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Protein

Kappa-conotoxin ViTx

Gene

VITX

Organism
Conus virgo (Virgin cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels. This toxin inhibits the mammalian potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3.1 Publication

Miscellaneous

This toxin has no effects on Kv1.2/KCNA2, Kv11/KCNH, and Kir2.1/KCNJ2 potassium channels, and on Nav1.5/SCN5A sodium channels.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin ViTx1 Publication
Short name:
Kappa-ViTx
Alternative name(s):
I2-superfamily conotoxin ViTx
Gene namesi
Name:VITX
OrganismiConus virgo (Virgin cone)
Taxonomic identifieri89427 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusVirgiconus

Organism-specific databases

ConoServeri845 ViTx precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000003511627 – 59Kappa-conotoxin ViTxAdd BLAST33
PropeptideiPRO_000003511763 – 675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 481 Publication
Disulfide bondi36 ↔ 511 Publication
Disulfide bondi42 ↔ 431 Publication
Disulfide bondi47 ↔ 551 Publication
Modified residuei59Isoleucine amideCurated1

Post-translational modificationi

Contains 4 disulfide bonds. Here are reported disulfide bonds proposed in [PubMed:16268797], even if the connectivity known for the framework XI is I-IV, II-VI, III-VII, V-VIII.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YZS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRLTSVSC FLLVIACLNL FQVVLTSRCF PPGIYCTPYL PCCWGICCGT
60
CRNVCHLRIG KRATFQE
Length:67
Mass (Da):7,599
Last modified:October 1, 2003 - v1
Checksum:i46671D012446F62D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38P → S AA sequence (PubMed:12893060).Curated1
Sequence conflicti49G → S AA sequence (PubMed:12893060).Curated1

Mass spectrometryi

Molecular mass is 3933.3 Da from positions 27 - 59. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560778 mRNA Translation: CAD90965.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560778 mRNA Translation: CAD90965.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZJSmodel-A27-61[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri845 ViTx precursor

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCI2_CONVR
AccessioniPrimary (citable) accession number: Q7YZS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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