Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iota-conotoxin-like r11b

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Produces excitatory symptoms when injected intracranially into mice and is lethal at higher doses. Exposure to frog cutaneous pectoris induces spontaneous and repetitive action potentials. This effect is slowly reversible. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like r11b
Alternative name(s):
I-superfamily conotoxin R11.14
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri842 RXIB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868711 – 46Iota-conotoxin-like r11bAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-hydroxyproline1 Publication1
Disulfide bondi5 ↔ 19By similarity
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi12 ↔ 22By similarity
Disulfide bondi18 ↔ 27By similarity
Disulfide bondi21 ↔ 38By similarity
Modified residuei294-hydroxyproline1 Publication1
Modified residuei44D-phenylalanine1 Publication1

Post-translational modificationi

The natural D-Phe form of the peptide is more potent than the synthetic L-Phe form.

Keywords - PTMi

D-amino acid, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7Z092
SMRiQ7Z092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z092-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
GPSFCKANGK PCSYHADCCN CCLSGICKPS TNVILPGCST SSFFRI
Length:46
Mass (Da):4,819
Last modified:October 1, 2003 - v1
Checksum:iEA48F7B3E4DA3B4E
GO

Mass spectrometryi

Molecular mass is 4857.6 Da from positions 1 - 46. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208961 mRNA Translation: AAP41543.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208961 mRNA Translation: AAP41543.1

3D structure databases

ProteinModelPortaliQ7Z092
SMRiQ7Z092
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri842 RXIB

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI1BB_CONRA
AccessioniPrimary (citable) accession number: Q7Z092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again