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Protein

Iota-conotoxin-like r11d

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Both natural (L-Thr form) and synthetic (D-Thr form) peptides cause paralysis and death following intracranial injection and grooming and hypersensitivity upon intraperitoneal injection into mice. The L-Thr form of the peptide is 7-fold more potent than the D-Thr form. Both natural peptide (L-Thr form) and synthetic peptide (D-Thr form) are active on nerve, and on muscle.By similarity1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like r11d
Alternative name(s):
R11.8
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri843 RXID

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868701 – 41Iota-conotoxin-like r11dAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 16By similarity
Modified residuei84-hydroxyproline1 Publication1
Disulfide bondi9 ↔ 19By similarity
Disulfide bondi15 ↔ 24By similarity
Disulfide bondi18 ↔ 35By similarity
Modified residuei264-hydroxyproline1 Publication1

Post-translational modificationi

Position 41 corresponds to a L-threonine, and not a D-threonine as firstly supposed.

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7Z091
SMRiQ7Z091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z091-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
GCKKDRKPCS YHADCCNCCL SGICAPSTNW ILPGCSTSTF T
Length:41
Mass (Da):4,373
Last modified:October 1, 2003 - v1
Checksum:iB1AD320F1A1B5B31
GO

Mass spectrometryi

Molecular mass is 4399.26 Da from positions 1 - 41. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208962 mRNA Translation: AAP41544.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208962 mRNA Translation: AAP41544.1

3D structure databases

ProteinModelPortaliQ7Z091
SMRiQ7Z091
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri843 RXID

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI1BD_CONRA
AccessioniPrimary (citable) accession number: Q7Z091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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