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UniProtKB - Q7YU15 (Q7YU15_DROME)
Protein
Submitted name:
Klarsicht, isoform B
Gene
klar
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- kinesin binding Source: FlyBase
GO - Biological processi
- compound eye morphogenesis Source: FlyBase
- compound eye photoreceptor development Source: FlyBase
- flight Source: FlyBase
- larval visceral muscle development Source: FlyBase
- lipid droplet transport along microtubule Source: FlyBase
- lipid transport Source: FlyBase
- locomotion Source: FlyBase
- lumen formation, open tracheal system Source: FlyBase
- membrane organization Source: FlyBase
- microtubule anchoring Source: FlyBase
- negative regulation of pole plasm oskar mRNA localization Source: FlyBase
- nuclear migration Source: FlyBase
- nucleus localization Source: FlyBase
- nucleus organization Source: FlyBase
- regulation of intracellular transport Source: FlyBase
- tube morphogenesis Source: FlyBase
Names & Taxonomyi
Protein namesi | Submitted name: Klarsicht, isoform BImportedSubmitted name: LD36052pImported |
Gene namesi | ORF Names:CG17046Imported, Dmel_CG17046Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0001316, klar |
VEuPathDBi | VectorBase:FBgn0001316 |
Subcellular locationi
Nucleus
- nuclear envelope Source: FlyBase
- nuclear outer membrane Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
- integral component of membrane Source: UniProtKB-UniRule
- perinuclear region of cytoplasm Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 1998 | CytoplasmicPROSITE-ProRule annotationAdd BLAST | 1998 | |
Topological domaini | 2020 – 2045 | Perinuclear spacePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Cellular componenti
Membrane, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0001316, Expressed in wing disc (Drosophila) and 40 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1990 – 2045 | KASHInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 140 | DisorderedSequence analysisAdd BLAST | 140 | |
Regioni | 345 – 410 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 442 – 475 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 514 – 536 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 583 – 614 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 643 – 682 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 783 – 814 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 899 – 940 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1029 – 1099 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 1317 – 1345 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1377 – 1453 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 1875 – 1988 | DisorderedSequence analysisAdd BLAST | 114 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1528 – 1548 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1592 – 1625 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 1843 – 1870 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 81 – 111 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 345 – 385 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 446 – 475 | Acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 514 – 531 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 583 – 605 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 791 – 814 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1049 – 1065 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1069 – 1084 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1326 – 1345 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1396 – 1420 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1439 – 1453 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1875 – 1894 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1935 – 1950 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the nesprin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
