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Entry version 143 (07 Apr 2021)
Sequence version 1 (01 Oct 2003)
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Protein

Transmembrane GTPase Marf

Gene

Marf

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:18799731, PubMed:20869429, PubMed:22396657, PubMed:24192653, PubMed:26214738). Mitochondrial fusion is the physical merging of mitochondria that gives rise to mitochondrial networks, and this process is counterbalanced by mitochondrial fission which fragments networks (PubMed:20869429, PubMed:22396657, PubMed:24192653). Promotes, but is not required for park recruitment to dysfunctional mitochondria (PubMed:20194754).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei345GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi147 – 152GTPBy similarity6
Nucleotide bindingi298 – 301GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5205685, PINK1-PRKN Mediated Mitophagy
R-DME-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane GTPase Marf (EC:3.6.5.-)
Alternative name(s):
Mitochondrial assembly regulatory factor
Mitofusin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Marf
Synonyms:dmfn
ORF Names:CG3869
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0029870, Marf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 637CytoplasmicSequence analysisAdd BLAST637
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei638 – 648Helical; Name=1Sequence analysisAdd BLAST11
Topological domaini649 – 668Mitochondrial intermembraneSequence analysisAdd BLAST20
Transmembranei669 – 689Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini690 – 810CytoplasmicSequence analysisAdd BLAST121

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethal at the early larval stage (L1/L2); mitochondria are fragmented and mitochondrial respiration is impaired (PubMed:26214738). RNAi-mediated knockdown is also lethal (PubMed:20869429). RNAi-mediated knockdown in specific tissues such as cardiomyocytes, muscles and larval neurons produces various phenotypes resulting from adherent, dysfunctional mitochondria (PubMed:18799731, PubMed:20869429, PubMed:22396657, PubMed:24192653). Mitochondria display characteristics such as abnormal cristae, fragmentation, elongation, decreased DNA content, increased ROS and depolarization (PubMed:20869429, PubMed:20194754, PubMed:22396657, PubMed:24192653). Mitochondria in larval muscles display increased mitochondrial flux and net velocity in both anterograde and retrograde directions (PubMed:20194754).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi221I → N: Shows high levels of reactive oxygen species (ROS) and accumulation of lipid droplets in pigment and epithelial glia. Lipid droplet accumulation occurs early, prior to the onset of neurodegeneration. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001276791 – 810Transmembrane GTPase MarfAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8Phosphothreonine1 Publication1
Modified residuei38Phosphoserine1 Publication1
Modified residuei553Phosphothreonine1 Publication1
Modified residuei554Phosphoserine1 Publication1
Modified residuei555Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by park and Mul1 (PubMed:24898855, PubMed:20194754). Ubiquitinated, probably by HUWE1, when dietary stearate (C18:0) levels are low; ubiquitination inhibits mitochondrial fusion (PubMed:26214738).3 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7YU24

PRoteomics IDEntifications database

More...
PRIDEi
Q7YU24

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7YU24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in embryos, accumulating in the mesoderm and endoderm during gut development. In the male germ line, it is expressed in spermatogonia, spermatocytes and early spermatids.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0029870, Expressed in head and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7YU24, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7YU24, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Mul1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58068, 33 interactors

Database of interacting proteins

More...
DIPi
DIP-58614N

Protein interaction database and analysis system

More...
IntActi
Q7YU24, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070873

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7YU24

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 382Dynamin-type GPROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 151G1 motifPROSITE-ProRule annotation8
Regioni170 – 171G2 motifPROSITE-ProRule annotation2
Regioni239 – 242G3 motifPROSITE-ProRule annotation4
Regioni298 – 301G4 motifPROSITE-ProRule annotation4
Regioni327G5 motifPROSITE-ProRule annotation1

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili427 – 476Sequence analysisAdd BLAST50
Coiled coili759 – 806Sequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0448, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013727

