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Entry version 111 (26 Feb 2020)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

Notch

Gene

N

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NotchImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NImported
ORF Names:CG3936Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004647 N

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q7YSQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q7YSQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004647 Expressed in embryo and 29 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 343ANK_REP_REGIONInterPro annotationAdd BLAST243
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati157 – 189ANKPROSITE-ProRule annotationAdd BLAST33
Repeati190 – 215ANKPROSITE-ProRule annotationAdd BLAST26
Repeati224 – 256ANKPROSITE-ProRule annotationAdd BLAST33
Repeati257 – 289ANKPROSITE-ProRule annotationAdd BLAST33
Repeati290 – 322ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57
Regioni379 – 464DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 24PolarSequence analysisAdd BLAST15
Compositional biasi379 – 406PolarSequence analysisAdd BLAST28
Compositional biasi431 – 455PolarSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000576_0_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q7YSQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DPHGQEMRNL NKQVAMQSQG VGQPGAHWSD DESDMPLPKR QRSDPVSGVG
60 70 80 90 100
LGNNGGYASD HTMVSEYEEA DQRVWSQAHL DVVDVRAIMT PPAHQDGGKH
110 120 130 140 150
DVDARGPCGL TPLMIAAVRG GGLDTGEDIE NNEDSTAQVI SDLLAQGAEL
160 170 180 190 200
NATMDKTGET SLHLAARFAR ADAAKRLLDA GADANCQDNT GRTPLHAAVA
210 220 230 240 250
ADAMGVFQIL LRNRATNLNA RMHDGTTPLI LAARLAIEGM VEDLITADAD
260 270 280 290 300
INAADNSGKT ALHWAAAVNN TEAVNILLMH HANRDAQDDK DETPLFLAAR
310 320 330 340 350
EGSYEACKAL LDNFANREIT DHMDRLPRDV ASERLHHDIV RLLDEHVPRS
360 370 380 390 400
PQMLSMTPQA MIGSPPPGQQ QPQLITQPTV ISAGNGGNNG NGNASGKQSN
410 420 430 440 450
QTAKQKAAKK AKLIEGSPDN GLDATGSLRR KASSKKTSAA SKKAANLNGL
460 470 480 490 500
NPGQLTGGVS GVPGVPPTNS AAQAAAAAAA AVAAMSHELE GSPVGVGMGG
510 520
NLPSPYDTSS MYSNAMAAPL ANGNPNT
Length:527
Mass (Da):55,017
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i759918E0CB1E13D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei527Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF360581 Genomic DNA Translation: AAL72168.1
AF360582 Genomic DNA Translation: AAL72169.1
AF360583 Genomic DNA Translation: AAL72170.1
AF360584 Genomic DNA Translation: AAL72171.1
AF360585 Genomic DNA Translation: AAL72172.1
AF360586 Genomic DNA Translation: AAL72173.1
AF360587 Genomic DNA Translation: AAL72174.1
AF360588 Genomic DNA Translation: AAL72175.1
AF360589 Genomic DNA Translation: AAL72176.1
AF360590 Genomic DNA Translation: AAL72177.1
AF360591 Genomic DNA Translation: AAL72178.1
AF360592 Genomic DNA Translation: AAL72179.1
AF360593 Genomic DNA Translation: AAL72180.1
AF360594 Genomic DNA Translation: AAL72181.1
AF360595 Genomic DNA Translation: AAL72182.1
AF360598 Genomic DNA Translation: AAL72185.1
AF360599 Genomic DNA Translation: AAL72186.1
AF360600 Genomic DNA Translation: AAL72187.1
AF360601 Genomic DNA Translation: AAL72188.1
AF360603 Genomic DNA Translation: AAL72190.1
AF360605 Genomic DNA Translation: AAL72192.1
AF360606 Genomic DNA Translation: AAL72193.1
AF360607 Genomic DNA Translation: AAL72194.1
AF360608 Genomic DNA Translation: AAL72195.1
AF360609 Genomic DNA Translation: AAL72196.1
AF360610 Genomic DNA Translation: AAL72197.1
AF360611 Genomic DNA Translation: AAL72198.1