HOGENOMi | CLU_001190_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR039906, Anc-1-like IPR012315, KASH |
PANTHERi | PTHR21524, PTHR21524, 3 hits |
Pfami | View protein in Pfam PF10541, KASH, 1 hit |
SMARTi | View protein in SMART SM01249, KASH, 1 hit |
PROSITEi | View protein in PROSITE PS51049, KASH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q7YU15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEMQQENETG REGVIPNSEK EVALISNQET EKAAMISGGK EGSVRDLESP
60 70 80 90 100
NETATTQKIE HTTKPLKLDG IFAMPATPPN RAGLTTKSAS SSRSSSLKKQ
110 120 130 140 150
RRGSRGSANL NVAGTGDGAP KRSAPGGGQL NYGTNSVGND LMKQSQSMTS
160 170 180 190 200
LKASNEEQQE SRDVIQAKLH LERPYNSLKK NSHSNKMHRY SWGSGNSQCS
210 220 230 240 250
STSLHSSATL GLGSSGKDDL WAAIQTNYNY IMDTNLLDTC KEARCEIEGA
260 270 280 290 300
ATVLEKSSEC SFKMLDETQR PEGLCEDPKE LRRWLREMEN KLESSPTITE
310 320 330 340 350
LTLFGNAELQ RHLAVHSVLY HEIASHARVV SSCIRAAEKE QQLQQQQQLS
360 370 380 390 400
SQQPASLTSN CSSESTSESA TKSSSLSSGF ASDPVTTPIG TAAAAPPSSS
410 420 430 440 450
THPSKKGEGN LERLRDRYHL LYLKAFELQL CLDNLLRKRS SAANGLDDDE
460 470 480 490 500
DEEEDTEDDS FGYEGEATED DLNEVNSDLD LENSESKSAT PAELILQRCQ
510 520 530 540 550
IAATQIVCGL DETQSQSRSQ QVPSQAKSPS ADQPRDCLAP QKILKSADAS
560 570 580 590 600
TDDDDEGWLY TATAAATLEV ATAATAAPTA AAATSSVDGL QSTAVSSTTA
610 620 630 640 650
TGGPLPPSDD SDKENKVALV SATTITAAAT ATATSIATLH SSNYDSSSAC
660 670 680 690 700
SSSNSNSNSN SNSNGRLTET SATSRVTQLQ MQIHSQSQSQ SQMELQINGN
710 720 730 740 750
AIDGRHIISN NNCYSSMQHQ PQNNNEGEAA EDLAKIKMGD DEAAADMANG
760 770 780 790 800
NATKSQQMSN GVYSRADSCN FTVWAAETVA SCHLPPRSPA KSAKSSKSQA
810 820 830 840 850
SNATVSGSTL VSPVKGKVSH DSIKQLVLEA EHLVRDAQET ALKTPTKQKH
860 870 880 890 900
SIIKISSTVK KREVTMPHPI KQRVEEWLEH QPSTPQLLTR SHTHELLPSC
910 920 930 940 950
KPDDCEASGE ASETDSVPQA GAGVNGGAPN GAGSDTSEGF TDSIATCMQT
960 970 980 990 1000
STNSYGNSTE RIGGSAEPIG QPVTPLGFGS SNQSLNVKIV KRSQTRRKSE
1010 1020 1030 1040 1050
RPWSVSCLSQ LTTDAAQLTT ARIVENSPSG LASHSISESA LDSLSPGPRP
1060 1070 1080 1090 1100
RAASSSGTGS NAAKKADSKG SLRRRKARKK RISAASAGRK SDSGSELGGD
1110 1120 1130 1140 1150
LTQTLMKSCE SMSSQQLQEF TNALLSIQKG AVVAPLSPKG DVSGVPSLAD
1160 1170 1180 1190 1200
GEGGETQLML PKFRVGSFTT AGLLATDTRL GALAALSNYM NEDEQQAELS
1210 1220 1230 1240 1250
TEDHHSSISE TAWDNYQEKY NSENYSEGFD SDAARRLLEF GDDYRNFIDS
1260 1270 1280 1290 1300
QSDCCSSLSA ANNLDSFSPP RMDSLQKHEL KTLHINQDTI TSTVDHARRQ
1310 1320 1330 1340 1350
RALELQYERR RKTLEVRRKS CQDMDESLMA SPQSDQQQQQ LQVTPSLSAS
1360 1370 1380 1390 1400
ATALMTTPKI QSTSHQISHR AESVGRKLDF GGMSHSAQSL LRRTSESDTS
1410 1420 1430 1440 1450
TRRRRTVTAD ERRRSSRNLE KCIKLIPATT SSSSGSDSED GEQEMRSLLQ
1460 1470 1480 1490 1500
QSRDRLDDTR ALKIRCHLLR PEDYNEIINT CRDNIRCLEA VLRGPPGTVL
1510 1520 1530 1540 1550
SNHCAGQTKD LLGAWEDLLS WSENASAARK LQQEMSVLKS SLQRLGDKPT
1560 1570 1580 1590 1600
PELLDTEPAI QIAVEALKLE QTQLTSYRTN MLRLNASVHS WLTKQERRLQ
1610 1620 1630 1640 1650
SALEEQEQQQ ESEQLKQQKL VEEEKGADVQ KELASTGAVA ITVTDSNGNQ
1660 1670 1680 1690 1700
