 2006 - v2
Checksum:i12A793215AA85418
GO

Mass spectrometryi

Molecular mass is 4632.68 Da from positions 37 - 79. Determined by MALDI. With hydroxyPro.1 Publication
Molecular mass is 4616.62 Da from positions 37 - 79. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208957 mRNA Translation: AAP41539.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208957 mRNA Translation: AAP41539.1

3D structure databases

ProteinModelPortaliQ7Z096
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1409 RXIC precursor

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI1BC_CONRA
AccessioniPrimary (citable) accession number: Q7Z096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: November 28, 2006
Last modified: October 10, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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