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7YU24

Identification of Orthologs from Complete Genome Data

More...
OMAi
GIMLKTI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7YU24

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022812, Dynamin_SF
IPR006884, Fzo/mitofusin_HR2
IPR030381, G_DYNAMIN_dom
IPR027088, Mitofusin-1
IPR027094, Mitofusin_fam
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10465, PTHR10465, 1 hit
PTHR10465:SF2, PTHR10465:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00350, Dynamin_N, 1 hit
PF04799, Fzo_mitofusin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51718, G_DYNAMIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7YU24-1) [UniParc]FASTAAdd to basket
Also known as: BImported, CImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAYLNRTIS MVTGQTGPAD DDRHASSTDT VDKSGPGSPL SRFNSSLQQS
60 70 80 90 100
GSTMAANLLP ESRLYQSNDK SPLQIFVRAK KKINDIYGEI EEYVHETTTF
110 120 130 140 150
INALHAEAEI VDKAERELFE SYVYKVAAIR EVLQRDHMKV AFFGRTSNGK
160 170 180 190 200
SSVINAMLRE KILPSGIGHT TNCFCQVEGS NGGEAYLMTE GSEEKLNVVN
210 220 230 240 250
IKQLANALCQ EKLCESSLVR IFWPRERCSL LRDDVVFVDS PGVDVSANLD
260 270 280 290 300
DWIDNHCLNA DVFVLVLNAE STMTRAEKQF FHTVSQKLSK PNIFILNNRW
310 320 330 340 350
DASANEPECQ ESVKSQHTER CIDFLTKELK VSNEKEAAER VFFVSARETL
360 370 380 390 400
QARIEEAKGN PPHMGAIAEG FQIRYFEFQD FERKFEECIS QSAVKTKFQQ
410 420 430 440 450
HSSRGKSVSG DMKSMLDNIY ERITIFRNLK QDQKNLLTER IQGTETQMMQ
460 470 480 490 500
VTREMKMKIH NMVEEVEEKV SKALNEEIWR LGVLIDEFNM PFHPERLVLN
510 520 530 540 550
IYKKELNAHV ESGLGSNLRA RLSMALAMNV ESAQTEMTDR MHALVPNEQL
560 570 580 590 600
LATSTKMVVR TQPFEMLYSL NCQNLCADFQ EDLEFKFSWG IAAMIQRFTG
610 620 630 640 650
KVRERSKKGQ PALVNRQSSI GHSVSTPTTT PVEATPVCLL PAPVVAGITP
660 670 680 690 700
EQLSLISRFA VSSIGSQGTV GGLVVAGVML KTIGWRVLVG VGALYGCIYL
710 720 730 740 750
YERLSWTNSA KERTFKSQYV RHATKKLKMI VDLTSANCSH QVQQELSSTF
760 770 780 790 800
ARLCRTVDTA TTDMNDELKT LDSQLNILEA NQKQLKLLRN KANYIQNELD
810
IFEHNYISPQ
Length:810
Mass (Da):91,372
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A3362BE1DD2A115
GO
Isoform 2 (identifier: Q7YU24-2) [UniParc]FASTAAdd to basket
Also known as: DImported

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: S → SELAK

Show »
Length:814
Mass (Da):91,814
Checksum:i131AA9CA5FE3322F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti621G → Q in AAM00196 (PubMed:12598526).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058137312S → SELAK in isoform 2. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF355475 mRNA Translation: AAM00196.1
AE014298 Genomic DNA Translation: AAS65267.2
AE014298 Genomic DNA Translation: AAF46162.2
AY095019 mRNA Translation: AAM11347.2
BT010027 mRNA Translation: AAQ22496.1

NCBI Reference Sequences

More...
RefSeqi
NP_572320.2, NM_132092.3 [Q7YU24-2]
NP_996357.1, NM_206634.2 [Q7YU24-1]
NP_996358.2, NM_206635.3 [Q7YU24-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070909; FBpp0089222; FBgn0029870 [Q7YU24-1]
FBtr0070910; FBpp0089221; FBgn0029870 [Q7YU24-1]
FBtr0343373; FBpp0310030; FBgn0029870 [Q7YU24-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
31581

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3869

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355475 mRNA Translation: AAM00196.1
AE014298 Genomic DNA Translation: AAS65267.2
AE014298 Genomic DNA Translation: AAF46162.2
AY095019 mRNA Translation: AAM11347.2
BT010027 mRNA Translation: AAQ22496.1
RefSeqiNP_572320.2, NM_132092.3 [Q7YU24-2]
NP_996357.1, NM_206634.2 [Q7YU24-1]
NP_996358.2, NM_206635.3 [Q7YU24-1]

3D structure databases

SMRiQ7YU24
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58068, 33 interactors
DIPiDIP-58614N
IntActiQ7YU24, 4 interactors
STRINGi7227.FBpp0070873

PTM databases

iPTMnetiQ7YU24

Proteomic databases

PaxDbiQ7YU24
PRIDEiQ7YU24

Genome annotation databases

EnsemblMetazoaiFBtr0070909; FBpp0089222; FBgn0029870 [Q7YU24-1]
FBtr0070910; FBpp0089221; FBgn0029870 [Q7YU24-1]
FBtr0343373; FBpp0310030; FBgn0029870 [Q7YU24-2]
GeneIDi31581
KEGGidme:Dmel_CG3869

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
31581
FlyBaseiFBgn0029870, Marf

Phylogenomic databases

eggNOGiKOG0448, Eukaryota
GeneTreeiENSGT00390000013727
InParanoidiQ7YU24
OMAiGIMLKTI
PhylomeDBiQ7YU24

Enzyme and pathway databases

ReactomeiR-DME-5205685, PINK1-PRKN Mediated Mitophagy
R-DME-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
31581, 1 hit in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Marf, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31581

Protein Ontology

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PROi
PR:Q7YU24

Gene expression databases

BgeeiFBgn0029870, Expressed in head and 27 other tissues
ExpressionAtlasiQ7YU24, baseline and differential
GenevisibleiQ7YU24, DM

Family and domain databases

InterProiView protein in InterPro
IPR022812, Dynamin_SF
IPR006884, Fzo/mitofusin_HR2
IPR030381, G_DYNAMIN_dom
IPR027088, Mitofusin-1
IPR027094, Mitofusin_fam
IPR027417, P-loop_NTPase
PANTHERiPTHR10465, PTHR10465, 1 hit
PTHR10465:SF2, PTHR10465:SF2, 1 hit
PfamiView protein in Pfam
PF00350, Dynamin_N, 1 hit
PF04799, Fzo_mitofusin, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51718, G_DYNAMIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARF_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YU24
Secondary accession number(s): Q0KHV7
, Q86DQ3, Q8T3J4, Q9W3Z9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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