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Protein

Iota-conotoxin-like R11.3

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like R11.3
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri1410 R11.3 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000026244720 – 34By similarityAdd BLAST15
ChainiPRO_000004488236 – 75Iota-conotoxin-like R11.3Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 53By similarity
Disulfide bondi46 ↔ 58By similarity
Disulfide bondi52 ↔ 63By similarity
Disulfide bondi57 ↔ 70By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ7Z090

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiQ7Z090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z090-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLCLTFLLV LMILASVTGE KLSEQTLRRA ARKNKGPRCW VGRVHCTYHK
60 70
DCCPSVCCFK GRCKPQSWGC WSGPT
Length:75
Mass (Da):8,476
Last modified:November 28, 2006 - v2
Checksum:iB871FC236DAA2D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208963 mRNA Translation: AAP41545.1
FJ959113 Genomic DNA Translation: ADB93083.1

Similar proteinsi

Entry informationi

Entry nameiCI1B3_CONRA
AccessioniPrimary (citable) accession number: Q7Z090
Secondary accession number(s): D6C4H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: November 28, 2006
Last modified: September 12, 2018
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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