AF360612 Genomic DNA Translation: AAL72199.1
AF360613 Genomic DNA Translation: AAL72200.1
AF360614 Genomic DNA Translation: AAL72201.1
AF360615 Genomic DNA Translation: AAL72202.1
AF360616 Genomic DNA Translation: AAL72203.1
AF360617 Genomic DNA Translation: AAL72204.1
AF360618 Genomic DNA Translation: AAL72205.1
AF360619 Genomic DNA Translation: AAL72206.1
AF360620 Genomic DNA Translation: AAL72207.1
AF360621 Genomic DNA Translation: AAL72208.1
AF360622 Genomic DNA Translation: AAL72209.1
AF360623 Genomic DNA Translation: AAL72210.1
AF360624 Genomic DNA Translation: AAL72211.1
AF360625 Genomic DNA Translation: AAL72212.1
AF360626 Genomic DNA Translation: AAL72213.1
AF360627 Genomic DNA Translation: AAL72214.1
AF360628 Genomic DNA Translation: AAL72215.1
AF360629 Genomic DNA Translation: AAL72216.1
AF360630 Genomic DNA Translation: AAL72217.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF360581 Genomic DNA Translation: AAL72168.1
AF360582 Genomic DNA Translation: AAL72169.1
AF360583 Genomic DNA Translation: AAL72170.1
AF360584 Genomic DNA Translation: AAL72171.1
AF360585 Genomic DNA Translation: AAL72172.1
AF360586 Genomic DNA Translation: AAL72173.1
AF360587 Genomic DNA Translation: AAL72174.1
AF360588 Genomic DNA Translation: AAL72175.1
AF360589 Genomic DNA Translation: AAL72176.1
AF360590 Genomic DNA Translation: AAL72177.1
AF360591 Genomic DNA Translation: AAL72178.1
AF360592 Genomic DNA Translation: AAL72179.1
AF360593 Genomic DNA Translation: AAL72180.1
AF360594 Genomic DNA Translation: AAL72181.1
AF360595 Genomic DNA Translation: AAL72182.1
AF360598 Genomic DNA Translation: AAL72185.1
AF360599 Genomic DNA Translation: AAL72186.1
AF360600 Genomic DNA Translation: AAL72187.1
AF360601 Genomic DNA Translation: AAL72188.1
AF360603 Genomic DNA Translation: AAL72190.1
AF360605 Genomic DNA Translation: AAL72192.1
AF360606 Genomic DNA Translation: AAL72193.1
AF360607 Genomic DNA Translation: AAL72194.1
AF360608 Genomic DNA Translation: AAL72195.1
AF360609 Genomic DNA Translation: AAL72196.1
AF360610 Genomic DNA Translation: AAL72197.1
AF360611 Genomic DNA Translation: AAL72198.1
AF360612 Genomic DNA Translation: AAL72199.1
AF360613 Genomic DNA Translation: AAL72200.1
AF360614 Genomic DNA Translation: AAL72201.1
AF360615 Genomic DNA Translation: AAL72202.1
AF360616 Genomic DNA Translation: AAL72203.1
AF360617 Genomic DNA Translation: AAL72204.1
AF360618 Genomic DNA Translation: AAL72205.1
AF360619 Genomic DNA Translation: AAL72206.1
AF360620 Genomic DNA Translation: AAL72207.1
AF360621 Genomic DNA Translation: AAL72208.1
AF360622 Genomic DNA Translation: AAL72209.1
AF360623 Genomic DNA Translation: AAL72210.1
AF360624 Genomic DNA Translation: AAL72211.1
AF360625 Genomic DNA Translation: AAL72212.1
AF360626 Genomic DNA Translation: AAL72213.1
AF360627 Genomic DNA Translation: AAL72214.1
AF360628 Genomic DNA Translation: AAL72215.1
AF360629 Genomic DNA Translation: AAL72216.1
AF360630 Genomic DNA Translation: AAL72217.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ7YSQ1
PRIDEiQ7YSQ1

Organism-specific databases

FlyBaseiFBgn0004647 N

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
HOGENOMiCLU_000576_0_1_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
N fly

Gene expression databases

BgeeiFBgn0004647 Expressed in embryo and 29 other tissues

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7YSQ1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YSQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: February 26, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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