VEALATGEAS TSTPAWDVHT LMSSEQEFHK HLKNEVSDMY SSWDEADARI
1710 1720 1730 1740 1750
NTQLEMLTNS LIAWRQLESG LSEFQLALGQ DRGTLKGLEG ALDKGQATPV
1760 1770 1780 1790 1800
ELAQNVKLVA KLLSEKVHVS QEQLLAVQQH LDPNHIYHIT KFTASNGSLS
1810 1820 1830 1840 1850
DSGISDGGAT SDGGLSERER RLGVLRRLAK QLELALAPGS EAMRSIAARM
1860 1870 1880 1890 1900
ESAEADLKHL QNTCRDLIVR TAASHQQKQQ IQQNQTQQVS PKANGHIKKQ
1910 1920 1930 1940 1950
AAKGKAEPQS PGRRGKGARK ARQAKKAGED QQVEEPSLSP EQQKMVLKQL
1960 1970 1980 1990 2000
KTLTSGDGGD DPSDDPSLLF NLESSEEDGE GADPAQTSKR GWAWRIARAA
2010 2020 2030 2040
VPMQVALFTI FCAACLMQPN CCDNLNNLSM SFTPQLRYIR GPPPI
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y0E4 | KLAR_DROME | Klarsicht protein | klar CG17046 | 2,262 | Annotation score: | ||
A8JNH1 | A8JNH1_DROME | GM19713p | klar Dmel\CG17046, Klar, klar-RC, kls, marb | 567 | Annotation score: | ||
Q9W0Q4 | Q9W0Q4_DROME | Klarsicht, isoform A | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 2,262 | Annotation score: | ||
M9PGK7 | M9PGK7_DROME | Klarsicht, isoform E | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 2,272 | Annotation score: | ||
X2JAH4 | X2JAH4_DROME | Klarsicht, isoform I | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 511 | Annotation score: | ||
M9PDJ0 | M9PDJ0_DROME | Klarsicht, isoform G | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,180 | Annotation score: | ||
M9PBH0 | M9PBH0_DROME | Klarsicht, isoform F | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,636 | Annotation score: | ||
A8JNH2 | A8JNH2_DROME | Klarsicht, isoform D | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,823 | Annotation score: | ||
X2J8G9 | X2J8G9_DROME | Klarsicht, isoform H | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,197 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT010042 mRNA Translation: AAQ22511.1 AE014296 Genomic DNA Translation: ABI31227.1 |
RefSeqi | NP_001036576.1, NM_001043111.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0110818; FBpp0110115; FBgn0001316 |
GeneIDi | 38067 |
KEGGi | dme:Dmel_CG17046 |
UCSCi | CG17046-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT010042 mRNA Translation: AAQ22511.1 AE014296 Genomic DNA Translation: ABI31227.1 |
RefSeqi | NP_001036576.1, NM_001043111.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 38067 |
Genome annotation databases
EnsemblMetazoai | FBtr0110818; FBpp0110115; FBgn0001316 |
GeneIDi | 38067 |
KEGGi | dme:Dmel_CG17046 |
UCSCi | CG17046-RB, d. melanogaster |
Organism-specific databases
CTDi | 38067 |
FlyBasei | FBgn0001316, klar |
VEuPathDBi | VectorBase:FBgn0001316 |
Phylogenomic databases
HOGENOMi | CLU_001190_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 38067, 0 hits in 1 CRISPR screen |
ChiTaRSi | klar, fly |
GenomeRNAii | 38067 |
Gene expression databases
Bgeei | FBgn0001316, Expressed in wing disc (Drosophila) and 40 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR039906, Anc-1-like IPR012315, KASH |
PANTHERi | PTHR21524, PTHR21524, 3 hits |
Pfami | View protein in Pfam PF10541, KASH, 1 hit |
SMARTi | View protein in SMART SM01249, KASH, 1 hit |
PROSITEi | View protein in PROSITE PS51049, KASH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7YU15_DROME | |
Accessioni | Q7YU15Primary (citable) accession number: Q7YU15 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2003 |
Last sequence update: | October 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |