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Entry version 120 (18 Sep 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Adapter protein unc-53

Gene

unc-53

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the migration and outgrowth of muscles, axons and excretory canals.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: WormBase
  • calmodulin binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Developmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adapter protein unc-53
Alternative name(s):
Uncoordinated protein 53
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-53
ORF Names:F45E10.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F45E10.1a ; CE31346 ; WBGene00006788 ; unc-53
F45E10.1b ; CE31347 ; WBGene00006788 ; unc-53
F45E10.1c ; CE33783 ; WBGene00006788 ; unc-53
F45E10.1d ; CE34019 ; WBGene00006788 ; unc-53
F45E10.1e ; CE34020 ; WBGene00006788 ; unc-53

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002869791 – 1654Adapter protein unc-53Add BLAST1654

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7YSI9

PRoteomics IDEntifications database

More...
PRIDEi
Q7YSI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00006788 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7YSI9 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with sem-5 (PubMed:12091307).

Interacts with cmd-1 in the presence of Ca2+ (PubMed:17854888).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
40003, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q7YSI9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F45E10.1c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 115Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili962 – 994Sequence analysisAdd BLAST33
Coiled coili1152 – 1184Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi166 – 438Ser-richAdd BLAST273
Compositional biasi661 – 920Ser-richAdd BLAST260
Compositional biasi1058 – 1099Ser-richAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGVF Eukaryota
ENOG410XRG8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154781

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7YSI9

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARDLECY

Database of Orthologous Groups

More...
OrthoDBi
113614at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR039041 Nav/unc-53
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR12784 PTHR12784, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307 CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform c (identifier: Q7YSI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTSNVELIP IYTDWANRHL SKGSLSKSIR DISNDFRDYR LVSQLINVIV
60 70 80 90 100
PINEFSPAFT KRLAKITSNL DGLETCLDYL KNLGLDCSKL TKTDIDSGNL
110 120 130 140 150
GAVLQLLFLL STYKQKLRQL KKDQKKLEQL PTSIMPPAVS KLPSPRVATS
160 170 180 190 200
ATASATNPNS NFPQMSTSRL QTPQSRISKI DSSKIGIKPK TSGLKPPSSS
210 220 230 240 250
TTSSNNTNSF RPSSRSSGNN NVGSTISTSA KSLESSSTYS SISNLNRPTS
260 270 280 290 300
QLQKPSRPQT QLVRVATTTK IGSSKLAAPK AVSTPKLASV KTIGAKQEPD
310 320 330 340 350
NSGGGGGGML KLKLFSSKNP SSSSNSPQPT RKAAAVPQQQ TLSKIAAPVK
360 370 380 390 400
SGLKPPTSKL GSATSMSKLC TPKVSYRKTD APIISQQDSK RCSKSSEEES
410 420 430 440 450
GYAGFNSTSP TSSSTEGSLS MHSTSSKSST SDEKSPSSDD LTLNASIVTA
460 470 480 490 500
IRQPIAATPV SPNIINKPVE EKPTLAVKGV KSTAKKDPPP AVPPRDTQPT
510 520 530 540 550
IGVVSPIMAH KKLTNDPVIS EKPEPEKLQS MSIDTTDVPP LPPLKSVVPL
560 570 580 590 600
KMTSIRQPPT YDVLLKQGKI TSPVKSFGYE QSSASEDSIV AHASAQVTPP
610 620 630 640 650
TKTSGNHSLE RRMGKNKTSE SSGYTSDAGV AMCAKMREKL KEYDDMTRRA
660 670 680 690 700
QNGYPDNFED SSSLSSGISD NNELDDISTD DLSGVDMATV ASKHSDYSHF
710 720 730 740 750
VRHPTSSSSK PRVPSRSSTS VDSRSRAEQE NVYKLLSQCR TSQRGAAATS
760 770 780 790 800
TFGQHSLRSP GYSSYSPHLS VSADKDTMSM HSQTSRRPSS QKPSYSGQFH
810 820 830 840 850
SLDRKCHLQE FTSTEHRMAA LLSPRRVPNS MSKYDSSAAA LNASGMSRSM
860 870 880 890 900
ILLESLSPRP PRRHQSPADS CIITASPSAP RRSHSPRGPT ARIPLSLASS
910 920 930 940 950
PVHVNNNWGS YSARSRGGSS TGIYGETFQL HRLSDEKSPA HSAKSEMGSQ
960 970 980 990 1000
LSLASTTAYG SLNEKYEHAI RDMARDLECY KNTVDSLTKK QENYGALFDL
1010 1020 1030 1040 1050
FEQKLRKLTQ HIDRSNLKPE EAIRFRQDIA HLRDISNHLA SNSAHANEGA
1060 1070 1080 1090 1100
GELLRQPSLE SVASHRSSMS SSSKSSKQEK ISLSSFGKNK KSWIRSSLSK
1110 1120 1130 1140 1150
FTKKKNKNYD EAHMPSISGS QGTLDNIDVI ELKQELKERD SALYEVRLDN
1160 1170 1180 1190 1200
LDRAREVDVL RETVNKLKTE NKQLKKEVDK LTNGPATRAS SRASIPVIYD
1210 1220 1230 1240 1250
DEHVYDAACS STSASQSSKR SSGCNSIKVT VNVDIAGEIS SIVNPDKEII
1260 1270 1280 1290 1300
VGYLAMPTSQ SCWKDIDVSI LGLFEVYLSR IDVEHQLGID ARDSILGYQI
1310 1320 1330 1340 1350
GELRRVIGDS TTMITSHPTD ILTSSTTIRM FMHGAAQSRV DSLVLDMLLP
1360 1370 1380 1390 1400
KQMILQLVKS ILTERRLVLA GATGIGKSKL AKTLAAYVSI RTNQSEDSIV
1410 1420 1430 1440 1450
NISIPENNKE ELLQVERRLE KILRSKESCI VILDNIPKNR IAFVVSVFAN
1460 1470 1480 1490 1500
VPLQNNEGPF VVCTVNRYQI PELQIHHNFK MSVMSNRLEG FILRYLRRRA
1510 1520 1530 1540 1550
VEDEYRLTVQ MPSELFKIID FFPIALQAVN NFIEKTNSVD VTVGPRACLN
1560 1570 1580 1590 1600
CPLTVDGSRE WFIRLWNENF IPYLERVARD GKKTFGRCTS FEDPTDIVSE
1610 1620 1630 1640 1650
KWPWFDGENP ENVLKRLQLQ DLVPSPANSS RQHFNPLESL IQLHATKHQT

IDNI
Length:1,654
Mass (Da):181,427
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD33B8C651BAF0453
GO
Isoform a (identifier: Q7YSI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-908: Missing.

Show »
Length:1,583
Mass (Da):173,909
Checksum:iE723794ADB04FC62
GO
Isoform b (identifier: Q7YSI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-908: Missing.
     1093-1093: W → WALSVDSQ

Note: No experimental confirmation available.
Show »
Length:1,549
Mass (Da):169,879
Checksum:i1415303851B38921
GO
Isoform e (identifier: Q7YSI9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Note: No experimental confirmation available.
Show »
Length:1,234
Mass (Da):136,761
Checksum:iA8584633257CEC54
GO
Isoform d (identifier: Q7YSI9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.
Show »
Length:1,520
Mass (Da):166,241
Checksum:iEA2E51EC7C5371EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EEU6G5EEU6_CAEEL
Calponin-homology (CH) domain-conta...
unc-53 CELE_F45E10.1, F45E10.1
1,542Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EBX1G5EBX1_CAEEL
Calponin-homology (CH) domain-conta...
unc-53 CELE_F45E10.1, F45E10.1
1,613Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C8JQR2C8JQR2_CAEEL
Adapter protein unc-53
unc-53 CELE_F45E10.1, F45E10.1
1,346Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1257P → S in AAM22693 (PubMed:12091307).Curated1
Sequence conflicti1600E → K in AAM22693 (PubMed:12091307).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0252701 – 420Missing in isoform e. CuratedAdd BLAST420
Alternative sequenceiVSP_0252711 – 134Missing in isoform d. CuratedAdd BLAST134
Alternative sequenceiVSP_025272797 – 908Missing in isoform b. CuratedAdd BLAST112
Alternative sequenceiVSP_025273838 – 908Missing in isoform a. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0252741093W → WALSVDSQ in isoform b. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF504312 mRNA Translation: AAM22693.1
Z50109, Z47810 Genomic DNA Translation: CAD44091.1
Z50109, Z47810 Genomic DNA Translation: CAD44092.1
Z47810, Z50109 Genomic DNA Translation: CAD44132.1
Z47810, Z50109 Genomic DNA Translation: CAD44133.1
Z50109, Z47810 Genomic DNA Translation: CAD89729.3
Z47810, Z50109 Genomic DNA Translation: CAD89730.3
Z50109, Z47810 Genomic DNA Translation: CAD91624.1
Z47810 Genomic DNA Translation: CAD91631.1
Z47810, Z50109 Genomic DNA Translation: CAD91632.1

NCBI Reference Sequences

More...
RefSeqi
NP_001022169.1, NM_001026998.3 [Q7YSI9-3]
NP_001022170.1, NM_001026999.5 [Q7YSI9-1]
NP_001022171.1, NM_001027000.3 [Q7YSI9-5]
NP_001022172.1, NM_001027001.3 [Q7YSI9-4]
NP_741045.1, NM_171039.2 [Q7YSI9-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F45E10.1a.1; F45E10.1a.1; WBGene00006788 [Q7YSI9-2]
F45E10.1b.1; F45E10.1b.1; WBGene00006788 [Q7YSI9-3]
F45E10.1c.1; F45E10.1c.1; WBGene00006788 [Q7YSI9-1]
F45E10.1d.1; F45E10.1d.1; WBGene00006788 [Q7YSI9-5]
F45E10.1e.1; F45E10.1e.1; WBGene00006788 [Q7YSI9-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174693

UCSC genome browser

More...
UCSCi
F45E10.1a c. elegans [Q7YSI9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504312 mRNA Translation: AAM22693.1
Z50109, Z47810 Genomic DNA Translation: CAD44091.1
Z50109, Z47810 Genomic DNA Translation: CAD44092.1
Z47810, Z50109 Genomic DNA Translation: CAD44132.1
Z47810, Z50109 Genomic DNA Translation: CAD44133.1
Z50109, Z47810 Genomic DNA Translation: CAD89729.3
Z47810, Z50109 Genomic DNA Translation: CAD89730.3
Z50109, Z47810 Genomic DNA Translation: CAD91624.1
Z47810 Genomic DNA Translation: CAD91631.1
Z47810, Z50109 Genomic DNA Translation: CAD91632.1
RefSeqiNP_001022169.1, NM_001026998.3 [Q7YSI9-3]
NP_001022170.1, NM_001026999.5 [Q7YSI9-1]
NP_001022171.1, NM_001027000.3 [Q7YSI9-5]
NP_001022172.1, NM_001027001.3 [Q7YSI9-4]
NP_741045.1, NM_171039.2 [Q7YSI9-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi40003, 2 interactors
IntActiQ7YSI9, 1 interactor
STRINGi6239.F45E10.1c

Proteomic databases

PaxDbiQ7YSI9
PRIDEiQ7YSI9

Genome annotation databases

EnsemblMetazoaiF45E10.1a.1; F45E10.1a.1; WBGene00006788 [Q7YSI9-2]
F45E10.1b.1; F45E10.1b.1; WBGene00006788 [Q7YSI9-3]
F45E10.1c.1; F45E10.1c.1; WBGene00006788 [Q7YSI9-1]
F45E10.1d.1; F45E10.1d.1; WBGene00006788 [Q7YSI9-5]
F45E10.1e.1; F45E10.1e.1; WBGene00006788 [Q7YSI9-4]
GeneIDi174693
UCSCiF45E10.1a c. elegans [Q7YSI9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
174693
WormBaseiF45E10.1a ; CE31346 ; WBGene00006788 ; unc-53
F45E10.1b ; CE31347 ; WBGene00006788 ; unc-53
F45E10.1c ; CE33783 ; WBGene00006788 ; unc-53
F45E10.1d ; CE34019 ; WBGene00006788 ; unc-53
F45E10.1e ; CE34020 ; WBGene00006788 ; unc-53

Phylogenomic databases

eggNOGiENOG410IGVF Eukaryota
ENOG410XRG8 LUCA
GeneTreeiENSGT00940000168701
HOGENOMiHOG000154781
InParanoidiQ7YSI9
OMAiARDLECY
OrthoDBi113614at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:Q7YSI9

Gene expression databases

BgeeiWBGene00006788 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)
ExpressionAtlasiQ7YSI9 baseline and differential

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR039041 Nav/unc-53
IPR027417 P-loop_NTPase
PANTHERiPTHR12784 PTHR12784, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC53_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YSI9
Secondary accession number(s): Q7YSI0
, Q7YXD0, Q8MLZ1, Q8MM94, Q8MV03
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: September 18, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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